{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:05:59Z","timestamp":1791515159215,"version":"4.3.4"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The function of perilipin 1 in human metabolism was recently highlighted by the description of PLIN1 variants associated with various pathologies. These include severe familial partial lipodystrophy and early onset acute coronary syndrome. Additionally, certain variants have been reported to have a protective effect on cardiovascular diseases. The role of this protein remains controversial in mice and variant interpretation in humans is still conflicting. This literature review has two primary objectives (i) to clarify the function of the PLIN1 gene in lipid metabolism and atherosclerosis by examining functional studies performed in cells (adipocytes) and mice and (ii) to understand the impact of PLIN1 variants identified in humans based on the variant\u2019s location within the protein and the type of variant (missense or frameshift). To achieve these objectives, we conducted an extensive analysis of the relevant literature on perilipin 1, its function in cellular models and mice, and the consequences of its mutations in humans. We also utilized bioinformatics tools and consulted the Human Genetics Cardiovascular Disease Knowledge Portal to enhance the pathogenicity assessment of PLIN1 missense variants.<\/jats:p>","DOI":"10.1093\/cvr\/cvae005","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:15:07Z","timestamp":1705076107000},"page":"237-248","source":"Crossref","is-referenced-by-count":38,"title":["Perilipin 1: a systematic review on its functions on lipid metabolism and atherosclerosis in mice and humans"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-687X","authenticated-orcid":false,"given":"Camille","family":"Desgrouas","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, INSERM, Marseille Medical Genetics , Faculte de m\u00e9decine, 27 Bd Jean Moulin 13005 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabea","family":"Thalheim","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, Marseille Medical Genetics , Faculte de m\u00e9decine, 27 Bd Jean Moulin 13005 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Cerino","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, Marseille Medical Genetics , Faculte de m\u00e9decine, 27 Bd Jean Moulin 13005 Marseille , France"},{"name":"AP-HM, Service de Biochimie , H\u00f4pital de la Timone 264 rue Saint Pierre 13005 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-310X","authenticated-orcid":false,"given":"Catherine","family":"Badens","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, Marseille Medical Genetics , Faculte de m\u00e9decine, 27 Bd Jean Moulin 13005 Marseille , France"},{"name":"AP-HM, Service de Biochimie , H\u00f4pital de la Timone 264 rue Saint Pierre 13005 Marseille , France"},{"name":"D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale, APHM, H\u00f4pital Timone Enfants , H\u00f4pital de la Timone 264 rue Saint Pierre 13005 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8657-1271","authenticated-orcid":false,"given":"Nathalie","family":"Bonello-Palot","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, INSERM, Marseille Medical Genetics , Faculte de m\u00e9decine, 27 Bd Jean Moulin 13005 Marseille , France"},{"name":"D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale, APHM, H\u00f4pital Timone Enfants , H\u00f4pital de la Timone 264 rue Saint Pierre 13005 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"2024041211102990500_cvae005-B1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1194\/jlr.R000034","article-title":"Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins","volume":"51","author":"Kimmel","year":"2010","journal-title":"J Lipid Res"},{"key":"2024041211102990500_cvae005-B2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","article-title":"The perilipin family of lipid droplet proteins: gatekeepers of intracellular lipolysis","volume":"1862","author":"Sztalryd","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2024041211102990500_cvae005-B3","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1016\/S0021-9258(18)99168-4","article-title":"Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets","volume":"266","author":"Greenberg","year":"1991","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/hh1801.096340","article-title":"Identification of genes potentially involved in rupture of human atherosclerotic plaques","volume":"89","author":"Faber","year":"2001","journal-title":"Circ Res"},{"key":"2024041211102990500_cvae005-B5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-2275(20)41207-6","article-title":"In vivo regulation of lipolysis in humans","volume":"35","author":"Coppack","year":"1994","journal-title":"J Lipid Res"},{"key":"2024041211102990500_cvae005-B6","doi-asserted-by":"crossref","first-page":"51535","DOI":"10.1074\/jbc.M309591200","article-title":"Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis","volume":"278","author":"Zhang","year":"2003","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B7","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.1074\/jbc.M108329200","article-title":"Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system","volume":"277","author":"Souza","year":"2002","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12882-018-0913-6","article-title":"The renal manifestations of type 4 familial partial lipodystrophy: a case report and review of literature","volume":"19","author":"Chen","year":"2018","journal-title":"BMC Nephrol"},{"key":"2024041211102990500_cvae005-B9","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1210\/jc.2019-00849","article-title":"Diagnostic challenge in PLIN1-associated familial partial lipodystrophy","volume":"104","author":"J\u00e9ru","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"2024041211102990500_cvae005-B10","doi-asserted-by":"crossref","first-page":"34998","DOI":"10.1074\/jbc.M111.278853","article-title":"Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5)","volume":"286","author":"Gandotra","year":"2011","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2337\/db14-0104","article-title":"Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy","volume":"64","author":"Kozusko","year":"2015","journal-title":"Diabetes"},{"key":"2024041211102990500_cvae005-B12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.atherosclerosis.2019.12.002","article-title":"High prevalence of mutations in perilipin 1 in patients with precocious acute coronary syndrome","volume":"293","author":"Bonello-Palot","year":"2020","journal-title":"Atherosclerosis"},{"key":"2024041211102990500_cvae005-B13","doi-asserted-by":"crossref","first-page":"e2318","DOI":"10.1210\/clinem\/dgac104","article-title":"PLIN1 haploinsufficiency causes a favorable metabolic profile","volume":"107","author":"Patel","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"2024041211102990500_cvae005-B14","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1210\/jc.2017-02662","article-title":"PLIN1 haploinsufficiency is not associated with lipodystrophy","volume":"103","author":"Laver","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2024041211102990500_cvae005-B15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/1476-511X-10-169","article-title":"Increased atherosclerosis in mice deficient in perilipin1","volume":"10","author":"Langlois","year":"2011","journal-title":"Lipids Health Dis"},{"key":"2024041211102990500_cvae005-B16","doi-asserted-by":"crossref","first-page":"e0123738","DOI":"10.1371\/journal.pone.0123738","article-title":"Perilipin1 deficiency in whole body or bone marrow-derived cells attenuates lesions in atherosclerosis-prone mice","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"2024041211102990500_cvae005-B17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.atherosclerosis.2018.01.019","article-title":"Overexpression of perilipin1 protects against atheroma progression in apolipoprotein E knockout mice","volume":"269","author":"Yamamoto","year":"2018","journal-title":"Atherosclerosis"},{"key":"2024041211102990500_cvae005-B18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.dib.2018.05.027","article-title":"The data of change in macrophage gene expression which induced by perilipin 1 overexpression","volume":"19","author":"Yamamoto","year":"2018","journal-title":"Data Brief"},{"key":"2024041211102990500_cvae005-B19","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.bbamem.2013.12.003","article-title":"Membrane attachment and structure models of lipid storage droplet protein 1","volume":"1838","author":"Lin","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2024041211102990500_cvae005-B20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/geno.1997.5179","article-title":"Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method","volume":"48","author":"Nishiu","year":"1998","journal-title":"Genomics"},{"key":"2024041211102990500_cvae005-B21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11010-008-9998-8","article-title":"Perilipin A and the control of triacylglycerol metabolism","volume":"326","author":"Brasaemle","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"2024041211102990500_cvae005-B22","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1073\/pnas.90.24.12035","article-title":"Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes","volume":"90","author":"Greenberg","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024041211102990500_cvae005-B23","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0022-2275(20)41129-0","article-title":"Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes","volume":"36","author":"Blanchette-Mackie","year":"1995","journal-title":"J Lipid Res"},{"key":"2024041211102990500_cvae005-B24","doi-asserted-by":"crossref","first-page":"16970","DOI":"10.1074\/jbc.270.28.16970","article-title":"Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells","volume":"270","author":"Servetnick","year":"1995","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0960-9822(03)00175-1","article-title":"Control of fat storage by a Drosophila PAT domain protein","volume":"13","author":"Gr\u00f6nke","year":"2003","journal-title":"Curr Biol"},{"key":"2024041211102990500_cvae005-B26","doi-asserted-by":"crossref","first-page":"21110","DOI":"10.1074\/jbc.M609592200","article-title":"The Metarhizium anisopliae perilipin homolog MPL1 regulates lipid metabolism, appressorial turgor pressure, and virulence","volume":"282","author":"Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbalip.2009.04.002","article-title":"PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores","volume":"1791","author":"Bickel","year":"2009","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2024041211102990500_cvae005-B28","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00335-01-2055-5","article-title":"The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin","volume":"12","author":"Lu","year":"2001","journal-title":"Mamm Genome"},{"key":"2024041211102990500_cvae005-B29","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0022-2836(03)00520-5","article-title":"A structural and functional role for 11-mer repeats in \u03b1-synuclein and other exchangeable lipid binding proteins","volume":"329","author":"Bussell","year":"2003","journal-title":"J Mol Biol"},{"key":"2024041211102990500_cvae005-B30","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1074\/jbc.M115.691048","article-title":"Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1\u20133","volume":"291","author":"Rowe","year":"2016","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1074\/jbc.M206602200","article-title":"The central domain is required to target and anchor perilipin A to lipid droplets","volume":"278","author":"Garcia","year":"2003","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B32","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1194\/jlr.M400291-JLR200","article-title":"Hydrophobic sequences target and anchor perilipin A to lipid droplets","volume":"45","author":"Subramanian","year":"2004","journal-title":"J Lipid Res"},{"key":"2024041211102990500_cvae005-B33","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1091\/mbc.E18-08-0534","article-title":"Dual binding motifs underpin the hierarchical association of perilipins1\u20133 with lipid droplets","volume":"30","author":"Ajjaji","year":"2019","journal-title":"Mol Biol Cell"},{"key":"2024041211102990500_cvae005-B34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat Methods"},{"key":"2024041211102990500_cvae005-B35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF chimerax: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci"},{"key":"2024041211102990500_cvae005-B36","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1093\/bioinformatics\/btn392","article-title":"HELIQUEST: a web server to screen sequences with specific \u03b1-helical properties","volume":"24","author":"Gautier","year":"2008","journal-title":"Bioinformatics"},{"key":"2024041211102990500_cvae005-B37","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1002\/cpbi.108","article-title":"Protein sequence analysis using the MPI bioinformatics toolkit","volume":"72","author":"Gabler","year":"2020","journal-title":"Curr Protoc Bioinformatics"},{"key":"2024041211102990500_cvae005-B38","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.str.2004.04.021","article-title":"Structure of a lipid droplet protein","volume":"12","author":"Hickenbottom","year":"2004","journal-title":"Structure"},{"key":"2024041211102990500_cvae005-B39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cellsig.2005.08.009","article-title":"Signalling mechanisms regulating lipolysis","volume":"18","author":"Carmen","year":"2006","journal-title":"Cell Signal"},{"key":"2024041211102990500_cvae005-B40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1388-1981(99)00179-1","article-title":"The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets","volume":"1483","author":"Brasaemle","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"2024041211102990500_cvae005-B41","doi-asserted-by":"crossref","first-page":"15837","DOI":"10.1074\/jbc.M601097200","article-title":"Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms","volume":"281","author":"Miyoshi","year":"2006","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B42","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1074\/jbc.M610580200","article-title":"Analysis of lipolytic protein trafficking and interactions in adipocytes","volume":"282","author":"Granneman","year":"2007","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B43","doi-asserted-by":"crossref","first-page":"e55511","DOI":"10.1371\/journal.pone.0055511","article-title":"Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis","volume":"8","author":"McDonough","year":"2013","journal-title":"PLoS One"},{"key":"2024041211102990500_cvae005-B44","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.1074\/jbc.M211005200","article-title":"Functional studies on native and mutated forms of perilipins","volume":"278","author":"Tansey","year":"2003","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B45","doi-asserted-by":"crossref","first-page":"e66837","DOI":"10.1371\/journal.pone.0066837","article-title":"Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion","volume":"8","author":"Orlicky","year":"2013","journal-title":"PLoS One"},{"key":"2024041211102990500_cvae005-B46","doi-asserted-by":"crossref","first-page":"11901","DOI":"10.1074\/jbc.M600171200","article-title":"The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion","volume":"281","author":"Marcinkiewicz","year":"2006","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B47","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1074\/jbc.M605770200","article-title":"Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes","volume":"282","author":"Miyoshi","year":"2007","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B48","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1089\/adt.2010.0302","article-title":"Quantification of hormone sensitive lipase phosphorylation and colocalization with lipid droplets in murine 3T3L1 and human subcutaneous adipocytes via automated digital microscopy and high-content analysis","volume":"9","author":"McDonough","year":"2011","journal-title":"Assay Drug Dev Technol"},{"key":"2024041211102990500_cvae005-B49","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.atherosclerosis.2011.10.026","article-title":"Expression of fat mobilizing genes in human epicardial adipose tissue","volume":"220","author":"Jaffer","year":"2012","journal-title":"Atherosclerosis"},{"key":"2024041211102990500_cvae005-B50","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jcp.28972","article-title":"The key microRNA on lipid droplet formation during adipogenesis from human mesenchymal stem cells","volume":"235","author":"Yi","year":"2020","journal-title":"J Cell Physiol"},{"key":"2024041211102990500_cvae005-B51","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1161\/01.ATV.0000174123.19103.52","article-title":"Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression","volume":"25","author":"Forcheron","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024041211102990500_cvae005-B52","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.atherosclerosis.2005.12.016","article-title":"Perilipin, a potential substitute for adipophilin in triglyceride storage in human macrophages","volume":"189","author":"Larigauderie","year":"2006","journal-title":"Atherosclerosis"},{"key":"2024041211102990500_cvae005-B53","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.atherosclerosis.2006.06.010","article-title":"Expression of perilipin isoforms in cell types involved in atherogenesis","volume":"190","author":"Hofnagel","year":"2007","journal-title":"Atherosclerosis"},{"key":"2024041211102990500_cvae005-B54","doi-asserted-by":"crossref","first-page":"170","DOI":"10.5551\/jat.63153","article-title":"Lipid droplet protein PLIN1 regulates inflammatory polarity in human macrophages and is involved in atherosclerotic plaque development by promoting stable lipid storage","volume":"30","author":"Cho","year":"2023","journal-title":"J Atheroscler Thromb"},{"key":"2024041211102990500_cvae005-B55","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.11.020","article-title":"The phenotype of infiltrating macrophages influences arteriosclerotic plaque vulnerability in the carotid artery","volume":"22","author":"Cho","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2024041211102990500_cvae005-B56","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/CIRCRESAHA.107.168070","article-title":"Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis","volume":"102","author":"Paul","year":"2008","journal-title":"Circ Res"},{"key":"2024041211102990500_cvae005-B57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1744-9987.2012.01080.x","article-title":"Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile","volume":"16","author":"Eleftheriadis","year":"2012","journal-title":"Ther Apher Dial"},{"key":"2024041211102990500_cvae005-B58","doi-asserted-by":"crossref","first-page":"e0117536","DOI":"10.1371\/journal.pone.0117536","article-title":"Defective differentiation of adipose precursor cells from lipodystrophic mice lacking perilipin 1","volume":"10","author":"Lyu","year":"2015","journal-title":"PLoS One"},{"key":"2024041211102990500_cvae005-B59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cvr\/cvu214","article-title":"Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction","volume":"105","author":"Liu","year":"2015","journal-title":"Cardiovasc Res"},{"key":"2024041211102990500_cvae005-B60","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbadis.2015.10.024","article-title":"Spontaneous hypertension occurs with adipose tissue dysfunction in perilipin-1 null mice","volume":"1862","author":"Zou","year":"2016","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2024041211102990500_cvae005-B61","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbalip.2017.11.007","article-title":"Spontaneous development of hepatosteatosis in perilipin-1 null mice with adipose tissue dysfunction","volume":"1863","author":"Wei","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2024041211102990500_cvae005-B62","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.101042998","article-title":"Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity","volume":"98","author":"Tansey","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024041211102990500_cvae005-B63","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/82630","article-title":"Absence of perilipin results in leanness and reverses obesity in lepr(db\/db) mice","volume":"26","author":"Martinez-Botas","year":"2000","journal-title":"Nat Genet"},{"key":"2024041211102990500_cvae005-B64","doi-asserted-by":"crossref","first-page":"35150","DOI":"10.1074\/jbc.M405499200","article-title":"Metabolic adaptations in the absence of perilipin","volume":"279","author":"Saha","year":"2004","journal-title":"J Biol Chem"},{"key":"2024041211102990500_cvae005-B65","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.atherosclerosis.2006.12.006","article-title":"Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129\/SvEv and C57BL\/6 genetic backgrounds","volume":"195","author":"Maeda","year":"2007","journal-title":"Atherosclerosis"},{"key":"2024041211102990500_cvae005-B66","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1007487","article-title":"Perilipin deficiency and autosomal dominant partial lipodystrophy","volume":"364","author":"Gandotra","year":"2011","journal-title":"N Engl J Med"},{"key":"2024041211102990500_cvae005-B67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ajhg.2021.11.021","article-title":"Rare coding variants in 35 genes associate with circulating lipid levels\u2014a multi-ancestry analysis of 170,000 exomes","volume":"109","author":"Hindy","year":"2022","journal-title":"Am J Hum Genet"},{"key":"2024041211102990500_cvae005-B68","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.bbrc.2014.12.053","article-title":"A functional variant in the exon 5 of PLIN1 reduces risk of central obesity by possible regulation of lipid storage","volume":"456","author":"Song","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"2024041211102990500_cvae005-B69","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/molbev\/msy211","article-title":"Genomic evidence of local adaptation to climate and diet in indigenous siberians","volume":"36","author":"Hallmark","year":"2019","journal-title":"Mol Biol Evol"},{"key":"2024041211102990500_cvae005-B70","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ajhg.2023.02.002","article-title":"Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank","volume":"110","author":"Nag","year":"2023","journal-title":"Am J Hum Genet"},{"key":"2024041211102990500_cvae005-B71","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/gepi.22511","article-title":"Efficient identification of trait-associated loss-of-function variants in the UK Biobank cohort by exome-sequencing based genotype imputation","volume":"47","author":"Yu","year":"2023","journal-title":"Genet Epidemiol"},{"key":"2024041211102990500_cvae005-B72","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1021\/pr400074f","article-title":"Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1","volume":"12","author":"Hennrich","year":"2013","journal-title":"J Proteome Res"},{"key":"2024041211102990500_cvae005-B73","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/jc.2011-1159","article-title":"Clinical review#: lipodystrophies: genetic and acquired body fat disorders","volume":"96","author":"Garg","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2024041211102990500_cvae005-B74","doi-asserted-by":"crossref","DOI":"10.1177\/10760296221128021","article-title":"Association between novel pro- and anti- inflammatory adipocytokines in patients with acute coronary syndrome","volume":"28","author":"Wei","year":"2022","journal-title":"Clin Appl Thromb Hemost"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae005\/56542011\/cvae005.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/3\/237\/57222120\/cvae005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/3\/237\/57222120\/cvae005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T11:11:18Z","timestamp":1712920278000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/120\/3\/237\/7517630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,1,12]]},"published-print":{"date-parts":[[2024,3,14]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae005","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,12]]}}}