{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:47:45Z","timestamp":1791841665050,"version":"4.3.4"},"reference-count":215,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ventricular arrhythmias in cardiac channelopathies are linked to autonomic triggers, which are sub-optimally targeted in current management strategies. Improved molecular understanding of cardiac channelopathies and cellular autonomic signalling could refine autonomic therapies to target the specific signalling pathways relevant to the specific aetiologies as well as the central nervous system centres involved in the cardiac autonomic regulation.<\/jats:p>\n               <jats:p>This review summarizes key anatomical and physiological aspects of the cardiac autonomic nervous system and its impact on ventricular arrhythmias in primary inherited arrhythmia syndromes. Proarrhythmogenic autonomic effects and potential therapeutic targets in defined conditions including the Brugada syndrome, early repolarization syndrome, long QT syndrome, and catecholaminergic polymorphic ventricular tachycardia will be examined. Pharmacological and interventional neuromodulation options for these cardiac channelopathies are discussed.<\/jats:p>\n               <jats:p>Promising new targets for cardiac neuromodulation include inhibitory and excitatory G-protein coupled receptors, neuropeptides, chemorepellents\/attractants as well as the vagal and sympathetic nuclei in the central nervous system. Novel therapeutic strategies utilizing invasive and non-invasive deep brain\/brain stem stimulation as well as the rapidly growing field of chemo-, opto-, or sonogenetics allowing cell-specific targeting to reduce ventricular arrhythmias are presented.<\/jats:p>","DOI":"10.1093\/cvr\/cvae009","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:29:51Z","timestamp":1704853791000},"page":"114-131","source":"Crossref","is-referenced-by-count":12,"title":["The proarrhythmogenic role of autonomics and emerging neuromodulation approaches to prevent sudden death in cardiac ion channelopathies"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-8384","authenticated-orcid":false,"given":"Johanna B","family":"Tonko","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Science, University College London , 5 University Street, London WC1E 6JF, London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier D","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London , 5 University Street, London WC1E 6JF, London , UK"},{"name":"Department for Cardiology, Bart\u2019s Heart Centre , West Smithfield EC1A 7BE, London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"2024031408350982300_cvae009-B1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.hrthm.2005.09.008","article-title":"Sudden death in the young","volume":"2","author":"Puranik","year":"2005","journal-title":"Heart Rhythm"},{"issue":"8","key":"2024031408350982300_cvae009-B2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jacbts.2020.07.004","article-title":"Cardiac sympathetic parasympathetic interaction: the endless story of yin and yang","volume":"5","author":"Dusi","year":"2020","journal-title":"JACC Basic Transl Sci"},{"issue":"3","key":"2024031408350982300_cvae009-B3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.RES.67.3.615","article-title":"Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. 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