{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:39:06Z","timestamp":1789573146219,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health & Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australia Project Grant","award":["GNT1159721"],"award-info":[{"award-number":["GNT1159721"]}]},{"name":"Senior Medical Research Fellowship"},{"DOI":"10.13039\/100008717","name":"Sylvia and Charles Viertel Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008717","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Heart Foundation Future Leader Fellowship","award":["105663"],"award-info":[{"award-number":["105663"]}]},{"name":"NHMRC Emerging Leader Fellowship","award":["GNT2017382"],"award-info":[{"award-number":["GNT2017382"]}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GTN2008017"],"award-info":[{"award-number":["GTN2008017"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Heart Foundation","award":["106698"],"award-info":[{"award-number":["106698"]}]},{"DOI":"10.13039\/100031243","name":"Faculty of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Monash Graduate Scholarship"},{"name":"The Baker Heart & Diabetes Institute"},{"name":"Victorian Government\u2019s Operational Infrastructure Support Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Animal models are regularly used to test the role of the gut microbiome in hypertension. Small-scale pre-clinical studies have investigated changes to the gut microbiome in the angiotensin II hypertensive model. However, the gut microbiome is influenced by internal and external experimental factors, which are not regularly considered in the study design. Once these factors are accounted for, it is unclear if microbiome signatures are reproduceable. We aimed to determine the influence of angiotensin II treatment on the gut microbiome using a large and diverse cohort of mice and to quantify the magnitude by which other factors contribute to microbiome variations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We conducted a retrospective study to establish a diverse mouse cohort resembling large human studies. We sequenced the V4 region of the 16S rRNA gene from 538 samples across the gastrointestinal tract of 303 male and female C57BL\/6J mice randomized into sham or angiotensin II treatment from different genotypes, diets, animal facilities, and age groups. Analysing over 17 million sequencing reads, we observed that angiotensin II treatment influenced \u03b1-diversity (P = 0.0137) and \u03b2-diversity (i.e. composition of the microbiome, P &amp;lt; 0.001). Bacterial abundance analysis revealed patterns consistent with a reduction in short-chain fatty acid producers, microbial metabolites that lower blood pressure. Furthermore, animal facility, genotype, diet, age, sex, intestinal sampling site, and sequencing batch had significant effects on both \u03b1- and \u03b2-diversity (all P &amp;lt; 0.001). Sampling site (6.8%) and diet (6%) had the largest impact on the microbiome, while angiotensin II and sex had the smallest effect (each 0.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our large-scale data confirmed findings from small-scale studies that angiotensin II impacted the gut microbiome. However, this effect was modest relative to most of the other factors studied. Accounting for these factors in future pre-clinical hypertensive studies will increase the likelihood that microbiome findings are replicable and translatable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvae062","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T19:31:33Z","timestamp":1710963093000},"page":"1155-1163","source":"Crossref","is-referenced-by-count":19,"title":["Influence of angiotensin II on the gut microbiome: modest effects in comparison to experimental factors"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-2123","authenticated-orcid":false,"given":"Rikeish","family":"R Muralitharan","sequence":"first","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"},{"name":"Institute for Medical Research, Ministry of Health Malaysia , Kuala Lumpur , Malaysia"},{"name":"Victorian Heart Institute, Monash University , 631 Blackburn Road, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Nakai","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-9550","authenticated-orcid":false,"given":"Matthew","family":"Snelson","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"},{"name":"Victorian Heart Institute, Monash University , 631 Blackburn Road, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-7481","authenticated-orcid":false,"given":"Tenghao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evany","family":"Dinakis","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xie","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Jama","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Paterson","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waled","family":"Shihata","sequence":"additional","affiliation":[{"name":"Heart Failure Research Group, Baker Heart and Diabetes Institute , 75 Commercial Road, 3004 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Wassef","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Disease Research (CCBDR), La Trobe Institute of Medical Science (LIMS), Bundoora , Victoria , Australia"},{"name":"Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University , Bundoora, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Vinh","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Disease Research (CCBDR), La Trobe Institute of Medical Science (LIMS), Bundoora , Victoria , Australia"},{"name":"Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University , Bundoora, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-9738","authenticated-orcid":false,"given":"Grant R","family":"Drummond","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Disease Research (CCBDR), La Trobe Institute of Medical Science (LIMS), Bundoora , Victoria , Australia"},{"name":"Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University , Bundoora, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Kaye","sequence":"additional","affiliation":[{"name":"Heart Failure Research Group, Baker Heart and Diabetes Institute , 75 Commercial Road, 3004 Melbourne , Australia"},{"name":"Department of Cardiology, Alfred Hospital , Melbourne , Australia"},{"name":"Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R","family":"Mackay","sequence":"additional","affiliation":[{"name":"Infection and Immunity Program, Monash Biodiscovery Institute, Monash University , Melbourne , Australia"},{"name":"Department of Biochemistry, Monash University , Melbourne , Australia"},{"name":"School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences) , Jinan 250014 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-9991","authenticated-orcid":false,"given":"Francine Z","family":"Marques","sequence":"additional","affiliation":[{"name":"Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University , 18 Innovation Walk, Clayton, 3800 Melbourne , Australia"},{"name":"Victorian Heart Institute, Monash University , 631 Blackburn Road, Clayton, 3800 Melbourne , Australia"},{"name":"Heart Failure Research Group, Baker Heart and Diabetes Institute , 75 Commercial Road, 3004 Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"2024090216320292000_cvae062-B1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"2024090216320292000_cvae062-B2","first-page":"336","article-title":"Variation in the gut microbiota of laboratory mice is related to both genetic and environmental factors","volume":"60","author":"Hufeldt","year":"2010","journal-title":"Comp Med"},{"key":"2024090216320292000_cvae062-B3","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1186\/gb-2013-14-1-r4","article-title":"Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice","volume":"14","author":"Hildebrand","year":"2013","journal-title":"Genome Biol"},{"key":"2024090216320292000_cvae062-B4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijmm.2016.03.004","article-title":"Analysis of factors contributing to variation in the C57BL\/6J fecal microbiota across German animal facilities","volume":"306","author":"Rausch","year":"2016","journal-title":"Int J Med Microbiol"},{"key":"2024090216320292000_cvae062-B5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jss.2016.12.008","article-title":"Vendor effects on murine gut microbiota influence experimental abdominal sepsis","volume":"211","author":"Hilbert","year":"2017","journal-title":"J Surg Res"},{"key":"2024090216320292000_cvae062-B6","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1038\/s41598-018-21986-7","article-title":"The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut","volume":"8","author":"Ericsson","year":"2018","journal-title":"Sci Rep"},{"key":"2024090216320292000_cvae062-B7","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fmicb.2018.01085","article-title":"Acclimation and institutionalization of the mouse microbiota following transportation","volume":"9","author":"Montonye","year":"2018","journal-title":"Front Microbiol"},{"key":"2024090216320292000_cvae062-B8","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.celrep.2019.04.023","article-title":"Comparison of co-housing and littermate methods for microbiota standardization in mouse models","volume":"27","author":"Robertson","year":"2019","journal-title":"Cell Rep"},{"key":"2024090216320292000_cvae062-B9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40635-020-00336-w","article-title":"Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia","volume":"8","author":"Wolff","year":"2020","journal-title":"Intensive Care Med Exp"},{"key":"2024090216320292000_cvae062-B10","doi-asserted-by":"crossref","first-page":"9841","DOI":"10.1038\/s41598-021-89185-5","article-title":"Cage and maternal effects on the bacterial communities of the murine gut","volume":"11","author":"Singh","year":"2021","journal-title":"Sci Rep"},{"key":"2024090216320292000_cvae062-B11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ame2.12257","article-title":"Characteristics of gut microbiota in representative mice strains: implications for biological research","volume":"5","author":"Guo","year":"2022","journal-title":"Animal Model Exp Med"},{"key":"2024090216320292000_cvae062-B12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40168-017-0237-y","article-title":"Normalization and microbial differential abundance strategies depend upon data characteristics","volume":"5","author":"Weiss","year":"2017","journal-title":"Microbiome"},{"key":"2024090216320292000_cvae062-B13","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/bph.15650","article-title":"Rodent models of hypertension","volume":"179","author":"Jama","year":"2022","journal-title":"Br J Pharmacol"},{"key":"2024090216320292000_cvae062-B14","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.115.05315","article-title":"Gut dysbiosis is linked to hypertension","volume":"65","author":"Yang","year":"2015","journal-title":"Hypertension"},{"key":"2024090216320292000_cvae062-B15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/HYPERTENSIONAHA.119.13155","article-title":"Gut microbiota plays a central role to modulate the plasma and fecal metabolomes in response to angiotensin II","volume":"74","author":"Cheema","year":"2019","journal-title":"Hypertension"},{"key":"2024090216320292000_cvae062-B16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/CS20180087","article-title":"Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure","volume":"132","author":"Kim","year":"2018","journal-title":"Clin Sci"},{"key":"2024090216320292000_cvae062-B17","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME J"},{"key":"2024090216320292000_cvae062-B18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"key":"2024090216320292000_cvae062-B19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"2024090216320292000_cvae062-B20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","article-title":"Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2\u2019s q2-feature-classifier plugin","volume":"6","author":"Bokulich","year":"2018","journal-title":"Microbiome"},{"key":"2024090216320292000_cvae062-B21","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2024090216320292000_cvae062-B22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41596-019-0264-1","article-title":"Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data","volume":"15","author":"Chong","year":"2020","journal-title":"Nat Protoc"},{"key":"2024090216320292000_cvae062-B23","doi-asserted-by":"crossref","first-page":"W310","DOI":"10.1093\/nar\/gkad407","article-title":"MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data","volume":"51","author":"Lu","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2024090216320292000_cvae062-B24","doi-asserted-by":"crossref","first-page":"e1009442","DOI":"10.1371\/journal.pcbi.1009442","article-title":"Multivariable association discovery in population-scale meta-omics studies","volume":"17","author":"Mallick","year":"2021","journal-title":"PLoS Comput Biol"},{"key":"2024090216320292000_cvae062-B25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41586-021-04177-9","article-title":"Combinatorial, additive and dose-dependent drug\u2013microbiome associations","volume":"600","author":"Forslund","year":"2021","journal-title":"Nature"},{"key":"2024090216320292000_cvae062-B26","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/CIRCULATIONAHA.116.024545","article-title":"High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice","volume":"135","author":"Marques","year":"2017","journal-title":"Circulation"},{"key":"2024090216320292000_cvae062-B27","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1161\/CIRCULATIONAHA.118.036652","article-title":"Short-chain fatty acid propionate protects from hypertensive cardiovascular damage","volume":"139","author":"Bartolomaeus","year":"2019","journal-title":"Circulation"},{"key":"2024090216320292000_cvae062-B28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s44161-022-00197-4","article-title":"Prebiotic intervention with HAMSAB in untreated essential hypertensive patients assessed in a phase II randomized trial","volume":"2","author":"Jama","year":"2023","journal-title":"Nat Cardiovasc Res"},{"key":"2024090216320292000_cvae062-B29","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.719599","article-title":"Glycan biosynthesis ability of gut microbiota increased in primary hypertension patients taking antihypertension medications and potentially promoted by macrophage-adenosine monophosphate-activated protein kinase","volume":"12","author":"Zheng","year":"2021","journal-title":"Front Microbiol"},{"key":"2024090216320292000_cvae062-B30","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.122.20752","article-title":"Sex differences in association between gut microbiome and essential hypertension based on ambulatory blood pressure monitoring","volume":"80","author":"Virwani","year":"2023","journal-title":"Hypertension"},{"key":"2024090216320292000_cvae062-B31","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s41588-018-0205-x","article-title":"Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits","volume":"50","author":"Evangelou","year":"2018","journal-title":"Nat Genet"},{"key":"2024090216320292000_cvae062-B32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13293-019-0236-8","article-title":"The role of the gut microbiome in sex differences in arterial pressure","volume":"10","author":"Beale","year":"2019","journal-title":"Biol Sex Differ"},{"key":"2024090216320292000_cvae062-B33","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.3390\/nu11122862","article-title":"Effect of diet on the gut microbiota: rethinking intervention duration","volume":"11","author":"Leeming","year":"2019","journal-title":"Nutrients"},{"key":"2024090216320292000_cvae062-B34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41581-022-00654-0","article-title":"The gut microbiome and hypertension","volume":"19","author":"O\u2019Donnell","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"2024090216320292000_cvae062-B35","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1101\/gr.151803.112","article-title":"Meta-analyses of studies of the human microbiota","volume":"23","author":"Lozupone","year":"2013","journal-title":"Genome Res"},{"key":"2024090216320292000_cvae062-B36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40168-020-00949-z","article-title":"Batch effects account for the main findings of an in utero human intestinal bacterial colonization study","volume":"9","author":"de Goffau","year":"2021","journal-title":"Microbiome"},{"key":"2024090216320292000_cvae062-B37","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/cvr\/cvac121","article-title":"Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage","volume":"119","author":"Avery","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2024090216320292000_cvae062-B38","doi-asserted-by":"crossref","first-page":"F345","DOI":"10.1152\/ajprenal.00072.2023","article-title":"Guidelines for microbiome studies in renal physiology","volume":"325","author":"Muralitharan","year":"2023","journal-title":"Am J Physiol Renal Physiol"},{"key":"2024090216320292000_cvae062-B39","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1161\/HYPERTENSIONAHA.119.13079","article-title":"Guidelines for transparency on gut microbiome studies in essential and experimental hypertension","volume":"74","author":"Marques","year":"2019","journal-title":"Hypertension"},{"key":"2024090216320292000_cvae062-B40","first-page":"11","article-title":"Mouse vendor influence on the bacterial and viral gut composition exceeds the effect of diet","volume":"12","author":"Rasmussen","year":"2019","journal-title":"Viruses"},{"key":"2024090216320292000_cvae062-B41","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"2024090216320292000_cvae062-B42","doi-asserted-by":"crossref","first-page":"20835","DOI":"10.1038\/s41598-020-77831-3","article-title":"Cage bedding modifies metabolic and gut microbiota profiles in mouse studies applying dietary restriction","volume":"10","author":"Gregor","year":"2020","journal-title":"Sci Rep"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae062\/57298656\/cvae062.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/10\/1155\/58996998\/cvae062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/10\/1155\/58996998\/cvae062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T14:59:52Z","timestamp":1725289192000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/120\/10\/1155\/7633834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,3,22]]},"published-print":{"date-parts":[[2024,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae062","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.04.08.536089","asserted-by":"object"}]},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,3,22]]}}}