{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:40:32Z","timestamp":1790602832236,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Groupe pour l\u2019Enseignement, la Pr\u00e9vention et la Recherche Cardiovasculaire en Alsace"},{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF), the most common cardiac arrhythmia favouring ischemic stroke and heart failure involves left atrial remodelling, fibrosis and a complex interplay between cardiovascular risk factors. This study examined whether activated factor X (FXa) induces pro-remodelling and pro-fibrotic responses in atrial endothelial cells (AECs) and human atrial tissues and determined the underlying mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>AECs collected from porcine hearts and human right atrial appendages (RAA) from patients undergoing heart surgery. Protein expression levels were assessed by Western blot and immunofluorescence staining, mRNA levels by RT-qPCR, formation of reactive oxygen species (ROS) and NO using fluorescent probes, thrombin and angiotensin II generation by specific assays, fibrosis by Sirius red staining and senescence by senescence-associated beta-galactosidase (SA-\u03b2-gal) activity. In AECs, FXa increased ROS formation, senescence (SA-\u03b2-gal activity, p53, p21), angiotensin II generation and the expression of pro-inflammatory (VCAM-1, MCP-1), pro-thrombotic (tissue factor), pro-fibrotic (TGF-\u03b2 and collagen-1\/3a) and pro-remodelling (MMP-2\/9) markers whereas eNOS levels and NO formation were reduced. These effects were prevented by inhibitors of FXa but not thrombin, protease-activated receptors antagonists (PAR-1\/2) and inhibitors of NADPH oxidases, ACE, AT1R, SGLT1\/SGLT2. FXa also increased expression levels of ACE1, AT1R, SGLT1\/2 proteins which were prevented by SGLT1\/2 inhibitors. Human RAA showed tissue factor mRNA levels that correlated with markers of endothelial activation, pro-remodelling and pro-fibrotic responses and SGLT1\/2 mRNA levels. They also showed protein expression levels of ACE1, AT1R, p22phox, SGLT1\/2, and immunofluorescence signals of nitrotyrosine and SGLT1\/2 colocalized with those of CD31. FXa increased oxidative stress levels which were prevented by inhibitors of the AT1R\/NADPH oxidases\/SGLT1\/2 pathway.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>FXa promotes oxidative stress triggering premature endothelial senescence and dysfunction associated with pro-thrombotic, pro-remodelling and pro-fibrotic responses in AECs and human RAA involving the AT1R\/NADPH oxidases\/SGLT1\/2 pro-oxidant pathway. Targeting this pathway may be of interest to prevent atrial remodelling and the progression of atrial fibrillation substrate.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvae101","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T11:09:11Z","timestamp":1715684951000},"page":"1138-1154","source":"Crossref","is-referenced-by-count":17,"title":["Activated factor X stimulates atrial endothelial cells and tissues to promote remodelling responses through AT1R\/NADPH oxidases\/SGLT1\/2"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1998-499X","authenticated-orcid":false,"given":"Walaa","family":"Fakih","sequence":"first","affiliation":[{"name":"University of Strasbourg, UR 3074, Translational Cardiovascular Medicine, Biomedicine Research Center of Strasbourg , 1 Rue Eug\u00e8ne Boeckel, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mroueh","sequence":"additional","affiliation":[{"name":"University of Strasbourg, UR 3074, Translational Cardiovascular Medicine, Biomedicine Research Center of Strasbourg , 1 Rue Eug\u00e8ne Boeckel, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dal-Seong","family":"Gong","sequence":"additional","affiliation":[{"name":"University of Strasbourg, UR 3074, Translational Cardiovascular Medicine, Biomedicine Research Center of Strasbourg , 1 Rue Eug\u00e8ne Boeckel, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4737-9882","authenticated-orcid":false,"given":"Shinnosuke","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"University of Strasbourg, UR 3074, Translational Cardiovascular Medicine, Biomedicine Research Center of Strasbourg , 1 Rue Eug\u00e8ne Boeckel, 67000 Strasbourg , France"},{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Paul","family":"Pieper","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG , Global Cardio-Metabolic Diseases, Birkendorfer Strasse 65, 88397 Biberach , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-4395","authenticated-orcid":false,"given":"Michel","family":"Kindo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Mazzucottelli","sequence":"additional","affiliation":[{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Mommerot","sequence":"additional","affiliation":[{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Kanso","sequence":"additional","affiliation":[{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-2737","authenticated-orcid":false,"given":"Patrick","family":"Ohlmann","sequence":"additional","affiliation":[{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-3041","authenticated-orcid":false,"given":"Olivier","family":"Morel","sequence":"additional","affiliation":[{"name":"University of Strasbourg, UR 3074, Translational Cardiovascular Medicine, Biomedicine Research Center of Strasbourg , 1 Rue Eug\u00e8ne Boeckel, 67000 Strasbourg , France"},{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-9287","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Schini-Kerth","sequence":"additional","affiliation":[{"name":"University of Strasbourg, UR 3074, Translational Cardiovascular Medicine, Biomedicine Research Center of Strasbourg , 1 Rue Eug\u00e8ne Boeckel, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-3740","authenticated-orcid":false,"given":"Laurence","family":"Jesel","sequence":"additional","affiliation":[{"name":"University of Strasbourg, UR 3074, Translational Cardiovascular Medicine, Biomedicine Research Center of Strasbourg , 1 Rue Eug\u00e8ne Boeckel, 67000 Strasbourg , France"},{"name":"Cardiology Department, Strasbourg University Hospital , 1 place de l\u2019H\u00f4pital, 67000 Strasbourg , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"2024090216323249100_cvae101-B1","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1093\/eurheartj\/ehab648","article-title":"Corrigendum to: 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Erratum for: Eur Heart J 2021;42:373\u2013498.","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J"},{"key":"2024090216323249100_cvae101-B2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.CIR.0000048892.83521.58","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a \u201cset up\u201d for vascular disease","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"key":"2024090216323249100_cvae101-B3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijcard.2013.03.031","article-title":"Microparticles in atrial fibrillation: a link between cell activation or apoptosis, tissue remodelling and thrombogenicity","volume":"168","author":"Jesel","year":"2013","journal-title":"Int J Cardiol"},{"key":"2024090216323249100_cvae101-B4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0377-1237(06)80057-2","article-title":"Hypercoagulable state","volume":"62","author":"Jaiprakash","year":"2006","journal-title":"Med J Armed Forces India"},{"key":"2024090216323249100_cvae101-B5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/jcm9010036","article-title":"Atrial fibrillation progression is associated with cell senescence burden as determined by p53 and p16 expression","volume":"9","author":"Jesel","year":"2019","journal-title":"J Clin Med"},{"key":"2024090216323249100_cvae101-B6","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.3390\/cells11192963","article-title":"The complex relation between atrial cardiomyopathy and thrombogenesis","volume":"11","author":"D\u2019Alessandro","year":"2022","journal-title":"Cells"},{"key":"2024090216323249100_cvae101-B7","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American heart association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"2024090216323249100_cvae101-B8","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.3390\/jcm8101570","article-title":"Thrombin induces angiotensin II-mediated senescence in arial endothelial cells: impact on pro-remodeling patterns","volume":"8","author":"Hasan","year":"2019","journal-title":"J Clin Med"},{"key":"2024090216323249100_cvae101-B9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.ATV.0000193624.28251.83","article-title":"What does it take to make the perfect clot?","volume":"26","author":"Monroe","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024090216323249100_cvae101-B10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbapap.2004.09.005","article-title":"Serine proteases and cardiac function","volume":"1751","author":"Wu","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"2024090216323249100_cvae101-B11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jacbts.2016.05.002","article-title":"Direct thrombin inhibitors prevent left atrial remodeling associated with heart failure in rats","volume":"1","author":"Jumeau","year":"2016","journal-title":"JACC Basic Transl Sci"},{"key":"2024090216323249100_cvae101-B12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/cvr\/cvt343","article-title":"Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants","volume":"101","author":"Spronk","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2024090216323249100_cvae101-B13","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1182\/blood-2014-06-582775","article-title":"Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity","volume":"124","author":"Stavenuiter","year":"2014","journal-title":"Blood"},{"key":"2024090216323249100_cvae101-B14","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1111\/j.1538-7836.2005.01377.x","article-title":"Protease-activated receptors in hemostasis, thrombosis and vascular biology","volume":"3","author":"Coughlin","year":"2005","journal-title":"J Thromb Haemost"},{"key":"2024090216323249100_cvae101-B15","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes","volume":"373","author":"Zinman","year":"2015","journal-title":"N Engl J Med"},{"key":"2024090216323249100_cvae101-B16","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1161\/CIRCULATIONAHA.119.044183","article-title":"Effect of dapagliflozin on atrial fibrillation in patients with type 2 diabetes mellitus: insights from the DECLARE-TIMI 58 trial","volume":"141","author":"Zelniker","year":"2020","journal-title":"Circulation"},{"key":"2024090216323249100_cvae101-B17","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1111\/jcmm.14233","article-title":"Angiotensin II-induced redox-sensitive SGLT1 and 2 expression promotes high glucose-induced endothelial cell senescence","volume":"24","author":"Khemais-Benkhiat","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2024090216323249100_cvae101-B18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12933-021-01252-3","article-title":"Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle-stimulated endothelial senescence and dysfunction: protective effect of gliflozins","volume":"20","author":"Park","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"2024090216323249100_cvae101-B19","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1046\/j.1538-7836.2003.00298.x","article-title":"What is all that thrombin for?","volume":"1","author":"Mann","year":"2003","journal-title":"J Thromb Haemost"},{"key":"2024090216323249100_cvae101-B20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1055\/s-0037-1613388","article-title":"Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis","volume":"89","author":"Aimes","year":"2003","journal-title":"Thromb Haemost"},{"key":"2024090216323249100_cvae101-B21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/bcp.12357","article-title":"Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2","volume":"78","author":"Cahill-Smith","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"2024090216323249100_cvae101-B22","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/CIRCULATIONAHA.111.019893","article-title":"Atrial fibrillation pathophysiology: implications for management","volume":"124","author":"Iwasaki","year":"2011","journal-title":"Circulation"},{"key":"2024090216323249100_cvae101-B23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/eurheartj\/ehw119","article-title":"Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation","volume":"38","author":"Spronk","year":"2017","journal-title":"Eur Heart J"},{"key":"2024090216323249100_cvae101-B24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejphar.2013.09.006","article-title":"Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue","volume":"718","author":"Bukowska","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"2024090216323249100_cvae101-B25","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.4049\/jimmunol.161.8.4318","article-title":"Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells","volume":"161","author":"Senden","year":"1998","journal-title":"J Immunol"},{"key":"2024090216323249100_cvae101-B26","doi-asserted-by":"crossref","first-page":"104257","DOI":"10.1016\/j.phrs.2019.104257","article-title":"Straight to the heart: pleiotropic antiarrhythmic actions of oral anticoagulants","volume":"145","author":"Fender","year":"2019","journal-title":"Pharmacol Res"},{"key":"2024090216323249100_cvae101-B27","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1093\/eurheartj\/ehz427","article-title":"A comprehensive analysis of the effects of rivaroxaban on stroke or transient ischaemic attack in patients with heart failure, coronary artery disease, and sinus rhythm: the COMMANDER HF trial","volume":"40","author":"Mehra","year":"2019","journal-title":"Eur Heart J"},{"key":"2024090216323249100_cvae101-B28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jacbts.2019.12.008","article-title":"Factor Xa inhibition, a new strategy for prevention of adverse cardiac remodeling in early stages?","volume":"5","author":"Bozkurt","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"2024090216323249100_cvae101-B29","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.3390\/ijms20184411","article-title":"Vascular endothelial cell biology: an update","volume":"20","author":"Kr\u00fcger-Genge","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024090216323249100_cvae101-B30","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.joca.2004.04.003","article-title":"Nitric oxide sustains nuclear factor kappaB activation in cytokine-stimulated chondrocytes","volume":"12","author":"Clancy","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"2024090216323249100_cvae101-B31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3317\/jraas.2007.021","article-title":"Angiotensin type 1 receptor blockade prevents endocardial dysfunction of rapidly paced atria in rats","volume":"8","author":"Yamashita","year":"2007","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"2024090216323249100_cvae101-B32","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.jacc.2007.11.083","article-title":"Acute onset human atrial fibrillation is associated with local cardiac platelet activation and endothelial dysfunction","volume":"51","author":"Akar","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2024090216323249100_cvae101-B33","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1253\/circj.CJ-13-1398","article-title":"Enhancement of endothelial function inhibits left atrial thrombi development in an animal model of spontaneous left atrial thrombosis","volume":"78","author":"Mawatari","year":"2014","journal-title":"Circ J"},{"key":"2024090216323249100_cvae101-B34","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1161\/01.CIR.0000039327.11661.16","article-title":"Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke","volume":"106","author":"Cai","year":"2002","journal-title":"Circulation"},{"key":"2024090216323249100_cvae101-B35","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1161\/CIRCRESAHA.108.181644","article-title":"P53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc","volume":"103","author":"Kim","year":"2008","journal-title":"Circ Res"},{"key":"2024090216323249100_cvae101-B36","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/ATVBAHA.114.303415","article-title":"Disturbed flow promotes endothelial senescence via a p53-dependent pathway","volume":"34","author":"Warboys","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024090216323249100_cvae101-B37","doi-asserted-by":"crossref","first-page":"57981","DOI":"10.18632\/oncotarget.19853","article-title":"Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation","volume":"8","author":"Xie","year":"2017","journal-title":"Oncotarget"},{"key":"2024090216323249100_cvae101-B38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2015.11.005","article-title":"Aging and the cardiac collagen matrix: novel mediators of fibrotic remodelling","volume":"93","author":"Horn","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2024090216323249100_cvae101-B39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.hrthm.2015.07.032","article-title":"Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the intermountain heart collaborative study","volume":"13","author":"Carlquist","year":"2016","journal-title":"Heart Rhythm"},{"key":"2024090216323249100_cvae101-B40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jtha.2023.09.022","article-title":"COVID-19 promotes endothelial dysfunction and thrombogenicity: role of proinflammatory cytokines\/SGLT2 prooxidant pathway","volume":"22","author":"Mroueh","year":"2023","journal-title":"J Thromb Haemost"},{"key":"2024090216323249100_cvae101-B41","first-page":"972","article-title":"The role of renin angiotensin system in atrial fibrillation","volume":"6","author":"Nair","year":"2014","journal-title":"J Atr Fibrillation"},{"key":"2024090216323249100_cvae101-B42","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0735-1097(03)00464-9","article-title":"Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation","volume":"41","author":"Kumagai","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2024090216323249100_cvae101-B43","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/hc4601.099402","article-title":"Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure","volume":"104","author":"Li","year":"2001","journal-title":"Circulation"},{"key":"2024090216323249100_cvae101-B44","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.jacc.2003.07.014","article-title":"Expression of angiotensin II receptors in human left and right atrial tissue in atrial fibrillation with and without underlying mitral valve disease","volume":"42","author":"Boldt","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2024090216323249100_cvae101-B45","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.jacc.2010.01.043","article-title":"Prevention of atrial fibrillation by renin-angiotensin system inhibition a meta-analysis","volume":"55","author":"Schneider","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2024090216323249100_cvae101-B46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCEP.111.965178","article-title":"Angiotensin II-antagonist in paroxysmal atrial fibrillation (ANTIPAF) trial","volume":"5","author":"Goette","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024090216323249100_cvae101-B47","doi-asserted-by":"crossref","first-page":"1005408","DOI":"10.3389\/fcvm.2023.1005408","article-title":"Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats","volume":"10","author":"Koizumi","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2024090216323249100_cvae101-B48","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12933-021-01293-8","article-title":"Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis","volume":"20","author":"Li","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"2024090216323249100_cvae101-B49","doi-asserted-by":"crossref","first-page":"e017483","DOI":"10.1161\/JAHA.119.017483","article-title":"Canagliflozin suppresses atrial remodeling in a canine atrial fibrillation model","volume":"10","author":"Nishinarita","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2024090216323249100_cvae101-B50","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1097\/FJC.0000000000001183","article-title":"Association of SGLT2 inhibitors with risk of atrial fibrillation and stroke in patients with and without type 2 diabetes: a systemic review and meta-analysis of randomized controlled trials","volume":"79","author":"Zheng","year":"2022","journal-title":"J Cardiovasc Pharmacol"},{"key":"2024090216323249100_cvae101-B51","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jacep.2022.08.004","article-title":"Efficacy of sodium-glucose cotransporter 2 inhibitors on outcomes after catheter ablation for atrial fibrillation","volume":"8","author":"Kishima","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2024090216323249100_cvae101-B52","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12933-020-01162-w","article-title":"The risk of new-onset atrial fibrillation in patients with type 2 diabetes mellitus treated with sodium glucose cotransporter 2 inhibitors versus dipeptidyl peptidase-4 inhibitors","volume":"19","author":"Ling","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"2024090216323249100_cvae101-B53","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2017.01.035","article-title":"Dapagliflozin, a selective SGLT2 inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts","volume":"104","author":"Lee","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"2024090216323249100_cvae101-B54","doi-asserted-by":"crossref","first-page":"100207","DOI":"10.1016\/j.metop.2022.100207","article-title":"SGLT2 inhibition reduces myocardial oxygen consumption","volume":"15","author":"S\u00f8ndergaard","year":"2022","journal-title":"Metabol Open"},{"key":"2024090216323249100_cvae101-B55","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3390\/cells10082150","article-title":"Effect of SGLT2-inhibitors on epicardial adipose tissue: a meta-analysis","volume":"10","author":"Masson","year":"2021","journal-title":"Cells"},{"key":"2024090216323249100_cvae101-B56","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3389\/fphys.2020.00912","article-title":"Sodium-glucose cotransporter 2 inhibitors potentially prevent atrial fibrillation by ameliorating ion handling and mitochondrial dysfunction","volume":"11","author":"Peng","year":"2020","journal-title":"Front Physiol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae101\/57725529\/cvae101.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/10\/1138\/58997052\/cvae101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/10\/1138\/58997052\/cvae101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T19:00:08Z","timestamp":1725303608000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/120\/10\/1138\/7671348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":56,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5,14]]},"published-print":{"date-parts":[[2024,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae101","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,5,14]]}}}