{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:16Z","timestamp":1792785856615,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730015"],"award-info":[{"award-number":["81730015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170504"],"award-info":[{"award-number":["82170504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470482"],"award-info":[{"award-number":["81470482"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974048"],"award-info":[{"award-number":["81974048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2021GCRC037"],"award-info":[{"award-number":["2021GCRC037"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Provincial Natural Science Foundation of China","award":["2019AAA032"],"award-info":[{"award-number":["2019AAA032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Abdominal aortic aneurysm (AAA) represents a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. Nevertheless, knowledge regarding changes in regulators associated with aortic status remains incomplete. A thorough understanding of cell types and signalling pathways involved in the development and progression of AAAs is essential for the development of medical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We harvested specimens of the abdominal aorta with different pathological features in Angiotensin II (AngII)-infused ApoE\u2212\/\u2212 mice, conducted scRNA-seq, and identified a unique population of interferon-inducible monocytes\/macrophages (IFNICs), which were amply found in the AAAs. Gene set variation analysis revealed that activation of the cytosolic DNA sensing cGAS-STING and JAK-STAT pathways promoted the secretion of type I interferons in monocytes\/macrophages and differentiated them into IFNICs. We generated myeloid cell-specific deletion of Sting1 (Lyz2-Cre+\/\u2212; Sting1flox\/flox) mice and performed bone marrow transplantation and found that myeloid cell-specific deletion of Sting1 or Ifnar1 significantly reduced the incidence of AAA, aortic rupture rate, and diameter of the abdominal aorta. Mechanistically, the activated pyroptosis- and inflammation-related signalling pathways, regulated by IRF7 in IFNICs, play critical roles in the developing AAAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IFNICs are a unique monocyte\/macrophage subset implicated in the development of AAAs and aortic rupture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvae117","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T13:45:55Z","timestamp":1717595155000},"page":"1351-1364","source":"Crossref","is-referenced-by-count":38,"title":["Single-cell RNA sequencing identifies interferon-inducible monocytes\/macrophages as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-3466","authenticated-orcid":false,"given":"Sheng","family":"Le","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Diagnosis of Hubei Province Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology , ShengLi Street 26, Wuhan 430014 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , China"},{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital of Zhengzhou University , No.1 East Jianshe Road, Zhengzhou 450052 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuan","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poyi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , JieFang Road 1277, Wuhan 430022 , 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