{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:26:49Z","timestamp":1790238409710,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170331"],"award-info":[{"award-number":["82170331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20337"],"award-info":[{"award-number":["U21A20337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Plan of Zhejiang Province","doi-asserted-by":"publisher","award":["2020C03017"],"award-info":[{"award-number":["2020C03017"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Circular RNAs (circRNAs) are considered important regulators of biological processes, but their impact on atherosclerosis development, a key factor in coronary artery disease (CAD), has not been fully elucidated. We aimed to investigate their potential use in patients with CAD and the pathogenesis of atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with stable angina (SA) or acute coronary syndrome (ACS) and controls were selected for transcriptomic screening and quantification of circRNAs in blood cells. We stained carotid plaque samples for circRNAs and performed gain- and loss-of-function studies in vitro. Western blots, protein interaction analysis, and molecular approaches were used to perform the mechanistic study. ApoE\u2212\/\u2212 mouse models were employed in functional studies with adeno-associated virus-mediated genetic intervention. We demonstrated elevated circARCN1 expression in peripheral blood mononuclear cells from patients with SA or ACS, especially in those with ACS. Furthermore, higher circARCN1 levels were associated with a higher risk of developing SA and ACS. We also observed elevated expression of circARCN1 in carotid artery plaques. Further analysis indicated that circARCN1 was mainly expressed in monocytes and macrophages, which was also confirmed in atherosclerotic plaques. Our in vitro studies provided evidence that circARCN1 affected the interaction between HuR and ubiquitin-specific peptidase 31 (USP31) mRNA, resulting in attenuated USP31-mediated NF-\u03baB activation. Interestingly, macrophage accumulation and inflammation in atherosclerotic plaques were markedly decreased when circARCN1 was knocked down with adeno-associated virus in macrophages of ApoE\u2212\/\u2212 mice, while circARCN1 overexpression in the model exacerbated atherosclerotic lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings provide solid evidence macrophagic-expressed circARCN1 plays a role in atherosclerosis development by regulating HuR-mediated USP31 mRNA stability and NF-\u03baB activation, suggesting that circARCN1 may serve as a factor for atherosclerotic lesion formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvae148","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T13:13:02Z","timestamp":1721394782000},"page":"1531-1549","source":"Crossref","is-referenced-by-count":21,"title":["CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages"],"prefix":"10.1093","volume":"120","author":[{"given":"Zhicheng","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liding","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidi","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuesheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangkai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Sheng","sequence":"additional","affiliation":[{"name":"Zhejiang Province Key Laboratory of Pancreatic Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of USTC, The RNA Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC) , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-2088","authenticated-orcid":false,"given":"Ge","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of USTC, The RNA Institute, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC) , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]},{"name":"Department of Biochemistry, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]},{"name":"Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-2273","authenticated-orcid":false,"given":"Qingbo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6754-1432","authenticated-orcid":false,"given":"Xiaogang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"2024110509265696200_cvae148-B1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.118.313816","article-title":"Atherosclerosis","volume":"123","author":"Kobiyama","year":"2018","journal-title":"Circ Res"},{"key":"2024110509265696200_cvae148-B2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"2024110509265696200_cvae148-B3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2017.09.008","article-title":"Monocyte-macrophages and T cells in atherosclerosis","volume":"47","author":"Tabas","year":"2017","journal-title":"Immunity"},{"key":"2024110509265696200_cvae148-B4","first-page":"389","article-title":"Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities","volume":"16","author":"B\u00e4ck","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2024110509265696200_cvae148-B5","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1161\/ATVBAHA.117.309730","article-title":"Macrophages","volume":"37","author":"Mallat","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024110509265696200_cvae148-B6","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1042\/CS20180306","article-title":"Atherosclerosis and inflammation: overview and updates","volume":"132","author":"Geovanini","year":"2018","journal-title":"Clin Sci (Lond)"},{"key":"2024110509265696200_cvae148-B7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"Immunity and inflammation in atherosclerosis","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ Res"},{"key":"2024110509265696200_cvae148-B8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/ATVBAHA.110.207415","article-title":"Recent advances on the role of cytokines in atherosclerosis","volume":"31","author":"Ait-Oufella","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024110509265696200_cvae148-B9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/ATVBAHA.119.312802","article-title":"Macrophages in atherosclerosis regression","volume":"40","author":"Barrett","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024110509265696200_cvae148-B10","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1080\/15476286.2016.1220473","article-title":"The emerging landscape of circular RNA in life processes","volume":"14","author":"Qu","year":"2017","journal-title":"RNA Biol"},{"key":"2024110509265696200_cvae148-B11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molcel.2018.06.034","article-title":"The biogenesis, functions, and challenges of circular RNAs","volume":"71","author":"Li","year":"2018","journal-title":"Mol Cell"},{"key":"2024110509265696200_cvae148-B12","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","article-title":"Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed","volume":"58","author":"Rybak-Wolf","year":"2015","journal-title":"Mol Cell"},{"key":"2024110509265696200_cvae148-B13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.atherosclerosis.2020.02.017","article-title":"Insights into the regulatory role of circRNA in angiogenesis and clinical implications","volume":"298","author":"Liu","year":"2020","journal-title":"Atherosclerosis"},{"key":"2024110509265696200_cvae148-B14","doi-asserted-by":"crossref","first-page":"12429","DOI":"10.1038\/ncomms12429","article-title":"Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans","volume":"7","author":"Holdt","year":"2016","journal-title":"Nat Commun"},{"key":"2024110509265696200_cvae148-B15","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1093\/nar\/gkz141","article-title":"circ-Sirt1 controls NF-kappaB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132\/212 in vascular smooth muscle cells","volume":"47","author":"Kong","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024110509265696200_cvae148-B16","doi-asserted-by":"crossref","first-page":"e147031","DOI":"10.1172\/JCI147031","article-title":"Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation","volume":"131","author":"Gong","year":"2021","journal-title":"J Clin Invest"},{"key":"2024110509265696200_cvae148-B17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0002-9149(83)80105-2","article-title":"A more meaningful scoring system for determining the severity of coronary heart disease","volume":"51","author":"Gensini","year":"1983","journal-title":"Am J Cardiol"},{"key":"2024110509265696200_cvae148-B18","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat Protoc"},{"key":"2024110509265696200_cvae148-B19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/gt.2014.3","article-title":"A macrophage-specific synthetic promoter for therapeutic application of adiponectin","volume":"21","author":"Kang","year":"2014","journal-title":"Gene Ther"},{"key":"2024110509265696200_cvae148-B20","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCULATIONAHA.117.027690","article-title":"A cytokine-like protein Dickkopf-related protein 3 is atheroprotective","volume":"136","author":"Yu","year":"2017","journal-title":"Circulation"},{"key":"2024110509265696200_cvae148-B21","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gkz1141","article-title":"FLASH: ultra-fast protocol to identify RNA-protein interactions in cells","volume":"48","author":"Ilik","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2024110509265696200_cvae148-B22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/7651_2014_99","article-title":"Peripheral blood mononuclear cells: isolation, freezing, thawing, and culture","volume":"1304","author":"Riedhammer","year":"2016","journal-title":"Methods Mol Biol"},{"key":"2024110509265696200_cvae148-B23","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat Rev Genet"},{"key":"2024110509265696200_cvae148-B24","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.117.312513","article-title":"Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry","volume":"122","author":"Winkels","year":"2018","journal-title":"Circ Res"},{"key":"2024110509265696200_cvae148-B25","doi-asserted-by":"crossref","first-page":"586163","DOI":"10.3389\/fonc.2020.586163","article-title":"Regulatory effects of circular RNAs on host genes in human cancer","volume":"10","author":"Wang","year":"2020","journal-title":"Front Oncol"},{"key":"2024110509265696200_cvae148-B26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"2024110509265696200_cvae148-B27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/978-1-4939-7562-4_17","article-title":"Identification of circRNAs for miRNA targets by argonaute2 RNA immunoprecipitation and luciferase screening assays","volume":"1724","author":"Li","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2024110509265696200_cvae148-B28","doi-asserted-by":"crossref","first-page":"e1581","DOI":"10.1002\/wrna.1581","article-title":"Understanding and targeting the disease-related RNA binding protein human antigen R (HuR)","volume":"11","author":"Schultz","year":"2020","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"2024110509265696200_cvae148-B29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1172\/JCI45021","article-title":"Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis","volume":"122","author":"Yiakouvaki","year":"2012","journal-title":"J Clin Invest"},{"key":"2024110509265696200_cvae148-B30","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.3389\/fimmu.2018.02732","article-title":"Divergent innate and epithelial functions of the RNA-binding protein HuR in intestinal inflammation","volume":"9","author":"Christodoulou-Vafeiadou","year":"2018","journal-title":"Front Immunol"},{"key":"2024110509265696200_cvae148-B31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.intimp.2018.09.023","article-title":"Endothelial HuR deletion reduces the expression of proatherogenic molecules and attenuates atherosclerosis","volume":"65","author":"Fu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"2024110509265696200_cvae148-B32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1161\/CIRCULATIONAHA.118.036854","article-title":"HuR-ry up: how hydrogen sulfide protects against atherosclerosis","volume":"139","author":"Barton","year":"2019","journal-title":"Circulation"},{"key":"2024110509265696200_cvae148-B33","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.7150\/thno.59546","article-title":"Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"2024110509265696200_cvae148-B34","author":"Zhou"},{"key":"2024110509265696200_cvae148-B35","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2024110509265696200_cvae148-B36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.molcel.2011.06.008","article-title":"Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR","volume":"43","author":"Lebedeva","year":"2011","journal-title":"Mol Cell"},{"key":"2024110509265696200_cvae148-B37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cellsig.2005.03.017","article-title":"Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB","volume":"18","author":"Tzimas","year":"2006","journal-title":"Cell Signal"},{"key":"2024110509265696200_cvae148-B38","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1158\/0008-5472.CAN-17-4052","article-title":"YAP1-mediated suppression of USP31 enhances NFkappaB activity to promote sarcomagenesis","volume":"78","author":"Ye","year":"2018","journal-title":"Cancer Res"},{"key":"2024110509265696200_cvae148-B39","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1161\/CIRCULATIONAHA.104.482570","article-title":"Biomarkers of cardiovascular disease: molecular basis and practical considerations","volume":"113","author":"Vasan","year":"2006","journal-title":"Circulation"},{"key":"2024110509265696200_cvae148-B40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41571-021-00585-y","article-title":"The emerging roles of circRNAs in cancer and oncology","volume":"19","author":"Kristensen","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"2024110509265696200_cvae148-B41","doi-asserted-by":"crossref","first-page":"117837","DOI":"10.1016\/j.lfs.2020.117837","article-title":"Circular RNAs in the pathogenesis of atherosclerosis","volume":"255","author":"Cao","year":"2020","journal-title":"Life Sci"},{"key":"2024110509265696200_cvae148-B42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/heartjnl-2018-314230","article-title":"Inflammation and atherosclerosis: what is on the horizon?","volume":"106","author":"Ruparelia","year":"2020","journal-title":"Heart"},{"key":"2024110509265696200_cvae148-B43","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jacc.2012.10.027","article-title":"Low-dose colchicine for secondary prevention of cardiovascular disease","volume":"61","author":"Nidorf","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2024110509265696200_cvae148-B44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/annrheumdis-2013-203523","article-title":"A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)","volume":"73","author":"Burmester","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"2024110509265696200_cvae148-B45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/rheumatology\/ket333","article-title":"Treatment of rheumatoid arthritis with etanercept with reference to disease-modifying anti-rheumatic drugs: long-term safety and survival using prospective, observational data","volume":"53","author":"Morgan","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"2024110509265696200_cvae148-B46","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"2024110509265696200_cvae148-B47","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1158\/0008-5472.CAN-14-0726","article-title":"Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development","volume":"74","author":"Giammanco","year":"2014","journal-title":"Cancer Res"},{"key":"2024110509265696200_cvae148-B48","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.1000444107","article-title":"Hur regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells","volume":"107","author":"Rhee","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024110509265696200_cvae148-B49","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/nm.4172","article-title":"Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation","volume":"22","author":"Stellos","year":"2016","journal-title":"Nat Med"},{"key":"2024110509265696200_cvae148-B50","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1016\/j.atherosclerosis.2007.04.008","article-title":"HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR","volume":"195","author":"Zhou","year":"2007","journal-title":"Atherosclerosis"},{"key":"2024110509265696200_cvae148-B51","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1042\/CS20130439","article-title":"Sirtuin 1 stabilization by HuR represses TNF-alpha- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic syndrome","volume":"127","author":"Ceolotto","year":"2014","journal-title":"Clin Sci (Lond)"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae148\/58707510\/cvae148.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/13\/1531\/60420843\/cvae148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/13\/1531\/60420843\/cvae148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T04:27:28Z","timestamp":1730780848000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/120\/13\/1531\/7717207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":51,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7,19]]},"published-print":{"date-parts":[[2024,11,5]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae148","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,7,19]]}}}