{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:47:29Z","timestamp":1790423249664,"version":"4.1.0"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Promotion of Junior Researchers","award":["GRK2381"],"award-info":[{"award-number":["GRK2381"]}]},{"name":"cGMP: From Bedside to Bench","award":["335549539"],"award-info":[{"award-number":["335549539"]}]},{"name":"Erwin-Schr\u00f6dinger-Programm"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Na+-activated Slack potassium (K+) channels are increasingly recognized as regulators of neuronal activity, yet little is known about their role in the cardiovascular system. Slack activity increases when intracellular Na+ concentration ([Na+]i) reaches pathophysiological levels. Elevated [Na+]i is a major determinant of the ischaemia and reperfusion (I\/R)-induced myocardial injury; thus, we hypothesized that Slack plays a role under these conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>K+ currents in cardiomyocytes (CMs) obtained from wildtype but not from global Slack knockout mice were sensitive to electrical inactivation of voltage-sensitive Na+ channels. Live-cell imaging demonstrated that K+ fluxes across the sarcolemma rely on Slack, while the depolarized resting membrane potential in Slack-deficient CMs led to excessive cytosolic Ca2+ accumulation and finally to hypoxia\/reoxygenation-induced cell death. Cardiac damage in an in vivo model of I\/R was exacerbated in global and CM-specific conditional Slack mutants and largely insensitive to mechanical conditioning manoeuvres. Finally, the protection conferred by mitochondrial ATP-sensitive K+ (mitoKATP) channels required functional Slack in CMs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Collectively, our study provides evidence for Slack's crucial involvement in the ion homeostasis of no or low O2-stressed CMs. Thereby, Slack activity opposes the I\/R-induced fatal Ca2+-uptake to CMs supporting the cardioprotective signaling attributed to mitoKATP function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvae155","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T22:52:47Z","timestamp":1722898367000},"page":"174-189","source":"Crossref","is-referenced-by-count":10,"title":["Slack K+ channels confer protection against myocardial ischaemia\/reperfusion injury"],"prefix":"10.1093","volume":"121","author":[{"given":"Anna","family":"Roslan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, Auf der Morgenstelle 8, University of Tuebingen , 72076 Tuebingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Paulus","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, Auf der Morgenstelle 8, University of Tuebingen , 72076 Tuebingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, Auf der Morgenstelle 8, University of Tuebingen , 72076 Tuebingen 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