{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:39:32Z","timestamp":1790998772689,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Sodium\/glucose transporter 2 (SGLT2 or SLC5A2) inhibitors lower blood glucose and are also approved treatments for heart failure independent of raised glucose. Various studies have showed that SGLT2 inhibitors relax arteries, but the underlying mechanisms are poorly understood and responses variable across arterial beds. We speculated that SGLT2 inhibitor-mediated arterial relaxation is dependent upon calcitonin gene-related peptide (CGRP) released from sensory nerves independent of glucose transport.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The functional effects of SGLT1 and 2 inhibitors (mizagliflozin, dapagliflozin, and empagliflozin) and the sodium\/hydrogen exchanger 1 (NHE1) blocker cariporide were determined on pre-contracted resistance arteries (mesenteric and cardiac septal arteries) as well as main renal conduit arteries from male Wistar rats using wire myography. SGLT2, CGRP, TRPV1, and NHE1 expression was determined by western blot and immunohistochemistry. Kv7.4\/5\/KCNE4 and TRPV1 currents were measured in the presence and absence of dapagliflozin and empagliflozin. All SGLT inhibitors (1\u2013100 \u00b5M) and cariporide (30 \u00b5M) relaxed mesenteric arteries but had negligible effect on renal or septal arteries. Immunohistochemistry with TRPV1 and CGRP antibodies revealed a dense innervation of sensory nerves in mesenteric arteries that were absent in renal and septal arteries. Consistent with a greater sensory nerve component, the TRPV1 agonist capsaicin relaxed mesenteric arteries more effectively than renal or septal arteries. In mesenteric arteries, relaxations to dapagliflozin, empagliflozin, and cariporide were attenuated by the CGRP receptor antagonist BIBN-4096, depletion of sensory nerves with capsaicin, and blockade of TRPV1 or Kv7 channels. Neither dapagliflozin nor empagliflozin activated heterologously expressed TRPV1 channels or Kv7 channels directly. Sensory nerves also expressed NHE1 but not SGLT2 and cariporide pre-application as well as knockdown of NHE1 by translation stop morpholinos prevented the relaxant response to SGLT2 inhibitors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SGLT2 inhibitors relax mesenteric arteries by promoting the release of CGRP from sensory nerves in a NHE1-dependent manner.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvae156","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T09:29:33Z","timestamp":1721986173000},"page":"1811-1824","source":"Crossref","is-referenced-by-count":17,"title":["Crucial role for sensory nerves and Na\/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation"],"prefix":"10.1093","volume":"120","author":[{"given":"Elizabeth A","family":"Forrester","sequence":"first","affiliation":[{"name":"Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George\u2019s University , Cranmer Terrace, London SW17 ORE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Ben\u00edtez-Angeles","sequence":"additional","affiliation":[{"name":"I Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn E","family":"Redford","sequence":"additional","affiliation":[{"name":"Bioelectricity Lab, Department of Physiology & Biophysics, School of Medicine, University of California , Irvine ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"I Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W","family":"Abbott","sequence":"additional","affiliation":[{"name":"Bioelectricity Lab, Department of Physiology & Biophysics, School of Medicine, University of California , Irvine ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-8843","authenticated-orcid":false,"given":"Vincenzo","family":"Barrese","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II , Naples ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Dora","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Oxford University , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P","family":"Albert","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George\u2019s University , Cranmer Terrace, London SW17 ORE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johs","family":"Dannesboe","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, Panum Institute, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Salles-Crawley","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George\u2019s University , Cranmer Terrace, London SW17 ORE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Jepps","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, Panum Institute, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-0492","authenticated-orcid":false,"given":"Iain A","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George\u2019s University , Cranmer Terrace, London SW17 ORE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"2024112514470021500_cvae156-B1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1463-1326.2011.01517.x","article-title":"Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors","volume":"14","author":"Grempler","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"2024112514470021500_cvae156-B2","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.34067\/KID.0002772021","article-title":"SGLT2 inhibitors: physiology and pharmacology","volume":"2","author":"Wright","year":"2021","journal-title":"Kidney360"},{"key":"2024112514470021500_cvae156-B3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/cvr\/cvae047","article-title":"SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits","volume":"120","author":"Preda","year":"2024","journal-title":"Cardiovasc Res"},{"key":"2024112514470021500_cvae156-B4","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"NEJM"},{"key":"2024112514470021500_cvae156-B5","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/CIRCULATIONAHA.119.042929","article-title":"Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction","volume":"140","author":"Nassif","year":"2019","journal-title":"Circulation"},{"key":"2024112514470021500_cvae156-B6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11906-023-01281-1","article-title":"Blood pressure effects of SGLT2 inhibitors: mechanisms and clinical evidence in different populations","volume":"25","author":"Beal","year":"2023","journal-title":"Curr Hypertens Rep"},{"key":"2024112514470021500_cvae156-B7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.lfs.2018.01.032","article-title":"The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels","volume":"197","author":"Li","year":"2018","journal-title":"Life Sci"},{"key":"2024112514470021500_cvae156-B8","doi-asserted-by":"crossref","first-page":"115153","DOI":"10.1016\/j.taap.2020.115153","article-title":"Empagliflozin dilates the rabbit aorta by activating PKG and voltage-dependent K+ channels","volume":"403","author":"Seo","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"key":"2024112514470021500_cvae156-B9","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.3390\/ijms221910842","article-title":"Empagliflozin relaxes resistance mesenteric arteries by stimulating multiple smooth muscle cell voltage-gated K+ (KV) channels","volume":"22","author":"Hasan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024112514470021500_cvae156-B10","doi-asserted-by":"crossref","first-page":"e09503","DOI":"10.1016\/j.heliyon.2022.e09503","article-title":"Dapagliflozin induces vasodilation in resistance-size mesenteric arteries by stimulating smooth muscle cell KV7 ion channels","volume":"8","author":"Hasan","year":"2022","journal-title":"Heliyon"},{"key":"2024112514470021500_cvae156-B11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jphs.2022.09.004","article-title":"Mechanism of canagliflozin-induced vasodilation in resistance mesenteric arteries and the regulation of systemic blood pressure","volume":"150","author":"Hasan","year":"2022","journal-title":"J Pharm Sci"},{"key":"2024112514470021500_cvae156-B12","doi-asserted-by":"crossref","first-page":"16873","DOI":"10.3390\/ijms242316873","article-title":"Investigating the cardiovascular benefits of dapagliflozin: vasodilatory effect on isolated rat coronary arteries","volume":"24","author":"Choi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024112514470021500_cvae156-B13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/335164a0","article-title":"Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat","volume":"335","author":"Kawasaki","year":"1988","journal-title":"Nature"},{"key":"2024112514470021500_cvae156-B14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00007.2020","article-title":"Sympathetic and sensory-motor nerves in peripheral small arteries","volume":"101","author":"Aalkjaer","year":"2021","journal-title":"Physiol Rev"},{"key":"2024112514470021500_cvae156-B15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/313054a0","article-title":"Calcitonin gene-related peptide is a potent vasodilator","volume":"313","author":"Brain","year":"1985","journal-title":"Nature"},{"key":"2024112514470021500_cvae156-B16","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/sj.bjp.0703456","article-title":"Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries","volume":"130","author":"Ralevic","year":"2000","journal-title":"Brit J Pharmacol"},{"key":"2024112514470021500_cvae156-B17","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/sj.bjp.0703376","article-title":"Endogenous calcitonin gene-related peptide (CGRP) mediates adrenergic-dependent vasodilation induced by nicotine in mesenteric resistance arteries of the rat","volume":"130","author":"Shiraki","year":"2000","journal-title":"Brit J Pharmacol"},{"key":"2024112514470021500_cvae156-B18","first-page":"779","article-title":"Wiping out CGRP: potential cardiovascular risks","volume":"37","author":"MaassenVanDenBrink","year":"2016","journal-title":"TiPS"},{"key":"2024112514470021500_cvae156-B19","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/ATVBAHA.114.303405","article-title":"Contribution of kv7.4\/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity","volume":"34","author":"Chadha","year":"2014","journal-title":"ATVB"},{"key":"2024112514470021500_cvae156-B20","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/ATVBAHA.118.311360","article-title":"Investigating the role of G\u03b2\u03b3 in Kv7 dependent relaxations of the rat vasculature","volume":"38","author":"Stott","year":"2018","journal-title":"ATVB"},{"key":"2024112514470021500_cvae156-B21","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/ATVBAHA.120.313997","article-title":"Acetaminophen (paracetamol) metabolites induce vasodilation and hypotension by activating Kv7 potassium channels directly and indirectly","volume":"40","author":"van der Horst","year":"2020","journal-title":"ATVB"},{"key":"2024112514470021500_cvae156-B22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circ Res"},{"key":"2024112514470021500_cvae156-B23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejphar.2017.04.010","article-title":"Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation","volume":"806","author":"Inoue","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"2024112514470021500_cvae156-B24","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev-pharmtox-010617-052912","article-title":"KCNQ-encoded potassium channels as therapeutic targets","volume":"58","author":"Barrese","year":"2018","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2024112514470021500_cvae156-B25","doi-asserted-by":"crossref","first-page":"E1657","DOI":"10.1073\/pnas.1715972115","article-title":"TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain","volume":"115","author":"Ort\u00edz-Renter\u00eda","year":"2018","journal-title":"PNAS"},{"key":"2024112514470021500_cvae156-B26","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1113\/jphysiol.2011.227132","article-title":"NHE1 knockout reduces blood pressure and arterial media\/lumen ratio with no effect on resting pHi in the vascular wall","volume":"590","author":"Boedtkjer","year":"2012","journal-title":"J Physiol"},{"issue":"689208","key":"2024112514470021500_cvae156-B27","article-title":"Local translation in nervous system pathologies","volume":"15","author":"Gamarra","year":"2021","journal-title":"Front Integr Neurosci"},{"key":"2024112514470021500_cvae156-B28","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1161\/ATVBAHA.120.315096","article-title":"SMIT (sodium-myo-inositol transporter) 1 regulates arterial contractility through the modulation of vascular Kv7 channels","volume":"40","author":"Barrese","year":"2020","journal-title":"ATVB"},{"key":"2024112514470021500_cvae156-B29","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s00125-016-4134-x","article-title":"Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+\/H+ exchanger in rats and rabbits","volume":"60","author":"Baartscheer","year":"2017","journal-title":"Diabetologia"},{"key":"2024112514470021500_cvae156-B30","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s00125-017-4509-7","article-title":"Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+\/H+ exchanger, lowering of cytosolic Na+ and vasodilation","volume":"61","author":"Uthman","year":"2018","journal-title":"Diabetologia"},{"key":"2024112514470021500_cvae156-B31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/HYPERTENSIONAHA.120.16466","article-title":"Mechanisms of SGLT2 (sodium-glucose transporter type 2) inhibition-induced relaxation in arteries from human visceral adipose tissue","volume":"77","author":"De Stefano","year":"2021","journal-title":"Hypertension"},{"key":"2024112514470021500_cvae156-B32","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/cvr\/cvab129","article-title":"Sodium-glucose co-transporter 2 inhibitor empagliflozin inhibits the cardiac Na+\/H+ exchanger 1: persistent inhibition under various experimental conditions","volume":"117","author":"Zuurbier","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2024112514470021500_cvae156-B33","doi-asserted-by":"crossref","first-page":"112515","DOI":"10.1016\/j.biopha.2021.112515","article-title":"Empagliflozin reduces oxidative stress through inhibition of the novel inflammation\/NHE\/[Na+]c\/ROS-pathway in human endothelial cells","volume":"146","author":"Uthman","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"2024112514470021500_cvae156-B34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12933-023-01756-0","article-title":"Empagliflozin suppressed cardiac fibrogenesis through sodium-hydrogen exchanger inhibition and modulation of the calcium homeostasis","volume":"22","author":"Chung","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"2024112514470021500_cvae156-B35","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1038\/s41467-021-23198-6","article-title":"Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle","volume":"12","author":"Betrie","year":"2021","journal-title":"Nat Commun"},{"key":"2024112514470021500_cvae156-B36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/cpdd.16","article-title":"Empagliflozin (BI 10773), a potent and selective SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects","volume":"2","author":"Seman","year":"2013","journal-title":"Clin Pharmacol Drug Dev"},{"key":"2024112514470021500_cvae156-B37","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"2024112514470021500_cvae156-B38","doi-asserted-by":"crossref","first-page":"8400","DOI":"10.1073\/pnas.122196999","article-title":"An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors","volume":"99","author":"Huang","year":"2002","journal-title":"PNAS"},{"key":"2024112514470021500_cvae156-B39","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/35082088","article-title":"Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5) P2-mediated inhibition","volume":"411","author":"Chuang","year":"2001","journal-title":"Nature"},{"key":"2024112514470021500_cvae156-B40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1476-5381.2012.01851.x","article-title":"The functions of TRPA1 and TRPV1: moving away from sensory nerves","volume":"166","author":"Fernandes","year":"2012","journal-title":"Brit J Pharmacol"},{"key":"2024112514470021500_cvae156-B41","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.RES.85.9.777","article-title":"The myocardial Na+-H+ exchange","volume":"85","author":"Karmazyn","year":"1999","journal-title":"Circ Res"},{"key":"2024112514470021500_cvae156-B42","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1007\/s10741-022-10220-2","article-title":"Alterations of sodium-hydrogen exchanger 1 function in response to SGLT2 inhibitors: what is the evidence?","volume":"27","author":"Wichaiyo","year":"2022","journal-title":"Heart Fail Rev"},{"key":"2024112514470021500_cvae156-B43","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/cvr\/cvaa323","article-title":"Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+\/H+ exchanger-1 or lower [Na+]i in the heart","volume":"117","author":"Chung","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2024112514470021500_cvae156-B44","doi-asserted-by":"crossref","first-page":"eaar3924","DOI":"10.1126\/scisignal.aar3924","article-title":"RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+\/H+ exchanger","volume":"11","author":"Artamonov","year":"2018","journal-title":"Sci Signal"},{"issue":"1108304","key":"2024112514470021500_cvae156-B45","article-title":"Hypoxia enhances interactions between Na+\/H+ exchanger isoform 1 and actin filaments via ezrin in pulmonary vascular smooth muscle","volume":"14","author":"Lade","year":"2023","journal-title":"Front Physiol"},{"key":"2024112514470021500_cvae156-B46","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1681\/ASN.2013060588","article-title":"Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+\/H+ exchanger isoform 3 activity in the renal proximal tubule","volume":"25","author":"Pessoa","year":"2014","journal-title":"J Am Soc Nephrol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae156\/58742959\/cvae156.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/14\/1811\/60810238\/cvae156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/14\/1811\/60810238\/cvae156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T14:47:27Z","timestamp":1732546047000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/120\/14\/1811\/7721236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":46,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7,26]]},"published-print":{"date-parts":[[2024,11,25]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae156","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,7,26]]}}}