{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:10:34Z","timestamp":1791396634072,"version":"4.3.3"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 DA03980"],"award-info":[{"award-number":["T32 DA03980"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F31 DA053796"],"award-info":[{"award-number":["F31 DA053796"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 MH118934"],"award-info":[{"award-number":["R01 MH118934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sudden unexpected death in epilepsy (SUDEP) poses a significant risk to life expectancy for individuals with epilepsy. Mechanistic insight, while incomplete, has advanced through clinical observational studies and animal models. Yet we lack preventative therapies, which will depend on understanding SUDEP mechanisms. Recurrent convulsive seizures are the major SUDEP risk factor. Cardiorespiratory dysfunction precedes SUDEP, but whether cardiac arrhythmias are major proximate culprits for SUDEP remains to be determined. Here, we highlight recent data from mouse models and clinical studies that provide increasing support for respiratory depression and decreasing evidence for tachyarrhythmia-induced SUDEP. Further, we review data from genetic and chemoconvulsant mouse models that have enabled a deeper understanding for how seizures initiated in the central nervous system propagate to the autonomic nervous system and drive seizure-induced respiratory depression and subsequent SUDEP, rather than supporting a proximate cardiac arrhythmia cause. Ongoing research will continue to identify predictive SUDEP biomarkers, improve animal models, and translate basic research into precision medicine approaches. Identifying and understanding the brainstem circuits vulnerable in seizure-induced apnoea will enable therapeutic interventions to enhance the quality of life and life expectancy for individuals with epilepsy.<\/jats:p>","DOI":"10.1093\/cvr\/cvae170","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:01:08Z","timestamp":1723075268000},"page":"2385-2394","source":"Crossref","is-referenced-by-count":12,"title":["Sudden unexpected death in epilepsy: respiratory vs. cardiac contributions"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9344-6594","authenticated-orcid":false,"given":"Susan","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Program in Neuroscience, Weill Cornell Medical College , 1300 York Avenue, New York, NY 10065, USA"},{"name":"Cardiovascular Research Institute, Weill Cornell Medicine , 413 E. 69th St, New York, NY 10021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-7394","authenticated-orcid":false,"given":"Theodore H","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and Brain and Mind Research Institute, Weill Cornell Medicine, Cornell University, New York-Presbyterian Hospital , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-0289","authenticated-orcid":false,"given":"Geoffrey S","family":"Pitt","sequence":"additional","affiliation":[{"name":"Graduate Program in Neuroscience, Weill Cornell Medical College , 1300 York Avenue, New York, NY 10065, USA"},{"name":"Cardiovascular Research Institute, Weill Cornell Medicine , 413 E. 69th St, New York, NY 10021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"2025062417110334400_cvae170-B1","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1111\/epi.13902","article-title":"Potential years lost and life expectancy in adults with newly diagnosed epilepsy","volume":"58","author":"Granbichler","year":"2017","journal-title":"Epilepsia"},{"key":"2025062417110334400_cvae170-B2","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/brain\/awh267","article-title":"Life expectancy in people with newly diagnosed epilepsy","volume":"127","author":"Gaitatzis","year":"2004","journal-title":"Brain"},{"key":"2025062417110334400_cvae170-B3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1528-1167.2011.03358.x","article-title":"Unifying the definitions of sudden unexpected death in 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