{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:41:00Z","timestamp":1792698060888,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030006"],"award-info":[{"award-number":["82030006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900218"],"award-info":[{"award-number":["81900218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270451"],"award-info":[{"award-number":["82270451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200471"],"award-info":[{"award-number":["82200471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20214Y0062"],"award-info":[{"award-number":["20214Y0062"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Commission","doi-asserted-by":"crossref","award":["23ZR1453700"],"award-info":[{"award-number":["23ZR1453700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Commission","doi-asserted-by":"crossref","award":["22YF1435300"],"award-info":[{"award-number":["22YF1435300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Commission","doi-asserted-by":"crossref","award":["22ZR1452800"],"award-info":[{"award-number":["22ZR1452800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>\u03b23-Adrenergic receptor (\u03b23-AR) is essential for cardiovascular homoeostasis through regulating adipose tissue function. Perivascular adipose tissue (PVAT) has been implicated in the pathogenesis of aortic dissection and aneurysm (AD\/AA). Here, we aim to investigate \u03b23-AR activation-mediated PVAT function in AD\/AA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Aortas from patients with thoracic aortic dissection (TAD) were collected to detect \u03b23-AR expression in PVAT. ApoE\u2212\/\u2212 and \u03b2-aminopropionitrile monofumarate (BAPN)-treated C57BL\/6 mice were induced with Angiotensin II (AngII) to simulate AD\/AA and subsequently received either placebo or mirabegron, a \u03b23-AR agonist. The results demonstrated an up-regulation of \u03b23-AR in PVAT of TAD patients and AD\/AA mice. Moreover, activation of \u03b23-AR by mirabegron significantly prevented AngII-induced AD\/AA formation in mice. RNA-sequencing analysis of adipocytes from PVAT revealed a notable increase of the lymphangiogenic factor, vascular endothelial growth factor C (VEGF-C), in mirabegron-treated mice. Consistently, enhanced lymphangiogenesis was found in PVAT with mirabegron treatment. Mechanistically, the number of CD4+\/CD8+ T cells and CD11c+ cells was reduced in PVAT but increased in adjacent draining lymph nodes of mirabegron-treated mice, indicating the improved draining and clearance of inflammatory cells in PVAT by lymphangiogenesis. Importantly, adipocyte-specific VEGF-C knockdown by the adeno-associated virus system restrained lymphangiogenesis and exacerbated inflammatory cell infiltration in PVAT, which ultimately abolished the protection of mirabegron on AD\/AA. In addition, the conditional medium derived from mirabegron-treated adipocytes activated the proliferation and tube formation of LECs, which was abrogated by the silencing of VEGF-C in adipocytes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings illustrated the therapeutic potential of \u03b23-AR activation by mirabegron on AD\/AA, which promoted lymphangiogenesis by increasing adipocyte-derived VEGF-C and, therefore, ameliorated PVAT inflammation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvae213","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T17:35:12Z","timestamp":1726594512000},"page":"2307-2319","source":"Crossref","is-referenced-by-count":24,"title":["Activation of \u03b23-adrenergic receptor by mirabegron prevents aortic dissection\/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue"],"prefix":"10.1093","volume":"120","author":[{"given":"Ze-Bei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]},{"name":"Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-4716","authenticated-orcid":false,"given":"Jing-Rong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Jin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 197 Ruijin, 2 Road, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"2024123117114856200_cvae213-B1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/CIRCRESAHA.113.300308","article-title":"Adrenergic nervous system in heart failure: pathophysiology and therapy","volume":"113","author":"Lymperopoulos","year":"2013","journal-title":"Circ Res"},{"key":"2024123117114856200_cvae213-B2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/cvr\/cvw056","article-title":"Cardiac salvage by tweaking with beta-3-adrenergic receptors","volume":"111","author":"Balligand","year":"2016","journal-title":"Cardiovasc Res"},{"key":"2024123117114856200_cvae213-B3","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/eurheartj\/ehx366","article-title":"Cardiac myocyte beta3-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling","volume":"39","author":"Hermida","year":"2018","journal-title":"Eur Heart J"},{"key":"2024123117114856200_cvae213-B4","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1002\/j.1460-2075.1991.tb04940.x","article-title":"Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes","volume":"10","author":"Nahmias","year":"1991","journal-title":"EMBO J"},{"key":"2024123117114856200_cvae213-B5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/1873-3468.12107","article-title":"Beta3 adrenergic receptor is involved in vascular injury in deoxycorticosterone acetate-salt hypertensive mice","volume":"590","author":"Sheng","year":"2016","journal-title":"FEBS Lett"},{"key":"2024123117114856200_cvae213-B6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/CIRCRESAHA.121.320470","article-title":"Brown adipocyte ADRB3 mediates cardioprotection via suppressing exosomal iNOS","volume":"131","author":"Lin","year":"2022","journal-title":"Circ Res"},{"key":"2024123117114856200_cvae213-B7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2014.12.009","article-title":"Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist","volume":"21","author":"Cypess","year":"2015","journal-title":"Cell Metab"},{"key":"2024123117114856200_cvae213-B8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1751-7176.2012.00590.x","article-title":"Misdiagnosis of aortic dissection: experience of 361 patients","volume":"14","author":"Zhan","year":"2012","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2024123117114856200_cvae213-B9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2024123117114856200_cvae213-B10","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.jvs.2020.01.047","article-title":"A 10-year study of surgical results of descending aorta aneurysm repair following chronic aortic dissection","volume":"72","author":"Cho","year":"2020","journal-title":"J Vasc Surg"},{"key":"2024123117114856200_cvae213-B11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(22)01970-5","article-title":"Acute aortic dissection","volume":"401","author":"Carrel","year":"2023","journal-title":"Lancet"},{"key":"2024123117114856200_cvae213-B12","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jvs.2015.12.056","article-title":"Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms","volume":"65","author":"Folkesson","year":"2017","journal-title":"J Vasc Surg"},{"key":"2024123117114856200_cvae213-B13","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1172\/JCI71609","article-title":"Development of the mammalian lymphatic vasculature","volume":"124","author":"Yang","year":"2014","journal-title":"J Clin Invest"},{"key":"2024123117114856200_cvae213-B14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","article-title":"The lymphatic vasculature in the 21(st) century: novel functional roles in homeostasis and disease","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"key":"2024123117114856200_cvae213-B15","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1172\/JCI71607","article-title":"Inflammation-associated lymphangiogenesis: a double-edged sword?","volume":"124","author":"Kim","year":"2014","journal-title":"J Clin Invest"},{"key":"2024123117114856200_cvae213-B16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/CIRCRESAHA.115.306544","article-title":"Lymphatic system in cardiovascular medicine","volume":"118","author":"Aspelund","year":"2016","journal-title":"Circ Res"},{"key":"2024123117114856200_cvae213-B17","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1002\/ctm2.374","article-title":"VEGF-C\/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis","volume":"11","author":"Lin","year":"2021","journal-title":"Clin Transl Med"},{"key":"2024123117114856200_cvae213-B18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/CIRCULATIONAHA.113.004940","article-title":"Enhanced expression of \u03b23-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase","volume":"129","author":"Belge","year":"2014","journal-title":"Circulation"},{"key":"2024123117114856200_cvae213-B19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/jpet.120.000140","article-title":"\u03b23-Adrenergic receptor agonist prevents diastolic dysfunction in an Angiotensin II-induced cardiomyopathy mouse model","volume":"376","author":"Kamiya","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"key":"2024123117114856200_cvae213-B20","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/cvr\/cvaa133","article-title":"Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm","volume":"117","author":"Cooper","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2024123117114856200_cvae213-B21","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/HYPERTENSIONAHA.117.09822","article-title":"Vascular ADAM17 (a disintegrin and metalloproteinase domain 17) is required for Angiotensin II\/beta-aminopropionitrile-induced abdominal aortic aneurysm","volume":"70","author":"Kawai","year":"2017","journal-title":"Hypertension"},{"key":"2024123117114856200_cvae213-B22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCULATIONAHA.121.056640","article-title":"Legumain is an endogenous modulator of integrin alphavbeta3 triggering vascular degeneration, dissection, and rupture","volume":"145","author":"Pan","year":"2022","journal-title":"Circulation"},{"key":"2024123117114856200_cvae213-B23","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.2174\/1381612821666150826094746","article-title":"Dissecting abdominal aortic aneurysm in Angiotensin II-infused mice: the importance of imaging","volume":"21","author":"Trachet","year":"2015","journal-title":"Curr Pharm Des"},{"key":"2024123117114856200_cvae213-B24","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cvr\/cvx128","article-title":"Angiotensin II infusion into ApoE","volume":"113","author":"Trachet","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2024123117114856200_cvae213-B25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/dom.13516","article-title":"Acute metabolic and cardiovascular effects of mirabegron in healthy individuals","volume":"21","author":"Loh","year":"2019","journal-title":"Diabetes Obes Metab"},{"key":"2024123117114856200_cvae213-B26","doi-asserted-by":"crossref","first-page":"e155478","DOI":"10.1172\/JCI155478","article-title":"Lymphangiogenesis requires Ang2\/Tie\/PI3 K signaling for VEGFR3 cell-surface expression","volume":"132","author":"Korhonen","year":"2022","journal-title":"J Clin Invest"},{"key":"2024123117114856200_cvae213-B27","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1111\/bph.14121","article-title":"Mirabegron: potential off target effects and uses beyond the bladder","volume":"175","author":"Dehvari","year":"2018","journal-title":"Br J Pharmacol"},{"key":"2024123117114856200_cvae213-B28","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/1440-1681.13566","article-title":"The effects of mirabegron on obesity-induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue","volume":"48","author":"Peres Valgas da Silva","year":"2021","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2024123117114856200_cvae213-B29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-immunol-041015-055354","article-title":"The lymphatic system: integral roles in immunity","volume":"35","author":"Randolph","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"2024123117114856200_cvae213-B30","doi-asserted-by":"crossref","first-page":"45263","DOI":"10.1038\/srep45263","article-title":"Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis","volume":"7","author":"Rademakers","year":"2017","journal-title":"Sci Rep"},{"key":"2024123117114856200_cvae213-B31","doi-asserted-by":"crossref","first-page":"e140685","DOI":"10.1172\/JCI140685","article-title":"Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation","volume":"132","author":"Glinton","year":"2022","journal-title":"J Clin Invest"},{"key":"2024123117114856200_cvae213-B32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s10020-021-00406-z","article-title":"ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m(6)A modification to improve wound healing of diabetic foot ulcers","volume":"27","author":"Zhou","year":"2021","journal-title":"Mol Med"},{"key":"2024123117114856200_cvae213-B33","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ng1642","article-title":"Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity","volume":"37","author":"Harvey","year":"2005","journal-title":"Nat Genet"},{"key":"2024123117114856200_cvae213-B34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cmet.2013.04.002","article-title":"Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL","volume":"17","author":"Lim","year":"2013","journal-title":"Cell Metab"},{"key":"2024123117114856200_cvae213-B35","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature14483","article-title":"Cardiac lymphatics are heterogeneous in origin and respond to injury","volume":"522","author":"Klotz","year":"2015","journal-title":"Nature"},{"key":"2024123117114856200_cvae213-B36","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1038\/s41467-018-06152-x","article-title":"LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"key":"2024123117114856200_cvae213-B37","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ejvs.2021.02.034","article-title":"Inflammatory gene expression of human perivascular adipose tissue in abdominal aortic aneurysms","volume":"61","author":"Meekel","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2024123117114856200_cvae213-B38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ejvs.2005.10.030","article-title":"Chronic inflammation, immune response, and infection in abdominal aortic aneurysms","volume":"31","author":"Lindholt","year":"2006","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2024123117114856200_cvae213-B39","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.4049\/jimmunol.1203228","article-title":"CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice","volume":"190","author":"Zhou","year":"2013","journal-title":"J Immunol"},{"key":"2024123117114856200_cvae213-B40","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1042\/CS20190924","article-title":"Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits Angiotensin II-induced abdominal aortic aneurysm formation and growth","volume":"133","author":"Krishna","year":"2019","journal-title":"Clin Sci (Lond)"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae213\/60836263\/cvae213.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/17\/2307\/60836263\/cvae213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/120\/17\/2307\/60836263\/cvae213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T17:12:07Z","timestamp":1735665127000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/120\/17\/2307\/7759431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":40,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2024,9,17]]},"published-print":{"date-parts":[[2024,12,31]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae213","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,9,17]]}}}