{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:47Z","timestamp":1787008667476,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370421"],"award-info":[{"award-number":["82370421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170428"],"award-info":[{"award-number":["82170428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300485"],"award-info":[{"award-number":["82300485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013008"],"award-info":[{"award-number":["2024A1515013008"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects of Guangzhou","award":["202201011067"],"award-info":[{"award-number":["202201011067"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Calcific aortic valve disease (CAVD) is a common heart valve disease with significant clinical consequences. The mechanisms that drive the pathogenesis of CAVD remain to be fully elucidated. N6-methyladenosine (m6A), the most prevalent RNA epigenetic regulator, has recently been implicated in cardiovascular disease, but its role in CAVD has yet to be investigated. In this study, we investigated the potential function of m6A modification in CAVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using clinical samples from CAVD patients in combination with human valve interstitial cell (hVIC) calcification model, we screened the expression of m6A modulators and discovered that alkB homolog 5, RNA demethylase (ALKBH5), a key m6A demethylase, was significantly down-regulated in calcified hVICs and human aortic valves. Consistently, increased m6A levels were seen in calcified hVICs, and treatment with 3-deazaadenosine (DAA), an inhibitor of m6A modification, significantly reduced hVIC osteogenic differentiation and calcification. In addition, we showed that silencing of ALKBH5 expression increased global m6A levels and accelerated hVIC osteogenic differentiation and calcification, whereas overexpression of ALKBH5 resulted in the opposite effect. We demonstrated that ALKBH5 directly modulate m6A levels of TGFBR2 and its mRNA stability, leading to altered TGFBR2 expression and SMAD2 signalling in hVICs. We further showed that inhibition of TGFBR2 or knockdown of SMAD2 attenuated ALKBH5 knockdown-induced hVIC osteogenic differentiation and calcification. The expression of the m6A reader protein YTH N6-methyladenosine RNA binding protein F1 (YTHDF1) was up-regulated during the process of hVIC calcification. Intriguingly, we revealed that the ALKBH5 silencing-induced increased hVIC osteogenic differentiation and calcification were abolished after knockdown of YTHDF1. These data suggest a potential role YTHDF1 in aortic valve calcification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed that ALKBH5 attenuated aortic valve calcification through the TGFBR2\/SMAD2 signalling pathway via direct m6A modification of TGFBR2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvae253","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:28:55Z","timestamp":1733729335000},"page":"190-204","source":"Crossref","is-referenced-by-count":12,"title":["The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification"],"prefix":"10.1093","volume":"121","author":[{"given":"Yueheng","family":"Wang","sequence":"first","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengping","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University , 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiao","family":"Yu","sequence":"additional","affiliation":[{"name":"GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University , Guangzhou 511436 ,","place":["China"]},{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Guangzhou Medical University , Guangzhou 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky E","family":"Macrae","sequence":"additional","affiliation":[{"name":"Division of Functional Genetics, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh , Midlothian ,","place":["UK"]},{"name":"School of Life Sciences, Faculty of Science and Engineering, Anglia Ruskin University , Cambridge CB1 1PT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Fu","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-438X","authenticated-orcid":false,"given":"Dongxing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University , Guangzhou, Guangdong 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"2025041515193185500_cvae253-B1","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1161\/CIRCULATIONAHA.122.063481","article-title":"Toll-like receptor 3 mediates aortic stenosis through a conserved mechanism of calcification","volume":"147","author":"Gollmann-Tepek\u00f6yl\u00fc","year":"2023","journal-title":"Circulation"},{"key":"2025041515193185500_cvae253-B2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/cvr\/cvaa090","article-title":"Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1\/2 signalling pathway","volume":"117","author":"Chen","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2025041515193185500_cvae253-B3","doi-asserted-by":"crossref","first-page":"e006339","DOI":"10.1161\/JAHA.117.006339","article-title":"Valve interstitial cells: the key to understanding the pathophysiology of heart valve calcification","volume":"6","author":"Rutkovskiy","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2025041515193185500_cvae253-B4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.110.234278","article-title":"The regulation of valvular and vascular sclerosis by osteogenic morphogens","volume":"109","author":"Bostr\u00f6m","year":"2011","journal-title":"Circ Res"},{"key":"2025041515193185500_cvae253-B5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCINTERVENTIONS.112.971028","article-title":"Cellular mechanisms of aortic valve calcification","volume":"5","author":"Leopold","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"2025041515193185500_cvae253-B6","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1093\/eurheartj\/ehx653","article-title":"Calcific aortic valve stenosis: hard disease in the heart: a biomolecular approach towards diagnosis and treatment","volume":"39","author":"Peeters","year":"2018","journal-title":"Eur Heart J"},{"key":"2025041515193185500_cvae253-B7","doi-asserted-by":"crossref","first-page":"e143023","DOI":"10.1172\/jci.insight.143023","article-title":"Shifting osteogenesis in vascular calcification","volume":"6","author":"Yao","year":"2021","journal-title":"JCI Insight"},{"key":"2025041515193185500_cvae253-B8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-022-01055-2","article-title":"Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials","volume":"7","author":"Shi","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2025041515193185500_cvae253-B9","doi-asserted-by":"crossref","first-page":"791646","DOI":"10.3389\/fcvm.2021.791646","article-title":"The complex interplay of inflammation, metabolism, epigenetics, and sex in calcific disease of the aortic valve","volume":"8","author":"Ferrari","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2025041515193185500_cvae253-B10","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJMra1402513","article-title":"The key role of epigenetics in human disease prevention and mitigation","volume":"378","author":"Feinberg","year":"2018","journal-title":"N Engl J Med"},{"key":"2025041515193185500_cvae253-B11","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","article-title":"Epigenetics in human obesity and type 2 diabetes","volume":"29","author":"Ling","year":"2019","journal-title":"Cell Metab"},{"key":"2025041515193185500_cvae253-B12","doi-asserted-by":"crossref","first-page":"20366","DOI":"10.1002\/jcp.28638","article-title":"The methylation of Notch1 promoter mediates the osteogenesis differentiation in human aortic valve interstitial cells through Wnt\/\u03b2-catenin signaling","volume":"234","author":"Zhou","year":"2019","journal-title":"J Cell Physiol"},{"key":"2025041515193185500_cvae253-B13","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/CIRCULATIONAHA.116.023116","article-title":"Altered DNA methylation of long noncoding RNA H19 in calcific aortic valve disease promotes mineralization by silencing NOTCH1","volume":"134","author":"Hadji","year":"2016","journal-title":"Circulation"},{"key":"2025041515193185500_cvae253-B14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.tig.2017.04.003","article-title":"M6a in mRNA: an ancient mechanism for fine-tuning gene expression","volume":"33","author":"Roignant","year":"2017","journal-title":"Trends Genet"},{"key":"2025041515193185500_cvae253-B15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11684-018-0654-8","article-title":"RNA m6A modification and its function in diseases","volume":"12","author":"Tong","year":"2018","journal-title":"Front Med"},{"key":"2025041515193185500_cvae253-B16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2025041515193185500_cvae253-B17","doi-asserted-by":"crossref","first-page":"e23294","DOI":"10.1096\/fj.202301292R","article-title":"Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction","volume":"37","author":"Gao","year":"2023","journal-title":"FASEB J"},{"key":"2025041515193185500_cvae253-B18","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1002\/ctm2.402","article-title":"Loss of m6A demethylase ALKBH5 promotes post-ischemic angiogenesis via post-transcriptional stabilization of WNT5A","volume":"11","author":"Zhao","year":"2021","journal-title":"Clin Transl Med"},{"key":"2025041515193185500_cvae253-B19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","article-title":"FTO-dependent N6-methyladenosine regulates cardiac function during remodeling and repair","volume":"139","author":"Mathiyalagan","year":"2019","journal-title":"Circulation"},{"key":"2025041515193185500_cvae253-B20","first-page":"e21162","article-title":"Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts","volume":"35","author":"Li","year":"2021","journal-title":"FASEB J"},{"key":"2025041515193185500_cvae253-B21","doi-asserted-by":"crossref","first-page":"101887","DOI":"10.1016\/j.jbc.2022.101887","article-title":"PALMD regulates aortic valve calcification via altered glycolysis and NF-\u03baB-mediated inflammation","volume":"298","author":"Wang","year":"2022","journal-title":"J Biol Chem"},{"key":"2025041515193185500_cvae253-B22","doi-asserted-by":"crossref","first-page":"eabk2709","DOI":"10.1126\/scitranslmed.abk2709","article-title":"Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms","volume":"14","author":"Wang","year":"2022","journal-title":"Sci Transl Med"},{"key":"2025041515193185500_cvae253-B23","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.athoracsur.2006.10.026","article-title":"Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events","volume":"83","author":"Clark-Greuel","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"2025041515193185500_cvae253-B24","doi-asserted-by":"crossref","first-page":"770065","DOI":"10.3389\/fcvm.2022.770065","article-title":"Increased TGF\u03b21 and SMAD3 contribute to age-related aortic valve calcification","volume":"9","author":"Chakrabarti","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2025041515193185500_cvae253-B25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/ATVBAHA.115.306091","article-title":"Valve endothelial cell-derived Tgf\u03b21 signaling promotes nuclear localization of Sox9 in interstitial cells associated with attenuated calcification","volume":"36","author":"Huk","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025041515193185500_cvae253-B26","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol Cell"},{"key":"2025041515193185500_cvae253-B27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol Cell"},{"key":"2025041515193185500_cvae253-B28","doi-asserted-by":"crossref","first-page":"e1318","DOI":"10.1002\/ctm2.1318","article-title":"ALKBH5\/YTHDF2-mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting cullin neddylation","volume":"13","author":"Shao","year":"2023","journal-title":"Clin Transl Med"},{"key":"2025041515193185500_cvae253-B29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jare.2023.09.004","article-title":"ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction","volume":"61","author":"Yang","year":"2024","journal-title":"J Adv Res"},{"key":"2025041515193185500_cvae253-B30","doi-asserted-by":"crossref","first-page":"668377","DOI":"10.3389\/fcell.2021.668377","article-title":"KIAA1429 and ALKBH5 oppositely influence aortic dissection progression via regulating the maturation of pri-miR-143-3p in an m6A-dependent manner","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2025041515193185500_cvae253-B31","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","article-title":"Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies","volume":"111","author":"Freeman","year":"2005","journal-title":"Circulation"},{"key":"2025041515193185500_cvae253-B32","doi-asserted-by":"crossref","first-page":"eadg0478","DOI":"10.1126\/sciadv.adg0478","article-title":"Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis","volume":"9","author":"Zhong","year":"2023","journal-title":"Sci Adv"},{"key":"2025041515193185500_cvae253-B33","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1161\/CIRCULATIONAHA.123.065213","article-title":"AVCAPIR: a novel procalcific PIWI-interacting RNA in calcific aortic valve disease","volume":"149","author":"Han","year":"2024","journal-title":"Circulation"},{"key":"2025041515193185500_cvae253-B34","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1093\/eurheartj\/ehab316","article-title":"DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells","volume":"42","author":"Wang","year":"2021","journal-title":"Eur Heart J"},{"key":"2025041515193185500_cvae253-B35","doi-asserted-by":"crossref","first-page":"e84433","DOI":"10.1371\/journal.pone.0084433","article-title":"Defining the role of fluid shear stress in the expression of early signaling markers for calcific aortic valve disease","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"2025041515193185500_cvae253-B36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fphys.2018.00201","article-title":"Toll-like receptors, inflammation, and calcific aortic valve disease","volume":"9","author":"Garc\u00eda-Rodr\u00edguez","year":"2018","journal-title":"Front Physiol"},{"key":"2025041515193185500_cvae253-B37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/CIRCRESAHA.113.300153","article-title":"Fibrocalcific aortic valve disease: opportunity to understand disease mechanisms using mouse models","volume":"113","author":"Weiss","year":"2013","journal-title":"Circ Res"},{"key":"2025041515193185500_cvae253-B38","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41419-021-03869-4","article-title":"The N6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"2025041515193185500_cvae253-B39","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/1873-3468.14145","article-title":"The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability","volume":"595","author":"Feng","year":"2021","journal-title":"FEBS Lett"},{"key":"2025041515193185500_cvae253-B40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0003-4975(02)04312-6","article-title":"Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis","volume":"75","author":"Jian","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2025041515193185500_cvae253-B41","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.3390\/ijms22147575","article-title":"TGF-\u03b2 signaling: from tissue fibrosis to tumor microenvironment","volume":"22","author":"Chung","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025041515193185500_cvae253-B42","doi-asserted-by":"crossref","first-page":"1113061","DOI":"10.3389\/fmolb.2023.1113061","article-title":"TGF\u03b2 signaling pathways in human health and disease","volume":"10","author":"Chen","year":"2023","journal-title":"Front Mol Biosci"},{"key":"2025041515193185500_cvae253-B43","doi-asserted-by":"crossref","first-page":"e031353","DOI":"10.1161\/JAHA.123.031353","article-title":"Aging-associated ALKBH5-m6A modification exacerbates doxorubicin-induced cardiomyocyte apoptosis via AT-rich interaction domain 2","volume":"13","author":"Chen","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"2025041515193185500_cvae253-B44","doi-asserted-by":"crossref","first-page":"e15269","DOI":"10.7717\/peerj.15269","article-title":"M6a eraser ALKBH5 mitigates the apoptosis of cardiomyocytes in ischemia reperfusion injury through m6A\/SIRT1 axis","volume":"11","author":"Liu","year":"2023","journal-title":"PeerJ"},{"key":"2025041515193185500_cvae253-B45","doi-asserted-by":"crossref","first-page":"e22283","DOI":"10.1096\/fj.202200005RR","article-title":"RNA demethylase ALKBH5 inhibits TGF-\u03b2-induced EMT by regulating TGF-\u03b2\/SMAD signaling in non-small cell lung cancer","volume":"36","author":"Sun","year":"2022","journal-title":"FASEB J"},{"key":"2025041515193185500_cvae253-B46","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res"},{"key":"2025041515193185500_cvae253-B47","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m(6)A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol Cell"},{"key":"2025041515193185500_cvae253-B48","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"2025041515193185500_cvae253-B49","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1164\/rccm.202009-3419OC","article-title":"YTHDF1 regulates pulmonary hypertension through translational control of MAGED1","volume":"203","author":"Hu","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2025041515193185500_cvae253-B50","doi-asserted-by":"crossref","first-page":"113587","DOI":"10.1016\/j.yexcr.2023.113587","article-title":"METTL14\/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome","volume":"427","author":"Yang","year":"2023","journal-title":"Exp Cell Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae253\/61008746\/cvae253.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/1\/190\/61008746\/cvae253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/1\/190\/61008746\/cvae253.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T11:19:45Z","timestamp":1744715985000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/121\/1\/190\/7919778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12,10]]},"published-print":{"date-parts":[[2025,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae253","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,12,10]]}}}