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An additional imaging modality is currently needed to help evaluate the prognosis of AAA as well as early detection of AAA formation. This study evaluated the most effective inflammatory markers for AAA using single-cell sequencing and, from these, developed probes to facilitate in vivo multimodal imaging of AAA inflammation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Single-cell RNA sequencing (scRNAseq) of the human aortic aneurysms, GSE155468 and GSE166676 data sets, identified CXCR4 as the most representative marker. Anti-CXCR4-PE antibody was conjugated to superparamagnetic iron oxide nanoparticles to synthesize Fe3O4-anti-CXCR4-PE probes. The biocompatibility and specificity of the probes were validated in vivo and in vitro. Magnetic particle imaging (MPI) and fluorescence imaging (FLI) were performed to assess inflammation in early and advanced AAA mouse models. CXCR4-specific receptor inhibitor, AMD3100, was used for confirming CXCR4 as an excellent target for AAA imaging and therapy. scRNAseq indicated that chemokine-related pathways were upregulated in aortic aneurysms, and CXCR4 was the chemokine receptor that marks all AAA-related immune cells and inflammatory vascular cells. Fe3O4-anti-CXCR4-PE effectively recognized immune cells and inflammatory vascular cells, as strong MPI and FLI signals corresponded to increased CXCR4, CD45, and CD68 levels that represented AAA severity and rupture risk. Importantly, Fe3O4-anti-CXCR4-PE can help identify early AAA formation when ultrasound is undiagnosable. Finally, AMD3100 treatment in AAA mouse model inhibited AAA expansion and rupture and reduced aortic wall inflammation by inhibiting accumulation of immune cells and haematopoietic stem cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CXCR4 marks immune cells and inflammatory vascular cells in AAA and is associated with AAA prognosis in a mouse model of AAA. CXCR4-targeting multimodal MPI\/FLI provides a novel approach for AAA prognosis prediction and early detection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvae255","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:01:58Z","timestamp":1733882518000},"page":"324-338","source":"Crossref","is-referenced-by-count":9,"title":["CXCR4-targeted sensitive magnetic particle imaging for abdominal aortic aneurysm early detection and prognosis evaluation by recognizing total inflammatory cells"],"prefix":"10.1093","volume":"121","author":[{"given":"Genmao","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, 2nd Hospital of Shanxi Medical University , No. 382, Wuyi Road, Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, 2nd Hospital of Shanxi Medical 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Shanxi Medical University , No. 382, Wuyi Road, Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhen","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, 2nd Hospital of Shanxi Medical University , No. 382, Wuyi Road, Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-0432","authenticated-orcid":false,"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Imaging of Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences , No.95, Zhongguancun East Road, Beijing 100190 ,","place":["China"]},{"name":"National Key Laboratory of Kidney Diseases , No.28, Fuxing road, Beijing 100853 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