{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:52:09Z","timestamp":1792122729760,"version":"4.4.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fundaci\u00f3 Investigaci\u00f3 Marato","award":["TV3 #20154310"],"award-info":[{"award-number":["TV3 #20154310"]}]},{"name":"Fundaci\u00f3 Investigaci\u00f3 Marato","award":["PID2021-128891OB-I00"],"award-info":[{"award-number":["PID2021-128891OB-I00"]}]},{"name":"Fundaci\u00f3 Investigaci\u00f3 Marato","award":["PID2019-107160RB-I00"],"award-info":[{"award-number":["PID2019-107160RB-I00"]}]},{"name":"Fundaci\u00f3 Investigaci\u00f3 Marato","award":["PLEC2021-007664"],"award-info":[{"award-number":["PLEC2021-007664"]}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERCV CB16\/11\/00411"],"award-info":[{"award-number":["CIBERCV CB16\/11\/00411"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BHF Transitional Fellowship"},{"name":"Imperial College 502 London BHF Centre of Research Excellence","award":["RE\/18\/4\/34215"],"award-info":[{"award-number":["RE\/18\/4\/34215"]}]},{"DOI":"10.13039\/501100019573","name":"BHF","doi-asserted-by":"publisher","award":["BHF-503 PG\/23\/11336"],"award-info":[{"award-number":["BHF-503 PG\/23\/11336"]}],"id":[{"id":"10.13039\/501100019573","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Generalitat of Catalunya-Secretaria d\u2019Universitats i Recerca del Departament d\u2019Economia i coneixement de la Generalitat","award":["2017SGR1480"],"award-info":[{"award-number":["2017SGR1480"]}]},{"name":"Generalitat of Catalunya-Secretaria d\u2019Universitats i Recerca del Departament d\u2019Economia i coneixement de la Generalitat","award":["2016PROD00043"],"award-info":[{"award-number":["2016PROD00043"]}]},{"DOI":"10.13039\/501100003030","name":"Agencia Gesti\u00f3n Ayudas Universitarias Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CERCA programme\/Generalitat de Catalu\u00f1a"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Recurrent acute myocardial infarction (RE-AMI) is a frequent complication after STEMI, and its association with stent thrombosis can be life-threatening. Intravenous atorvastatin (IV-atorva) administration during AMI has been shown to limit infarct size and adverse cardiac remodelling. We determined by cardiac magnetic resonance (CMR) whether the cardioprotection exerted by IV-atorva at the index AMI event translates into a better prognosis upon RE-AMI in dyslipidemic pigs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Hypercholesterolemic pigs underwent a first AMI (90-min coronary balloon occlusion). During ongoing ischaemia, animals received IV-atorva or vehicle. Forty days later, animals underwent RE-AMI and were sacrificed on Day 43. All animals remained on p.o. atorvastatin and a high-cholesterol diet from the first AMI until sacrifice. Serial CMR analysis was performed on Day 3 post-AMI, prior- (Day 40) and post-RE-AMI (Day 43). No differences were detected in oedema formation in both animal groups during AMI and RE-AMI. Gadolinium DE-CMR revealed smaller infarcts in IV-atorva-treated animals at index event at 3 and 40 days post-AMI compared to vehicle-administered pigs (P &amp;lt; 0.05). CMR analyses post-RE-AMI revealed smaller infarcts in the animals treated with IV-atorva at index event than in the vehicle-administered pigs. These IV-atorva at index event benefits were associated with higher left ventricular (LV) ejection fraction and normal LV wall motion in the jeopardized myocardium at RE-AMI (P &amp;lt; 0.05 vs. vehicle). The scar region of RE-AMI of animals treated with IV-atorva at index event showed reduced cardiac inflammatory infiltrate, apoptosis and senescence activation, and increased reparative fibrosis and neovessel formation vs. vehicle-administered pigs. Animals treated with IV-atorva at index event also showed lower C-reactive protein and higher interleukin-10 plasma levels in the setting of RE-AMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The cardioprotection afforded by IV-atorva administration during an index-AMI event shows a legacy effect attenuating myocardial damage and preserving cardiac contractile function upon RE-AMI. The potential benefits of this intravenous approach should be tested in the clinical setting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvae264","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:51:43Z","timestamp":1736157103000},"page":"283-295","source":"Crossref","is-referenced-by-count":10,"title":["Cardioprotection exerted by intravenous statin at index myocardial infarction event attenuates cardiac damage upon recurrent infarction"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-8873","authenticated-orcid":false,"given":"Gemma","family":"Vilahur","sequence":"first","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Ben-Aicha","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7362-4330","authenticated-orcid":false,"given":"Manuel","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Radiology Department, Liverpool Heart and Chest Hospital , Thomas Drive, Liverpool L14 3PE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Radike","sequence":"additional","affiliation":[{"name":"Radiology Department, Liverpool Heart and Chest Hospital , Thomas Drive, Liverpool L14 3PE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-9036","authenticated-orcid":false,"given":"Guiomar","family":"Mendieta","sequence":"additional","affiliation":[{"name":"Cardiology Service, Clinic Cardiovascular Institute, Hospital Cl\u00ednic of Barcelona , Barcelona 08036 ,","place":["Spain"]},{"name":"August Pi I Sunyer Institute of Biomedical Research (IDIBAPS) , Barcelona 08036 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisaidy","family":"Ramos","sequence":"additional","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastia","family":"Alcover","sequence":"additional","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Casani","sequence":"additional","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-4106","authenticated-orcid":false,"given":"Gemma","family":"Arderiu","sequence":"additional","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-954X","authenticated-orcid":false,"given":"Teresa","family":"Padr\u00f3","sequence":"additional","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Borrell-Pages","sequence":"additional","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-2459","authenticated-orcid":false,"given":"Lina","family":"Badimon","sequence":"additional","affiliation":[{"name":"Research Institute-Sant Pau, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau , c\/Sant Antoni M\u00aa Claret 167, Barcelona 08025 ,","place":["Spain"]},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]},{"name":"Cardiovascular Research Chair, Universitat Aut\u00f2noma de Barcelona (UAB) , Barcelona 08075 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"2025042204365694900_cvae264-B1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jacc.2023.06.025","article-title":"Mortality trends after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction","volume":"82","author":"Thrane","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B2","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"key":"2025042204365694900_cvae264-B3","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1093\/eurheartj\/ehx515","article-title":"Improved outcomes in patients with ST-elevation myocardial infarction during the last 20 years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995\u20132014","volume":"38","author":"Szummer","year":"2017","journal-title":"Eur Heart J"},{"key":"2025042204365694900_cvae264-B4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/CIRCINTERVENTIONS.114.001360","article-title":"Incidence, predictors, and implications of reinfarction after primary percutaneous coronary intervention in ST-segment-elevation myocardial infarction: the harmonizing outcomes with revascularization and stents in acute myocardial infarction trial","volume":"7","author":"Stone","year":"2014","journal-title":"Circ Cardiovasc Interv"},{"key":"2025042204365694900_cvae264-B5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.31083\/j.rcm2203080","article-title":"Current management and prognosis of patients with recurrent myocardial infarction","volume":"22","author":"De Luca","year":"2021","journal-title":"Rev Cardiovasc Med"},{"key":"2025042204365694900_cvae264-B6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1056\/NEJMoa1002358","article-title":"A prospective natural-history study of coronary atherosclerosis","volume":"364","author":"Stone","year":"2011","journal-title":"N Engl J Med"},{"key":"2025042204365694900_cvae264-B7","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.amjmed.2005.02.010","article-title":"Recurrent infarction causes the most deaths following myocardial infarction with left ventricular dysfunction","volume":"118","author":"Orn","year":"2005","journal-title":"Am J Med"},{"key":"2025042204365694900_cvae264-B8","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jjcc.2015.11.013","article-title":"Treatment and outcomes of patients with recurrent myocardial infarction: a prospective observational cohort study","volume":"68","author":"Radovanovic","year":"2016","journal-title":"J Cardiol"},{"key":"2025042204365694900_cvae264-B9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/heartjnl-2020-317165","article-title":"Incidence, predictors, and prognostic impact of recurrent acute myocardial infarction in China","volume":"107","author":"Song","year":"2020","journal-title":"Heart"},{"key":"2025042204365694900_cvae264-B10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00395-019-0760-z","article-title":"Molecular pathways involved in the cardioprotective effects of intravenous statin administration during ischemia","volume":"115","author":"Mendieta","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"2025042204365694900_cvae264-B11","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.jacc.2020.01.042","article-title":"Intravenous statin administration during myocardial infarction compared with oral post-infarct administration","volume":"75","author":"Mendieta","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B12","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jacc.2019.05.020","article-title":"Intravenous statin administration during ischemia exerts cardioprotective effects","volume":"74","author":"Mendieta","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B13","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/eurheartj\/ehad324","article-title":"Statins revisited: therapeutic applications beyond lipid lowering?","volume":"44","author":"Badimon","year":"2023","journal-title":"Eur Heart J"},{"key":"2025042204365694900_cvae264-B14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.atherosclerosis.2009.02.009","article-title":"Induction of RISK by HMG-CoA reductase inhibition affords cardioprotection after myocardial infarction","volume":"206","author":"Vilahur","year":"2009","journal-title":"Atherosclerosis"},{"key":"2025042204365694900_cvae264-B15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ijcard.2014.06.040","article-title":"HMG-CoA reductase inhibition prior reperfusion improves reparative fibrosis post-myocardial infarction in a preclinical experimental model","volume":"175","author":"Vilahur","year":"2014","journal-title":"Int J Cardiol"},{"key":"2025042204365694900_cvae264-B16","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"2025042204365694900_cvae264-B17","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.116.024014","article-title":"Protective effects of ticagrelor on myocardial injury after infarction","volume":"134","author":"Vilahur","year":"2016","journal-title":"Circulation"},{"key":"2025042204365694900_cvae264-B18","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jacc.2008.07.010","article-title":"J-point elevation in survivors of primary ventricular fibrillation and matched control subjects: incidence and clinical significance","volume":"52","author":"Rosso","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B19","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/cvr\/cvy201","article-title":"P2y12 antagonists and cardiac repair post-myocardial infarction: global and regional heart function analysis and molecular assessments in pigs","volume":"114","author":"Vilahur","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2025042204365694900_cvae264-B20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.recesp.2022.06.007","article-title":"Comparison of two cardiac magnetic resonance imaging postprocessing software tools in a pig model of myocardial infarction","volume":"76","author":"Radike","year":"2023","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2025042204365694900_cvae264-B21","doi-asserted-by":"crossref","first-page":"e13860","DOI":"10.1111\/eci.13860","article-title":"A comprehensive and longitudinal cardiac magnetic resonance imaging study of the impact of coronary ischemia duration on myocardial damage in a highly translatable animal model","volume":"53","author":"Radike","year":"2023","journal-title":"Eur J Clin Invest"},{"key":"2025042204365694900_cvae264-B22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13287-017-0509-2","article-title":"Allogenic adipose-derived stem cell therapy overcomes ischemia-induced microvessel rarefaction in the myocardium: systems biology study","volume":"8","author":"Vilahur","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"2025042204365694900_cvae264-B23","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.yjmcc.2010.12.021","article-title":"Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction","volume":"50","author":"Vilahur","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"2025042204365694900_cvae264-B24","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"2025042204365694900_cvae264-B25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00395-021-00893-5","article-title":"IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST action","volume":"116","author":"Lecour","year":"2021","journal-title":"Basic Res Cardiol"},{"key":"2025042204365694900_cvae264-B26","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/ijms20030514","article-title":"Post-genomic methodologies and preclinical animal models: chances for the translation of cardioprotection to the clinic","volume":"20","author":"Badimon","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025042204365694900_cvae264-B27","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.jacc.2005.11.065","article-title":"Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging","volume":"47","author":"Thiele","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B28","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1161\/CIRCULATIONAHA.117.030693","article-title":"Cardiovascular magnetic resonance in acute ST-segment-elevation myocardial infarction: recent advances, controversies, and future directions","volume":"137","author":"Bulluck","year":"2018","journal-title":"Circulation"},{"key":"2025042204365694900_cvae264-B29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jcmg.2017.01.008","article-title":"Myocardial infarct size by CMR in clinical cardioprotection studies: insights from randomized controlled trials","volume":"10","author":"Bulluck","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025042204365694900_cvae264-B30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/CIRCIMAGING.108.802199","article-title":"Rapid initial reduction of hyperenhanced myocardium after reperfused first myocardial infarction suggests recovery of the peri-infarction zone: one-year follow-up by MRI","volume":"2","author":"Engblom","year":"2009","journal-title":"Circ Cardiovasc Imaging"},{"key":"2025042204365694900_cvae264-B31","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ahj.2007.06.038","article-title":"Short- and long-term changes in myocardial function, morphology, edema, and infarct mass after ST-segment elevation myocardial infarction evaluated by serial magnetic resonance imaging","volume":"154","author":"Ripa","year":"2007","journal-title":"Am Heart J"},{"key":"2025042204365694900_cvae264-B32","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.jacc.2004.01.043","article-title":"Infarct resorption, compensatory hypertrophy, and differing patterns of ventricular remodeling following myocardial infarctions of varying size","volume":"43","author":"Fieno","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.117.310901","article-title":"Effect of ischemia duration and protective interventions on the temporal dynamics of tissue composition after myocardial infarction","volume":"121","author":"Fernandez-Jimenez","year":"2017","journal-title":"Circ Res"},{"key":"2025042204365694900_cvae264-B34","doi-asserted-by":"crossref","first-page":"e002834","DOI":"10.1161\/JAHA.115.002834","article-title":"Temporal evolution of myocardial hemorrhage and edema in patients after acute ST-segment elevation myocardial infarction: pathophysiological insights and clinical implications","volume":"5","author":"Carrick","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2025042204365694900_cvae264-B35","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.jacc.2016.01.069","article-title":"Relationship between infarct size and outcomes following primary PCI: patient-level analysis from 10 randomized trials","volume":"67","author":"Stone","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/ehjci\/jes271","article-title":"Final infarct size measured by cardiovascular magnetic resonance in patients with ST elevation myocardial infarction predicts long-term clinical outcome: an observational study","volume":"14","author":"Lonborg","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025042204365694900_cvae264-B37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/europace\/eus259","article-title":"J-waves in patients with an acute ST-elevation myocardial infarction who underwent successful percutaneous coronary intervention: prevalence, pathogenesis, and clinical implication","volume":"15","author":"Nakayama","year":"2013","journal-title":"Europace"},{"key":"2025042204365694900_cvae264-B38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1177\/2047487312462804","article-title":"Statins reduce new-onset atrial fibrillation in a first-time myocardial infarction population: a nationwide propensity score-matched study","volume":"21","author":"Bang","year":"2014","journal-title":"Eur J Prev Cardiol"},{"key":"2025042204365694900_cvae264-B39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/europace\/euq044","article-title":"Usefulness of statins in preventing atrial fibrillation in patients with permanent pacemaker: a systematic review","volume":"12","author":"Santangeli","year":"2010","journal-title":"Europace"},{"key":"2025042204365694900_cvae264-B40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000538551","article-title":"Drug target Mendelian randomization study of PCSK9 and HMG-CoA reductase inhibition and atrial fibrillation","volume":"149","author":"Li","year":"2024","journal-title":"Cardiology"},{"key":"2025042204365694900_cvae264-B41","doi-asserted-by":"crossref","first-page":"e031243","DOI":"10.1161\/JAHA.123.031243","article-title":"Pattern and prognostic impact of regional wall motion abnormalities in 255 697 men and 236 641 women investigated with echocardiography","volume":"12","author":"Playford","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2025042204365694900_cvae264-B42","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s11886-022-01766-6","article-title":"Ischemic cardiomyopathy and heart failure after acute myocardial infarction","volume":"24","author":"Del Buono","year":"2022","journal-title":"Curr Cardiol Rep"},{"key":"2025042204365694900_cvae264-B43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"2025042204365694900_cvae264-B44","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jacc.2019.12.056","article-title":"Diminished reactive hematopoiesis and cardiac inflammation in a mouse model of recurrent myocardial infarction","volume":"75","author":"Cremer","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2025042204365694900_cvae264-B45","doi-asserted-by":"crossref","first-page":"173090","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"2025042204365694900_cvae264-B46","doi-asserted-by":"crossref","first-page":"e10234","DOI":"10.15252\/emmm.201810234","article-title":"Targeting senescent cells in translational medicine","volume":"11","author":"Paez-Ribes","year":"2019","journal-title":"EMBO Mol Med"},{"key":"2025042204365694900_cvae264-B47","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1111\/bph.14931","article-title":"Hyperlipidaemia and cardioprotection: animal models for translational studies","volume":"177","author":"Andreadou","year":"2020","journal-title":"Br J Pharmacol"},{"key":"2025042204365694900_cvae264-B48","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.3390\/jcm10245889","article-title":"When more means less: the prognosis of recurrent acute myocardial infarctions","volume":"10","author":"Plakht","year":"2021","journal-title":"J Clin Med"},{"key":"2025042204365694900_cvae264-B49","doi-asserted-by":"crossref","first-page":"e014907","DOI":"10.1161\/JAHA.119.014907","article-title":"Association between subsequent hospitalizations and recurrent acute myocardial infarction within 1 year after acute myocardial infarction","volume":"9","author":"Wang","year":"2020","journal-title":"J Am Heart Assoc"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvae264\/61340830\/cvae264.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/2\/283\/61340830\/cvae264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/2\/283\/61340830\/cvae264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T08:37:12Z","timestamp":1745311032000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/121\/2\/283\/7943080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1,3]]},"published-print":{"date-parts":[[2025,4,22]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvae264","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2025,1]]}}}