{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:25:16Z","timestamp":1781796316908,"version":"3.54.5"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070403"],"award-info":[{"award-number":["82070403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270374"],"award-info":[{"award-number":["82270374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Program of Guangdong Province","doi-asserted-by":"publisher","award":["2021A0505030031"],"award-info":[{"award-number":["2021A0505030031"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory","award":["2018GZR110105001"],"award-info":[{"award-number":["2018GZR110105001"]}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Science and Technology Plan","doi-asserted-by":"publisher","award":["2023B01J1011"],"award-info":[{"award-number":["2023B01J1011"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Science and Technology Plan","doi-asserted-by":"publisher","award":["2023B03J1243"],"award-info":[{"award-number":["2023B03J1243"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Science and Technology Innovation Talent of Guangdong TeZhi Plan","award":["2019TQ05Y136"],"award-info":[{"award-number":["2019TQ05Y136"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Calcific aortic valve disease (CAVD) has become an increasingly important global medical problem without effective pharmacological intervention. Accumulating evidence indicates that aortic valve calcification is driven by inflammation. Interleukin-1 receptor-associated kinase M (IRAK-M) is a well-known negative regulator of inflammation, but its role in CAVD remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Here, we stimulated aortic valve interstitial cells (AVICs) with low-dose lipopolysaccharide (LPS) to mimic the inflammatory response in aortic valve calcification and observed the expression pattern of IRAK-M. Furthermore, we generated IRAK-M\u2212\/\u2212 mice to explore the effect of IRAK-M deficiency on the aortic valve in vivo. Additionally, overexpression and knockdown experiments were performed to verify the role of IRAK-M in AVICs. Methylated RNA immunoprecipitation-quantitative polymerase chain reaction was used to detect the N6-methyladenosine (m6A) level of IRAK-M, and recombinant interleukin (IL)-37-treated AVICs were used to determine the regulatory relationship between IL-37 and IRAK-M. We found that IRAK-M expression was upregulated in the early stages of inflammation as part of a negative feedback mechanism to modulate the immune response. However, persistent inflammation increased overall m6A levels, ultimately leading to reduced IRAK-M expression. In vivo, IRAK-M\u2212\/\u2212 mice exhibited a propensity for aortic valve thickening and calcification. Overexpression and knockdown experiments showed that IRAK-M inhibited inflammation and osteogenic responses in AVICs. In addition, IL-37 restored IRAK-M expression by inhibiting m6A-mediated IRAK-M degradation to suppress inflammation and aortic valve calcification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings confirm that inflammation and epigenetic modifications synergistically regulate IRAK-M expression. Moreover, IRAK-M represents a potential target for mitigating aortic valve calcification. Meanwhile, IL-37 exhibited inhibitory effects on CAVD development both in vivo and in vitro, giving us hope that CAVD can be treated with drugs rather than surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf012","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T17:04:21Z","timestamp":1738861461000},"page":"492-506","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin-37 attenuates aortic valve lesions by inhibiting <i>N<\/i>6-methyladenosine-mediated interleukin-1 receptor-associated kinase M degradation"],"prefix":"10.1093","volume":"121","author":[{"given":"Gaopeng","family":"Xian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University , 1838 Northern Guangzhou Ave, Guangzhou 510515 ,","place":["China"]},{"name":"Key Laboratory for Organ Failure Research, Ministry of Education of the People's Republic of China , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine , Boston, MA 02118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongtu","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University , 1838 Northern Guangzhou Ave, Guangzhou 510515 ,","place":["China"]},{"name":"Key Laboratory for Organ Failure Research, Ministry of Education of the People's Republic of China , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University , 1838 Northern Guangzhou Ave, Guangzhou 510515 ,","place":["China"]},{"name":"Key Laboratory for Organ Failure Research, Ministry of Education of the People's Republic of China , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangchao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong , Shatin, New Territories ,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory for Organ Failure Research, Ministry of Education of the People's Republic of China , Guangzhou 510515 ,","place":["China"]},{"name":"Department of Rheumatology, Nanfang Hospital, Southern Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingli","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University , 1838 Northern Guangzhou Ave, Guangzhou 510515 ,","place":["China"]},{"name":"Key Laboratory for Organ Failure Research, Ministry of Education of the People's Republic of China , Guangzhou 510515 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University , Guangzhou 510515 ,","place":["China"]},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-8237","authenticated-orcid":false,"given":"Qingchun","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University , 1838 Northern Guangzhou Ave, Guangzhou 510515 ,","place":["China"]},{"name":"Key Laboratory for Organ Failure Research, Ministry of 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