{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:10Z","timestamp":1791295690024,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Netherlands Organization for Scientific Research","doi-asserted-by":"publisher","award":["918.16.610"],"award-info":[{"award-number":["918.16.610"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Netherlands Organization for Scientific Research","doi-asserted-by":"publisher","award":["917.18.338"],"award-info":[{"award-number":["917.18.338"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2018T059"],"award-info":[{"award-number":["2018T059"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands CardioVascular Research Initiative","award":["CVON-2017-10"],"award-info":[{"award-number":["CVON-2017-10"]}]},{"name":"Netherlands CardioVascular Research Initiative","award":["CVON-2018-29"],"award-info":[{"award-number":["CVON-2018-29"]}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 La Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["#202038"],"award-info":[{"award-number":["#202038"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Science","award":["#RYC2021-030866-I"],"award-info":[{"award-number":["#RYC2021-030866-I"]}]},{"name":"Research Foundation\u2013Flanders","award":["WOG W0014200N"],"award-info":[{"award-number":["WOG W0014200N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pre-capillary pulmonary hypertension (precPH) results in increased right atrial (RA) stretch and pressure. The right atrium is the major source of bone morphogenetic protein 10 (BMP10) in adults, primarily produced by RA cardiomyocytes. The aim of this study was to investigate BMP10 expression in the right heart and systemic circulation and to identify potential triggers for increased BMP10 secretion associated with precPH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We examined BMP10 mRNA and protein expressions in RA tissue. Circulating BMP10 plasma levels were determined using enzyme-linked immunosorbent assay. BMP10 transcriptional activity was studied using a BMP-responsive element luciferase assay. Correlation analyses were performed between circulating BMP10 and RA dilatation as well as right ventricular (RV) function. Finally, we determined the impact of pressure unloading on BMP10 activity in chronic thromboembolic pulmonary hypertension (CTEPH) patients before and after pulmonary endarterectomy (PEA). BMP10 mRNA\u2019s protein and activity were significantly increased in the precPH right atrium. While circulating BMP10 protein levels were elevated, no significant changes were observed in BMP10 transcriptional activity between precPH and controls. Interestingly, RA dilatation, increased RA pressure, high N-terminal pro b-type natriuretic peptide levels, and reduced RV ejection fraction were associated with high BMP10 activity. Finally, pressure unloading after PEA in a cohort of CTEPH patients resulted in reduced BMP10 activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>RA BMP10 expression and plasma levels are increased in precPH, likely triggered by excessive RA dilatation and pressure overload. Future studies are needed to determine whether increased BMP10 release is an adaptive mechanism or a potential therapeutic target.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf028","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:40:01Z","timestamp":1740361201000},"page":"1254-1268","source":"Crossref","is-referenced-by-count":8,"title":["Bone morphogenetic protein 10 is increased in pre-capillary pulmonary hypertension patients"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-8343","authenticated-orcid":false,"given":"Aida","family":"Lluci\u00e0-Valldeperas","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"van Wezenbeek","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne A","family":"Groeneveldt","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan","family":"Smal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"S\u00e1nchez-Duffhues","sequence":"additional","affiliation":[{"name":"Department of Cell and Chemical Biology, Leiden UMC , Einthovenweg 20, 2333 ZC Leiden ,","place":["The Netherlands"]},{"name":"Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA) , Av. del Hospital Universitario s\/n, 33011 Oviedo, Asturias ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Becher","sequence":"additional","affiliation":[{"name":"Department of Cell and Chemical Biology, Leiden UMC , Einthovenweg 20, 2333 ZC Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azar","family":"Kianzad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara M A","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen N","family":"Wessels","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-7865","authenticated-orcid":false,"given":"M Louis","family":"Handoko","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian J","family":"Meijboom","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Tim","family":"Marcus","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Symersky","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans W M","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Amsterdam UMC location Vrije Universiteit Amsterdam , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Vonk-Noordegraaf","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm Jan","family":"Bogaard","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Jos\u00e9","family":"Goumans","sequence":"additional","affiliation":[{"name":"Department of Cell and Chemical Biology, Leiden UMC , Einthovenweg 20, 2333 ZC Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances S","family":"de Man","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX Laboratory , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis , De Boelelaan 1117, 1081HV Amsterdam ,","place":["The 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