{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:23:58Z","timestamp":1787315038469,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["2021Y9142"],"award-info":[{"award-number":["2021Y9142"]}]},{"name":"Fund for Young and Middle-aged Experts with Outstanding Contributions to Health in Fujian Province","award":["2021ZQNZD005"],"award-info":[{"award-number":["2021ZQNZD005"]}]},{"name":"University-Industry Research Joint Innovation Project of Science and Technology, Fujian Province","award":["2020Y4016"],"award-info":[{"award-number":["2020Y4016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Effective therapeutic drugs for calcific aortic valve disease (CAVD) are lacking, although its incidence has been increasing over the past decade and is predicted to continue rising in the future. This study aimed to explore the role and potential mechanisms of liver X receptor \u03b1 (LXR\u03b1) in CAVD, which offers a promising approach for treating CAVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Osteogenic stimulation was performed following which a substantial downregulation of LXR\u03b1 was observed in human calcific aortic valves and valvular interstitial cells. Further functional investigations revealed that silencing LXR\u03b1 exacerbated calcification both in vitro and in vivo. We showed that LXR\u03b1 suppressed the protein kinase R-like endoplasmic reticulum kinase\/eukaryotic initiation factor 2\/activating transcription factor 4 pathway, which controls endoplasmic reticulum stress (ERS) and promotes osteogenic differentiation, thereby slowing the course of CAVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our research offers fresh perspectives on how LXR\u03b1 controls the pathophysiology of CAVD via regulating ERS. The findings suggest that targeting LXR\u03b1 is a potential treatment strategy for treating aortic valve calcification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf044","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:21:53Z","timestamp":1741911713000},"page":"957-970","source":"Crossref","is-referenced-by-count":1,"title":["Protective functions of liver X receptor \u03b1 on calcified aortic valve: involvement of regulating endoplasmic reticulum-mediated osteogenic differentiation"],"prefix":"10.1093","volume":"121","author":[{"given":"Lishan","family":"Zeng","sequence":"first","affiliation":[{"name":"Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Key Laboratory of Metabolic Heart Disease in Fujian Province, Clinical Research Centre of Metabolic Cardiovascular Disease in Fujian Province , 20 Chazhong Road, Fuzhou 350005 ,","place":["China"]},{"name":"Cardiovascular Department, 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The First Affiliated Hospital, Fujian Medical University, Fujian Institute of Hypertension , 20 Chazhong Road, Fuzhou 350005 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Key Laboratory of Metabolic Heart Disease in Fujian Province, Clinical Research Centre of Metabolic Cardiovascular Disease in Fujian Province , 20 Chazhong Road, Fuzhou 350005 ,","place":["China"]},{"name":"Cardiovascular Department, National Regional Medical Center, Binhai Branch of the First Affiliated Hospital, Fujian Medical University , Fuzhou 350212 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Key Laboratory of Metabolic 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