{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:56:32Z","timestamp":1789163792766,"version":"build-2803163510"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL167917"],"award-info":[{"award-number":["R01HL167917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35HL144993"],"award-info":[{"award-number":["R35HL144993"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL172335"],"award-info":[{"award-number":["R01HL172335"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL172365"],"award-info":[{"award-number":["R01HL172365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56HL155528"],"award-info":[{"award-number":["R56HL155528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL163019"],"award-info":[{"award-number":["R01HL163019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL160808"],"award-info":[{"award-number":["R01HL160808"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16SFRN2873002"],"award-info":[{"award-number":["16SFRN2873002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16SFRN28850003"],"award-info":[{"award-number":["16SFRN28850003"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["SFRN28730004"],"award-info":[{"award-number":["SFRN28730004"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["SFRN28730006"],"award-info":[{"award-number":["SFRN28730006"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34630066"],"award-info":[{"award-number":["19CDA34630066"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23SCEFIA1153739"],"award-info":[{"award-number":["23SCEFIA1153739"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate how psychosocial stress contributes to accelerated thrombosis, focusing on platelet activation and hyperreactivity. The specific objective was to identify novel platelet regulators involved in stress-mediated thrombosis, with a particular emphasis on the tetraspanin CD37.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>To explore how stress contributes to platelet hyperreactivity, platelets were isolated from (i) mice that experienced chronic variable stress and stress-free controls (n = 8\/group) and (ii) human subjects with self-reported high- and no-stress levels (n = 18\/group), followed by RNA-sequencing. By comparing mutually expressed transcripts, a subset of genes differentially expressed following psychosocial stress was identified in both human and mouse platelets. In both mice and humans, platelet CD37 positively associates with platelet aggregation responses that underlie thrombosis, with Cd37\u2212\/\u2212 platelets exhibiting impaired integrin \u03b1IIb\u03b23 signalling, characterized by reduced platelet fibrinogen spreading and decreased agonist-induced \u03b1IIb\u03b23 activation. Consistent with a role for CD37 in regulating platelet activation responses, chimeric mice that received Cd37\u2212\/\u2212 bone marrow experienced a significantly increased time to vessel occlusion in the carotid artery FeCl3 model compared to mice reconstituted with wild-type bone marrow. CD37 deficiency did not alter haemostasis, as platelet count, coagulation metrics, prothrombin time, and partial thromboplastin time did not differ in Cd37\u2212\/\u2212 mice relative to wild-type mice. Consistent with this, bleeding time did not differ between wild-type and Cd37\u2212\/\u2212 mice following tail tip transection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides new insights into the platelet-associated mechanisms underlying stress-mediated thrombosis. Identifying CD37 as a novel regulator of platelet activation responses offers potential therapeutic targets for reducing the thrombotic risk associated with psychosocial stress. The findings also contribute to understanding how psychosocial stress accelerates thrombotic events and underscore the importance of platelet activation in this process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>NCT02106429, NCT03022552<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf051","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T05:40:04Z","timestamp":1742708404000},"page":"943-956","source":"Crossref","is-referenced-by-count":5,"title":["Tetraspanin CD37 regulates platelet hyperreactivity and thrombosis"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-0122","authenticated-orcid":false,"given":"Marcin A","family":"Sowa","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-0152","authenticated-orcid":false,"given":"Carmen","family":"Hannemann","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2236-8936","authenticated-orcid":false,"given":"Ivan","family":"Pinos","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharti","family":"Biwas","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dai","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M","family":"Corr","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macintosh G","family":"Cornwell","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]},{"name":"Institute for Systems Genetics, New York University Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamelia","family":"Drenkova","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela H","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2998-3007","authenticated-orcid":false,"given":"Tanya","family":"Spruill","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-0655","authenticated-orcid":false,"given":"Harmony R","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Sarah Ross Soter Center for Women\u2019s Cardiovascular Research, New York University Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S","family":"Hochman","sequence":"additional","affiliation":[{"name":"Sarah Ross Soter Center for Women\u2019s Cardiovascular Research, New York University Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly V","family":"Ruggles","sequence":"additional","affiliation":[{"name":"Institute for Systems Genetics, New York University Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Washington University in St. Louis , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coen","family":"van Solingen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J","family":"Moore","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Berger","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0751-1578","authenticated-orcid":false,"given":"Tessa J","family":"Barrett","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, New York University Grossman School of Medicine , 435 e 30th St, New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"2026041420143494100_cvaf051-B1","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart Disease and Stroke Statistics-2021 update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"2026041420143494100_cvaf051-B2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0140-6736(04)17019-0","article-title":"Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study","volume":"364","author":"Rosengren","year":"2004","journal-title":"Lancet"},{"key":"2026041420143494100_cvaf051-B3","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/eurheartj\/ehn018","article-title":"Risk factors for myocardial infarction in women and men: insights from the INTERHEART study","volume":"29","author":"Anand","year":"2008","journal-title":"Eur Heart J"},{"key":"2026041420143494100_cvaf051-B4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet"},{"key":"2026041420143494100_cvaf051-B5","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.it.2017.08.002","article-title":"Exosomes, DAMPs and miRNA: features of stress physiology and immune homeostasis","volume":"38","author":"Fleshner","year":"2017","journal-title":"Trends Immunol"},{"key":"2026041420143494100_cvaf051-B6","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1073\/pnas.1310655110","article-title":"Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via beta-adrenergic induction of myelopoiesis","volume":"110","author":"Powell","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026041420143494100_cvaf051-B7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt","year":"2014","journal-title":"Nat Med"},{"key":"2026041420143494100_cvaf051-B8","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.jacc.2012.06.044","article-title":"Perceived stress in myocardial infarction: long-term mortality and health status outcomes","volume":"60","author":"Arnold","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2026041420143494100_cvaf051-B9","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1161\/01.CIR.0000143840.77061.E9","article-title":"Exaggerated blood pressure responses during mental stress are prospectively related to enhanced carotid atherosclerosis in middle-aged Finnish men","volume":"110","author":"Jennings","year":"2004","journal-title":"Circulation"},{"key":"2026041420143494100_cvaf051-B10","author":"American Psychological Association"},{"key":"2026041420143494100_cvaf051-B11","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax0481","article-title":"Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis","volume":"11","author":"Barrett","year":"2019","journal-title":"Sci Transl Med"},{"key":"2026041420143494100_cvaf051-B12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosis.2018.12.029","article-title":"Circulating monocyte-platelet aggregates are a robust marker of platelet activity in cardiovascular disease","volume":"282","author":"Allen","year":"2019","journal-title":"Atherosclerosis"},{"key":"2026041420143494100_cvaf051-B13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.atherosclerosis.2020.05.018","article-title":"Platelets as therapeutic targets to prevent atherosclerosis","volume":"307","author":"Nording","year":"2020","journal-title":"Atherosclerosis"},{"key":"2026041420143494100_cvaf051-B14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/00006842-199111000-00006","article-title":"Platelets and coronary heart disease: potential psychophysiologic mechanisms","volume":"53","author":"Markovitz","year":"1991","journal-title":"Psychosom Med"},{"key":"2026041420143494100_cvaf051-B15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/oxfordjournals.eurheartj.a015346","article-title":"Effects of mental and physical stress on platelet function in patients with stable angina pectoris and healthy controls","volume":"18","author":"Wallen","year":"1997","journal-title":"Eur Heart J"},{"key":"2026041420143494100_cvaf051-B16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1475-097X.1993.tb00330.x","article-title":"Platelet activation in mental stress","volume":"13","author":"Naesh","year":"1993","journal-title":"Clin Physiol"},{"key":"2026041420143494100_cvaf051-B17","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ahj.2014.12.002","article-title":"Platelet aggregation and mental stress induced myocardial ischemia: results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study","volume":"169","author":"Jiang","year":"2015","journal-title":"Am Heart J"},{"key":"2026041420143494100_cvaf051-B18","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.CIR.71.6.1129","article-title":"Platelet activation and secretion associated with emotional stress","volume":"71","author":"Levine","year":"1985","journal-title":"Circulation"},{"key":"2026041420143494100_cvaf051-B19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrcardio.2017.189","article-title":"Effects of stress on the development and progression of cardiovascular disease","volume":"15","author":"Kivimaki","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"2026041420143494100_cvaf051-B20","doi-asserted-by":"crossref","first-page":"e010931","DOI":"10.1161\/CIRCIMAGING.120.010931","article-title":"Disentangling the links between psychosocial stress and cardiovascular disease","volume":"13","author":"Osborne","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"2026041420143494100_cvaf051-B21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3109\/09537104.2015.1083543","article-title":"Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction","volume":"27","author":"Eicher","year":"2016","journal-title":"Platelets"},{"key":"2026041420143494100_cvaf051-B22","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood-2016-03-703157","article-title":"Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease","volume":"128","author":"Montenont","year":"2016","journal-title":"Blood"},{"key":"2026041420143494100_cvaf051-B23","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1161\/CIRCULATIONAHA.105.607333","article-title":"Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events","volume":"113","author":"Healy","year":"2006","journal-title":"Circulation"},{"key":"2026041420143494100_cvaf051-B24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jacc.2017.10.072","article-title":"Platelet-derived MRP-14 induces monocyte activation in patients with symptomatic peripheral artery disease","volume":"71","author":"Dann","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026041420143494100_cvaf051-B25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1182\/blood-2014-04-512756","article-title":"A tour through the transcriptional landscape of platelets","volume":"124","author":"Schubert","year":"2014","journal-title":"Blood"},{"key":"2026041420143494100_cvaf051-B26","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/ATVBAHA.119.313280","article-title":"Megakaryocyte and platelet transcriptomics for discoveries in human health and disease","volume":"40","author":"Davizon-Castillo","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026041420143494100_cvaf051-B27","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/ATVBAHA.122.318020","article-title":"Aspirin for the primary prevention of cardiovascular disease: time for a platelet-guided approach","volume":"42","author":"Cofer","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026041420143494100_cvaf051-B28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ccell.2022.08.006","article-title":"Detection and localization of early- and late-stage cancers using platelet RNA","volume":"40","author":"In \u2018t Veld","year":"2022","journal-title":"Cancer Cell"},{"key":"2026041420143494100_cvaf051-B29","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/s41596-019-0139-5","article-title":"RNA sequencing and swarm intelligence-enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA","volume":"14","author":"Best","year":"2019","journal-title":"Nat Protoc"},{"key":"2026041420143494100_cvaf051-B30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jacbts.2017.10.005","article-title":"Platelet transcriptome profiling in HIV and ATP-Binding Cassette subfamily C member 4 (ABCC4) as a mediator of platelet activity","volume":"3","author":"Marcantoni","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"2026041420143494100_cvaf051-B31","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1182\/blood-2012-04-416594","article-title":"The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways","volume":"120","author":"Burkhart","year":"2012","journal-title":"Blood"},{"key":"2026041420143494100_cvaf051-B32","doi-asserted-by":"crossref","first-page":"12358","DOI":"10.1038\/s41598-021-91661-x","article-title":"Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions","volume":"11","author":"Huang","year":"2021","journal-title":"Sci Rep"},{"key":"2026041420143494100_cvaf051-B33","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1111\/j.1538-7836.2009.03613.x","article-title":"Platelet tetraspanins: small but interesting","volume":"7","author":"Tomlinson","year":"2009","journal-title":"J Thromb Haemost"},{"key":"2026041420143494100_cvaf051-B34","doi-asserted-by":"crossref","first-page":"e208741","DOI":"10.1001\/jamanetworkopen.2020.8741","article-title":"Association of perceived stress levels with long-term mortality in patients with peripheral artery disease","volume":"3","author":"Malik","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2026041420143494100_cvaf051-B35","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/194927b0","article-title":"Aggregation of blood platelets by adenosine diphosphate and its reversal","volume":"194","author":"Born","year":"1962","journal-title":"Nature"},{"key":"2026041420143494100_cvaf051-B36","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1111\/jth.15534","article-title":"Platelets contribute to disease severity in COVID-19","volume":"19","author":"Barrett","year":"2021","journal-title":"J Thromb Haemost"},{"key":"2026041420143494100_cvaf051-B37","doi-asserted-by":"crossref","first-page":"eabh2434","DOI":"10.1126\/sciadv.abh2434","article-title":"Platelets amplify endotheliopathy in COVID-19","volume":"7","author":"Barrett","year":"2021","journal-title":"Sci Adv"},{"key":"2026041420143494100_cvaf051-B38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026041420143494100_cvaf051-B39","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2026041420143494100_cvaf051-B40","author":"Andrews"},{"key":"2026041420143494100_cvaf051-B41","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"2026041420143494100_cvaf051-B42","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"2026041420143494100_cvaf051-B43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2026041420143494100_cvaf051-B44","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jacbts.2024.05.014","article-title":"Inhibiting the P2Y(12) receptor in megakaryocytes and platelets suppresses interferon-associated responses","volume":"9","author":"Sowa","year":"2024","journal-title":"JACC Basic Transl Sci"},{"key":"2026041420143494100_cvaf051-B45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41377-023-01204-4","article-title":"Superresolution structured illumination microscopy reconstruction algorithms: a review","volume":"12","author":"Chen","year":"2023","journal-title":"Light Sci Appl"},{"key":"2026041420143494100_cvaf051-B46","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1128\/MCB.20.15.5363-5369.2000","article-title":"Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions","volume":"20","author":"Knobeloch","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2026041420143494100_cvaf051-B47","doi-asserted-by":"crossref","first-page":"109595","DOI":"10.1016\/j.celrep.2021.109595","article-title":"Chronic stress primes innate immune responses in mice and humans","volume":"36","author":"Barrett","year":"2021","journal-title":"Cell Rep"},{"key":"2026041420143494100_cvaf051-B48","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1182\/blood-2015-07-661371","article-title":"Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets","volume":"127","author":"Rowley","year":"2016","journal-title":"Blood"},{"key":"2026041420143494100_cvaf051-B49","article-title":"Ferric chloride-induced thrombosis mouse model on carotid artery and mesentery vessel","volume":"100","author":"Bonnard","year":"2015","journal-title":"J Vis Exp"},{"key":"2026041420143494100_cvaf051-B50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.redox.2012.11.001","article-title":"Ferric chloride-induced murine carotid arterial injury: a model of redox pathology","volume":"1","author":"Li","year":"2013","journal-title":"Redox Biol"},{"key":"2026041420143494100_cvaf051-B51","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2337\/db18-0981","article-title":"Glucose metabolism is required for platelet hyperactivation in a murine model of type 1 diabetes","volume":"68","author":"Fidler","year":"2019","journal-title":"Diabetes"},{"key":"2026041420143494100_cvaf051-B52","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/ATVBAHA.119.314008","article-title":"Activated platelets induce endothelial cell inflammatory response in psoriasis via COX-1","volume":"40","author":"Garshick","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026041420143494100_cvaf051-B53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4161\/cib.1.1.6406","article-title":"Tetraspanins: small transmembrane proteins with big impact on membrane microdomain structures","volume":"1","author":"Singethan","year":"2008","journal-title":"Commun Integr Biol"},{"key":"2026041420143494100_cvaf051-B54","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.4049\/jimmunol.1402414","article-title":"Tetraspanin CD37 regulates beta2 integrin-mediated adhesion and migration in neutrophils","volume":"195","author":"Wee","year":"2015","journal-title":"J Immunol"},{"key":"2026041420143494100_cvaf051-B55","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3389\/fimmu.2018.01247","article-title":"Monocyte subsets have distinct patterns of tetraspanin expression and different capacities to form multinucleate giant cells","volume":"9","author":"Champion","year":"2018","journal-title":"Front Immunol"},{"key":"2026041420143494100_cvaf051-B56","doi-asserted-by":"crossref","first-page":"ra82","DOI":"10.1126\/scisignal.2003113","article-title":"The tetraspanin CD37 orchestrates the alpha(4)beta(1) integrin-Akt signaling axis and supports long-lived plasma cell survival","volume":"5","author":"van Spriel","year":"2012","journal-title":"Sci Signal"},{"key":"2026041420143494100_cvaf051-B57","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.4049\/jimmunol.172.5.2953","article-title":"A regulatory role for CD37 in T cell proliferation","volume":"172","author":"van Spriel","year":"2004","journal-title":"J Immunol"},{"key":"2026041420143494100_cvaf051-B58","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/eji.201242730","article-title":"Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration","volume":"43","author":"Gartlan","year":"2013","journal-title":"Eur J Immunol"},{"key":"2026041420143494100_cvaf051-B59","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/eji.200838798","article-title":"Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC","volume":"39","author":"Sheng","year":"2009","journal-title":"Eur J Immunol"},{"key":"2026041420143494100_cvaf051-B60","doi-asserted-by":"crossref","first-page":"jcs214551","DOI":"10.1242\/jcs.214551","article-title":"C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37","volume":"131","author":"de Winde","year":"2018","journal-title":"J Cell Sci"},{"key":"2026041420143494100_cvaf051-B61","doi-asserted-by":"crossref","first-page":"ISF-449","DOI":"10.12688\/f1000research.23598.2","article-title":"Differential dynamics of early stages of platelet adhesion and spreading on collagen IV- and fibrinogen-coated surfaces","volume":"9","author":"Horev","year":"2020","journal-title":"F1000Res"},{"key":"2026041420143494100_cvaf051-B62","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J Health Soc Behav"},{"key":"2026041420143494100_cvaf051-B63","doi-asserted-by":"crossref","first-page":"jcs218222","DOI":"10.1242\/jcs.218222","article-title":"SRF\u2019ing and SAP\u2019ing\u2014the role of MRTF proteins in cell migration","volume":"131","author":"Gau","year":"2018","journal-title":"J Cell Sci"},{"key":"2026041420143494100_cvaf051-B64","doi-asserted-by":"crossref","first-page":"C70","DOI":"10.1152\/ajpcell.00386.2006","article-title":"Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus","volume":"292","author":"Miano","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026041420143494100_cvaf051-B65","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1093\/eurheartj\/eht216","article-title":"Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: the Whitehall II prospective cohort study","volume":"34","author":"Nabi","year":"2013","journal-title":"Eur Heart J"},{"key":"2026041420143494100_cvaf051-B66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1476-511X-13-77","article-title":"Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats","volume":"13","author":"Wang","year":"2014","journal-title":"Lipids Health Dis"},{"key":"2026041420143494100_cvaf051-B67","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1160\/TH16-10-0817","article-title":"Susceptibility to chronic social stress increases plaque progression, vulnerability and platelet activation","volume":"117","author":"Giannarelli","year":"2017","journal-title":"Thromb Haemost"},{"key":"2026041420143494100_cvaf051-B68","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1038\/s41598-019-38679-4","article-title":"Stress-induced mast cell activation contributes to atherosclerotic plaque destabilization","volume":"9","author":"Lagraauw","year":"2019","journal-title":"Sci Rep"},{"key":"2026041420143494100_cvaf051-B69","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41591-024-02953-4","article-title":"Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes","volume":"30","author":"Pekayvaz","year":"2024","journal-title":"Nat Med"},{"key":"2026041420143494100_cvaf051-B70","first-page":"175","article-title":"Bioinformatic analysis of the possible regulative network of miR-30a\/e in cardiomyocytes 2 days post myocardial infarction","volume":"34","author":"Wang","year":"2018","journal-title":"Acta Cardiol Sin"},{"key":"2026041420143494100_cvaf051-B71","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1152\/physiolgenomics.00074.2011","article-title":"Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction","volume":"43","author":"Port","year":"2011","journal-title":"Physiol Genomics"},{"key":"2026041420143494100_cvaf051-B72","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/08964280209596039","article-title":"Psychosocial stress and cardiovascular disease: pathophysiological links","volume":"27","author":"Bairey Merz","year":"2002","journal-title":"Behav Med"},{"key":"2026041420143494100_cvaf051-B73","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrm1736","article-title":"Tetraspanin functions and associated microdomains","volume":"6","author":"Hemler","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026041420143494100_cvaf051-B74","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri1548","article-title":"The tetraspanin web modulates immune-signalling complexes","volume":"5","author":"Levy","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"2026041420143494100_cvaf051-B75","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/PL00000933","article-title":"Tetraspanins","volume":"58","author":"Boucheix","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"2026041420143494100_cvaf051-B76","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1182\/blood-2009-02-203828","article-title":"Platelet membrane proteomics: a novel repository for functional research","volume":"114","author":"Lewandrowski","year":"2009","journal-title":"Blood"},{"key":"2026041420143494100_cvaf051-B77","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1042\/BJ20081126","article-title":"Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains","volume":"417","author":"Protty","year":"2009","journal-title":"Biochem J"},{"key":"2026041420143494100_cvaf051-B78","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.2174\/138955707782795656","article-title":"Tetraspanins-structural and signalling scaffolds that regulate platelet function","volume":"7","author":"Goschnick","year":"2007","journal-title":"Mini Rev Med Chem"},{"key":"2026041420143494100_cvaf051-B79","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.yexcr.2015.11.006","article-title":"Homozygous loss of mouse tetraspanin CD82 enhances integrin alphaIIbbeta3 expression and clot retraction in platelets","volume":"339","author":"Uchtmann","year":"2015","journal-title":"Exp Cell Res"},{"key":"2026041420143494100_cvaf051-B80","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1182\/blood-2006-02-004267","article-title":"Impaired \u201coutside-in\u201d integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice","volume":"108","author":"Goschnick","year":"2006","journal-title":"Blood"},{"key":"2026041420143494100_cvaf051-B81","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1182\/blood-2003-12-4430","article-title":"The tetraspanin superfamily member CD151 regulates outside-in integrin alphaIIbbeta3 signaling and platelet function","volume":"104","author":"Lau","year":"2004","journal-title":"Blood"},{"key":"2026041420143494100_cvaf051-B82","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0074-7696(02)17014-8","article-title":"Actin dynamics in platelets","volume":"217","author":"Bearer","year":"2002","journal-title":"Int Rev Cytol"},{"key":"2026041420143494100_cvaf051-B83","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.3390\/ijms21249531","article-title":"CD37 in B cell derived tumors-more than just a docking point for monoclonal antibodies","volume":"21","author":"Bobrowicz","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026041420143494100_cvaf051-B84","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nrd2659","article-title":"Targeting of tetraspanin proteins\u2013potential benefits and strategies","volume":"7","author":"Hemler","year":"2008","journal-title":"Nat Rev Drug Discov"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaf051\/62573795\/cvaf051.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/6\/943\/62573795\/cvaf051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/6\/943\/62573795\/cvaf051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:25:38Z","timestamp":1776212738000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/121\/6\/943\/8092434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":84,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3,24]]},"published-print":{"date-parts":[[2025,6,12]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvaf051","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,3,24]]}}}