{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:46Z","timestamp":1787008666003,"version":"build-2736575974"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100010447","name":"DZHK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006603","name":"BMBF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005971","name":"German Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005970","name":"German Foundation of Heart Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Pulmonary hypertension (PH) is a common complication of left heart disease (LHD) that leads to right heart failure and death. Pulmonary artery (PA) stiffening has recently emerged as an important diagnostic and prognostic parameter in PH. The present study aimed to develop and validate an ultrasonographic index to identify PA stiffening in PH due to LHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>First, ultrasonographic stiffness index (US-SI) was derived from pulmonary arterial (PA) radial strain (PA-RS), diameter, and stroke volume in rat model and correlated with ex vivo measured \u2018true\u2019 PA stiffness E. Then, US-SI was validated in a cohort of 24 LHD patients with or without PH prior to heart transplantation and again compared with \u2018true\u2019 PA stiffness measured ex vivo in collected PA specimens. In rats, ultrasonographic PA-RS and US-SI correlated closely with E, and both were able to detect \u2018true\u2019 PA stiffening with \u226580% sensitivity and specificity. In LHD patients, even though ultrasonographic right PA radial strain or US-SI correlated similarly with E, observer assessment and testing for diagnostic validity identified US-SI as more robust and accurate method that detects \u2018true\u2019 PA stiffening with 83.3% sensitivity and 95.8% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both PA strain and US-SI allow for ultrasonographic detection of PA stiffening in patients or animal models with LHD; however, US-SI identifies patients with stiffened PA with higher diagnostic validity and accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf066","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:38:06Z","timestamp":1745307486000},"page":"1433-1447","source":"Crossref","is-referenced-by-count":4,"title":["Identification of pulmonary artery stiffening due to left heart disease by ultrasonography"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-2037","authenticated-orcid":false,"given":"Mariya M","family":"Kucherenko","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, 10117 Berlin ,","place":["Germany"]},{"name":"Institute of Physiology, Charit\u00e9 University Medicine Berlin, Corporate Member of Freie University Berlin and Humboldt-University Berlin , Charit\u00e9platz 1, 10117 Berlin ,","place":["Germany"]},{"name":"DZHK: German Centre for Cardiovascular Research, Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin 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,","place":["Germany"]},{"name":"Institute of Physiology, Charit\u00e9 University Medicine Berlin, Corporate Member of Freie University Berlin and Humboldt-University Berlin , Charit\u00e9platz 1, 10117 Berlin ,","place":["Germany"]},{"name":"DZHK: German Centre for Cardiovascular Research, Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Hegemann","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Charit\u00e9platz 1, 10117 Berlin ,","place":["Germany"]},{"name":"Institute of Physiology, Charit\u00e9 University Medicine Berlin, Corporate Member of Freie University Berlin and Humboldt-University Berlin , Charit\u00e9platz 1, 10117 Berlin ,","place":["Germany"]},{"name":"DZHK: German Centre for Cardiovascular Research, Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhua","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Charit\u00e9 University Medicine Berlin, Corporate Member of Freie University Berlin and Humboldt-University Berlin , Charit\u00e9platz 1, 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Hennig","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , 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