{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:24:10Z","timestamp":1785864250955,"version":"3.56.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"publisher","award":["16CVD02"],"award-info":[{"award-number":["16CVD02"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000118","name":"National Institutes of Health Office","doi-asserted-by":"publisher","award":["OT2 OD023848"],"award-info":[{"award-number":["OT2 OD023848"]}],"id":[{"id":"10.13039\/100000118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["U01 EB025138"],"award-info":[{"award-number":["U01 EB025138"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F32 HL160163"],"award-info":[{"award-number":["F32 HL160163"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Acute myocardial ischaemia causes fatal arrhythmias as result of a flow of \u2018injury current\u2019. Left stellate ganglion stimulation (LSGS) modulates the injury current and is arrhythmogenic during left anterior ventricular wall ischaemia. The role of right stellate ganglion stimulation (RSGS) in arrhythmogenesis is unclear. We hypothesized that RSGS is proarrhythmic during left lateral ventricular wall ischaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In 11 anaesthetized female pigs, ventricular repolarization was measured in unipolar epicardial electrograms from the left lateral ventricular wall. Seven subsequent episodes of acute ischaemia (5\u2005min) were produced by occlusion of the circumflex coronary artery (CX), separated by 20\u2005min of reperfusion. The second occlusion served as a control. After 3\u2005min of ischaemia during the third occlusion, LSGS was initiated for 30\u2005s. In the 4th occlusion, RSGS was performed. After decentralization of both left and right stellate ganglia and vagal nerves, LSGS and RSGS were initiated (6th and 7th occlusions). RSGS during ischaemia was more arrhythmogenic than LSGS or control with more spontaneous ventricular premature beats (3\u20135\u2005min of ischaemia) and two instances of ventricular fibrillation. The LSGS-induced effect on repolarization was absent in myocardium that had been ischaemic for 3\u2005min by CX occlusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LSGS-induced repolarization shortening is absent in ischaemic myocardium. RSGS was more arrhythmogenic following CX occlusion than LSGS or control. These data demonstrate that the arrhythmogenic influence of RSGS or LSGS is contingent on the location of ischaemic zone supporting the clinical findings that bilateral sympathectomy is superior to left sympathectomy alone.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf121","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T17:35:44Z","timestamp":1752514544000},"source":"Crossref","is-referenced-by-count":2,"title":["Right stellate ganglion stimulation modulates arrhythmogenesis in acute left lateral ventricular ischaemia"],"prefix":"10.1093","author":[{"given":"Joseph","family":"Hadaya","sequence":"first","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6449-145X","authenticated-orcid":false,"given":"Bastiaan J D","family":"Boukens","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Department of Cardiology, LUMC , Leiden ,","place":["The Netherlands"]},{"name":"Department of Physiology, University of Maastricht , Universiteitssingel 50, P.O. Box 616, Maastricht 6200 MD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel J","family":"Janse","sequence":"additional","affiliation":[{"name":"Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, P.O. Box 22660, Amsterdam 1100 DD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Cha","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al-Hassan","family":"Dajani","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Challita","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9433-6119","authenticated-orcid":false,"given":"Ruben","family":"Coronel","sequence":"additional","affiliation":[{"name":"Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, P.O. Box 22660, Amsterdam 1100 DD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Ardell","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyanam","family":"Shivkumar","sequence":"additional","affiliation":[{"name":"UCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-0170","authenticated-orcid":false,"given":"Veronique M F","family":"Meijborg","sequence":"additional","affiliation":[{"name":"Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, P.O. Box 22660, Amsterdam 1100 DD ,","place":["The Netherlands"]},{"name":"Laboratory for Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht , Heidelberglaan 100, P.O. 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