{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:32:48Z","timestamp":1787027568209,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD); however, the relationship between Lp(a) and the capacity for vascular repair remains unclear. Depletion of vascular regenerative (VR) progenitor cells has been shown to be a novel indicator of compromised vascular repair in people living with cardiometabolic disorders. The purpose of this study was to determine if elevated levels of Lp(a) modify VR cell content properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The cross-sectional, multi-site Lipoprotein(a) and Vascular Regenerative Cell Content CardioLink-16 [Lp(a)-VRCE] study enrolled 40 individuals\u201420 with Lp(a) \u2265100\u2005nmol\/L and 20 with Lp(a) &amp;lt;100\u2005nmol\/L. Isolated peripheral blood mononuclear cells were analysed by multi-parameter flow cytometry. VR progenitor cells were identified based on high aldehyde dehydrogenase (ALDH) activity, in combination with primitive vs. mature lineage-specific cell surface markers. The Lp(a) \u2265100\u2005nmol\/L group exhibited baseline characteristic differences compared with the Lp(a) &amp;lt;100\u2005nmol\/L group such as lower estimated glomerular filtration rate (86.9 vs. 100.1\u2005mL\/min\/1.73\u2005m2), lower total cholesterol (4.0 vs. 4.8\u2005mmol\/L), greater statin use (90 vs. 60%), and a higher prevalence of ASCVD (60 vs. 25%). The Lp(a) \u2265100\u2005nmol\/L group had lower frequencies of pro-angiogenic ALDHhiSSClowCD133+ (P = 0.0008) and ALDHhiSSClowCD34+CD133+ (P = 0.005) progenitor cells with pro-angiogenic secretory function. Compared with those in the Lp(a) &amp;lt;100\u2005nmol\/L group, individuals in the Lp(a) \u2265100\u2005nmol\/L group demonstrated a higher frequency of M1-polarized pro-inflammatory monocytes (ALDHhiSSCmidCD86+CD163\u2212; P = 0.007) and a lower frequency of ALDHhiSSChiCD49d+ granulocyte precursor cells (P = 0.04) that are involved in vessel repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this translational study, people with an Lp(a) \u2265100\u2005nmol\/L had fewer VR cells and more pro-inflammatory polarized monocyte precursor cells than those with Lp(a) levels &amp;lt;100\u2005nmol\/L. These findings suggest that vessel repair activities may be compromised in individuals with elevated Lp(a) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>Lp(a)-VRCE ClinicalTrials.gov: NCT06626659<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf142","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:31:24Z","timestamp":1755603084000},"page":"2127-2130","source":"Crossref","is-referenced-by-count":3,"title":["Vascular regenerative deficiencies in people with elevated lipoprotein(a): the Lp(a)-VRCE CardioLink-16 translational study"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-2044","authenticated-orcid":false,"given":"Michael","family":"Moroney","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, St Michael\u2019s Hospital of Unity Health Toronto , 30 Bond Street, Toronto, ON , M5B 1W5","place":["Canada"]},{"name":"School of Medicine, Royal College of Surgeons in Ireland , 123 St Stephen\u2019s Green, Dublin 2 D02 YN77 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5089-1366","authenticated-orcid":false,"given":"Jack H","family":"Casey","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, St Michael\u2019s Hospital of Unity Health Toronto , 30 Bond Street, Toronto, ON , M5B 1W5","place":["Canada"]},{"name":"School of Medicine, Royal College of Surgeons in Ireland , 123 St Stephen\u2019s Green, Dublin 2 D02 YN77 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1036-4767","authenticated-orcid":false,"given":"Hwee","family":"Teoh","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, St Michael\u2019s Hospital of Unity Health Toronto , 30 Bond Street, Toronto, ON , M5B 1W5","place":["Canada"]},{"name":"Division of Endocrinology and Metabolism, St Michael\u2019s Hospital of Unity Health Toronto , 30 Bond Street, Toronto, ON , M5B 1W5","place":["Canada"]},{"name":"Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institution of St. Michael\u2019s Hospital , 209 Victoria Street, Toronto, ON , M5B 1T8","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-478X","authenticated-orcid":false,"given":"Aishwarya","family":"Krishnaraj","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, St Michael\u2019s Hospital of Unity Health Toronto , 30 Bond Street, Toronto, ON , M5B 1W5","place":["Canada"]},{"name":"Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institution of St. Michael\u2019s Hospital , 209 Victoria Street, Toronto, ON , M5B 1T8","place":["Canada"]},{"name":"Department of Pharmacology 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