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Iron deficiency (ID) is a common pregnancy complication that elicits numerous cardiovascular adaptations. Though generally considered deleterious in pregnancy, whether ID mitigates or exacerbates maternal cardiovascular dysfunction in HDP has not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Pregnant spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats were fed either an iron-replete or an iron-restricted diet prior to and throughout pregnancy. Pregnant dams underwent tail-cuff plethysmography and echocardiography throughout pregnancy, as well as pressure\u2013volume loop assessments and in vivo blood pressure (BP) measurements on GD21 (term = GD22). Data were analysed by two-way ANOVA with Holm\u2013\u0160\u00edd\u00e1k\u2019s post hoc test. Dietary iron restriction caused progressive BP lowering throughout gestation that was most apparent in SHR dams. By GD21, all ID dams had moderate anaemia, whereas ID foetuses of both strains exhibited signs of severe anaemia, asymmetric growth restriction, and placentomegaly. Maternal ID was associated with left ventricular remodeling in both strains, albeit circulating N-terminal pro-B-type natriuretic peptide levels\u2014a marker of pathological stretch\u2014were reduced in ID-SHR dams. Maternal ID hearts exhibited enhanced ventricular performance reflected by increased stroke volume and cardiac output relative to their iron-replete counterparts. ID also improved cardiac efficiency and ventriculo-arterial coupling, and these latter effects were most pronounced in SHR dams.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ID in pregnancy was associated with greater BP lowering and improved cardiac performance in SHR dams compared to normotensive WKY dams, albeit ID foetuses from both strains exhibited growth restriction and placentomegaly. These findings highlight a complex interaction between ID anaemia in pre-existing hypertension in pregnancy and, if translated to humans, could have important implications for the identification and management of both prevalent health conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf149","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:29:39Z","timestamp":1756207779000},"page":"1956-1968","source":"Crossref","is-referenced-by-count":1,"title":["Effects of iron deficiency anaemia on maternal haemodynamics and cardiac function in pregnant spontaneously hypertensive rats"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-8780","authenticated-orcid":false,"given":"Jad-Julian R","family":"Rachid","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton T6G 1C9 ,","place":["Canada"]},{"name":"Women and Children\u2019s Health Research 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,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-6977","authenticated-orcid":false,"given":"Alyssa R","family":"Wiedemeyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton T6G 1C9 ,","place":["Canada"]},{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton T6G 1C9 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-7840","authenticated-orcid":false,"given":"Ronan M N","family":"Noble","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta, Edmonton T6G 1C9 ,","place":["Canada"]},{"name":"Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton T6G 1C9 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