{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:18:52Z","timestamp":1790313532088,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400442"],"award-info":[{"award-number":["82400442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300413"],"award-info":[{"award-number":["82300413"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200410"],"award-info":[{"award-number":["82200410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2021YFA1101900"],"award-info":[{"award-number":["2021YFA1101900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Hubei Provincial Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCZRYB202500107"],"award-info":[{"award-number":["JCZRYB202500107"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024T170309"],"award-info":[{"award-number":["2024T170309"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Calcific aortic valve disease (CAVD) is becoming more prevalent with the population ageing; however, there is currently no medical therapy available. During early lipid deposition, low-density lipoprotein (LDL) mediates chronic inflammation and accelerates calcification progression. However, the mechanism still needs to be further explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The study identified the transcription factor FOXS in human valvular interstitial cells (VICs) as a pivotal regulator in aortic valve calcification. Bulk RNA-seq and qRT-PCR analysis were conducted to establish that FOXS1 is induced by oxidized LDL (oxLDL) in VICs. To elucidate the role of FOXS1 in osteogenic differentiation, small interfering RNA and recombinant adenovirus were utilized to modulate FOXS1 expression in VICs. High-fat diet (HFD)-fed Apoe\u2212\/\u2212Foxs1\u2212\/\u2212 mice served as an in vivo model to investigate the role of FOXS1 in aortic valve calcification. Analysis from bulk RNA-seq, qRT-PCR, and western blot indicated significant activation of FOXS1 by oxLDL in VICs, with silencing of FOXS1 inhibiting oxLDL-induced osteogenic differentiation. Deletion of FOXS1 markedly reduced aortic valve calcification in HFD-fed Apoe\u2212\/\u2212 mice, as shown by decreased calcium deposition in the aortic valve leaflets. RNA-seq and chromatin immunoprecipitation sequencing were performed to reveal the regulatory mechanisms of FOXS1, uncovering direct interactions with the promoter of BSCL2, which subsequently inhibits the expression of ABCA1 and ABCG1 via the PPAR\u03b3\/LXR\u03b1 axis. The study demonstrated that FOXS1 mediates VICs\u2019 cholesterol transport dysfunction through BSCL2, ABCA1, and ABCG1 using Bodipy-cholesterol and showed that intracellular cholesterol accumulation can activate the NLRP3 inflammasome, promoting osteogenic differentiation of VICs. Additionally, it was found that IMM-H007 and recombinant BSCL2 could reduce aortic valve calcification both in vitro and in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified that an oxLDL-induced transcription factor FOXS1 inhibits ABCA1 and ABCG1 expression via the BSCL2\/PPAR\u03b3\/LXR\u03b1 axis and promotes cholesterol transport dysfunction and the activation of NLRP3 inflammasome in VICs, thereby accelerating the progression of CAVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf159","type":"journal-article","created":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T11:38:49Z","timestamp":1758454729000},"page":"1941-1955","source":"Crossref","is-referenced-by-count":14,"title":["Oxidized LDL-induced FOXS1 mediates cholesterol transport dysfunction and inflammasome activation to drive aortic valve calcification"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6910-4287","authenticated-orcid":false,"given":"Chen","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Road, No. 1277, Wuhan, Hubei 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingyi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Road, No. 1277, Wuhan, Hubei 430022 ,","place":["China"]},{"name":"Department of Cardiovascular Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences , Fucheng Road, No. 167, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Road, No. 1277, Wuhan, Hubei 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology , Zhuodaoquan South Road, No. 116, Wuhan, Hubei 430079 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Road, No. 1277, Wuhan, Hubei 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-2372","authenticated-orcid":false,"given":"Qiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Provincial Hospital Affiliated to Shandong First Medical University , Jingwu Road, No. 324, Jinan, Shandong 250021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Road, No. 1277, Wuhan, Hubei 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-7797","authenticated-orcid":false,"given":"Zongtao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Road, No. 1277, Wuhan, Hubei 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University , Guangzhou Road, No. 300, Nanjing, Jiangsu 210029 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-7084","authenticated-orcid":false,"given":"Nianguo","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Jiefang Road, No. 1277, Wuhan, Hubei 430022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"2025102409265343200_cvaf159-B1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/CIRCULATIONAHA.119.043391","article-title":"Global Burden of Disease Study nonrheumatic valve disease C. Global, regional, and national burden of calcific aortic valve and degenerative mitral valve diseases, 1990\u20132017","volume":"141","author":"Yadgir","year":"2020","journal-title":"Circulation"},{"key":"2025102409265343200_cvaf159-B2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41569-023-00845-7","article-title":"Calcific aortic valve disease: mechanisms, prevention and treatment","volume":"20","author":"Moncla","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"2025102409265343200_cvaf159-B3","doi-asserted-by":"crossref","first-page":"e2307319","DOI":"10.1002\/advs.202307319","article-title":"Morusin alleviates aortic valve calcification by inhibiting valve interstitial cell senescence through Ccnd1\/Trim25\/Nrf2 axis","volume":"11","author":"Liu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2025102409265343200_cvaf159-B4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.atherosclerosis.2014.11.026","article-title":"Early aortic valve inflammation precedes calcification: a longitudinal FDG-PET\/CT study","volume":"238","author":"Abdelbaky","year":"2015","journal-title":"Atherosclerosis"},{"key":"2025102409265343200_cvaf159-B5","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa050461","article-title":"Treating to new targets I. Intensive lipid lowering with atorvastatin in patients with stable coronary disease","volume":"352","author":"LaRosa","year":"2005","journal-title":"N Engl J Med"},{"key":"2025102409265343200_cvaf159-B6","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"2025102409265343200_cvaf159-B7","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMoa043876","article-title":"Lipid lowering trial IoRI. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis","volume":"352","author":"Cowell","year":"2005","journal-title":"N Engl J Med"},{"key":"2025102409265343200_cvaf159-B8","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJMoa0804602","article-title":"Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis","volume":"359","author":"Rossebo","year":"2008","journal-title":"N Engl J Med"},{"key":"2025102409265343200_cvaf159-B9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/10408363.2014.992063","article-title":"Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases","volume":"52","author":"Trpkovic","year":"2015","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2025102409265343200_cvaf159-B10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41576-022-00512-6","article-title":"Generating specificity in genome regulation through transcription factor sensitivity to chromatin","volume":"23","author":"Isbel","year":"2022","journal-title":"Nat Rev Genet"},{"key":"2025102409265343200_cvaf159-B11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrc3539","article-title":"Forkhead box proteins: tuning forks for transcriptional harmony","volume":"13","author":"Lam","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"2025102409265343200_cvaf159-B12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.lfs.2015.12.001","article-title":"Forkhead box transcription factors in embryonic heart development and congenital heart disease","volume":"144","author":"Zhu","year":"2016","journal-title":"Life Sci"},{"key":"2025102409265343200_cvaf159-B13","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCULATIONAHA.106.632430","article-title":"Transcriptional genomics associates FOX transcription factors with human heart failure","volume":"114","author":"Hannenhalli","year":"2006","journal-title":"Circulation"},{"key":"2025102409265343200_cvaf159-B14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/CIRCRESAHA.112.277442","article-title":"Foxo1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell-cycle withdrawal and IGF1 gene regulation","volume":"112","author":"Sengupta","year":"2013","journal-title":"Circ Res"},{"key":"2025102409265343200_cvaf159-B15","doi-asserted-by":"crossref","first-page":"E6556","DOI":"10.1073\/pnas.1721245115","article-title":"Disrupting LXRalpha phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation","volume":"115","author":"Gage","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025102409265343200_cvaf159-B16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/CIRCULATIONAHA.120.046356","article-title":"Genomic binding patterns of forkhead box protein O1 reveal its unique role in cardiac hypertrophy","volume":"142","author":"Pfleger","year":"2020","journal-title":"Circulation"},{"key":"2025102409265343200_cvaf159-B17","doi-asserted-by":"crossref","first-page":"103215","DOI":"10.1016\/j.redox.2024.103215","article-title":"FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease","volume":"73","author":"Jiang","year":"2024","journal-title":"Redox Biol"},{"key":"2025102409265343200_cvaf159-B18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10741-020-09992-2","article-title":"Targeting the forkhead box protein P1 pathway as a novel therapeutic approach for cardiovascular diseases","volume":"27","author":"Liu","year":"2022","journal-title":"Heart Fail Rev"},{"key":"2025102409265343200_cvaf159-B19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/CIRCULATIONAHA.119.039767","article-title":"Endothelial forkhead box transcription factor P1 regulates pathological cardiac remodeling through transforming growth factor-beta1-endothelin-1 signal pathway","volume":"140","author":"Liu","year":"2019","journal-title":"Circulation"},{"key":"2025102409265343200_cvaf159-B20","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s13287-021-02458-8","article-title":"CD90(low) glioma-associated mesenchymal stromal\/stem cells promote temozolomide resistance by activating FOXS1-mediated epithelial-mesenchymal transition in glioma cells","volume":"12","author":"Xue","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"2025102409265343200_cvaf159-B21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12967-022-03525-1","article-title":"Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt\/beta-catenin signaling pathway to regulate colorectal cancer progression","volume":"20","author":"Zhang","year":"2022","journal-title":"J Transl Med"},{"key":"2025102409265343200_cvaf159-B22","doi-asserted-by":"crossref","first-page":"115893","DOI":"10.1016\/j.bcp.2023.115893","article-title":"FOXS1 promotes prostate cancer progression through the Hedgehog\/Gli1 pathway","volume":"218","author":"Wang","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"2025102409265343200_cvaf159-B23","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1128\/MCB.25.13.5616-5625.2005","article-title":"Lack of the central nervous system- and neural crest-expressed forkhead gene Foxs1 affects motor function and body weight","volume":"25","author":"Heglind","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2025102409265343200_cvaf159-B24","doi-asserted-by":"crossref","first-page":"105691","DOI":"10.1016\/j.jbc.2024.105691","article-title":"FOXS1 is increased in liver fibrosis and regulates TGFbeta responsiveness and proliferation pathways in human hepatic stellate cells","volume":"300","author":"Bates","year":"2024","journal-title":"J Biol Chem"},{"key":"2025102409265343200_cvaf159-B25","doi-asserted-by":"crossref","first-page":"e23698","DOI":"10.1096\/fj.202302654RR","article-title":"FOXS1 acts as an oncogene and induces EMT through FAK\/PI3K\/AKT pathway by upregulating HILPDA in prostate cancer","volume":"38","author":"Ren","year":"2024","journal-title":"FASEB J"},{"key":"2025102409265343200_cvaf159-B26","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1038\/s41598-019-41717-w","article-title":"FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer","volume":"9","author":"Wang","year":"2019","journal-title":"Sci Rep"},{"key":"2025102409265343200_cvaf159-B27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-physiol-031620-094944","article-title":"The ABCs of sterol transport","volume":"83","author":"Plummer","year":"2021","journal-title":"Annu Rev Physiol"},{"key":"2025102409265343200_cvaf159-B28","doi-asserted-by":"crossref","first-page":"34508","DOI":"10.1074\/jbc.M006738200","article-title":"ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages","volume":"275","author":"Oram","year":"2000","journal-title":"J Biol Chem"},{"key":"2025102409265343200_cvaf159-B29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cmet.2005.01.002","article-title":"ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation","volume":"1","author":"Kennedy","year":"2005","journal-title":"Cell Metab"},{"key":"2025102409265343200_cvaf159-B30","doi-asserted-by":"crossref","first-page":"9774","DOI":"10.1073\/pnas.0403506101","article-title":"ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins","volume":"101","author":"Wang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025102409265343200_cvaf159-B31","first-page":"3900","article-title":"Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice","volume":"117","author":"Yvan-Charvet","year":"2007","journal-title":"J Clin Invest"},{"key":"2025102409265343200_cvaf159-B32","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1161\/01.RES.0000185320.82962.F7","article-title":"Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation","volume":"97","author":"Moore","year":"2005","journal-title":"Circ Res"},{"key":"2025102409265343200_cvaf159-B33","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.113.301086","article-title":"Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice","volume":"112","author":"Westerterp","year":"2013","journal-title":"Circ Res"},{"key":"2025102409265343200_cvaf159-B34","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/CIRCULATIONAHA.108.793869","article-title":"Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions","volume":"118","author":"Yvan-Charvet","year":"2008","journal-title":"Circulation"},{"key":"2025102409265343200_cvaf159-B35","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.117.032636","article-title":"Cholesterol efflux pathways suppress inflammasome activation, NETosis, and atherogenesis","volume":"138","author":"Westerterp","year":"2018","journal-title":"Circulation"},{"key":"2025102409265343200_cvaf159-B36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/11921","article-title":"Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1","volume":"22","author":"Rust","year":"1999","journal-title":"Nat Genet"},{"key":"2025102409265343200_cvaf159-B37","doi-asserted-by":"crossref","first-page":"19719","DOI":"10.1073\/pnas.1113021108","article-title":"ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter","volume":"108","author":"Tarling","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025102409265343200_cvaf159-B38","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3389\/fphar.2020.00826","article-title":"Caffeic acid phenethyl ester ameliorates calcification by inhibiting activation of the AKT\/NF-kappaB\/NLRP3 inflammasome pathway in human aortic valve interstitial cells","volume":"11","author":"Liu","year":"2020","journal-title":"Front Pharmacol"},{"key":"2025102409265343200_cvaf159-B39","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.1039\/D1FO00813G","article-title":"Cardamonin inhibits osteogenic differentiation of human valve interstitial cells and ameliorates aortic valve calcification via interfering in the NF-kappaB\/NLRP3 inflammasome pathway","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct"},{"key":"2025102409265343200_cvaf159-B40","doi-asserted-by":"crossref","first-page":"e2202577119","DOI":"10.1073\/pnas.2202577119","article-title":"Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3","volume":"119","author":"The","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025102409265343200_cvaf159-B41","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1194\/jlr.M054742","article-title":"Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice","volume":"56","author":"Huang","year":"2015","journal-title":"J Lipid Res"},{"key":"2025102409265343200_cvaf159-B42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.117.032291","article-title":"Spatiotemporal multi-omics mapping generates a molecular atlas of the aortic valve and reveals networks driving disease","volume":"138","author":"Schlotter","year":"2018","journal-title":"Circulation"},{"key":"2025102409265343200_cvaf159-B43","doi-asserted-by":"crossref","first-page":"28240","DOI":"10.1074\/jbc.M003337200","article-title":"Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor\/retinoid X receptor","volume":"275","author":"Costet","year":"2000","journal-title":"J Biol Chem"},{"key":"2025102409265343200_cvaf159-B44","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis","volume":"7","author":"Chawla","year":"2001","journal-title":"Mol Cell"},{"key":"2025102409265343200_cvaf159-B45","doi-asserted-by":"crossref","first-page":"e97572","DOI":"10.15252\/embj.201797572","article-title":"Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism","volume":"37","author":"Ding","year":"2018","journal-title":"EMBO J"},{"key":"2025102409265343200_cvaf159-B46","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.15252\/embj.201695170","article-title":"Seipin regulates ER-lipid droplet contacts and cargo delivery","volume":"35","author":"Salo","year":"2016","journal-title":"EMBO J"},{"key":"2025102409265343200_cvaf159-B47","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrendo.2015.123","article-title":"Congenital generalized lipodystrophies\u2014new insights into metabolic dysfunction","volume":"11","author":"Patni","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"2025102409265343200_cvaf159-B48","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.metabol.2015.12.015","article-title":"Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations","volume":"65","author":"Mori","year":"2016","journal-title":"Metabolism"},{"key":"2025102409265343200_cvaf159-B49","doi-asserted-by":"crossref","first-page":"e736","DOI":"10.1002\/ctm2.736","article-title":"BSCL2\/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism","volume":"12","author":"Zhou","year":"2022","journal-title":"Clin Transl Med"},{"key":"2025102409265343200_cvaf159-B50","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41419-018-0471-7","article-title":"Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of alpha-synuclein and neuroinflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis"},{"key":"2025102409265343200_cvaf159-B51","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41419-024-06737-z","article-title":"Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation","volume":"15","author":"Cui","year":"2024","journal-title":"Cell Death Dis"},{"key":"2025102409265343200_cvaf159-B52","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1038\/s41467-022-33202-2","article-title":"Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARgamma during hyperlipidemia","volume":"13","author":"Lee","year":"2022","journal-title":"Nat Commun"},{"key":"2025102409265343200_cvaf159-B53","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.atherosclerosis.2022.03.005","article-title":"Blocking the NLRP3 inflammasome reduces osteogenic calcification and M1 macrophage polarization in a mouse model of calcified aortic valve stenosis","volume":"347","author":"Lu","year":"2022","journal-title":"Atherosclerosis"},{"key":"2025102409265343200_cvaf159-B54","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ijcard.2022.08.029","article-title":"MicroRNA-29b regulates pyroptosis involving calcific aortic valve disease through the STAT3\/SOCS1 pathway","volume":"371","author":"Fang","year":"2023","journal-title":"Int J Cardiol"},{"key":"2025102409265343200_cvaf159-B55","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tem.2016.11.002","article-title":"Context-dependent role of oxidized lipids and lipoproteins in inflammation","volume":"28","author":"Miller","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"2025102409265343200_cvaf159-B56","doi-asserted-by":"crossref","first-page":"12236","DOI":"10.3390\/ijms232012236","article-title":"The impacts of cholesterol, oxysterols, and cholesterol lowering dietary compounds on the immune system","volume":"23","author":"Yanagisawa","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025102409265343200_cvaf159-B57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12950-019-0211-5","article-title":"Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease","volume":"16","author":"Ho","year":"2019","journal-title":"J Inflamm (Lond)"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaf159\/64359093\/cvaf159.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaf159\/64359093\/cvaf159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaf159\/64359093\/cvaf159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:27:03Z","timestamp":1761312423000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/121\/12\/1941\/8262735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,9,24]]},"published-print":{"date-parts":[[2025,10,24]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvaf159","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,24]]}}}