{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:18:36Z","timestamp":1780082316645,"version":"3.54.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91539117"],"award-info":[{"award-number":["91539117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870357"],"award-info":[{"award-number":["81870357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470433"],"award-info":[{"award-number":["82470433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Vasostatin-2, a bioactive peptide derived from chromogranin A, has cardiovascular-protective and anti-inflammatory properties. However, its role in injury-induced vascular remodelling remains unclear. This study aimed to investigate whether serum vasostatin-2 levels are related to restenosis in patients following percutaneous coronary intervention (PCI), and whether this peptide influences vascular neointimal hyperplasia in a mouse model of femoral artery injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Serum vasostatin-2 levels were evaluated in patients with (n = 442) and without (n = 442) restenosis after PCI. Recombinant vasostatin-2 or saline was administered in a mouse model of femoral artery injury. A combination of multi-omics (Bulk RNA sequencing, CUT&amp;Tag detection, and glutathione S-transferase pull-down\/mass spectrometry analysis) was employed to investigate underlying mechanisms. Patients with restenosis had lower serum vasostatin-2 levels than those without restenosis (P &amp;lt; 0.001). Vasostatin-2 protein significantly inhibited neointimal hyperplasia and suppressed the vascular smooth muscle cell (VSMC) phenotype switch after injury. Mechanistically, vasostatin-2 was proven to bind angiotensin-converting enzyme 2 (ACE2) and activate the downstream nuclear receptor subfamily 1 group D member 1 (NR1D1)-growth arrest-specific 1 (Gas1) pathway, thereby facilitating apoptosis of VSMCs and inhibiting their proliferation. ACE2-binding incompetent vasostatin-2 mutants and NR1D1 deficiency in VSMCs weakened vasostatin-2 effect on neointimal hyperplasia in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Decreased serum vasostatin-2 levels are associated with coronary artery restenosis in patients with coronary angioplasty. Vasostatin-2 attenuates vascular injury-induced neointimal growth in mice and inhibits the proliferation of VSMCs in vitro through the ACE2\/NR1D1\/Gas1 pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf192","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:55:34Z","timestamp":1762606534000},"page":"2260-2277","source":"Crossref","is-referenced-by-count":1,"title":["Vasostatin-2 attenuates injury-induced neointimal hyperplasia through the ACE2\/MasR\/PPAR\u03b3\/NR1D1\/Gas1 axis"],"prefix":"10.1093","volume":"121","author":[{"given":"Qiujing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda","family":"Madonna","sequence":"additional","affiliation":[{"name":"Cardiology Division 1-Pisa University Hospital, University of Pisa , Pisa 56124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipaerguli","family":"Maimati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-8008","authenticated-orcid":false,"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-574X","authenticated-orcid":false,"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[{"name":"Cardiology Division 1-Pisa University Hospital, University of Pisa , Pisa 56124 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2025112201570592000_cvaf192-B1","doi-asserted-by":"crossref","first-page":"15818","DOI":"10.1073\/pnas.2006348117","article-title":"Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade","volume":"117","author":"Wang","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025112201570592000_cvaf192-B2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cellsig.2018.08.019","article-title":"Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity","volume":"52","author":"Frismantiene","year":"2018","journal-title":"Cell Signal"},{"key":"2025112201570592000_cvaf192-B3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/cvr\/cvy006","article-title":"From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta","volume":"114","author":"Michel","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2025112201570592000_cvaf192-B4","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvy010","article-title":"Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness","volume":"114","author":"Durham","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2025112201570592000_cvaf192-B5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/cvr\/cvy021","article-title":"Role of smooth muscle cells in coronary artery bypass grafting failure","volume":"114","author":"Wadey","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2025112201570592000_cvaf192-B6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jacc.2022.05.017","article-title":"Coronary in-stent restenosis: JACC state-of-the-art review","volume":"80","author":"Giustino","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2025112201570592000_cvaf192-B7","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1161\/CIRCULATIONAHA.120.049922","article-title":"Fate and state of vascular smooth muscle cells in atherosclerosis","volume":"143","author":"Miano","year":"2021","journal-title":"Circulation"},{"key":"2025112201570592000_cvaf192-B8","doi-asserted-by":"crossref","first-page":"107091","DOI":"10.1016\/j.vph.2022.107091","article-title":"Transcriptional regulation of vascular smooth muscle cell proliferation, differentiation and senescence: novel targets for therapy","volume":"146","author":"Khachigian","year":"2022","journal-title":"Vascul Pharmacol"},{"key":"2025112201570592000_cvaf192-B9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41569-019-0234-x","article-title":"Drug-eluting coronary stents: insights from preclinical and pathology studies","volume":"17","author":"Torii","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2025112201570592000_cvaf192-B10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0167-0115(83)90145-3","article-title":"Chromogranin: widespread immunoreactivity in polypeptide hormone producing tissues and in serum","volume":"6","author":"O'Connor","year":"1983","journal-title":"Regul Pept"},{"key":"2025112201570592000_cvaf192-B11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/HJH.0b013e328341a429","article-title":"Chromogranin A: a novel factor acting at the cross road between the neuroendocrine and the cardiovascular systems","volume":"29","author":"Di Comite","year":"2011","journal-title":"J Hypertens"},{"key":"2025112201570592000_cvaf192-B12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/cvr\/cvae008","article-title":"Vasostatins: new molecular targets for atherosclerosis, post-ischaemic angiogenesis, and arteriogenesis","volume":"120","author":"Madonna","year":"2024","journal-title":"Cardiovasc Res"},{"key":"2025112201570592000_cvaf192-B13","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/eurheartj\/ehs122","article-title":"Reduced serum levels of vasostatin-2, an anti-inflammatory peptide derived from chromogranin A, are associated with the presence and severity of coronary artery disease","volume":"33","author":"Lu","year":"2012","journal-title":"Eur Heart J"},{"key":"2025112201570592000_cvaf192-B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2016.06.065","article-title":"Association of decreased serum vasostatin-2 level with ischemic chronic heart failure and with MACE in 3-year follow-up: vasostatin-2 prevents heart failure in myocardial infarction rats","volume":"221","author":"Pan","year":"2016","journal-title":"Int J Cardiol"},{"key":"2025112201570592000_cvaf192-B15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1160\/TH16-06-0475","article-title":"The anti-inflammatory vasostatin-2 attenuates atherosclerosis in ApoE(\u2212\/\u2212) mice and inhibits monocyte\/macrophage recruitment","volume":"117","author":"Xiong","year":"2017","journal-title":"Thromb Haemost"},{"issue":"19","key":"2025112201570592000_cvaf192-B16","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/eurheartj\/ehad082","article-title":"Vasostatin-2 associates with coronary collateral vessel formation in diabetic patients and promotes angiogenesis via angiotensin-converting enzyme 2","volume":"44","author":"Bao","year":"2023","journal-title":"Eur Heart J"},{"key":"2025112201570592000_cvaf192-B17","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.bbrc.2015.12.097","article-title":"Vasostatin-2 inhibits cell proliferation and adhesion in vascular smooth muscle cells, which are associated with the progression of atherosclerosis","volume":"469","author":"Hou","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"2025112201570592000_cvaf192-B18","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1161\/CIRCULATIONAHA.104.513952","article-title":"Late loss in lumen diameter and binary restenosis for drug-eluting stent comparison","volume":"111","author":"Mauri","year":"2005","journal-title":"Circulation"},{"key":"2025112201570592000_cvaf192-B19","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1016\/j.jcin.2020.08.035","article-title":"Drug-coated balloon versus drug-eluting stent for small coronary vessel disease: PICCOLETO II randomized clinical trial","volume":"13","author":"Cortese","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"2025112201570592000_cvaf192-B20","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat Commun"},{"key":"2025112201570592000_cvaf192-B21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/ATVBAHA.116.308210","article-title":"Association of serum HMGB2 levels with in-stent restenosis: HMGB2 promotes neointimal hyperplasia in mice with femoral artery injury and proliferation and migration of VSMCs","volume":"37","author":"He","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025112201570592000_cvaf192-B22","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1093\/cvr\/cvad110","article-title":"Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5","volume":"119","author":"Zhu","year":"2023","journal-title":"Cardiovasc Res"},{"key":"2025112201570592000_cvaf192-B23","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.3390\/ijms232012455","article-title":"Nr1d1 mediated cell senescence in mouse heart-derived sca-1(+)CD31(\u2212) cells","volume":"23","author":"Pu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025112201570592000_cvaf192-B24","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-12-0341","article-title":"Angiotensin-converting enzyme 2, angiotensin-(1\u20137) and Mas: new players of the renin-angiotensin system","volume":"216","author":"Santos","year":"2013","journal-title":"J Endocrinol"},{"key":"2025112201570592000_cvaf192-B25","doi-asserted-by":"crossref","first-page":"25869","DOI":"10.1073\/pnas.2005330117","article-title":"Nuclear receptor REVERBalpha is a state-dependent regulator of liver energy metabolism","volume":"117","author":"Hunter","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025112201570592000_cvaf192-B26","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.jacc.2022.03.370","article-title":"Disruption of circadian rhythms by shift work exacerbates reperfusion injury in myocardial infarction","volume":"79","author":"Zhao","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2025112201570592000_cvaf192-B27","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1093\/eurheartj\/ehac109","article-title":"Circadian nuclear receptor Rev-erbalpha is expressed by platelets and potentiates platelet activation and thrombus formation","volume":"43","author":"Shi","year":"2022","journal-title":"Eur Heart J"},{"key":"2025112201570592000_cvaf192-B28","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1161\/CIRCULATIONAHA.121.057623","article-title":"Nuclear receptor NR1D1 regulates abdominal aortic aneurysm development by targeting the mitochondrial tricarboxylic acid cycle enzyme aconitase-2","volume":"146","author":"Sun","year":"2022","journal-title":"Circulation"},{"key":"2025112201570592000_cvaf192-B29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/FJC.0000000000001446","article-title":"Role of nuclear receptor subfamily 1 group D member 1 in the proliferation, migration of vascular smooth muscle cell, and vascular intimal hyperplasia","volume":"82","author":"Wang","year":"2023","journal-title":"J Cardiovasc Pharmacol"},{"key":"2025112201570592000_cvaf192-B30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0092-8674(92)90429-G","article-title":"The growth arrest-specific gene, gas1, is involved in growth suppression","volume":"70","author":"Del Sal","year":"1992","journal-title":"Cell"},{"key":"2025112201570592000_cvaf192-B31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ncomms1812","article-title":"Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm","volume":"3","author":"Negoro","year":"2012","journal-title":"Nat Commun"},{"key":"2025112201570592000_cvaf192-B32","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1016\/j.ajpath.2016.07.014","article-title":"REV-ERBalpha activates C\/EBP homologous protein to control small heterodimer partner-mediated oscillation of alcoholic fatty liver","volume":"186","author":"Yang","year":"2016","journal-title":"Am J Pathol"},{"key":"2025112201570592000_cvaf192-B33","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3390\/ijms25020770","article-title":"Functional characterization of circadian nuclear receptors REV-ERBalpha and REV-ERBbeta in human osteosarcoma cell cultures","volume":"25","author":"Cho","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025112201570592000_cvaf192-B34","doi-asserted-by":"crossref","first-page":"37672","DOI":"10.1074\/jbc.M304664200","article-title":"The orphan nuclear receptor rev-erb\u03b1 is a peroxisome proliferator-activated receptor (PPAR) \u03b3 target gene and promotes PPAR\u03b3-induced adipocyte differentiation","volume":"278","author":"Fontaine","year":"2003","journal-title":"J Biol Chem"},{"key":"2025112201570592000_cvaf192-B35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1479-5876-11-229","article-title":"Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice","volume":"11","author":"Zhang","year":"2013","journal-title":"J Transl Med"},{"key":"2025112201570592000_cvaf192-B36","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1080\/15384101.2023.2228089","article-title":"Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases","volume":"22","author":"Molaei","year":"2023","journal-title":"Cell Cycle"},{"key":"2025112201570592000_cvaf192-B37","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1007\/s00018-007-7254-0","article-title":"The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties","volume":"64","author":"Helle","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"2025112201570592000_cvaf192-B38","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1042\/CS20180451","article-title":"Inhibitory effects of vasostatin-1 against atherogenesis","volume":"132","author":"Sato","year":"2018","journal-title":"Clin Sci (Lond)"},{"key":"2025112201570592000_cvaf192-B39","doi-asserted-by":"crossref","first-page":"e2302801","DOI":"10.1002\/adma.202302801","article-title":"Cellular membrane-engineered nanovesicles as a three-stage booster to target the lesion core","volume":"35","author":"Huang","year":"2023","journal-title":"Adv Mater"},{"key":"2025112201570592000_cvaf192-B40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.atherosclerosis.2018.12.025","article-title":"Decreased circulating catestatin levels are associated with coronary artery disease: the emerging anti-inflammatory role","volume":"281","author":"Chen","year":"2019","journal-title":"Atherosclerosis"},{"key":"2025112201570592000_cvaf192-B41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025112201570592000_cvaf192-B42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus","volume":"94","author":"Wan","year":"2020","journal-title":"J Virol"},{"key":"2025112201570592000_cvaf192-B43","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2021.01.004","article-title":"Multi-organ proteomic landscape of COVID-19 autopsies","volume":"184","author":"Nie","year":"2021","journal-title":"Cell"},{"key":"2025112201570592000_cvaf192-B44","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.cmet.2022.01.008","article-title":"Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry","volume":"34","author":"Li","year":"2022","journal-title":"Cell Metab"},{"key":"2025112201570592000_cvaf192-B45","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2901-9","article-title":"Identification of SARS-CoV-2 inhibitors using lung and colonic organoids","volume":"589","author":"Han","year":"2021","journal-title":"Nature"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaf192\/65285729\/cvaf192.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/14\/2260\/65285729\/cvaf192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/121\/14\/2260\/65285729\/cvaf192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:57:17Z","timestamp":1763794637000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/121\/14\/2260\/8322555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":45,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2025,11,13]]},"published-print":{"date-parts":[[2025,11,22]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvaf192","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10]]}}}