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Excessive foam cell accumulation triggers apoptosis and necrosis, promoting necrotic core formation and plaque destabilization. Despite the therapeutic appeal of targeting foam cells in atherosclerosis treatment and prevention, developing effective targeted therapies remains challenging. This review provides a comprehensive overview of foam cell origins and pathogenic roles, as well as the cross-talk between foam cells and residual atherosclerotic risks. We examine potential foam cell interventions, focusing on the pleiotropic properties of clinical drugs and natural product potential. Finally, we propose strategies for foam cell ablation to facilitate the development of foam cell-targeted precision therapies for atherosclerosis.<\/jats:p>","DOI":"10.1093\/cvr\/cvaf202","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:37:09Z","timestamp":1761568629000},"page":"2334-2346","source":"Crossref","is-referenced-by-count":24,"title":["New insights into foam cells in atherosclerosis"],"prefix":"10.1093","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-7833","authenticated-orcid":false,"given":"Jian","family":"Ai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University , Wuxi, Jiangsu 214122 ,","place":["China"]},{"name":"School of Food Science and Technology, Jiangnan University , Wuxi, Jiangsu 214122 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