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Although platelet function is crucially determined by kinases, the impact of Casein Kinase 2\u03b1 (CK2\u03b1) on platelet activation during arterial thrombosis and myocardial remodeling following ischemia and reperfusion (I\/R) injury is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using platelet-specific deletion of Csnk2a1 in mice, the evaluation of the CK2\u03b1-dependent platelet phosphoproteome revealed a diminished phosphorylation of the IP3 receptor type-1 in Csnk2a1-deficient mice. This finding was accompanied by attenuated IP3-induced Ca2+ mobilization, impaired integrin \u03b1IIb\u03b23 activation, abrogated platelet aggregation and secretion, as well as defective spreading on fibrinogen in response to collagen-related peptide. Accordingly, without affecting primary hemostasis, thrombotic vascular occlusion in vivo was diminished in Csnk2a1-deficient mice. When subjected to a myocardial I\/R injury model, these mice displayed improved cardiac outcome when compared with wildtype mice. Raman spectromics, spatial metabolomics and molecular approaches revealed locally a CK2\u03b1-dependent release of chondroitin sulfate and transforming growth factor-\u03b2 from platelets, which was associated with significantly reduced ventricular fibrosis and improved heart function in Csnk2a1-deficient mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Altogether, our results disclose CK2\u03b1 as pivotal player in platelet activation and pathogenesis of post-ischemic myocardial remodeling, including myocardial fibrosis and left ventricular impairment following myocardial ischemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf269","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:22:43Z","timestamp":1768220563000},"page":"132-145","source":"Crossref","is-referenced-by-count":1,"title":["Platelet Casein Kinase 2\u03b1 is a pivotal player in arterial thrombotic occlusion and post-ischemic myocardial remodeling"],"prefix":"10.1093","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1086-9176","authenticated-orcid":false,"given":"Melina","family":"Fischer","sequence":"first","affiliation":[{"name":"DFG Heisenberg Group Cardiovascular Thrombo-Inflammation and Translational Thrombocardiology, University of T\u00fcbingen, T\u00fcbingen ,","place":["Germany"]},{"name":"Department of Cardiology and Angiology, University of T\u00fcbingen , Otfried-M\u00fcller-Str.10, T\u00fcbingen 72076 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8954-4810","authenticated-orcid":false,"given":"Manuel","family":"Sigle","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University of T\u00fcbingen , Otfried-M\u00fcller-Str.10, T\u00fcbingen 72076 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mailin-Christin","family":"Manke","sequence":"additional","affiliation":[{"name":"DFG Heisenberg Group Cardiovascular Thrombo-Inflammation and Translational Thrombocardiology, University of T\u00fcbingen, T\u00fcbingen ,","place":["Germany"]},{"name":"Department of Cardiology and Angiology, University of T\u00fcbingen , Otfried-M\u00fcller-Str.10, T\u00fcbingen 72076 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-5430","authenticated-orcid":false,"given":"Julia","family":"Marzi","sequence":"additional","affiliation":[{"name":"Department for Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, University of T\u00fcbingen , T\u00fcbingen ,","place":["Germany"]},{"name":"NMI Natural and Medical Sciences Institute at the University T\u00fcbingen , Reutlingen 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