{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:20:33Z","timestamp":1787170833309,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French national research agency","doi-asserted-by":"publisher","award":["ANR-16-IDEX-0007"],"award-info":[{"award-number":["ANR-16-IDEX-0007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French national research agency","doi-asserted-by":"publisher","award":["ANR-21-CE14-0016"],"award-info":[{"award-number":["ANR-21-CE14-0016"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French national research agency","doi-asserted-by":"publisher","award":["ANR-15-CE17-0008-01"],"award-info":[{"award-number":["ANR-15-CE17-0008-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French national research agency","doi-asserted-by":"publisher","award":["ANR-23-CE14-0001"],"award-info":[{"award-number":["ANR-23-CE14-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["R22131NN"],"award-info":[{"award-number":["R22131NN"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["RAD22168NNA"],"award-info":[{"award-number":["RAD22168NNA"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013414","name":"Regional Council of Pays de la Loire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012390","name":"SystemsX.ch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP6-IST-2004-027703"],"award-info":[{"award-number":["FP6-IST-2004-027703"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Intracranial aneurysm (IA) is a common cerebrovascular abnormality characterized by localized dilation and wall thinning in cerebral arteries, which can rupture and lead to fatal subarachnoid haemorrhage. Although genetic factors can contribute to IA, the genetic pre-disposition of IA is largely unknown. This study aims to identify rare functional variants associated with IA in families with multiple affected subjects and explore their impact on IA pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>By combining whole-exome sequencing and identity-by-descent analyses, we have identified two rare missense variants in the CTSO gene associated to IA in two large families with multiple affected subjects. We found that the cysteine-type papain-like cathepsin O (CTSO) encoded by CTSO is expressed in the circle of Willis of mice and in the wall of human IA domes. Stretching of vascular smooth muscle cells (VSMC) induced CTSO secretion. CTSO controls VSMC migration and adhesion to the extracellular matrix, and directly interacts with fibronectin (FN). CTSO depletion, or expression of the two CTSO variants, which are poorly secreted, increased the amount of FN. Moreover, CTSO depletion augmented VSMC stiffness, which was reduced by the addition of exogenous CTSO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, our findings identify CTSO as a potential new player in arterial remodelling, regulating FN deposition and VSMC function, supporting the causal role of rare coding CTSO variants in familial forms of IA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvaf279","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:43:54Z","timestamp":1767876234000},"page":"98-111","source":"Crossref","is-referenced-by-count":3,"title":["Identification of rare missense variants reducing cathepsin O secretion in families with intracranial aneurysm"],"prefix":"10.1093","volume":"122","author":[{"given":"Mil\u00e8ne","family":"Fr\u00e9neau","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Blanchet","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxence","family":"Bodet","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-2987","authenticated-orcid":false,"given":"Sandro","family":"Benichi","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Adel","family":"Mrad","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-316X","authenticated-orcid":false,"given":"Surya Prakash Rao","family":"Batta","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2751-3653","authenticated-orcid":false,"given":"Marc","family":"Rio","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Bonnaud","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-9787","authenticated-orcid":false,"given":"Pierre","family":"Lindenbaum","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-3293","authenticated-orcid":false,"given":"Fabien","family":"Laporte","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-3847","authenticated-orcid":false,"given":"St\u00e9phane","family":"Cu\u00e9not","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CNRS, Institut des Mat\u00e9riaux Jean Rouxel, IMN , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-2597","authenticated-orcid":false,"given":"Thibaud","family":"Quillard","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-7880","authenticated-orcid":false,"given":"Mike","family":"Maillasson","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CNRS, INSERM, BioCore , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-3553","authenticated-orcid":false,"given":"Sandrine","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Faculty of Medicine, University of Geneva , CH-1211 Geneva ,","place":["Switzerland"]},{"name":"Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals and University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-0044","authenticated-orcid":false,"given":"Brenda R","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Faculty of Medicine, University of Geneva , CH-1211 Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-2757","authenticated-orcid":false,"given":"Philippe","family":"Bijlenga","sequence":"additional","affiliation":[{"name":"Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals and University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-4463","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Deleuze","sequence":"additional","affiliation":[{"name":"CEA, Centre National de Recherche en G\u00e9nomique Humaine (CNRGH), Universit\u00e9 Paris-Saclay , F-91057 Evry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-7348","authenticated-orcid":false,"given":"Christian","family":"Dina","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Chatel","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bourcereau","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Nantes , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Jouan","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Nantes , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Consoli","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Foch Hospital, University Versailles Saint-Quentin en Yvelines , F-92073 Suresnes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1891-9157","authenticated-orcid":false,"given":"Cyril","family":"Dargazanli","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Centre Montpellier , F-34000 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-7464","authenticated-orcid":false,"given":"Julien","family":"Ognard","sequence":"additional","affiliation":[{"name":"Radiology Department, University Hospital , F-29000 Brest ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4665-1461","authenticated-orcid":false,"given":"Hubert","family":"Desal","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]},{"name":"Department of Neuroradiology, CHU Nantes , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2788-2512","authenticated-orcid":false,"given":"Anne-Cl\u00e9mence","family":"Vion","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-4019","authenticated-orcid":false,"given":"Romain","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]},{"name":"Department of Neuroradiology, CHU Nantes , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-3931","authenticated-orcid":false,"given":"Gervaise","family":"Loirand","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7751-2280","authenticated-orcid":false,"given":"Richard","family":"Redon","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l\u2019institut du thorax , F-44000 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2026022323464844200_cvaf279-B1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"Vlak","year":"2011","journal-title":"Lancet Neurol"},{"key":"2026022323464844200_cvaf279-B2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1474-4422(09)70126-7","article-title":"Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis","volume":"8","author":"Nieuwkamp","year":"2009","journal-title":"Lancet Neurol"},{"key":"2026022323464844200_cvaf279-B3","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/STROKEAHA.111.000679","article-title":"Risk of rupture of an intracranial aneurysm based on patient characteristics: a case-control study","volume":"44","author":"Vlak","year":"2013","journal-title":"Stroke"},{"key":"2026022323464844200_cvaf279-B4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neurad.2015.01.002","article-title":"Genetic investigations on intracranial aneurysm: update and perspectives","volume":"42","author":"Bourcier","year":"2015","journal-title":"J Neuroradiol"},{"key":"2026022323464844200_cvaf279-B5","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41588-020-00725-7","article-title":"Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors","volume":"52","author":"Bakker","year":"2020","journal-title":"Nat Genet"},{"key":"2026022323464844200_cvaf279-B6","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ajhg.2016.09.001","article-title":"RNF213 is associated with intracranial aneurysms in the French-Canadian population","volume":"99","author":"Zhou","year":"2016","journal-title":"Am J Hum Genet"},{"key":"2026022323464844200_cvaf279-B7","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1161\/STROKEAHA.116.014161","article-title":"THSD1 (thrombospondin type 1 domain containing protein 1) mutation in the pathogenesis of intracranial aneurysm and subarachnoid hemorrhage","volume":"47","author":"Santiago-Sim","year":"2016","journal-title":"Stroke"},{"key":"2026022323464844200_cvaf279-B8","doi-asserted-by":"crossref","first-page":"e812","DOI":"10.1016\/j.wneu.2017.10.094","article-title":"Exome sequencing identifies LOXL2 mutation as a cause of familial intracranial aneurysm","volume":"109","author":"Wu","year":"2018","journal-title":"World Neurosurg"},{"key":"2026022323464844200_cvaf279-B9","doi-asserted-by":"crossref","first-page":"e2170","DOI":"10.1212\/WNL.0000000000006614","article-title":"PCNT point mutations and familial intracranial aneurysms","volume":"91","author":"Lorenzo-Betancor","year":"2018","journal-title":"Neurology"},{"key":"2026022323464844200_cvaf279-B10","doi-asserted-by":"crossref","first-page":"e002099","DOI":"10.1161\/CIRCGEN.117.002099","article-title":"Rho guanine nucleotide exchange factor ARHGEF17 is a risk gene for intracranial aneurysms","volume":"11","author":"Yang","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"2026022323464844200_cvaf279-B11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ajhg.2017.12.006","article-title":"Rare coding variants in ANGPTL6 are associated with familial forms of intracranial aneurysm","volume":"102","author":"Bourcier","year":"2018","journal-title":"Am J Hum Genet"},{"key":"2026022323464844200_cvaf279-B12","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/s41591-021-01572-7","article-title":"PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans","volume":"27","author":"Barak","year":"2021","journal-title":"Nat Med"},{"key":"2026022323464844200_cvaf279-B13","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1172\/JCI42918","article-title":"Specialized roles for cysteine cathepsins in health and disease","volume":"120","author":"Reiser","year":"2010","journal-title":"J Clin Invest"},{"key":"2026022323464844200_cvaf279-B14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/neuros\/nyw135","article-title":"Understanding the pathophysiology of intracranial aneurysm: the ICAN project","volume":"80","author":"Bourcier","year":"2017","journal-title":"Neurosurgery"},{"key":"2026022323464844200_cvaf279-B15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"2026022323464844200_cvaf279-B16","doi-asserted-by":"publisher","author":"Poplin","DOI":"10.1101\/20178"},{"key":"2026022323464844200_cvaf279-B17","doi-asserted-by":"crossref","first-page":"100168","DOI":"10.1016\/j.xgen.2022.100168","article-title":"Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK biobank exomes","volume":"2","author":"Karczewski","year":"2022","journal-title":"Cell Genom"},{"key":"2026022323464844200_cvaf279-B18","doi-asserted-by":"crossref","first-page":"6710","DOI":"10.1038\/s41467-024-51087-1","article-title":"Human genetic structure in Northwest France provides new insights into West European historical demography","volume":"15","author":"Alves","year":"2024","journal-title":"Nat Commun"},{"key":"2026022323464844200_cvaf279-B19","first-page":"557","article-title":"Identity by descent estimation with dense genome-wide genotype data","volume":"35","author":"Han","year":"2011","journal-title":"Genet Epidemiol"},{"key":"2026022323464844200_cvaf279-B20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/jnen\/nly031","article-title":"Correlating clinical risk factors and histological features in ruptured and unruptured human intracranial aneurysms: the Swiss AneuX study","volume":"77","author":"Morel","year":"2018","journal-title":"J Neuropathol Exp Neurol"},{"key":"2026022323464844200_cvaf279-B21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cardiores.2006.07.017","article-title":"Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation","volume":"72","author":"Gou\u00ebffic","year":"2006","journal-title":"Cardiovasc Res"},{"key":"2026022323464844200_cvaf279-B22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40824-018-0141-y","article-title":"Nanoengineered, cell-derived extracellular matrix influences ECM-related gene expression of mesenchymal stem cells","volume":"22","author":"Ozguldez","year":"2018","journal-title":"Biomater Res"},{"key":"2026022323464844200_cvaf279-B23","doi-asserted-by":"crossref","first-page":"105343","DOI":"10.1016\/j.jmbbm.2022.105343","article-title":"Mechanical relaxations of hydrogels governed by their physical or chemical crosslinks","volume":"133","author":"Cuenot","year":"2022","journal-title":"J Mech Behav Biomed"},{"key":"2026022323464844200_cvaf279-B24","doi-asserted-by":"crossref","first-page":"119629","DOI":"10.1016\/j.carbpol.2022.119629","article-title":"Interactions between infernan and calcium: from the molecular level to the mechanical properties of microgels","volume":"292","author":"Zykwinska","year":"2022","journal-title":"Carbohydr Polym"},{"key":"2026022323464844200_cvaf279-B25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.107.1.307","article-title":"Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells","volume":"107","author":"Hedin","year":"1988","journal-title":"J Cell Biol"},{"key":"2026022323464844200_cvaf279-B26","doi-asserted-by":"crossref","first-page":"115542","DOI":"10.1016\/j.bone.2020.115542","article-title":"The role of bone morphogenetic protein signaling in vascular calcification","volume":"141","author":"Yang","year":"2020","journal-title":"Bone"},{"key":"2026022323464844200_cvaf279-B27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/ane.12286","article-title":"Arterial stiffness as a risk factor for cerebral aneurysm","volume":"130","author":"Matsukawa","year":"2014","journal-title":"Acta Neurol Scand"},{"key":"2026022323464844200_cvaf279-B28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2217\/fnl.13.40","article-title":"Inflammation and human cerebral aneurysms: current and future treatment prospects","volume":"8","author":"Hudson","year":"2013","journal-title":"Future Neurol"},{"key":"2026022323464844200_cvaf279-B29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.biochi.2015.07.020","article-title":"Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10","volume":"122","author":"Ketscher","year":"2016","journal-title":"Biochimie"},{"key":"2026022323464844200_cvaf279-B30","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3390\/cells9071679","article-title":"The ins and outs of cathepsins: physiological function and role in disease management","volume":"9","author":"Yadati","year":"2020","journal-title":"Cells"},{"key":"2026022323464844200_cvaf279-B31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41569-018-0002-3","article-title":"Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials","volume":"15","author":"Liu","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"2026022323464844200_cvaf279-B32","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1161\/STROKEAHA.107.513648","article-title":"Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms","volume":"39","author":"Aoki","year":"2008","journal-title":"Stroke"},{"key":"2026022323464844200_cvaf279-B33","first-page":"185","article-title":"Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms","volume":"24","author":"Marchese","year":"2010","journal-title":"J Biol Regul Homeost Agents"},{"key":"2026022323464844200_cvaf279-B34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/STROKEAHA.109.562009","article-title":"Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?","volume":"41","author":"Pera","year":"2010","journal-title":"Stroke"},{"key":"2026022323464844200_cvaf279-B35","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/STROKEAHA.108.532036","article-title":"Genomics of human intracranial aneurysm wall","volume":"40","author":"Shi","year":"2009","journal-title":"Stroke"},{"key":"2026022323464844200_cvaf279-B36","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1016\/j.wneu.2019.06.002","article-title":"Gene expression in intracranial aneurysms-comparison analysis of aneurysmal walls and extracranial arteries with real-time polymerase chain reaction and immunohistochemistry","volume":"130","author":"Tyagi","year":"2019","journal-title":"World Neurosurg"},{"key":"2026022323464844200_cvaf279-B37","doi-asserted-by":"crossref","first-page":"105498","DOI":"10.1016\/j.jmbbm.2022.105498","article-title":"A numerical investigation of the mechanics of intracranial aneurysms walls: assessing the influence of tissue hyperelastic laws and heterogeneous properties on the stress and stretch fields","volume":"136","author":"Oliveira","year":"2022","journal-title":"J Mech Behav Biomed"},{"key":"2026022323464844200_cvaf279-B38","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/cvr\/cvy009","article-title":"Smooth muscle cell and arterial aging: basic and clinical aspects","volume":"114","author":"Lacolley","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2026022323464844200_cvaf279-B39","doi-asserted-by":"crossref","first-page":"e62461","DOI":"10.1371\/journal.pone.0062461","article-title":"The focal adhesion: a regulated component of aortic stiffness","volume":"8","author":"Saphirstein","year":"2013","journal-title":"PLoS One"},{"key":"2026022323464844200_cvaf279-B40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/HYPERTENSIONAHA.114.04456","article-title":"Augmented vascular smooth muscle cell stiffness and adhesion when hypertension is superimposed on aging","volume":"65","author":"Sehgel","year":"2015","journal-title":"Hypertension"},{"key":"2026022323464844200_cvaf279-B41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.devcel.2010.06.010","article-title":"Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes","volume":"19","author":"Lobert","year":"2010","journal-title":"Dev Cell"},{"key":"2026022323464844200_cvaf279-B42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/bj2820273","article-title":"Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues","volume":"282","author":"Buck","year":"1992","journal-title":"Biochem J"},{"key":"2026022323464844200_cvaf279-B43","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/jcm10010078","article-title":"Cathepsin B localizes in the caveolae and participates in the proteolytic cascade in trabecular meshwork cells. Potential new drug target for the treatment of glaucoma","volume":"10","author":"Nettesheim","year":"2020","journal-title":"J Clin Med"},{"key":"2026022323464844200_cvaf279-B44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/CIRCRESAHA.110.221846","article-title":"Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging","volume":"107","author":"Qiu","year":"2010","journal-title":"Circ Res"},{"key":"2026022323464844200_cvaf279-B45","doi-asserted-by":"crossref","first-page":"e001744","DOI":"10.1161\/JAHA.114.001744","article-title":"Relation of murine thoracic aortic structural and cellular changes with aging to passive and active mechanical properties","volume":"4","author":"Wheeler","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2026022323464844200_cvaf279-B46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-092419-060810","article-title":"Vascular mechanobiology: homeostasis, adaptation, and disease","volume":"23","author":"Humphrey","year":"2021","journal-title":"Annu Rev Biomed Eng"},{"key":"2026022323464844200_cvaf279-B47","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1161\/ATVBAHA.123.318237","article-title":"Extracellular matrix remodeling in vascular disease: defining its regulators and pathological influence","volume":"43","author":"Lin","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026022323464844200_cvaf279-B48","doi-asserted-by":"crossref","first-page":"165587","DOI":"10.1016\/j.bbadis.2019.165587","article-title":"Impaired vascular smooth muscle cell force-generating capacity and phenotypic deregulation in Marfan syndrome mice","volume":"1866","author":"Nolasco","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026022323464844200_cvaf279-B49","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/ATVBAHA.114.304412","article-title":"Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome","volume":"35","author":"Crosas-Molist","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026022323464844200_cvaf279-B50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/STROKEAHA.120.032107","article-title":"Intracranial aneurysms are associated with Marfan syndrome: single cohort retrospective study in 118 patients using brain imaging","volume":"52","author":"Kim","year":"2021","journal-title":"Stroke"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvaf279\/66317062\/cvaf279.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/1\/98\/66317062\/cvaf279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/1\/98\/66317062\/cvaf279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:46:56Z","timestamp":1771908416000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/122\/1\/98\/8417745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,9]]},"published-print":{"date-parts":[[2026,2,24]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvaf279","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]}}}