{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:09:17Z","timestamp":1782576557659,"version":"3.54.5"},"reference-count":290,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council under","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South African National Research Foundation","award":["TTK220324671"],"award-info":[{"award-number":["TTK220324671"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Normal cardiac tissue glucose homeostasis is essential for the physiological function of the heart and the prevention of diabetic cardiomyopathies. The onset of diabetes mellitus has been reported to precede cardiovascular complications including cardiomyopathy, aortic stenosis, cardiac hypertrophy and hypertension. In addition to metabolic derangements, chronic medications such as HIV-antiretrovirals have also been associated with the risk factors of CVDs such as insulin resistance, dyslipidaemia, inflammation and oxidative stress and impaired glucose tolerance. Previous ART regimens have been associated with systemic insulin resistance and ectopic fat accumulation, leading to impaired glucose tolerance. The underlying molecular mechanisms behind the development of diabetic cardiomyopathies in persons chronically taking HIV-antiretrovirals remains unclear. Prediabetes is a condition of impaired glucose tolerance that is associated with low-grade inflammation and oxidative stress, which are precursors of CVDs. The link between chronic HIV-antiretroviral medication and prediabetes remains elusive. However, the increase in dispensation of HIV-antiretroviral medications has been associated with an increase in cases of prediabetes and diabetes, which could contribute to the development of CVDs. Hence, this review aims to provide insight into how the use of ARVs interacts with glucose metabolism and cardiovascular disease risk factors in patients on chronic HIV-antiretrovirals.<\/jats:p>","DOI":"10.1093\/cvr\/cvag036","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:08:32Z","timestamp":1769515712000},"page":"446-466","source":"Crossref","is-referenced-by-count":2,"title":["HIV-pharmacotherapy and pathogenesis of diabetes-induced cardiovascular complications: an updated narrative review"],"prefix":"10.1093","volume":"122","author":[{"given":"Khanyisa","family":"Maswanganyi","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Health Sciences, University of Pretoria , Gauteng ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andile","family":"Khathi","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Science, College of Health Sciences, University of Kwa-Zulu Natal , Durban ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-1545","authenticated-orcid":false,"given":"Mlindeli","family":"Gamede","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Health Sciences, University of Pretoria , Gauteng ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"2026032611344830900_cvag036-B1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1055\/a-1018-9078","article-title":"Definition, classification and diagnosis of diabetes mellitus","volume":"127","author":"Petersmann","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"2026032611344830900_cvag036-B2","author":"Sapra"},{"key":"2026032611344830900_cvag036-B3","doi-asserted-by":"crossref","first-page":"12259","DOI":"10.1038\/s41598-018-30755-5","article-title":"Hematoxylin and eosin staining of intact tissues via delipidation and ultrasound","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"2026032611344830900_cvag036-B4","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"2026032611344830900_cvag036-B5","doi-asserted-by":"crossref","first-page":"e0134410","DOI":"10.1371\/journal.pone.0134410","article-title":"Glucose metabolism disorders, HIV and antiretroviral therapy among Tanzanian adults","volume":"10","author":"Maganga","year":"2015","journal-title":"PLoS One"},{"key":"2026032611344830900_cvag036-B6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ecl.2021.05.002","article-title":"Screening for diabetes and prediabetes","volume":"50","author":"Duan","year":"2021","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2026032611344830900_cvag036-B7","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: a high-risk state for diabetes development","volume":"379","author":"Tab\u00e1k","year":"2012","journal-title":"Lancet"},{"key":"2026032611344830900_cvag036-B8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ecl.2017.10.001","article-title":"Prediabetes and cardiovascular disease: pathophysiology and interventions for prevention and risk reduction","volume":"47","author":"Brannick","year":"2018","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2026032611344830900_cvag036-B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-020-09791-2","article-title":"Burden of prediabetes, undiagnosed, and poorly or potentially sub-controlled diabetes: Lolland-Falster health study","volume":"20","author":"Bruun-Rasmussen","year":"2020","journal-title":"BMC Public Health"},{"key":"2026032611344830900_cvag036-B10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.17925\/USE.2016.12.02.94","article-title":"Prediabetes and adolescence\u2014trends, causes, effects, and screening","volume":"12","author":"Stefanaki","year":"2016","journal-title":"US Endocrinol"},{"key":"2026032611344830900_cvag036-B11","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.2337\/db06-0319","article-title":"Pathogenesis of pre-diabetes: mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and\/or impaired glucose tolerance","volume":"55","author":"Bock","year":"2006","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B12","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.3390\/nu14102168","article-title":"Is there a correlation between dietary and blood cholesterol? Evidence from epidemiological data and clinical interventions","volume":"14","author":"Fernandez","year":"2022","journal-title":"Nutrients"},{"key":"2026032611344830900_cvag036-B13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12902-023-01270-0","article-title":"The association between healthy lifestyle score and risk of metabolic syndrome in Iranian adults: a cross-sectional study","volume":"23","author":"Vajdi","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"2026032611344830900_cvag036-B14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","article-title":"Why does obesity cause diabetes?","volume":"34","author":"Klein","year":"2022","journal-title":"Cell Metab"},{"key":"2026032611344830900_cvag036-B15","doi-asserted-by":"crossref","first-page":"7839101","DOI":"10.1155\/2017\/7839101","article-title":"Macrovascular complications in patients with diabetes and prediabetes","volume":"2017","author":"Huang","year":"2017","journal-title":"Biomed Res Int"},{"key":"2026032611344830900_cvag036-B16","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41569-023-00964-1","article-title":"Immune and inflammatory mechanisms in hypertension","volume":"21","author":"Guzik","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"2026032611344830900_cvag036-B17","doi-asserted-by":"crossref","first-page":"579036","DOI":"10.3389\/fcvm.2020.579036","article-title":"Key player in cardiac hypertrophy, emphasizing the role of toll-like receptor 4","volume":"7","author":"Xiao","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"2026032611344830900_cvag036-B18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/01.mol.0000137229.00020.fe","article-title":"Hyperlipidaemia and aortic valve disease","volume":"15","author":"Rosseb\u00f8","year":"2004","journal-title":"Curr Opin Lipidol"},{"key":"2026032611344830900_cvag036-B19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/CIRCULATIONAHA.107.702795","article-title":"Metabolic mechanisms in heart failure","volume":"116","author":"Ashrafian","year":"2007","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B20","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/j.jacc.2006.09.010","article-title":"Time to address the cardiac metabolic \u201ctriple whammy\u201d ischemic heart failure in diabetic patients","volume":"48","author":"Horowitz","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2026032611344830900_cvag036-B21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12872-023-03406-5","article-title":"The presence of diabetes mellitus or pre-diabetes mellitus increases mortality from heart disease in a Taiwanese population: a 10-year follow-up study","volume":"23","author":"Tsai","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"key":"2026032611344830900_cvag036-B22","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1161\/CIRCULATIONAHA.116.022194","article-title":"Clinical update: cardiovascular disease in diabetes Mellitus","volume":"133","author":"Wang","year":"2016","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B23","doi-asserted-by":"crossref","first-page":"e12268","DOI":"10.1097\/MD.0000000000012268","article-title":"Risk of diabetes mellitus in HIV-infected patients receiving highly active antiretroviral therapy: a nationwide population-based study","volume":"97","author":"Lin","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2026032611344830900_cvag036-B24","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.3390\/ijms21134725","article-title":"Statin treatment-induced development of type 2 diabetes: from clinical evidence to mechanistic insights","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026032611344830900_cvag036-B25","author":"Global HIV & AIDS statistics\u2014fact sheet"},{"key":"2026032611344830900_cvag036-B26","author":"UNAIDS"},{"key":"2026032611344830900_cvag036-B27","first-page":"507","article-title":"Antiretroviral therapy-associated metabolic complications: review of the recent studies","volume":"12","author":"Thet","year":"2020","journal-title":"HIV\/AIDS (Auckl)"},{"key":"2026032611344830900_cvag036-B28","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2337\/diabetes.52.7.1695","article-title":"HIV protease inhibitors acutely impair glucose-stimulated insulin release","volume":"52","author":"Koster","year":"2003","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B29","doi-asserted-by":"crossref","first-page":"e2844","DOI":"10.1097\/MD.0000000000002844","article-title":"Risk factors for incident diabetes in a cohort taking first-line nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy","volume":"95","author":"Karamchand","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2026032611344830900_cvag036-B30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/2230-8210.202029","article-title":"Antiretroviral therapy-induced insulin resistance and oxidative deoxy nucleic acid damage in human immunodeficiency virus-1 patients","volume":"21","author":"Honnapurmath","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"key":"2026032611344830900_cvag036-B31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/1874192401105010049","article-title":"HIV and HAART-associated dyslipidemia","volume":"5","author":"Feeney","year":"2011","journal-title":"Open Cardiovasc Med J"},{"key":"2026032611344830900_cvag036-B32","first-page":"e11539","article-title":"An outlook on the impact of HIV infection and highly active antiretroviral therapy on the cardiovascular system\u2014a review","volume":"12","author":"Antony","year":"2020","journal-title":"Cureus"},{"key":"2026032611344830900_cvag036-B33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/jama.2016.8900","article-title":"Antiretroviral drugs for treatment and prevention of HIV infection in adults 2016. Recommendations of the international antiviral society-USA panel","volume":"316","author":"G\u00fcnthard","year":"2016","journal-title":"JAMA"},{"key":"2026032611344830900_cvag036-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4102\/sajhivmed.v21i1.1152","article-title":"Southern African guidelines on the safe, easy and effective use of pre-exposure prophylaxis: 2020","volume":"21","author":"Bekker","year":"2020","journal-title":"South Afr J HIV Med"},{"key":"2026032611344830900_cvag036-B35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/COH.0000000000000702","article-title":"Cardiovascular toxicity of contemporary antiretroviral therapy","volume":"16","author":"Vos","year":"2021","journal-title":"Curr Opin HIV AIDS"},{"key":"2026032611344830900_cvag036-B36","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1161\/CIRCULATIONAHA.118.036211","article-title":"Time to recognize HIV infection as a major cardiovascular risk factor","volume":"138","author":"Hsue","year":"2018","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.36011\/cpp.2022.4.e14","article-title":"Cardiovascular diseases in HIV patients","volume":"4","author":"Chang","year":"2022","journal-title":"Cardiovasc Prev Pharmacother"},{"key":"2026032611344830900_cvag036-B38","doi-asserted-by":"crossref","first-page":"e012673","DOI":"10.1161\/JAHA.119.012673","article-title":"Glucose metabolism in cardiac hypertrophy and heart failure","volume":"8","author":"Tran","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2026032611344830900_cvag036-B39","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ijbiomac.2022.03.004","article-title":"Role of polyphenols in combating type 2 diabetes and insulin resistance","volume":"206","author":"Shahwan","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"2026032611344830900_cvag036-B40","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.bbamcr.2012.08.009","article-title":"Regulation and dysregulation of glucose transport in cardiomyocytes","volume":"1833","author":"Montessuit","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2026032611344830900_cvag036-B41","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00424-020-02417-x","article-title":"Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease","volume":"472","author":"Chadt","year":"2020","journal-title":"Pfl\u00fcgers Arch"},{"key":"2026032611344830900_cvag036-B42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12551-015-0186-2","article-title":"Glucose transporters: physiological and pathological roles","volume":"8","author":"Navale","year":"2016","journal-title":"Biophys Rev"},{"key":"2026032611344830900_cvag036-B43","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.3390\/nu11102432","article-title":"Regulation of skeletal muscle glucose transport and glucose metabolism by exercise training","volume":"11","author":"Evans","year":"2019","journal-title":"Nutrients"},{"key":"2026032611344830900_cvag036-B44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-12-383864-3.00008-9","volume-title":"Human Biochemistry","author":"Litwack","year":"2018"},{"key":"2026032611344830900_cvag036-B45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/j.2040-4603.2016.tb00680.x","article-title":"Glucose transporters in cardiac metabolism and hypertrophy","volume":"6","author":"Shao","year":"2015","journal-title":"Compr Physiol"},{"key":"2026032611344830900_cvag036-B46","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1210\/en.2017-03120","article-title":"\u03b2-cell control of insulin production during starvation-refeeding in male rats","volume":"159","author":"Boland","year":"2018","journal-title":"Endocrinology"},{"issue":"6","key":"2026032611344830900_cvag036-B47","doi-asserted-by":"crossref","first-page":"e1000278","DOI":"10.1371\/journal.pone.0100278","article-title":"Prediction of membrane transport proteins and their substrate specificities using primary sequence information.","volume":"9","author":"Mishra","year":"2014","journal-title":"PLoS One"},{"key":"2026032611344830900_cvag036-B48","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1161\/ATVBAHA.111.241984","article-title":"Insulin resistance: metabolic mechanisms and consequences in the heart","volume":"32","author":"Abel","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026032611344830900_cvag036-B49","doi-asserted-by":"crossref","first-page":"E130","DOI":"10.1152\/ajpendo.00158.2021","article-title":"Insulin signaling in the heart","volume":"321","author":"Abel","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026032611344830900_cvag036-B50","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCRESAHA.116.306206","article-title":"Insulin signaling and heart failure","volume":"118","author":"Riehle","year":"2016","journal-title":"Circ Res"},{"key":"2026032611344830900_cvag036-B51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"2026032611344830900_cvag036-B52","doi-asserted-by":"crossref","first-page":"a13","DOI":"10.4102\/aveh.v74i1.13","article-title":"Polyol pathway: a possible mechanism of diabetes complications in the eye","volume":"74","author":"Mathebula","year":"2015","journal-title":"Afr Vis Eye Health"},{"key":"2026032611344830900_cvag036-B53","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s11010-022-04587-x","article-title":"Impairment of insulin signaling pathway PI3K\/Akt\/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review","volume":"478","author":"Ramasubbu","year":"2023","journal-title":"Mol Cell Biochem"},{"key":"2026032611344830900_cvag036-B54","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00424-012-1156-1","article-title":"The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells","volume":"464","author":"Koziel","year":"2012","journal-title":"Pflugers Arch"},{"key":"2026032611344830900_cvag036-B55","first-page":"292","article-title":"Mediators of hyperglycemia and the pathogenesis of matrix accumulation in diabetic renal disease","volume":"21","author":"Ziyadeh","year":"1995","journal-title":"Miner Electrolyte Metab"},{"key":"2026032611344830900_cvag036-B56","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1172\/JCI118117","article-title":"Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2","volume":"96","author":"Xia","year":"1995","journal-title":"J Clin Invest"},{"key":"2026032611344830900_cvag036-B57","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.3390\/ijms19061657","article-title":"Some biological consequences of the inhibition of Na,K-ATPase by translationally controlled tumor protein (TCTP)","volume":"19","author":"Jung","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026032611344830900_cvag036-B58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/acprof:oso\/9780195326697.003.0002","volume-title":"Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging","author":"Qiao","year":"2009"},{"key":"2026032611344830900_cvag036-B59","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2026032611344830900_cvag036-B60","first-page":"621","article-title":"Glycation as the glucose link to diabetic complications","volume":"100","author":"Gugliucci","year":"2000","journal-title":"J Osteopath Med"},{"key":"2026032611344830900_cvag036-B61","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.3390\/nu11092090","article-title":"Oxidative stress in cardiovascular diseases: still a therapeutic target?","volume":"11","author":"Senoner","year":"2019","journal-title":"Nutrients"},{"key":"2026032611344830900_cvag036-B62","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1152\/physiol.00021.2012","article-title":"No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium","volume":"27","author":"Louch","year":"2012","journal-title":"Physiology"},{"key":"2026032611344830900_cvag036-B63","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.acvd.2020.06.006","article-title":"Myocardial glucotoxicity: mechanisms and potential therapeutic targets","volume":"113","author":"Battault","year":"2020","journal-title":"Arch Cardiovasc Dis"},{"key":"2026032611344830900_cvag036-B64","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.yjmcc.2019.11.147","article-title":"Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs","volume":"138","author":"Stroik","year":"2020","journal-title":"J Mol Cell Cardiol"},{"key":"2026032611344830900_cvag036-B65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.febslet.2004.04.059","article-title":"Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?","volume":"567","author":"Szabadkai","year":"2004","journal-title":"FEBS Lett"},{"key":"2026032611344830900_cvag036-B66","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1016\/S2352-3018(23)00272-2","article-title":"Longitudinal trends in causes of death among adults with HIV on antiretroviral therapy in Europe and North America from 1996 to 2020: a collaboration of cohort studies","volume":"11","author":"Trickey","year":"2024","journal-title":"Lancet HIV"},{"key":"2026032611344830900_cvag036-B67","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/13557858.2012.778642","article-title":"Cardiovascular disease in low- and middle-income countries: an urgent priority","volume":"17","author":"Wurie","year":"2012","journal-title":"Ethn Health"},{"key":"2026032611344830900_cvag036-B68","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/COH.0b013e328347876c","article-title":"Cardiovascular disease in HIV infection","volume":"6","author":"Palella FJ","year":"2011","journal-title":"Curr Opin HIV AIDS"},{"key":"2026032611344830900_cvag036-B69","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3844\/ajidsp.2006.159.166","article-title":"Metabolic abnormalities associated with the use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors","volume":"2","author":"Rao","year":"2006","journal-title":"Am J Infect Dis"},{"key":"2026032611344830900_cvag036-B70","doi-asserted-by":"crossref","first-page":"99","DOI":"10.15420\/cfr.2018.18.2","article-title":"Metabolic modulation of cardiac metabolism in heart failure","volume":"4","author":"Rosano","year":"2018","journal-title":"Card Fail Rev"},{"key":"2026032611344830900_cvag036-B71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12933-020-01177-3","article-title":"Insulin directly stimulates mitochondrial glucose oxidation in the heart","volume":"19","author":"Karwi","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"2026032611344830900_cvag036-B72","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ Res"},{"key":"2026032611344830900_cvag036-B73","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3892\/mmr.2020.11175","article-title":"Diabetic-induced alterations in hepatic glucose and lipid metabolism: the role of type 1 and type 2 diabetes mellitus","volume":"22","author":"Jiang","year":"2020","journal-title":"Mol Med Rep"},{"key":"2026032611344830900_cvag036-B74","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jama.2012.7961","article-title":"Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel.","volume":"308","author":"Thompson","year":"2012","journal-title":"JAMA"},{"key":"2026032611344830900_cvag036-B75","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/COH.0b013e328329c62f","article-title":"The consequences of HIV infection and antiretroviral therapy use for cardiovascular disease risk: shifting paradigms","volume":"4","author":"Baker","year":"2009","journal-title":"Curr Opin HIV AIDS"},{"key":"2026032611344830900_cvag036-B76","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ Res"},{"key":"2026032611344830900_cvag036-B77","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1007\/s40121-025-01229-9","article-title":"The role of protease inhibitors in HIV treatment: who still needs them in 2025?","volume":"14","author":"Sempere","year":"2025","journal-title":"Infect Dis Ther"},{"key":"2026032611344830900_cvag036-B78","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3390\/v13050839","article-title":"HIV protease: historical perspective and current research","volume":"13","author":"Weber","year":"2021","journal-title":"Viruses"},{"key":"2026032611344830900_cvag036-B79","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jgar.2021.10.023","article-title":"HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral therapy in KwaZulu-Natal Province, South Africa","volume":"29","author":"Chimukangara","year":"2022","journal-title":"J Glob Antimicrob Resist"},{"key":"2026032611344830900_cvag036-B80","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/00325481.2015.1015927","article-title":"Lipodystrophy: syndrome of severe insulin resistance","volume":"127","author":"Bindlish","year":"2015","journal-title":"Postgrad Med"},{"key":"2026032611344830900_cvag036-B81","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1097\/00002030-200203290-00002","article-title":"Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study","volume":"16","author":"Noor","year":"2002","journal-title":"AIDS"},{"key":"2026032611344830900_cvag036-B82","first-page":"105","article-title":"Glucose disorders associated with antiretroviral therapy: an overview","volume":"2","author":"Mastan","year":"2015","journal-title":"Biomed Pharmacol J"},{"key":"2026032611344830900_cvag036-B83","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1055\/s-2003-44709","article-title":"Therapeutic dose of HIV-1 protease inhibitor saquinavir does not permanently influence early insulin signaling","volume":"111","author":"Algenstaedt","year":"2003","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"2026032611344830900_cvag036-B84","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jacc.2018.04.083","article-title":"Protease inhibitors and cardiovascular outcomes in patients with HIV and heart failure","volume":"72","author":"Alvi","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026032611344830900_cvag036-B85","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.beem.2010.10.017","article-title":"Molecular mechanisms for insulin resistance in treated HIV-infection","volume":"25","author":"Hruz","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2026032611344830900_cvag036-B86","doi-asserted-by":"crossref","first-page":"20251","DOI":"10.1074\/jbc.C000228200","article-title":"The mechanism of insulin resistance caused by HIV protease inhibitor therapy","volume":"275","author":"Murata","year":"2000","journal-title":"J Biol Chem"},{"key":"2026032611344830900_cvag036-B87","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2337\/diabetes.51.4.937","article-title":"Indinavir induces acute and reversible peripheral insulin resistance in rats","volume":"51","author":"Hruz","year":"2002","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B88","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1097\/00002030-199807000-00003","article-title":"A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors","volume":"12","author":"Carr","year":"1998","journal-title":"AIDS"},{"key":"2026032611344830900_cvag036-B89","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.2165\/11204950-000000000-00000","article-title":"Lopinavir\/ritonavir","volume":"70","author":"Croxtall","year":"2010","journal-title":"Drugs"},{"key":"2026032611344830900_cvag036-B90","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3851\/IMP2752","article-title":"Impact of darunavir, atazanavir and lopinavir boosted with ritonavir on cultured human endothelial cells: beneficial effect of pravastatin","volume":"19","author":"Auclair","year":"2014","journal-title":"Antivir Ther"},{"key":"2026032611344830900_cvag036-B91","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1310\/hct1305-256","article-title":"Effect of darunavir on lipid profile in HIV-infected patients","volume":"13","author":"Overton","year":"2012","journal-title":"HIV Clin Trials"},{"key":"2026032611344830900_cvag036-B92","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1089\/aid.2011.0327","article-title":"Metabolic effects of darunavir\/ritonavir versus atazanavir\/ritonavir in treatment-naive, HIV type 1-infected subjects over 48 weeks","volume":"28","author":"Aberg","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"key":"2026032611344830900_cvag036-B93","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3390\/vaccines12101176","article-title":"Antiretroviral therapy with ritonavir-boosted atazanavir- and lopinavir-containing regimens correlates with diminished HIV-1 neutralization","volume":"12","author":"Yuste","year":"2024","journal-title":"Vaccines (Basel)"},{"key":"2026032611344830900_cvag036-B94","first-page":"174","article-title":"Switching to atazanavir improves metabolic disorders in antiretroviral-experienced patients with severe hyperlipidemia","volume":"39","author":"M\u00f6bius","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026032611344830900_cvag036-B95","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1093\/jac\/dkq231","article-title":"Lipid profiles in HIV-infected adults receiving atazanavir and atazanavir\/ritonavir: systematic review and meta-analysis of randomized controlled trials","volume":"65","author":"Carey","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"2026032611344830900_cvag036-B96","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s40121-016-0132-z","article-title":"Atazanavir and cardiovascular risk among human immunodeficiency virus-infected patients: a systematic review","volume":"5","author":"Chow","year":"2016","journal-title":"Infect Dis Ther"},{"key":"2026032611344830900_cvag036-B97","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1097\/00002030-200105040-00001","article-title":"Metabolic effects of indinavir in healthy HIV-seronegative men","volume":"15","author":"Noor","year":"2001","journal-title":"AIDS"},{"key":"2026032611344830900_cvag036-B98","first-page":"a007161","article-title":"HIV-1 antiretroviral drug therapy","volume":"2","author":"Eggleton","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2026032611344830900_cvag036-B99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7448\/IAS.16.1.18567","article-title":"Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability","volume":"16","author":"Usach","year":"2013","journal-title":"J Int AIDS Soc"},{"key":"2026032611344830900_cvag036-B100","doi-asserted-by":"crossref","first-page":"1118653","DOI":"10.3389\/fphys.2023.1118653","article-title":"Direct and indirect cardiovascular and cardiometabolic sequelae of the combined anti-retroviral therapy on people living with HIV","volume":"14","author":"Batta","year":"2023","journal-title":"Front Physiol"},{"key":"2026032611344830900_cvag036-B101","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.atherosclerosis.2008.09.016","article-title":"Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice","volume":"204","author":"Tohyama","year":"2009","journal-title":"Atherosclerosis"},{"key":"2026032611344830900_cvag036-B102","doi-asserted-by":"crossref","first-page":"P121","DOI":"10.1186\/1758-2652-11-S1-P121","article-title":"Lipid changes in patients receiving nevirapine (NVP) in combination with tenofovir\/emtricitabine: results from the CCIAT trial","volume":"11","author":"Davis","year":"2008","journal-title":"J Int AIDS Soc"},{"key":"2026032611344830900_cvag036-B103","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.2165\/00003495-200060060-00013","article-title":"Delavirdine: a review of its use in HIV infection","volume":"60","author":"Scott","year":"2000","journal-title":"Drugs"},{"key":"2026032611344830900_cvag036-B104","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.4102\/sajhivmed.v21i1.1115","article-title":"Southern African HIV clinicians society guidelines for antiretroviral therapy in adults: 2020 update","volume":"21","author":"Nel","year":"2020","journal-title":"South Afr J HIV Med"},{"key":"2026032611344830900_cvag036-B105","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1093\/jac\/dkv195","article-title":"A randomized, controlled trial of the effect of rilpivirine versus efavirenz on cardiovascular risk in healthy volunteers","volume":"70","author":"Gupta","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2026032611344830900_cvag036-B106","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0140-6736(11)60983-5","article-title":"Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial","volume":"378","author":"Cohen","year":"2011","journal-title":"Lancet"},{"key":"2026032611344830900_cvag036-B107","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0140-6736(11)60936-7","article-title":"Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial","volume":"378","author":"Molina","year":"2011","journal-title":"Lancet"},{"key":"2026032611344830900_cvag036-B108","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/cid\/ciu234","article-title":"Lipid levels and changes in body fat distribution in treatment-naive, HIV-1\u2013infected adults treated with rilpivirine or efavirenz for 96 weeks in the ECHO and THRIVE trials","volume":"59","author":"Tebas","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2026032611344830900_cvag036-B109","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12981-019-0222-6","article-title":"Efficacy and improvement of lipid profile after switching to rilpivirine in resource limited setting: real life clinical practice","volume":"16","author":"Gatechompol","year":"2019","journal-title":"AIDS Res Ther"},{"key":"2026032611344830900_cvag036-B110","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/jac\/dkr533","article-title":"Lipid profiles for etravirine versus efavirenz in treatment-naive patients in the randomized, double-blind SENSE trial","volume":"67","author":"F\u00e4tkenheuer","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"2026032611344830900_cvag036-B111","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/apc.2011.0011","article-title":"Endothelial, inflammatory, coagulation, metabolic effects and safety of etravirine in HIV-uninfected volunteers","volume":"25","author":"Gupta","year":"2011","journal-title":"AIDS Patient Care STDS"},{"key":"2026032611344830900_cvag036-B112","doi-asserted-by":"crossref","first-page":"114554","DOI":"10.1016\/j.ejmech.2022.114554","article-title":"HIV nucleoside reverse transcriptase inhibitors","volume":"240","author":"Amblard","year":"2022","journal-title":"Eur J Med Chem"},{"key":"2026032611344830900_cvag036-B113","doi-asserted-by":"crossref","first-page":"102878","DOI":"10.1016\/j.arr.2025.102878","article-title":"Nucleoside reverse transcriptase inhibitors as a therapeutic opportunity to counteract inflammaging and age-related diseases: new evidence from epidemiological data","volume":"112","author":"Olivieri","year":"2025","journal-title":"Ageing Res Rev"},{"key":"2026032611344830900_cvag036-B114","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1161\/CIRCULATIONAHA.113.004574","article-title":"Heart failure in patients with human immunodeficiency virus infection","volume":"129","author":"Remick","year":"2014","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0022-3476(95)70275-X","article-title":"Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus","volume":"127","author":"Domanski","year":"1995","journal-title":"J Pediatr"},{"key":"2026032611344830900_cvag036-B116","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/heart.89.7.793","article-title":"HIV and cardiovascular medicine","volume":"89","author":"Prendergast","year":"2003","journal-title":"Heart"},{"key":"2026032611344830900_cvag036-B117","first-page":"20","article-title":"Dilated Cardiomyopathy induced by Zidovudine-based Antiretroviral Regimen","volume":"7","author":"Nair","year":"2017","journal-title":"Bull Drug React"},{"key":"2026032611344830900_cvag036-B118","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0008-6363(03)00364-X","article-title":"Zidovudine-induced alterations in the heart and vascular smooth muscle of the rat","volume":"60","author":"Ruga","year":"2003","journal-title":"Cardiovasc Res"},{"key":"2026032611344830900_cvag036-B119","doi-asserted-by":"crossref","first-page":"e496","DOI":"10.1016\/S2352-3018(25)00043-8","article-title":"Effects of antiretrovirals on major adverse cardiovascular events in the REPRIEVE trial: a longitudinal cohort analysis","volume":"12","author":"Fichtenbaum","year":"2025","journal-title":"Lancet HIV"},{"key":"2026032611344830900_cvag036-B120","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1097\/QAD.0b013e32832e7140","article-title":"Association of Abacavir and impaired endothelial function in treated and suppressed HIV-infected patients","volume":"23","author":"Hsue","year":"2009","journal-title":"Aids"},{"key":"2026032611344830900_cvag036-B121","doi-asserted-by":"crossref","first-page":"1604972","DOI":"10.3389\/fphar.2025.1604972","article-title":"Metabolic effects and cardiovascular disease risks of TDF or TAF in patients with chronic hepatitis B: a systematic review and meta-analysis","volume":"16","author":"Zhou","year":"2025","journal-title":"Front Pharmacol"},{"key":"2026032611344830900_cvag036-B122","doi-asserted-by":"crossref","first-page":"e0002648","DOI":"10.1371\/journal.pgph.0002648","article-title":"Discontinuation of tenofovir disoproxil fumarate from initial ART regimens because of renal adverse events: an analysis of data from four multi-country clinical trials","volume":"4","author":"Ngongondo","year":"2024","journal-title":"PLOS Glob Public Health"},{"key":"2026032611344830900_cvag036-B123","doi-asserted-by":"crossref","first-page":"758","DOI":"10.7326\/M20-4853","article-title":"Weight and metabolic changes after switching from tenofovir disoproxil fumarate to tenofovir alafenamide in people living with HIV: a cohort study","volume":"174","author":"Surial","year":"2021","journal-title":"Ann Intern Med"},{"key":"2026032611344830900_cvag036-B124","doi-asserted-by":"crossref","first-page":"e2332968","DOI":"10.1001\/jamanetworkopen.2023.32968","article-title":"Use of tenofovir alafenamide fumarate for HIV pre-exposure prophylaxis and incidence of hypertension and initiation of statins","volume":"6","author":"Rivera","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2026032611344830900_cvag036-B125","first-page":"13","article-title":"Kidney disease and HIV infection","volume":"25","author":"Wyatt","year":"2017","journal-title":"Top Antivir Med"},{"key":"2026032611344830900_cvag036-B126","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/cid\/ciy083","article-title":"Metabolic effects of preexposure prophylaxis with coformulated tenofovir disoproxil fumarate and emtricitabine","volume":"67","author":"Glidden","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2026032611344830900_cvag036-B127","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/cid\/civ296","article-title":"The lipid-lowering effect of tenofovir\/emtricitabine: a randomized, crossover, double-blind, placebo-controlled trial","volume":"61","author":"Santos","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2026032611344830900_cvag036-B128","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.3390\/v14122591","article-title":"Different pathways conferring integrase strand-transfer inhibitors resistance","volume":"14","author":"Richetta","year":"2022","journal-title":"Viruses"},{"key":"2026032611344830900_cvag036-B129","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/QAI.0000000000002357","article-title":"Brief report: integrase strand transfer inhibitors are associated with lower risk of incident cardiovascular disease in people living with HIV","volume":"84","author":"O'Halloran","year":"2020","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026032611344830900_cvag036-B130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijid.2019.12.029","article-title":"Weight gain and dyslipidemia among virally suppressed HIV-positive patients switching to co-formulated elvitegravir\/cobicistat\/emtricitabine\/tenofovir alafenamide","volume":"92","author":"Kuo","year":"2020","journal-title":"Int J Infect Dis"},{"key":"2026032611344830900_cvag036-B131","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1093\/cid\/civ193","article-title":"Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257","volume":"60","author":"Ofotokun","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2026032611344830900_cvag036-B132","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1093\/infdis\/jiac175","article-title":"Dolutegravir suppresses thermogenesis via disrupting uncoupling protein 1 expression and mitochondrial function in Brown\/Beige adipocytes in preclinical models","volume":"226","author":"Jung","year":"2022","journal-title":"J Infect Dis"},{"key":"2026032611344830900_cvag036-B133","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.3390\/cells11111841","article-title":"Inhibition of adipose tissue beiging by HIV integrase inhibitors, dolutegravir and bictegravir, is associated with adipocyte hypertrophy, hypoxia, elevated fibrosis, and insulin resistance in simian adipose tissue and human adipocytes","volume":"11","author":"Ayissi K","year":"2022","journal-title":"Cells"},{"key":"2026032611344830900_cvag036-B134","doi-asserted-by":"crossref","first-page":"e549","DOI":"10.1093\/cid\/ciaa259","article-title":"The integrase inhibitors dolutegravir and raltegravir exert proadipogenic and profibrotic effects and induce insulin resistance in human\/simian adipose tissue and human adipocytes","volume":"71","author":"Gorwood","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2026032611344830900_cvag036-B135","doi-asserted-by":"crossref","first-page":"23267","DOI":"10.1038\/s41598-025-06145-z","article-title":"Hypertension among people living with HIV receiving dolutegravir-based antiretroviral therapy in Ethiopia: a cross-sectional study","volume":"15","author":"Jemal","year":"2025","journal-title":"Sci Rep"},{"key":"2026032611344830900_cvag036-B136","doi-asserted-by":"crossref","first-page":"106020","DOI":"10.1016\/j.antiviral.2024.106020","article-title":"Bictegravir alters glucose tolerance in vivo and causes hepatic mitochondrial dysfunction","volume":"231","author":"Garc\u00eda-Mart\u00ednez","year":"2024","journal-title":"Antiviral Res"},{"key":"2026032611344830900_cvag036-B137","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.mcna.2010.11.002","article-title":"Definition of prediabetes","volume":"95","author":"Buysschaert","year":"2011","journal-title":"Med Clin North Am"},{"key":"2026032611344830900_cvag036-B138","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.2337\/dc22-2376","article-title":"Global prevalence of prediabetes","volume":"46","author":"Rooney","year":"2023","journal-title":"Diabetes Care"},{"key":"2026032611344830900_cvag036-B139","doi-asserted-by":"crossref","first-page":"e0278347","DOI":"10.1371\/journal.pone.0278347","article-title":"Prevalence and correlates of pre-diabetes in adults of mixed ethnicities in the South African population: a systematic review and meta-analysis","volume":"17","author":"Sosibo","year":"2022","journal-title":"PLoS One"},{"key":"2026032611344830900_cvag036-B140","doi-asserted-by":"crossref","first-page":"e26059","DOI":"10.1002\/jia2.26059","article-title":"Prevalence and influences of diabetes and prediabetes among adults living with HIV in Africa: a systematic review and meta-analysis","volume":"26","author":"Peer","year":"2023","journal-title":"J Int AIDS Soc"},{"key":"2026032611344830900_cvag036-B141","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12981-020-00284-1","article-title":"Prediabetes among HIV-infected individuals receiving antiretroviral therapy: prevalence, diagnostic tests, and associated factors","volume":"17","author":"Phuphuakrat","year":"2020","journal-title":"AIDS Res Ther"},{"key":"2026032611344830900_cvag036-B142","doi-asserted-by":"crossref","first-page":"e000907","DOI":"10.1136\/bmjdrc-2019-000907","article-title":"Ethnic variation in the conversion of prediabetes to diabetes among immigrant populations relative to Canadian-born residents: a population-based cohort study","volume":"8","author":"Fazli","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2026032611344830900_cvag036-B143","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/QAD.0000000000002718","article-title":"Incident type 2 diabetes mellitus after initiation of common HIV antiretroviral drugs","volume":"35","author":"Hsu","year":"2021","journal-title":"AIDS"},{"key":"2026032611344830900_cvag036-B144","doi-asserted-by":"crossref","first-page":"1045628","DOI":"10.3389\/fendo.2022.1045628","article-title":"Impaired fasting glucose levels among perinatally HIV-infected adolescents and youths in Dar es Salaam, Tanzania","volume":"13","author":"Nkinda","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026032611344830900_cvag036-B145","doi-asserted-by":"crossref","first-page":"e00292","DOI":"10.1002\/edm2.292","article-title":"Increased risk of prediabetes among virally suppressed adults with HIV in Central Kenya detected using glycated haemoglobin and fasting blood glucose","volume":"4","author":"Njoroge","year":"2021","journal-title":"Endocrinol Diabetes Metab"},{"key":"2026032611344830900_cvag036-B146","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12889-021-10318-6","article-title":"Prevalence and predictors of diabetes mellitus among persons living with HIV: a retrospective cohort study conducted in 4 public healthcare facilities in KwaZulu-Natal","volume":"21","author":"Umar","year":"2021","journal-title":"BMC Public Health"},{"key":"2026032611344830900_cvag036-B147","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.pcd.2023.10.004","article-title":"Prevalence of pre-diabetes in adults aged 25\u201345 years in a Durban-based clinical setting, South Africa: a retrospective study","volume":"17","author":"Sosibo","year":"2023","journal-title":"Prim Care Diabetes"},{"key":"2026032611344830900_cvag036-B148","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<554::AID-DIA626>3.0.CO;2-E","article-title":"Comparison of the current WHO and new ADA criteria for the diagnosis of diabetes mellitus in three ethnic groups in the UK","volume":"15","author":"Unwin","year":"1998","journal-title":"Diabet Med"},{"key":"2026032611344830900_cvag036-B149","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4239\/wjd.v6.i2.296","article-title":"Prediabetes diagnosis and treatment: a review","volume":"6","author":"Bansal","year":"2015","journal-title":"World J Diabetes"},{"key":"2026032611344830900_cvag036-B150","first-page":"594","article-title":"Pathophysiology of prediabetes","volume":"103","author":"Bhansali","year":"2005","journal-title":"J Indian Med Assoc"},{"key":"2026032611344830900_cvag036-B151","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S1359-6101(03)00052-2","article-title":"Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-\u03b1","volume":"14","author":"Ruan","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026032611344830900_cvag036-B152","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2337\/diabetes.51.5.1319","article-title":"Tumor necrosis factor-\u03b1 suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-\u03baB activation by TNF-\u03b1 is obligatory","volume":"51","author":"Ruan","year":"2002","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B153","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s43152-024-00056-3","article-title":"Cellular and molecular mechanisms of insulin resistance","volume":"5","author":"Chandrasekaran","year":"2024","journal-title":"Curr Tissue Microenviron Rep"},{"key":"2026032611344830900_cvag036-B154","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2337\/dc11-0442","article-title":"Globalization of diabetes: the role of diet, lifestyle, and genes","volume":"34","author":"Hu","year":"2011","journal-title":"Diabetes Care"},{"key":"2026032611344830900_cvag036-B155","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00129784-200202020-00003","article-title":"Management of protease inhibitor-associated hyperlipidemia","volume":"2","author":"Penzak","year":"2002","journal-title":"Am J Cardiovasc Drugs"},{"key":"2026032611344830900_cvag036-B156","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2337\/diabetes.52.4.918","article-title":"Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens","volume":"52","author":"Woerle","year":"2003","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B157","first-page":"41","article-title":"Metabolic complications of antiretroviral therapies","volume":"10","author":"Dube","year":"1998","journal-title":"AIDS Clin Care"},{"key":"2026032611344830900_cvag036-B158","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1172\/JCI119870","article-title":"Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation","volume":"100","author":"Adams","year":"1997","journal-title":"J Clin Invest"},{"key":"2026032611344830900_cvag036-B159","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1086\/313854","article-title":"HIV protease inhibitor-related lipodystrophy syndrome","volume":"30","author":"Carr","year":"2000","journal-title":"Clin Infect Dis"},{"key":"2026032611344830900_cvag036-B160","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1161\/01.ATV.20.12.2625","article-title":"HIV protease inhibitors stimulate hepatic triglyceride synthesis","volume":"20","author":"Lenhard","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026032611344830900_cvag036-B161","first-page":"360","article-title":"HIV protease inhibitor-induced hyperlipidemia and lipodystrophy is mediated through regulation of sterol responsive element binding protein (SREBP) responsive genes.","volume":"102","author":"Kuhel","year":"2000","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B162","first-page":"e44131","article-title":"Predictors of prediabetes among communities without a family history of type 2 diabetes mellitus: a case-control study","volume":"15","author":"Liberty","year":"2023","journal-title":"Cureus"},{"key":"2026032611344830900_cvag036-B163","doi-asserted-by":"crossref","first-page":"778","DOI":"10.2337\/db12-0073","article-title":"Insulin resistance and type 2 diabetes","volume":"61","author":"Taylor","year":"2012","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B164","first-page":"451","article-title":"Predictors of conversion from prediabetic state to type 2 diabetes mellitus in Jordan","volume":"54","author":"Al-dajah","year":"2018","journal-title":"Alex J Med"},{"key":"2026032611344830900_cvag036-B165","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1038\/s41598-024-52023-5","article-title":"Identifying top ten predictors of type 2 diabetes through machine learning analysis of UK biobank data","volume":"14","author":"Lugner","year":"2024","journal-title":"Sci Rep"},{"key":"2026032611344830900_cvag036-B166","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11904-020-00483-5","article-title":"Obesity and weight gain in persons with HIV","volume":"17","author":"Bailin","year":"2020","journal-title":"Curr HIV\/AIDS Rep"},{"key":"2026032611344830900_cvag036-B167","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1089\/aid.2015.0147","article-title":"Rising obesity prevalence and weight gain among adults starting antiretroviral therapy in the United States and Canada","volume":"32","author":"Koethe","year":"2016","journal-title":"AIDS Res Hum Retroviruses"},{"key":"2026032611344830900_cvag036-B168","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3851\/IMP2348","article-title":"HIV infection and obesity: where did all the wasting go?","volume":"17","author":"Tate","year":"2012","journal-title":"Antivir Ther"},{"key":"2026032611344830900_cvag036-B169","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/135965350701200214","article-title":"Insulin resistance, glucose intolerance and diabetes mellitus in HIV-infected patients","volume":"12","author":"Florescu","year":"2007","journal-title":"Antivir Ther"},{"key":"2026032611344830900_cvag036-B170","doi-asserted-by":"crossref","first-page":"120329","DOI":"10.1016\/j.lfs.2022.120329","article-title":"Divergent effects of HIV reverse transcriptase inhibitors on pancreatic beta-cell function and survival: potential role of oxidative stress and mitochondrial dysfunction","volume":"294","author":"Maandi","year":"2022","journal-title":"Life Sci"},{"key":"2026032611344830900_cvag036-B171","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2337\/ds17-0009","article-title":"Prevalence of and risk factors for prediabetes in patients infected with HIV","volume":"31","author":"Arafath","year":"2018","journal-title":"Diabetes Spectr"},{"key":"2026032611344830900_cvag036-B172","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.thromres.2018.07.003","article-title":"The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro","volume":"169","author":"Loelius","year":"2018","journal-title":"Thromb Res"},{"key":"2026032611344830900_cvag036-B173","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1742-6405-3-19","article-title":"The effect of different combination therapies on oxidative stress markers in HIV infected patients in Cameroon","volume":"3","author":"Ngondi","year":"2006","journal-title":"AIDS Res Ther"},{"key":"2026032611344830900_cvag036-B174","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/2040622314530461","article-title":"Dolutegravir: clinical efficacy and role in HIV therapy","volume":"5","author":"Fantauzzi","year":"2014","journal-title":"Ther Adv Chronic Dis"},{"key":"2026032611344830900_cvag036-B175","first-page":"e30556","article-title":"Effect of dolutegravir on plasma glucose among human immunodeficiency virus patients in a community health center setting","volume":"14","author":"Bahamdain","year":"2022","journal-title":"Cureus"},{"key":"2026032611344830900_cvag036-B176","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects","volume":"11","author":"Boudina","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"key":"2026032611344830900_cvag036-B177","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pcad.2023.05.002","article-title":"Biomarkers for the diagnosis of heart failure in people with diabetes: a consensus report from diabetes technology society","volume":"79","author":"Yeung","year":"2023","journal-title":"Prog Cardiovasc Dis"},{"key":"2026032611344830900_cvag036-B178","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12933-014-0168-x","article-title":"Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes","volume":"14","author":"Fontes-Carvalho","year":"2015","journal-title":"Cardiovasc Diabetol"},{"key":"2026032611344830900_cvag036-B179","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2337\/dbi23-0019","article-title":"Redefining diabetic cardiomyopathy: perturbations in substrate metabolism at the heart of its pathology","volume":"73","author":"Heather","year":"2024","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B180","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/B978-012656975-9\/50034-1","volume-title":"Heart Physiology and Pathophysiology (Fourth Edition)","author":"Kantor","year":"2001"},{"key":"2026032611344830900_cvag036-B181","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4093\/dmj.2017.41.1.1","article-title":"My sweetheart is broken: role of glucose in diabetic cardiomyopathy","volume":"41","author":"Brahma","year":"2017","journal-title":"Diabetes Metab J"},{"key":"2026032611344830900_cvag036-B182","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/cvr\/cvx011","article-title":"An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy","volume":"113","author":"Frati","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2026032611344830900_cvag036-B183","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.2337\/db14-1107","article-title":"Removal of abnormal myofilament O-GlcNAcylation restores Ca2+ sensitivity in diabetic cardiac muscle","volume":"64","author":"Ramirez-Correa","year":"2015","journal-title":"Diabetes"},{"key":"2026032611344830900_cvag036-B184","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1038\/s41467-021-24869-0","article-title":"Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis","volume":"12","author":"Shankar","year":"2021","journal-title":"Nat Commun"},{"key":"2026032611344830900_cvag036-B185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12471-017-0946-7","article-title":"Potential new mechanisms of pro-arrhythmia in arrhythmogenic cardiomyopathy: focus on calcium sensitive pathways","volume":"25","author":"van Opbergen","year":"2017","journal-title":"Neth Heart J"},{"key":"2026032611344830900_cvag036-B186","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.hfc.2012.06.005","article-title":"Insulin resistance and heart failure: molecular mechanisms","volume":"8","author":"Aroor","year":"2012","journal-title":"Heart Fail Clin"},{"key":"2026032611344830900_cvag036-B187","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1161\/CIRCULATIONAHA.105.554360","article-title":"Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity","volume":"112","author":"Boudina","year":"2005","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B188","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41569-019-0219-9","article-title":"HIV infection and coronary heart disease: mechanisms and management","volume":"16","author":"Hsue","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2026032611344830900_cvag036-B189","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/CIRCULATIONAHA.117.033369","article-title":"Global burden of atherosclerotic cardiovascular disease in people living with HIV","volume":"138","author":"Shah","year":"2018","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B190","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jchf.2018.10.006","article-title":"Cardiac dysfunction among people living with HIV: a systematic review and meta-analysis","volume":"7","author":"Erqou","year":"2019","journal-title":"JACC Heart Fail"},{"key":"2026032611344830900_cvag036-B191","first-page":"101","article-title":"The epidemiology, mechanisms, diagnosis and treatment of cardiovascular disease in adult patients with HIV","volume":"13","author":"Henning","year":"2023","journal-title":"Am J Cardiovasc Dis"},{"key":"2026032611344830900_cvag036-B192","doi-asserted-by":"crossref","first-page":"ofw032","DOI":"10.1093\/ofid\/ofw032","article-title":"START or SMART? Timing of antiretroviral therapy initiation and cardiovascular risk for people with human immunodeficiency virus infection","volume":"3","author":"Siedner","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"2026032611344830900_cvag036-B193","doi-asserted-by":"crossref","first-page":"e70727","DOI":"10.1002\/hsr2.70727","article-title":"Addressing cardiometabolic challenges in HIV: insights, impact, and best practices for optimal management\u2014a narrative review","volume":"8","author":"Mugisha","year":"2025","journal-title":"Health Sci Rep"},{"key":"2026032611344830900_cvag036-B194","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/COH.0000000000000241","article-title":"HIV infection and immune activation: the role of coinfections","volume":"11","author":"Boulougoura","year":"2016","journal-title":"Curr Opin HIV AIDS"},{"key":"2026032611344830900_cvag036-B195","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tim.2012.09.001","article-title":"Microbial translocation, immune activation, and HIV disease","volume":"21","author":"Klatt","year":"2013","journal-title":"Trends Microbiol"},{"key":"2026032611344830900_cvag036-B196","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jacbts.2020.03.015","article-title":"Innate immune receptors, key actors in cardiovascular diseases","volume":"5","author":"Ja\u00e9n","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"2026032611344830900_cvag036-B197","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.jacc.2022.08.756","article-title":"Circulating T cells and cardiovascular risk in people with and without HIV infection","volume":"80","author":"Kundu","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026032611344830900_cvag036-B198","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1093\/infdis\/jiaa245","article-title":"Myocardial steatosis among antiretroviral therapy\u2013treated people with human immunodeficiency virus participating in the REPRIEVE trial","volume":"222","author":"Neilan","year":"2020","journal-title":"J Infect Dis"},{"key":"2026032611344830900_cvag036-B199","doi-asserted-by":"crossref","first-page":"e26525","DOI":"10.1002\/jia2.26525","article-title":"REPRIEVE final results: what does it mean for guidelines in low- and middle-income countries?","volume":"28","author":"Sokhela","year":"2025","journal-title":"J Int AIDS Soc"},{"key":"2026032611344830900_cvag036-B200","doi-asserted-by":"crossref","first-page":"537","DOI":"10.7196\/SAMJ.2016.v106i6.10721","article-title":"HIV\/AIDS: emerging threat to cardiovascular health in sub-Saharan Africa","volume":"106","author":"Strijdom","year":"2016","journal-title":"S Afr Med J"},{"key":"2026032611344830900_cvag036-B201","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1161\/CIRCULATIONAHA.113.001719","article-title":"Comprehensive cardiac magnetic resonance imaging and spectroscopy reveal a high burden of myocardial disease in HIV patients","volume":"128","author":"Holloway","year":"2013","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B202","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/jod.jod_21_18","article-title":"HIV and antiretroviral therapy-induced metabolic syndrome in people living with HIV and its implications for care: a critical review","volume":"10","author":"Masuku","year":"2019","journal-title":"J Diabetolo"},{"key":"2026032611344830900_cvag036-B203","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2119\/2007-00119.Tilg","article-title":"Inflammatory mechanisms in the regulation of insulin resistance","volume":"14","author":"Tilg","year":"2008","journal-title":"Mol Med"},{"key":"2026032611344830900_cvag036-B204","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/clpt.2014.64","article-title":"Antiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-\u03b3 inhibition","volume":"96","author":"Selvaraj","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"2026032611344830900_cvag036-B205","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fendo.2018.00514","article-title":"Insulin resistance in HIV-patients: causes and consequences","volume":"9","author":"Pedro","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026032611344830900_cvag036-B206","doi-asserted-by":"crossref","first-page":"e3003","DOI":"10.1371\/journal.pone.0003003","article-title":"HIV replication enhances production of free fatty acids, low density lipoproteins and many key proteins involved in lipid metabolism: a proteomics study","volume":"3","author":"Rasheed","year":"2008","journal-title":"PLoS One"},{"key":"2026032611344830900_cvag036-B207","doi-asserted-by":"crossref","first-page":"507141","DOI":"10.1155\/2009\/507141","article-title":"Antiretroviral-related adipocyte dysfunction and lipodystrophy in HIV-infected patients: alteration of the PPAR\u03b3-dependent pathways","volume":"2009","author":"Caron","year":"2009","journal-title":"PPAR Res"},{"key":"2026032611344830900_cvag036-B208","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.hfc.2018.12.013","article-title":"Left ventricular mass and thickness: why does it matter?","volume":"15","author":"Dini","year":"2019","journal-title":"Heart Fail Clin"},{"key":"2026032611344830900_cvag036-B209","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol Rev"},{"key":"2026032611344830900_cvag036-B210","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00424-020-02444-8","article-title":"Glucose transporters in cardiovascular system in health and disease","volume":"472","author":"Bertrand","year":"2020","journal-title":"Pfl\u00fcgers Arch"},{"key":"2026032611344830900_cvag036-B211","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12872-023-03083-4","article-title":"The prevalence of left ventricular hypertrophy associated with type-2 diabetes in Shiraz, Iran: a cross-sectional study","volume":"23","author":"Parsa","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"key":"2026032611344830900_cvag036-B212","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/01.CIR.103.1.102","article-title":"Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: hypertension genetic epidemiology network (HyperGEN) study","volume":"103","author":"Palmieri","year":"2001","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B213","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2022.03.019","article-title":"Oxidative stress in the pathophysiology of type 2 diabetes and related complications: current therapeutics strategies and future perspectives","volume":"184","author":"Bhatti","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"2026032611344830900_cvag036-B214","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.freeradbiomed.2021.02.040","article-title":"Oxidative stress in cardiac hypertrophy: from molecular mechanisms to novel therapeutic targets","volume":"166","author":"Ramachandra","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"2026032611344830900_cvag036-B215","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/HYPERTENSIONAHA.119.14400","article-title":"DPP (dipeptidyl peptidase)-4 inhibitor attenuates ang II (angiotensin II)\u2013induced cardiac hypertrophy via GLP (glucagon-like peptide)-1\u2013dependent suppression of nox (nicotinamide adenine dinucleotide phosphate oxidase) 4-HDAC (histone deacetylase) 4 pathway","volume":"75","author":"Okabe","year":"2020","journal-title":"Hypertension"},{"key":"2026032611344830900_cvag036-B216","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1742-1241.2006.01267.x","article-title":"Insulin resistance and HIV infection: a review","volume":"61","author":"Aboud","year":"2007","journal-title":"Int J Clin Pract"},{"key":"2026032611344830900_cvag036-B217","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/met.2004.2.241","article-title":"Insulin resistance and diabetes mellitus in HIV-infected patients receiving antiretroviral therapy","volume":"2","author":"Calza","year":"2004","journal-title":"Metab Syndr Relat Disord"},{"key":"2026032611344830900_cvag036-B218","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/13510002.2016.1215643","article-title":"Hyperglycaemia, oxidative stress and inflammatory markers","volume":"22","author":"Butkowski","year":"2017","journal-title":"Redox Rep"},{"key":"2026032611344830900_cvag036-B219","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.RES.0000043825.01705.1B","article-title":"Inflammatory mediators and the failing heart: past, present, and the foreseeable future","volume":"91","author":"Mann","year":"2002","journal-title":"Circ Res"},{"key":"2026032611344830900_cvag036-B220","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ Res"},{"key":"2026032611344830900_cvag036-B221","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1161\/CIRCRESAHA.124.323891","article-title":"Inflammation in HIV and its impact on atherosclerotic cardiovascular disease","volume":"134","author":"Obare","year":"2024","journal-title":"Circ Res"},{"key":"2026032611344830900_cvag036-B222","volume-title":"Current Perspectives in HIV Infection","author":"Freitas","year":"2013"},{"key":"2026032611344830900_cvag036-B223","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1016\/j.atherosclerosis.2007.04.008","article-title":"HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR","volume":"195","author":"Zhou","year":"2007","journal-title":"Atherosclerosis"},{"key":"2026032611344830900_cvag036-B224","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12929-018-0490-9","article-title":"The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects","volume":"25","author":"Osuji","year":"2018","journal-title":"J Biomed Sci"},{"key":"2026032611344830900_cvag036-B225","doi-asserted-by":"crossref","first-page":"746382","DOI":"10.3389\/fcvm.2021.746382","article-title":"Left ventricular hypertrophy in diabetic cardiomyopathy: a target for intervention","volume":"8","author":"Mohan","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2026032611344830900_cvag036-B226","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.emc.2010.01.011","article-title":"Metabolic and hepatobiliary side effects of antiretroviral therapy (ART)","volume":"28","author":"Lugassy","year":"2010","journal-title":"Emerg Med Clin North Am"},{"key":"2026032611344830900_cvag036-B227","doi-asserted-by":"crossref","first-page":"103","DOI":"10.24920\/004066","article-title":"Association between lipid profiles and left ventricular hypertrophy: new evidence from a retrospective study","volume":"37","author":"Huang","year":"2022","journal-title":"Chin Med Sci J"},{"key":"2026032611344830900_cvag036-B228","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/hiv.12239","article-title":"Assessment of arterial elasticity among HIV-positive participants with high CD4 cell counts: a substudy of the INSIGHT strategic timing of AntiRetroviral treatment (START) trial","volume":"16","author":"Baker","year":"2015","journal-title":"HIV Med"},{"key":"2026032611344830900_cvag036-B229","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/ccd.28146","article-title":"Hemodynamic characterization of aortic stenosis states.","volume":"93(5)","author":"Abbas","year":"2019","journal-title":"Catheterization and Cardiovascular Interventions"},{"key":"2026032611344830900_cvag036-B230","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCULATIONAHA.111.025270","article-title":"Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness","volume":"124","author":"Falcao-Pires","year":"2011","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B231","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.3390\/ijms22126212","article-title":"Diabetes mellitus and its implications in aortic stenosis patients","volume":"22","author":"Mourino-Alvarez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026032611344830900_cvag036-B232","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12933-023-02009-w","article-title":"Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach","volume":"22","author":"Mart\u00edn-N\u00fa\u00f1ez","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"2026032611344830900_cvag036-B233","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.33963\/KP.a2021.0137","article-title":"Diabetes mellitus as a risk factor for aortic stenosis: from new mechanisms to clinical implications","volume":"79","author":"Natorska","year":"2021","journal-title":"Kardiol Pol"},{"key":"2026032611344830900_cvag036-B234","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1001\/jama.290.16.2159","article-title":"Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the epidemiology of diabetes interventions and complications (EDIC) study","volume":"290","author":"Writing Team for the Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications Research Group","year":"2003","journal-title":"JAMA"},{"key":"2026032611344830900_cvag036-B235","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10753-012-9579-6","article-title":"Inflammation is associated with the remodeling of calcific aortic valve disease","volume":"36","author":"Cot\u00e9","year":"2013","journal-title":"Inflammation"},{"key":"2026032611344830900_cvag036-B236","doi-asserted-by":"crossref","first-page":"e21382","DOI":"10.1096\/fj.202002013RR","article-title":"Tumor necrosis factor-\u03b1 promotes and exacerbates calcification in heart valve myofibroblast populations","volume":"35","author":"Gonzalez Rodriguez","year":"2021","journal-title":"FASEB J"},{"key":"2026032611344830900_cvag036-B237","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2026032611344830900_cvag036-B238","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jss.2014.03.051","article-title":"Aortic valve calcification is mediated by a differential response of aortic valve interstitial cells to inflammation","volume":"190","author":"Venardos","year":"2014","journal-title":"J Surg Res"},{"key":"2026032611344830900_cvag036-B239","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nature09421","article-title":"Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands","volume":"467","author":"West","year":"2010","journal-title":"Nature"},{"key":"2026032611344830900_cvag036-B240","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jjcc.2017.11.007","article-title":"Mechanisms of aortic stenosis","volume":"71","author":"Akahori","year":"2018","journal-title":"J Cardiol"},{"key":"2026032611344830900_cvag036-B241","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.yjmcc.2014.02.014","article-title":"P2y2 receptor represses IL-6 expression by valve interstitial cells through Akt: implication for calcific aortic valve disease","volume":"72","author":"El Husseini","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2026032611344830900_cvag036-B242","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yjmcc.2003.09.015","article-title":"Receptor activator of nuclear factor \u03baB ligand and osteoprotegerin regulate aortic valve calcification","volume":"36","author":"Kaden","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"2026032611344830900_cvag036-B243","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1590\/S0066-782X2012005000110","article-title":"Potent antiretroviral therapy for human immunodeficiency virus infection increases aortic stiffness","volume":"99","author":"Eira","year":"2012","journal-title":"Arq Bras Cardiol"},{"key":"2026032611344830900_cvag036-B244","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.diabres.2016.03.012","article-title":"Increased risk of dysglycaemia in South Africans with HIV; especially those on protease inhibitors","volume":"119","author":"Levitt","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"key":"2026032611344830900_cvag036-B245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/5491838","article-title":"Prevalence and associated risk factors of hypertension: a cross-sectional study in urban Varanasi","volume":"2017","author":"Singh","year":"2017","journal-title":"Int J Hypertens"},{"key":"2026032611344830900_cvag036-B246","volume-title":"Essential Hypertension","author":"Iqbal","year":"2023"},{"key":"2026032611344830900_cvag036-B247","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12981-023-00576-2","article-title":"Hypertension among persons living with HIV\/AIDS and its association with HIV-related health factors","volume":"21","author":"Denu","year":"2024","journal-title":"AIDS Res Ther"},{"key":"2026032611344830900_cvag036-B248","doi-asserted-by":"crossref","first-page":"959256","DOI":"10.1155\/2015\/959256","article-title":"Epidemiology of hypertension stages in two countries in sub-Sahara Africa: factors associated with hypertension stages","volume":"2015","author":"Gebreselassie","year":"2015","journal-title":"Int J Hypertens"},{"key":"2026032611344830900_cvag036-B249","doi-asserted-by":"crossref","first-page":"147","DOI":"10.11604\/pamj.2019.34.147.17518","article-title":"Prevalence and risk factors associated with hypertension among adults in a rural setting: the case of Ombe, Cameroon","volume":"34","author":"Princewel","year":"2019","journal-title":"Pan Afr Med J"},{"key":"2026032611344830900_cvag036-B250","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jash.2017.06.004","article-title":"Global prevalence of hypertension among people living with HIV: a systematic review and meta-analysis","volume":"11","author":"Xu","year":"2017","journal-title":"J Am Soc Hypertens"},{"key":"2026032611344830900_cvag036-B251","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-021-10502-8","article-title":"Trends, prevalence and factors associated with hypertension and diabetes among South African adults living with HIV, 2005\u20132017","volume":"21","author":"Chiwandire","year":"2021","journal-title":"BMC Public Health"},{"key":"2026032611344830900_cvag036-B252","doi-asserted-by":"crossref","first-page":"e0001931","DOI":"10.1371\/journal.pgph.0001931","article-title":"Regional prevalence of hypertension among people diagnosed with diabetes in Africa, a systematic review and meta-analysis","volume":"3","author":"Hinneh","year":"2023","journal-title":"PLOS Glob Public Health"},{"key":"2026032611344830900_cvag036-B253","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41440-018-0034-4","article-title":"Hypertension with diabetes mellitus: physiology and pathology","volume":"41","author":"Ohishi","year":"2018","journal-title":"Hypertens Res"},{"key":"2026032611344830900_cvag036-B254","volume-title":"Hypertension in Diabetes","author":"Naha","year":"2000"},{"key":"2026032611344830900_cvag036-B255","doi-asserted-by":"crossref","first-page":"3691349","DOI":"10.1155\/2017\/3691349","article-title":"Effects of hyperglycemia on vascular smooth muscle Ca(2+) signaling","volume":"2017","author":"El-Najjar","year":"2017","journal-title":"Biomed Res Int"},{"key":"2026032611344830900_cvag036-B256","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1001\/archinte.164.16.1737","article-title":"Diabetes mellitus, the renin-angiotensin-aldosterone system, and the heart","volume":"164","author":"Lim","year":"2004","journal-title":"Arch Intern Med"},{"key":"2026032611344830900_cvag036-B257","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11906-011-0187-x","article-title":"Cell signaling of angiotensin II on vascular tone: novel mechanisms","volume":"13","author":"Nguyen Dinh Cat","year":"2011","journal-title":"Curr Hypertens Rep"},{"key":"2026032611344830900_cvag036-B258","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol Rev"},{"key":"2026032611344830900_cvag036-B259","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/HYPERTENSIONAHA.118.10893","article-title":"Hypertension in HIV-infected adults: novel pathophysiologic mechanisms","volume":"72","author":"Fahme","year":"2018","journal-title":"Hypertension"},{"key":"2026032611344830900_cvag036-B260","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3851\/IMP1533","article-title":"HIV protease inhibitors activate the adipocyte renin angiotensin system","volume":"15","author":"Boccara","year":"2010","journal-title":"Antivir Ther"},{"key":"2026032611344830900_cvag036-B261","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MNH.0b013e3283437fcd","article-title":"Angiotensin type 2 receptor in hypertensive cardiovascular disease","volume":"20","author":"Savoia","year":"2011","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2026032611344830900_cvag036-B262","first-page":"2589","article-title":"Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective","volume":"117","author":"Murray","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2026032611344830900_cvag036-B263","doi-asserted-by":"crossref","first-page":"115325","DOI":"10.1016\/j.bcp.2022.115325","article-title":"Nitric oxide deficiency is a primary driver of hypertension","volume":"206","author":"Bryan","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"2026032611344830900_cvag036-B264","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","article-title":"Association between insulin resistance and the development of cardiovascular disease","volume":"17","author":"Ormazabal","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"2026032611344830900_cvag036-B265","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/biof.3","article-title":"Nitric oxide and vascular insulin resistance","volume":"35","author":"Wu","year":"2009","journal-title":"BioFactors"},{"key":"2026032611344830900_cvag036-B266","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/jc.2006-1819","article-title":"Insulin and endothelin: an interplay contributing to hypertension development?","volume":"92","author":"Sarafidis","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2026032611344830900_cvag036-B267","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1475-2891-7-10","article-title":"The underlying mechanisms for development of hypertension in the metabolic syndrome","volume":"7","author":"Yanai","year":"2008","journal-title":"Nutr J"},{"key":"2026032611344830900_cvag036-B268","first-page":"671","article-title":"Role of hyperinsulinemia and insulin resistance in hypertension: metabolic syndrome revisited","volume":"36","author":"da Silva","year":"2020","journal-title":"Can J Cardiol"},{"key":"2026032611344830900_cvag036-B269","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cca.2015.06.013","article-title":"Association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals","volume":"448","author":"Klafke","year":"2015","journal-title":"Clin Chim Acta"},{"key":"2026032611344830900_cvag036-B270","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/01.aids.0000222074.45372.00","article-title":"Antiretroviral medications associated with elevated blood pressure among patients receiving highly active antiretroviral therapy","volume":"20","author":"Crane","year":"2006","journal-title":"Aids"},{"key":"2026032611344830900_cvag036-B271","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/00002030-200403050-00008","article-title":"The metabolic effects of lopinavir\/ritonavir in HIV-negative men","volume":"18","author":"Lee","year":"2004","journal-title":"AIDS"},{"key":"2026032611344830900_cvag036-B272","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1016\/j.jacc.2020.09.610","article-title":"VLDL cholesterol accounts for one-half of the risk of myocardial infarction associated with apoB-containing lipoproteins","volume":"76","author":"Balling","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026032611344830900_cvag036-B273","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3410\/M3-5","article-title":"The role of blood flow in determining the sites of atherosclerotic plaques","volume":"3","author":"Warboys","year":"2011","journal-title":"F1000 Med Rep"},{"key":"2026032611344830900_cvag036-B274","volume-title":"Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach","author":"World Health Organization","year":"2021"},{"key":"2026032611344830900_cvag036-B275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11892-021-01382-8","article-title":"Diabetes in people living with HIV","volume":"21","author":"Sarkar","year":"2021","journal-title":"Curr Diab Rep"},{"key":"2026032611344830900_cvag036-B276","doi-asserted-by":"crossref","first-page":"e0250676","DOI":"10.1371\/journal.pone.0250676","article-title":"Diagnosis, risk factors and management of diabetes mellitus in HIV-infected persons in France: a real-life setting study","volume":"16","author":"Kousignian","year":"2021","journal-title":"PLoS One"},{"key":"2026032611344830900_cvag036-B277","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1758-5996-3-2","article-title":"Understanding diabetes in patients with HIV\/AIDS","volume":"3","author":"Kalra","year":"2011","journal-title":"Diabetol Metab Syndr"},{"key":"2026032611344830900_cvag036-B278","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41392-024-01931-z","article-title":"Glucagon-like peptide-1 receptor: mechanisms and advances in therapy","volume":"9","author":"Zheng","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026032611344830900_cvag036-B279","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1479164112441526","article-title":"GLP-1 receptor agonists: a clinical perspective on cardiovascular effects","volume":"9","author":"Mundil","year":"2012","journal-title":"Diab Vasc Dis Res"},{"key":"2026032611344830900_cvag036-B280","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/HYPERTENSIONAHA.119.11684","article-title":"Antihypertensive and renal mechanisms of SGLT2 (sodium-glucose linked transporter 2) inhibitors","volume":"75","author":"Wilcox","year":"2020","journal-title":"Hypertension"},{"key":"2026032611344830900_cvag036-B281","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jacbts.2020.02.004","article-title":"Mechanisms of cardiovascular benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors: a state-of-the-art review","volume":"5","author":"Lopaschuk","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"2026032611344830900_cvag036-B282","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.119.039996","article-title":"Dapagliflozin and cardiovascular outcomes in patients with type 2 diabetes mellitus and previous myocardial infarction","volume":"139","author":"Furtado","year":"2019","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B283","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1001\/jamacardio.2022.4873","article-title":"Performance of cardiovascular risk prediction models among people living with HIV: a systematic review and meta-analysis","volume":"8","author":"Soares","year":"2023","journal-title":"JAMA Cardiol"},{"key":"2026032611344830900_cvag036-B284","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1161\/CIR.0000000000000695","article-title":"Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association","volume":"140","author":"Feinstein","year":"2019","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B285","volume-title":"HIV Antiretroviral Therapy","author":"Kemnic","year":"2023"},{"key":"2026032611344830900_cvag036-B286","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1161\/CIRCULATIONAHA.106.179294","article-title":"Primary prevention of cardiovascular diseases in people with diabetes Mellitus","volume":"115","author":"Buse","year":"2007","journal-title":"Circulation"},{"key":"2026032611344830900_cvag036-B287","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1559827614538750","article-title":"Health benefits of exercise for people living with HIV: a review of the literature","volume":"10","author":"Jaggers","year":"2016","journal-title":"Am J Lifestyle Med"},{"key":"2026032611344830900_cvag036-B288","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12981-019-0226-2","article-title":"Statins and aspirin in the prevention of cardiovascular disease among HIV-positive patients between controversies and unmet needs: review of the literature and suggestions for a friendly use","volume":"16","author":"Maggi","year":"2019","journal-title":"AIDS Res Ther"},{"key":"2026032611344830900_cvag036-B289","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/COH.0000000000000752","article-title":"Statins for primary cardiovascular disease prevention among people with HIV: emergent directions","volume":"17","author":"Fitch","year":"2022","journal-title":"Curr Opin HIV AIDS"},{"key":"2026032611344830900_cvag036-B290","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/ATVBAHA.122.318020","article-title":"Aspirin for the primary prevention of cardiovascular disease: time for a platelet-guided approach","volume":"42","author":"Cofer","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvag036\/66675159\/cvag036.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/4\/446\/66675159\/cvag036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/4\/446\/66675159\/cvag036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:35:21Z","timestamp":1774539321000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/122\/4\/446\/8450138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":290,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,1,29]]},"published-print":{"date-parts":[[2026,3,26]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvag036","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,1,29]]}}}