{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:01:28Z","timestamp":1774591288888,"version":"3.50.1"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020951","name":"Fonds de Recherche du Quebec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020951","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds National de la Recherche Scientifique"},{"name":"FRS-FNRS"},{"name":"Wallonia-Brussels Federation"},{"name":"FRQ-FNRS","award":["PINT-BILAT-P 2018"],"award-info":[{"award-number":["PINT-BILAT-P 2018"]}]},{"name":"FRS-FNRS","award":["T.0009.21"],"award-info":[{"award-number":["T.0009.21"]}]},{"name":"FRS-FNRS","award":["T.0007.23"],"award-info":[{"award-number":["T.0007.23"]}]},{"name":"FRS-FNRS","award":["EQP - Tomo4D- U.N069.20"],"award-info":[{"award-number":["EQP - Tomo4D- U.N069.20"]}]},{"name":"Action de Recherche Concert\u00e9e de la Communaut\u00e9 Wallonie-Bruxelles, Belgium","award":["ARC 18\/23-094"],"award-info":[{"award-number":["ARC 18\/23-094"]}]},{"name":"Action de Recherche Concert\u00e9e de la Communaut\u00e9 Wallonie-Bruxelles, Belgium","award":["19\/24-097"],"award-info":[{"award-number":["19\/24-097"]}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["S007219N"],"award-info":[{"award-number":["S007219N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ASBL Jean Degroof-Marcel Van Massenhove funding"},{"name":"UCLouvain Foundation Saint-Luc"},{"name":"FNRS, Belgium"},{"name":"KUL","award":["C1, C14\/21\/093"],"award-info":[{"award-number":["C1, C14\/21\/093"]}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","award":["G097021N"],"award-info":[{"award-number":["G097021N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"Melbourne University","doi-asserted-by":"publisher","award":["GPUM\/21\/036"],"award-info":[{"award-number":["GPUM\/21\/036"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU-METAHEART","award":["CA22169"],"award-info":[{"award-number":["CA22169"]}]},{"DOI":"10.13039\/501100000921","name":"COST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Recent clinical studies have reported that myo-inositol is consistently elevated in plasma of patients with heart failure (HF), yet its role in cardiac dysfunction remains poorly understood. Myo-inositol is specifically transported into cells by the sodium-myo-inositol co-transporter-1 (SMIT1), a member of the sodium-glucose co-transporter (SGLT) family expressed in the heart. While myo-inositol is essential for phosphoinositide signalling, osmoregulation, and metabolic homeostasis, dysregulation of SMIT1-mediated myo-inositol transport may contribute to key pathological mechanisms in HF. This study aims to elucidate the role of SMIT1 in the failing heart, especially during left ventricular remodelling that precedes it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We used a mouse model of pressure overload induced by transverse aortic constriction in wild-type (WT) mice and mice lacking SMIT1 (Smit1\u2212\/\u2212), and primary cultured cardiomyocytes. By combining molecular, structural and functional studies, RNA-sequencing, and calcium measurements, we demonstrate the contribution of myo-inositol and SMIT1 to pathological hypertrophy and the progression towards HF. We found that in comparison to WT controls, Smit1\u2212\/\u2212 mice were protected against aortic banding induced systolic dysfunction, cardiac fibrosis and hypertrophy. This hypertrophic response was driven by SMIT1 expression in cardiomyocytes, where it favours intracellular myo-inositol and Na+ entry, leading to inositol 1,4,5-trisphosphate (IP3)- and Ca2+-dependent pro-hypertrophic signalling. Following haemodynamic stress, deletion of SMIT1 significantly altered IP3\/calcium effectors, including Carabin, which modulates cardiac hypertrophy through inhibition of the calcineurin\/nuclear factor of activated T-cell and Ras\/ERK1\/2 pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work provides important insights into the role of myo-inositol and SMIT1 in cardiomyocytes. We demonstrate that SMIT1 is a key driver of pathological hypertrophy by inducing an IP3\/Ca2+-dependent pro-hypertrophic transcriptional reprogramming in cardiomyocytes. These findings identify SMIT1 as a promising therapeutic target for preventing or treating pathological cardiac hypertrophy and HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag040","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:42:04Z","timestamp":1769776924000},"page":"578-592","source":"Crossref","is-referenced-by-count":1,"title":["Sodium-\n                    <i>myo<\/i>\n                    -inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice"],"prefix":"10.1093","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-6576","authenticated-orcid":false,"given":"Alice","family":"Marino","sequence":"first","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Cumps","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Guilbert","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9line","family":"Geiser","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Baufays","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]},{"name":"Division of Cardiology, Cliniques Universitaires Saint-Luc, Universit\u00e9 catholique de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Ginion","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fert\u00e9","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-2314","authenticated-orcid":false,"given":"Sylvain","family":"Battault","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"De Matos","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Ambroise","sequence":"additional","affiliation":[{"name":"Centre de technologies mol\u00e9culaires appliqu\u00e9es, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coert J","family":"Zuurbier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lezoualc'h","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Universit\u00e9 de Toulouse, UMR-1297 Inserm , Toulouse ,","place":["France"]},{"name":"Universit\u00e9 Toulouse, France Universit\u00e9 Toulouse III-Paul Sabatier , Toulouse ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Pestiaux","sequence":"additional","affiliation":[{"name":"Mechatronic, Electrical Energy and Dynamic Systems, Institute of Mechanics, Materials and Civil Engineering, Universit\u00e9 catholique de Louvain , Louvain-la-Neuve ,","place":["Belgium"]},{"name":"Pole of Morphology, Institute of Experimental and Clinical Research, Universit\u00e9 catholique de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Pyka","sequence":"additional","affiliation":[{"name":"Mechatronic, Electrical Energy and Dynamic Systems, Institute of Mechanics, Materials and Civil Engineering, Universit\u00e9 catholique de Louvain , Louvain-la-Neuve ,","place":["Belgium"]},{"name":"Pole of Morphology, Institute of Experimental and Clinical Research, Universit\u00e9 catholique de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-8324","authenticated-orcid":false,"given":"Greet","family":"Kerckhofs","sequence":"additional","affiliation":[{"name":"Mechatronic, Electrical Energy and Dynamic Systems, Institute of Mechanics, Materials and Civil Engineering, Universit\u00e9 catholique de Louvain , Louvain-la-Neuve ,","place":["Belgium"]},{"name":"Pole of Morphology, Institute of Experimental and Clinical Research, Universit\u00e9 catholique de Louvain , Brussels ,","place":["Belgium"]},{"name":"Department of Materials Engineering, KU Leuven , Heverlee ,","place":["Belgium"]},{"name":"Prometheus, Division for Skeletal Tissue Engineering, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Llewelyn","family":"Roderick","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-7099","authenticated-orcid":false,"given":"Luc","family":"Bertrand","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-2075","authenticated-orcid":false,"given":"Sandrine","family":"Horman","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Beauloye","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche Cardiovasculaire, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain , Av. Hippocrate 55, Brussels 1200 ,","place":["Belgium"]},{"name":"Division of Cardiology, Cliniques Universitaires Saint-Luc, Universit\u00e9 catholique de Louvain , Brussels ,","place":["Belgium"]},{"name":"Division of Cardiovascular Intensive Care, Cliniques Universitaires Saint-Luc, Universit\u00e9 catholique de Louvain , Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"2026032612481625400_cvag040-B1","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"2026032612481625400_cvag040-B2","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.jacc.2019.01.056","article-title":"Empagliflozin ameliorates adverse left ventricular remodeling in nondiabetic heart failure by enhancing myocardial energetics","volume":"73","author":"Santos-Gallego","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026032612481625400_cvag040-B3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijcard.2017.05.032","article-title":"Sodium-dependent glucose transporters (SGLT) in human ischemic heart: a new potential pharmacological target","volume":"243","author":"Di Franco","year":"2017","journal-title":"Int J Cardiol"},{"key":"2026032612481625400_cvag040-B4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/CIRCULATIONAHA.122.061688","article-title":"Sodium glucose cotransporter-2 inhibitor empagliflozin reduces infarct size independently of sodium glucose cotransporter-2","volume":"147","author":"Chen","year":"2023","journal-title":"Circulation"},{"key":"2026032612481625400_cvag040-B5","doi-asserted-by":"crossref","first-page":"41166","DOI":"10.1038\/srep41166","article-title":"Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart","volume":"7","author":"Van Steenbergen","year":"2017","journal-title":"Sci Rep"},{"key":"2026032612481625400_cvag040-B6","doi-asserted-by":"crossref","first-page":"H838","DOI":"10.1152\/ajpheart.00736.2019","article-title":"New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans","volume":"320","author":"Fert\u00e9","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026032612481625400_cvag040-B7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00234656","article-title":"Kinetics and specificity of the renal Na+\/myo-inositol cotransporter expressed in Xenopus oocytes","volume":"143","author":"Hager","year":"1995","journal-title":"J Membr Biol"},{"key":"2026032612481625400_cvag040-B8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.mam.2012.11.002","article-title":"Glucose transport families SLC5 and SLC50","volume":"34","author":"Wright","year":"2013","journal-title":"Mol Aspects Med"},{"key":"2026032612481625400_cvag040-B9","doi-asserted-by":"crossref","first-page":"936486","DOI":"10.1155\/2012\/936486","article-title":"Reactive oxygen species in health and disease","volume":"2012","author":"Alfadda","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"2026032612481625400_cvag040-B10","doi-asserted-by":"crossref","first-page":"105264","DOI":"10.1016\/j.ebiom.2024.105264","article-title":"Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research project","volume":"107","author":"Pouleur","year":"2024","journal-title":"EBioMedicine"},{"key":"2026032612481625400_cvag040-B11","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1161\/ATVBAHA.123.320547","article-title":"SMIT1 expression in arterial tissue: a potential new trigger of vascular dysfunctions and ROS production in rats","volume":"44","author":"Grandperrin","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026032612481625400_cvag040-B12","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1161\/ATVBAHA.120.315096","article-title":"SMIT (Sodium-myo-inositol transporter) 1 regulates arterial contractility through the modulation of vascular Kv7 channels","volume":"40","author":"Barrese","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026032612481625400_cvag040-B13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3390\/biom10040521","article-title":"Myo-inositol transporter SLC5A3 associates with degenerative changes and inflammation in sporadic inclusion body myositis","volume":"10","author":"De Paepe","year":"2020","journal-title":"Biomolecules"},{"key":"2026032612481625400_cvag040-B14","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-020-2496-1","article-title":"A single-cell transcriptomic atlas characterizes ageing tissues in the mouse","volume":"583","author":"Tabula Muris Consortium","year":"2020","journal-title":"Nature"},{"key":"2026032612481625400_cvag040-B15","doi-asserted-by":"crossref","first-page":"E3290","DOI":"10.1073\/pnas.1606348113","article-title":"Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels","volume":"113","author":"Dai","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026032612481625400_cvag040-B16","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.biochi.2013.05.011","article-title":"Potential role and therapeutic interests of myo-inositol in metabolic diseases","volume":"95","author":"Croze","year":"2013","journal-title":"Biochimie"},{"key":"2026032612481625400_cvag040-B17","doi-asserted-by":"crossref","first-page":"100921","DOI":"10.1016\/j.jbior.2022.100921","article-title":"Regulations of myo-inositol homeostasis: mechanisms, implications, and perspectives","volume":"87","author":"Su","year":"2023","journal-title":"Adv Biol Regul"},{"key":"2026032612481625400_cvag040-B18","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3389\/fneur.2018.00846","article-title":"Induction of osmolyte pathways in skeletal muscle inflammation: novel biomarkers for myositis","volume":"9","author":"De Paepe","year":"2018","journal-title":"Front Neurol"},{"key":"2026032612481625400_cvag040-B19","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2337\/db16-0880","article-title":"Identification and functional implications of sodium\/Myo-inositol cotransporter 1 in pancreatic \u03b2-cells and type 2 diabetes","volume":"66","author":"Li","year":"2017","journal-title":"Diabetes"},{"key":"2026032612481625400_cvag040-B20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.20452\/pamw.2780","article-title":"The rs9982601 polymorphism of the region between the SLC5A3\/MRPS6 and KCNE2 genes associated with a prevalence of myocardial infarction and subsequent long-term mortality","volume":"125","author":"Szpakowicz","year":"2015","journal-title":"Pol Arch Med Wewn"},{"key":"2026032612481625400_cvag040-B21","doi-asserted-by":"crossref","first-page":"1096916","DOI":"10.1155\/2017\/1096916","article-title":"Functional analysis of the coronary heart disease risk locus on chromosome 21q22","volume":"2017","author":"Beaney","year":"2017","journal-title":"Dis Markers"},{"key":"2026032612481625400_cvag040-B22","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/cvr\/cvad147","article-title":"Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the COnsortium of METabolomics Studies","volume":"119","author":"Nogal","year":"2023","journal-title":"Cardiovasc Res"},{"key":"2026032612481625400_cvag040-B23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12967-015-0661-3","article-title":"Metabolomic approach to profile functional and metabolic changes in heart failure","volume":"13","author":"Deidda","year":"2015","journal-title":"J Transl Med"},{"key":"2026032612481625400_cvag040-B24","doi-asserted-by":"crossref","first-page":"a035428","DOI":"10.1101\/cshperspect.a035428","article-title":"Calcium signaling in cardiomyocyte function","volume":"12","author":"Gilbert","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026032612481625400_cvag040-B25","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bpj.2020.08.001","article-title":"Ca(2+) release via IP(3) receptors shapes the cardiac Ca(2+) transient for hypertrophic signaling","volume":"119","author":"Hunt","year":"2020","journal-title":"Biophys J"},{"key":"2026032612481625400_cvag040-B26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCRESAHA.110.220038","article-title":"The IP3 receptor regulates cardiac hypertrophy in response to select stimuli","volume":"107","author":"Nakayama","year":"2010","journal-title":"Circ Res"},{"key":"2026032612481625400_cvag040-B27","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1529\/biophysj.107.110031","article-title":"Modeling hypertrophic IP3 transients in the cardiac myocyte","volume":"93","author":"Cooling","year":"2007","journal-title":"Biophys J"},{"key":"2026032612481625400_cvag040-B28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/CIRCULATIONAHA.114.010686","article-title":"Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+\/calmodulin-dependent protein kinase II signaling","volume":"131","author":"Bisserier","year":"2015","journal-title":"Circulation"},{"key":"2026032612481625400_cvag040-B29","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.yjmcc.2011.01.012","article-title":"CaMKII in myocardial hypertrophy and heart failure","volume":"51","author":"Anderson","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"2026032612481625400_cvag040-B30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1161\/CIRCRESAHA.109.194035","article-title":"CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes","volume":"105","author":"MacDonnell","year":"2009","journal-title":"Circ Res"},{"key":"2026032612481625400_cvag040-B31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000197782.21444.8f","article-title":"Control of cardiac growth by histone acetylation\/deacetylation","volume":"98","author":"Backs","year":"2006","journal-title":"Circ Res"},{"key":"2026032612481625400_cvag040-B32","doi-asserted-by":"crossref","first-page":"18297","DOI":"10.1074\/jbc.M213176200","article-title":"Loss of murine Na+\/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea","volume":"278","author":"Berry","year":"2003","journal-title":"J Biol Chem"},{"key":"2026032612481625400_cvag040-B33","doi-asserted-by":"crossref","first-page":"eaay2176","DOI":"10.1126\/scitranslmed.aay2176","article-title":"Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide","volume":"12","author":"Montiel","year":"2020","journal-title":"Sci Transl Med"},{"key":"2026032612481625400_cvag040-B34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41467-017-02795-4","article-title":"AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation","volume":"9","author":"G\u00e9linas","year":"2018","journal-title":"Nat Commun"},{"key":"2026032612481625400_cvag040-B35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.molcel.2009.02.005","article-title":"Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes","volume":"33","author":"Higazi","year":"2009","journal-title":"Mol Cell"},{"key":"2026032612481625400_cvag040-B36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00395-022-00967-y","article-title":"Insp(3)R-RyR Ca(2+) channel crosstalk facilitates arrhythmias in the failing human ventricle","volume":"117","author":"Jin","year":"2022","journal-title":"Basic Res Cardiol"},{"key":"2026032612481625400_cvag040-B37","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1038\/s41467-020-18160-x","article-title":"Intracellular sodium elevation reprograms cardiac metabolism","volume":"11","author":"Aksentijevi\u0107","year":"2020","journal-title":"Nat Commun"},{"key":"2026032612481625400_cvag040-B38","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1113\/jphysiol.2014.282319","article-title":"Na+\/Ca2+ exchange and Na+\/K+-ATPase in the heart","volume":"593","author":"Shattock","year":"2015","journal-title":"J Physiol"},{"key":"2026032612481625400_cvag040-B39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1042\/bj2360037","article-title":"myo-Inositol 1,4,5-trisphosphate mobilizes Ca2+ from isolated adipocyte endoplasmic reticulum but not from plasma membranes","volume":"236","author":"Delfert","year":"1986","journal-title":"Biochem J"},{"key":"2026032612481625400_cvag040-B40","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/01.RES.0000119923.64774.72","article-title":"Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans","volume":"94","author":"D\u00edaz","year":"2004","journal-title":"Circ Res"},{"key":"2026032612481625400_cvag040-B41","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation-contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"2026032612481625400_cvag040-B42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/cvr\/cvr013","article-title":"Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content","volume":"90","author":"Stokke","year":"2011","journal-title":"Cardiovasc Res"},{"key":"2026032612481625400_cvag040-B43","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N Engl J Med"},{"key":"2026032612481625400_cvag040-B44","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/emmm.201201595","article-title":"Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity","volume":"4","author":"Schickel","year":"2012","journal-title":"EMBO Mol Med"},{"key":"2026032612481625400_cvag040-B45","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature05476","article-title":"Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin","volume":"445","author":"Pan","year":"2007","journal-title":"Nature"},{"key":"2026032612481625400_cvag040-B46","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1182\/blood-2017-07-794875","article-title":"Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin","volume":"131","author":"Jiang","year":"2018","journal-title":"Blood"},{"key":"2026032612481625400_cvag040-B47","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.1161\/01.RES.87.12.e61","article-title":"Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles","volume":"87","author":"Yang","year":"2000","journal-title":"Circ Res"},{"key":"2026032612481625400_cvag040-B48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.tcm.2003.08.002","article-title":"Electrical remodeling in cardiac hypertrophy","volume":"13","author":"Hill","year":"2003","journal-title":"Trends Cardiovasc Med"},{"key":"2026032612481625400_cvag040-B49","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1158\/2159-8290.CD-20-1849","article-title":"SLC5A3-Dependent Myo-inositol auxotrophy in acute myeloid leukemia","volume":"12","author":"Wei","year":"2022","journal-title":"Cancer Discov"},{"key":"2026032612481625400_cvag040-B50","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41419-022-05017-y","article-title":"The sodium\/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth","volume":"13","author":"Cui","year":"2022","journal-title":"Cell Death Dis"},{"key":"2026032612481625400_cvag040-B51","doi-asserted-by":"crossref","first-page":"11406","DOI":"10.1073\/pnas.0905485106","article-title":"Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy","volume":"106","author":"Harzheim","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026032612481625400_cvag040-B52","doi-asserted-by":"crossref","first-page":"e002183","DOI":"10.1161\/JAHA.115.002183","article-title":"Intracellular Na+ concentration ([Na+]i) is elevated in diabetic hearts due to enhanced Na+-glucose cotransport","volume":"4","author":"Lambert","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2026032612481625400_cvag040-B53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yjmcc.2013.05.010","article-title":"Intracellular Na+ and cardiac metabolism","volume":"61","author":"Bay","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"2026032612481625400_cvag040-B54","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1161\/CIRCRESAHA.118.310082","article-title":"Calcium signaling and reactive oxygen Species in mitochondria","volume":"122","author":"Bertero","year":"2018","journal-title":"Circ Res"},{"key":"2026032612481625400_cvag040-B55","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/ijms18071362","article-title":"Ankyrin repeat domain 1 protein: a functionally pleiotropic protein with cardiac biomarker potential","volume":"18","author":"Ling","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2026032612481625400_cvag040-B56","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/cvr\/cvz291","article-title":"Myocardial overexpression of ANKRD1 causes sinus venosus defects and progressive diastolic dysfunction","volume":"116","author":"Piroddi","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2026032612481625400_cvag040-B57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/cvr\/cvv108","article-title":"Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy","volume":"106","author":"Zhong","year":"2015","journal-title":"Cardiovasc Res"},{"key":"2026032612481625400_cvag040-B58","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/cvr\/cvaa063","article-title":"Advancing our understanding of AnkRD1 in cardiac development and disease","volume":"116","author":"Murphy","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2026032612481625400_cvag040-B59","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1038\/s41467-022-34048-4","article-title":"Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues","volume":"13","author":"Maes","year":"2022","journal-title":"Nat Commun"},{"key":"2026032612481625400_cvag040-B60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12933-022-01480-1","article-title":"Direct cardiac effects of SGLT2 inhibitors","volume":"21","author":"Chen","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"2026032612481625400_cvag040-B61","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1463-1326.2011.01397.x","article-title":"Effect of a high-fat meal on the pharmacokinetics of dapagliflozin, a selective SGLT2 inhibitor, in healthy subjects","volume":"13","author":"Kasichayanula","year":"2011","journal-title":"Diabetes Obes Metab"},{"key":"2026032612481625400_cvag040-B62","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1124\/jpet.112.191593","article-title":"Tofogliflozin, a potent and highly specific sodium\/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice","volume":"341","author":"Suzuki","year":"2012","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvag040\/66945438\/cvag040.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/5\/578\/66945438\/cvag040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/5\/578\/66945438\/cvag040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:48:36Z","timestamp":1774543716000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/122\/5\/578\/8487915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":62,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,2,17]]},"published-print":{"date-parts":[[2026,3,26]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvag040","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,2,17]]}}}