{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T18:07:53Z","timestamp":1779473273255,"version":"3.53.1"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070248"],"award-info":[{"award-number":["82070248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300282"],"award-info":[{"award-number":["82300282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300476"],"award-info":[{"award-number":["82300476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Program for Professor of Special Appointment"},{"name":"Shanghai Institutions of Higher Learning","award":["0900000024"],"award-info":[{"award-number":["0900000024"]}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Program","doi-asserted-by":"publisher","award":["23J11900600"],"award-info":[{"award-number":["23J11900600"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure (HF) remains a highly prevalent condition with current therapeutic options, 5-year survival remains at 50%. Diseased cardiomyocytes have been demonstrated to exhibit telomeric shortening and through DNA damage response (DDR) activation leads to mitochondria dysfunction. How the orchestration between nuclear and mitochondrial transcription systems regulates myocardial function remains elusive. The aim of this study is to test if myocardial telomere re-protection can restore nuclear-mitochondrial balance and offer a strategy for treating HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>To re-protect telomeric ends, we designed an adeno-associated virus 9 (AAV9)-mediated delivery system carrying modified human telomerase protein (modhTERTY707F, D868A, JV101) under cardiac troponin T promoter regulation. The modhTERT is engineered to be catalytic inactive, nuclear localized, and bind to telomeric ends to turn off DDR. Telomeric repeat amplification protocol and quantitative fluorescence in situ hybridization assays were used to demonstrate loss of enzymatic function and localization of JV101. Using TPP1-knock out (TPP1KO) U2OS (telomerase-deficient) and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) lines generated by CRISPR\/Cas9 genome editing, we demonstrated that JV101 is recruited by TPP1 through TEL patch to telomeric ends. JV101 restored cardiac function in both Ang II infusion and myocardial ischaemia-reperfusion HF models and in Ang II-stressed hiPSC-CMs. RNA-Seq data suggests that uncapped telomeres activated p53 and using myocardial p53 deficient (p53cKO) mice we demonstrate that telomere-p53-mitochondrial dysfunction is the main signalling pathway driving HF. Molecularly, JV101 treatment silenced p53, rescued both mitochondrial biogenesis as well as prevented mitochondrial DNA N6-methyladenine (m6A) methylation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our work establishes the role of telomere-mitochondria DNA signalling during HF progression and provides proof-of-concept of telomere-targeting gene therapy to restore cardiac function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag077","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:52:47Z","timestamp":1775217167000},"page":"935-952","source":"Crossref","is-referenced-by-count":0,"title":["Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure"],"prefix":"10.1093","volume":"122","author":[{"given":"Yinlong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingying","family":"Yu","sequence":"additional","affiliation":[{"name":"Juvensis Therapeutics , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C H","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[{"name":"Juvensis Therapeutics , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Juvensis Therapeutics , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Juvensis Therapeutics , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Stanford University , Palo Alto, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euan A","family":"Ashley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Stanford University , Palo Alto, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lei","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3955-6554","authenticated-orcid":false,"given":"Jianyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 94309 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Heart Failure, Heart Center, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200120 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-4033","authenticated-orcid":false,"given":"Alex C Y","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Shanghai Institute of Precision Medicine, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"2026052213525585100_cvag077-B1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jacc.2013.11.053","article-title":"The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries","volume":"63","author":"Ambrosy","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2026052213525585100_cvag077-B2","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/eurjpc\/zwaa147","article-title":"Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017","volume":"28","author":"Bragazzi","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"2026052213525585100_cvag077-B3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ehf2.12005","article-title":"Heart failure: preventing disease and death worldwide","volume":"1","author":"Ponikowski","year":"2014","journal-title":"ESC Heart Fail"},{"key":"2026052213525585100_cvag077-B4","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/ejhf.1629","article-title":"Prevalence of heart failure and left ventricular dysfunction in China: the China hypertension survey, 2012-2015","volume":"21","author":"Hao","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2026052213525585100_cvag077-B5","doi-asserted-by":"crossref","first-page":"e008406","DOI":"10.1161\/CIRCHEARTFAILURE.121.008406","article-title":"Prevalence and incidence of heart failure among urban patients in China: a national population-based analysis","volume":"14","author":"Wang","year":"2021","journal-title":"Circ Heart Fail"},{"key":"2026052213525585100_cvag077-B6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1471-2407-10-105","article-title":"Long-term survival of cancer patients compared to heart failure and stroke: a systematic review","volume":"10","author":"Askoxylakis","year":"2010","journal-title":"BMC cancer"},{"key":"2026052213525585100_cvag077-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchf.2012.10.002","article-title":"Heart failure","volume":"1","author":"Braunwald","year":"2013","journal-title":"JACC Heart Fail"},{"key":"2026052213525585100_cvag077-B8","first-page":"e484","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"138","author":"Whelton","year":"2018","journal-title":"Circulation"},{"key":"2026052213525585100_cvag077-B9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41580-021-00328-y","article-title":"Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization","volume":"22","author":"Lim","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026052213525585100_cvag077-B10","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","article-title":"Dynamics of cell generation and turnover in the human heart","volume":"161","author":"Bergmann","year":"2015","journal-title":"Cell"},{"key":"2026052213525585100_cvag077-B11","first-page":"H2183","article-title":"Cardiomyocyte DNA synthesis and binucleation during murine development","volume":"271","author":"Soonpaa","year":"1996","journal-title":"Am J Physiol"},{"key":"2026052213525585100_cvag077-B12","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.cell.2015.10.035","article-title":"No evidence for cardiomyocyte number expansion in preadolescent mice","volume":"163","author":"Alkass","year":"2015","journal-title":"Cell"},{"key":"2026052213525585100_cvag077-B13","doi-asserted-by":"crossref","first-page":"13120","DOI":"10.1073\/pnas.1615340113","article-title":"Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy","volume":"113","author":"Chang","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026052213525585100_cvag077-B14","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1073\/pnas.0836098100","article-title":"Telomere attrition and Chk2 activation in human heart failure","volume":"100","author":"Oh","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026052213525585100_cvag077-B15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0531-5565(01)00218-2","article-title":"Telomere lengths are characteristic in each human individual","volume":"37","author":"Takubo","year":"2002","journal-title":"Exp Gerontol"},{"key":"2026052213525585100_cvag077-B16","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1038\/srep02401","article-title":"Association of telomere shortening in myocardium with heart weight gain and cause of death","volume":"3","author":"Terai","year":"2013","journal-title":"Sci Rep"},{"key":"2026052213525585100_cvag077-B17","doi-asserted-by":"crossref","first-page":"e005086","DOI":"10.1161\/JAHA.116.005086","article-title":"Cardiomyocyte-specific telomere shortening is a distinct signature of heart failure in humans","volume":"6","author":"Sharifi-Sanjani","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2026052213525585100_cvag077-B18","doi-asserted-by":"crossref","first-page":"9276","DOI":"10.1073\/pnas.1714538115","article-title":"Telomere shortening is a hallmark of genetic cardiomyopathies","volume":"115","author":"Chang","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026052213525585100_cvag077-B19","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1073\/pnas.1902452116","article-title":"Telomere shortening rate predicts species life span","volume":"116","author":"Whittemore","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026052213525585100_cvag077-B20","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1093\/nar\/gkae274","article-title":"Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence","volume":"52","author":"Li","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026052213525585100_cvag077-B21","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ncb2790","article-title":"Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy","volume":"15","author":"Mourkioti","year":"2013","journal-title":"Nat Cell Biol"},{"key":"2026052213525585100_cvag077-B22","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI90338","article-title":"Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency","volume":"127","author":"Theodoris","year":"2017","journal-title":"J Clin Invest"},{"key":"2026052213525585100_cvag077-B23","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nsmb.3451","article-title":"TRF2 binds branched DNA to safeguard telomere integrity","volume":"24","author":"Schmutz","year":"2017","journal-title":"Nat Struct Mol Biol"},{"key":"2026052213525585100_cvag077-B24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-018-0324-7","article-title":"53BP1-RIF1-shieldin counteracts DSB resection through CST- and Pol\u03b1-dependent fill-in","volume":"560","author":"Mirman","year":"2018","journal-title":"Nature"},{"key":"2026052213525585100_cvag077-B25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41594-022-00790-y","article-title":"Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening","volume":"29","author":"Barnes","year":"2022","journal-title":"Nat Struct Mol Biol"},{"key":"2026052213525585100_cvag077-B26","doi-asserted-by":"crossref","first-page":"e13782","DOI":"10.1111\/acel.13782","article-title":"Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy","volume":"22","author":"Henpita","year":"2023","journal-title":"Aging Cell"},{"key":"2026052213525585100_cvag077-B27","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.molcel.2024.02.028","article-title":"A kinetic dichotomy between mitochondrial and nuclear gene expression processes","volume":"84","author":"McShane","year":"2024","journal-title":"Mol Cell"},{"key":"2026052213525585100_cvag077-B28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/CIRCRESAHA.124.323800","article-title":"Mitochondrial structure and function in human heart failure","volume":"135","author":"Hinton","year":"2024","journal-title":"Circ Res"},{"key":"2026052213525585100_cvag077-B29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/CIRCULATIONAHA.104.524835","article-title":"Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction","volume":"112","author":"Ikeuchi","year":"2005","journal-title":"Circulation"},{"key":"2026052213525585100_cvag077-B30","doi-asserted-by":"crossref","first-page":"C929","DOI":"10.1152\/ajpcell.00508.2020","article-title":"Mitochondrial functional resilience after TFAM ablation in the adult heart","volume":"320","author":"Ghazal","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026052213525585100_cvag077-B31","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1161\/CIRCULATIONAHA.123.068358","article-title":"Rectifying METTL4-mediated N(6)-methyladenine excess in mitochondrial DNA alleviates heart failure","volume":"150","author":"Zhang","year":"2024","journal-title":"Circulation"},{"key":"2026052213525585100_cvag077-B32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.molcel.2020.02.018","article-title":"N(6)-deoxyadenosine methylation in mammalian mitochondrial DNA","volume":"78","author":"Hao","year":"2020","journal-title":"Mol Cell"},{"key":"2026052213525585100_cvag077-B33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09787","article-title":"Telomere dysfunction induces metabolic and mitochondrial compromise","volume":"470","author":"Sahin","year":"2011","journal-title":"Nature"},{"key":"2026052213525585100_cvag077-B34","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.stemcr.2021.04.018","article-title":"Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes","volume":"16","author":"Chang","year":"2021","journal-title":"Stem Cell Reports"},{"key":"2026052213525585100_cvag077-B35","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat Methods"},{"key":"2026052213525585100_cvag077-B36","doi-asserted-by":"crossref","first-page":"17034","DOI":"10.1038\/celldisc.2017.34","article-title":"Systematic analysis of human telomeric dysfunction using inducible telosome\/shelterin CRISPR\/Cas9 knockout cells","volume":"3","author":"Kim","year":"2017","journal-title":"Cell Discov"},{"key":"2026052213525585100_cvag077-B37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41556-022-00888-x","article-title":"Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells","volume":"24","author":"Fort","year":"2022","journal-title":"Nat Cell Biol"},{"key":"2026052213525585100_cvag077-B38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1126\/science.aah6752","article-title":"TZAP: a telomere-associated protein involved in telomere length control","volume":"355","author":"Li","year":"2017","journal-title":"Science"},{"key":"2026052213525585100_cvag077-B39","doi-asserted-by":"crossref","first-page":"e024582","DOI":"10.1161\/JAHA.121.024582","article-title":"p53-dependent mitochondrial compensation in heart failure with preserved ejection fraction","volume":"11","author":"Chen","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2026052213525585100_cvag077-B40","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1093\/eurheartj\/ehab503","article-title":"3\u2019 untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein","volume":"42","author":"Zhao","year":"2021","journal-title":"Eur Heart J"},{"key":"2026052213525585100_cvag077-B41","doi-asserted-by":"crossref","first-page":"e2206007","DOI":"10.1002\/advs.202206007","article-title":"The imbalance of p53-park7 signaling axis induces iron homeostasis dysfunction in doxorubicin-challenged cardiomyocytes","volume":"10","author":"Pan","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2026052213525585100_cvag077-B42","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1213\/ANE.0000000000003757","article-title":"An in vitro model for identifying cardiac Side effects of anesthetics","volume":"130","author":"Chang","year":"2020","journal-title":"Anesth Analg"},{"key":"2026052213525585100_cvag077-B43","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.ymthe.2023.02.016","article-title":"Delivery of mitochondria confers cardioprotection through mitochondria replenishment and metabolic compliance","volume":"31","author":"Zhang","year":"2023","journal-title":"Mol Ther"},{"key":"2026052213525585100_cvag077-B44","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-021-03415-4","article-title":"Structure of human telomerase holoenzyme with bound telomeric DNA","volume":"593","author":"Ghanim","year":"2021","journal-title":"Nature"},{"key":"2026052213525585100_cvag077-B45","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41422-021-00586-7","article-title":"Zipper head mechanism of telomere synthesis by human telomerase","volume":"31","author":"Wan","year":"2021","journal-title":"Cell Res"},{"key":"2026052213525585100_cvag077-B46","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1161\/01.RES.0000121104.05977.F3","article-title":"Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells","volume":"94","author":"Haendeler","year":"2004","journal-title":"Circ Res"},{"key":"2026052213525585100_cvag077-B47","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1161\/HYPERTENSIONAHA.121.18935","article-title":"Telomere shortening in hypertensive heart disease Depends on oxidative DNA damage and predicts impaired recovery of cardiac function in heart failure","volume":"79","author":"Brandt","year":"2022","journal-title":"Hypertension"},{"key":"2026052213525585100_cvag077-B48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature11648","article-title":"The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity","volume":"492","author":"Nandakumar","year":"2012","journal-title":"Nature"},{"key":"2026052213525585100_cvag077-B49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/gt.2010.105","article-title":"Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution","volume":"18","author":"Prasad","year":"2011","journal-title":"Gene Ther"},{"key":"2026052213525585100_cvag077-B50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jgm.1576","article-title":"A single direct injection into the left ventricular wall of an adeno-associated virus 9 (AAV9) vector expressing extracellular superoxide dismutase from the cardiac troponin-T promoter protects mice against myocardial infarction","volume":"13","author":"Prasad","year":"2011","journal-title":"J Gene Med"},{"key":"2026052213525585100_cvag077-B51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/emboj\/cdg013","article-title":"Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation","volume":"22","author":"Leri","year":"2003","journal-title":"EMBO J"},{"key":"2026052213525585100_cvag077-B52","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1038\/s41467-018-06639-7","article-title":"Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure","volume":"9","author":"Nomura","year":"2018","journal-title":"Nat Commun"},{"key":"2026052213525585100_cvag077-B53","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-022-04582-8","article-title":"Structure of active human telomerase with telomere shelterin protein TPP1","volume":"604","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"2026052213525585100_cvag077-B54","doi-asserted-by":"crossref","first-page":"10308","DOI":"10.1073\/pnas.191169098","article-title":"Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival","volume":"98","author":"Oh","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026052213525585100_cvag077-B55","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1038\/ncomms6863","article-title":"Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction","volume":"5","author":"Bar","year":"2014","journal-title":"Nat Commun"},{"key":"2026052213525585100_cvag077-B56","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.ymthe.2020.12.035","article-title":"Telomerase therapy attenuates cardiotoxic effects of doxorubicin","volume":"29","author":"Chatterjee","year":"2021","journal-title":"Mol Ther"},{"key":"2026052213525585100_cvag077-B57","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/CIRCULATIONAHA.120.051923","article-title":"Mitochondrial telomerase reverse transcriptase protects from myocardial ischemia\/reperfusion injury by improving Complex I composition and function","volume":"144","author":"Ale-Agha","year":"2021","journal-title":"Circulation"},{"key":"2026052213525585100_cvag077-B58","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1093\/nar\/gkp750","article-title":"Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53","volume":"37","author":"Wong","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2026052213525585100_cvag077-B59","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/CIRCRESAHA.109.205310","article-title":"P53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content","volume":"105","author":"Park","year":"2009","journal-title":"Circ Res"},{"key":"2026052213525585100_cvag077-B60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/415045a","article-title":"P53 mutant mice that display early ageing-associated phenotypes","volume":"415","author":"Tyner","year":"2002","journal-title":"Nature"},{"key":"2026052213525585100_cvag077-B61","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1101\/gad.1661708","article-title":"Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart","volume":"22","author":"Lai","year":"2008","journal-title":"Genes Dev"},{"key":"2026052213525585100_cvag077-B62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","article-title":"Premature ageing in mice expressing defective mitochondrial DNA polymerase","volume":"429","author":"Trifunovic","year":"2004","journal-title":"Nature"},{"key":"2026052213525585100_cvag077-B63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2008.06.016","article-title":"A mitochondrial protein compendium elucidates complex I disease biology","volume":"134","author":"Pagliarini","year":"2008","journal-title":"Cell"},{"key":"2026052213525585100_cvag077-B64","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1161\/CIRCULATIONAHA.120.047239","article-title":"Epigenetic reader BRD4 (bromodomain-containing protein 4) governs nucleus-encoded mitochondrial transcriptome to regulate cardiac function","volume":"142","author":"Kim","year":"2020","journal-title":"Circulation"},{"key":"2026052213525585100_cvag077-B65","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.stem.2024.09.008","article-title":"Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance","volume":"31","author":"Han","year":"2024","journal-title":"Cell Stem Cell"},{"key":"2026052213525585100_cvag077-B66","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41467-023-37291-5","article-title":"A defect in mitochondrial protein translation influences mitonuclear communication in the heart","volume":"14","author":"Gao","year":"2023","journal-title":"Nat Commun"},{"key":"2026052213525585100_cvag077-B67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2023.05.001","article-title":"Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function","volume":"260","author":"Wu","year":"2023","journal-title":"Transl Res"},{"key":"2026052213525585100_cvag077-B68","doi-asserted-by":"crossref","first-page":"e2203995","DOI":"10.1002\/advs.202203995","article-title":"Geometric constraints regulate energy metabolism and cellular contractility in vascular smooth muscle cells by coordinating mitochondrial DNA methylation","volume":"9","author":"Liu","year":"2022","journal-title":"Adv Sci"},{"key":"2026052213525585100_cvag077-B69","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41569-021-00566-9","article-title":"Towards precision medicine in heart failure","volume":"18","author":"Weldy","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2026052213525585100_cvag077-B70","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrg.2016.86","article-title":"Towards precision medicine","volume":"17","author":"Ashley","year":"2016","journal-title":"Nat Rev Genet"},{"key":"2026052213525585100_cvag077-B71","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0140-6736(16)00082-9","article-title":"Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial","volume":"387","author":"Greenberg","year":"2016","journal-title":"Lancet"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvag077\/67866015\/cvag077.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/7\/935\/67866015\/cvag077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/7\/935\/67866015\/cvag077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T17:53:08Z","timestamp":1779472388000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/122\/7\/935\/8606867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":71,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4,6]]},"published-print":{"date-parts":[[2026,5,22]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvag077","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,4]]}}}