{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:23:15Z","timestamp":1792585395925,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01 HL144477"],"award-info":[{"award-number":["R01 HL144477"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["HL165725"],"award-info":[{"award-number":["HL165725"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tufts Springboard Tier 1 Grant","award":["HL162200"],"award-info":[{"award-number":["HL162200"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["R01 HL159089"],"award-info":[{"award-number":["R01 HL159089"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["R01 HL133215"],"award-info":[{"award-number":["R01 HL133215"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["HL159907"],"award-info":[{"award-number":["HL159907"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["HL175911"],"award-info":[{"award-number":["HL175911"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["1187744"],"award-info":[{"award-number":["1187744"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["R01 HL163172"],"award-info":[{"award-number":["R01 HL163172"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["HL149891"],"award-info":[{"award-number":["HL149891"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["HL105993"],"award-info":[{"award-number":["HL105993"]}]},{"name":"Tufts Springboard Tier 1 Grant","award":["R01 HL089847"],"award-info":[{"award-number":["R01 HL089847"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Walter Benjamin programme","award":["539486371"],"award-info":[{"award-number":["539486371"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Doxorubicin (DR), a widely prescribed chemotherapy, has an unfortunate side effect of cardiotoxicity resulting from DNA damage and cardiac cell death. Cardiac atrophy, fibrosis and a cytotoxic CD8+ T-cell response, alongside increased cardiac and circulating interferon-inducible chemokines are hallmarks for DR cardiotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We discovered that the activation of the stimulator of interferon genes (STING) in several distinct cardiac cell compartments is central to CD8+ T-cell cardiotropism and DR cardiotoxicity. DR activates STING in cardiac fibroblasts, endothelial cells (ECs), and myeloid cells in vivo and in vitro. Myeloid STING is required for CD8+ T-cell activation and cardiotropism, whereas EC-STING mediates CD8+ T-cell cardiotropism towards CXCL9\/10 and transendothelial migration. In contrast, cardiac fibroblast STING is dispensable for the cardiac CD8+ T-cell immune response but drives fibroblast transformation. We report CXCR3+ T cells and CXCL9\/CXCL10 are more abundant in the hearts of DR cardiotoxicity patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our work positions STING as a cell-specific driver of CD8+ T-cell cardiac inflammation and fibroblast activation in DR cardiotoxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag098","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:44:54Z","timestamp":1780573494000},"page":"1224-1242","source":"Crossref","is-referenced-by-count":3,"title":["STING promotes CD8 T-cell cardiotropism and fibrosis from distinct cellular compartments in doxorubicin cardiomyopathy"],"prefix":"10.1093","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-6354","authenticated-orcid":false,"given":"Abraham 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