{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:06:23Z","timestamp":1790273183310,"version":"4.1.0"},"reference-count":153,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NWO-ZonMW"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy along with (micro)vascular abnormalities. These include cardiac and peripheral vascular dysfunction, as well as structural vascular changes. This review summarizes the modalities for assessing (micro)vascular function and explores how vascular changes relate to disease progression, including structural remodelling, fibrosis, and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A systematic search of multiple databases was conducted to identify studies investigating vascular changes in patients with HCM, varying in disease severity. Human studies were included without time restrictions and studies involving hypertrophy secondary to other conditions (e.g. hypertension, aortic stenosis) were excluded.<\/jats:p>\n                    <jats:p>A total of 130 studies were included. Vascular changes were assessed with Positron Emission Tomography (n = 24), Cardiac Magnetic Resonance Imaging (n = 21), angiography (n = 18), scintigraphy and Single Photon Emission Computed Tomography (n = 30), peripheral measures (n = 12), and histology (n = 29). Perfusion abnormalities were common in HCM. While resting myocardial blood flow appears to be similar between HCM patients and controls, myocardial perfusion reserve is consistently reduced, correlating with early disease features, structural remodelling, and adverse outcomes. Peripheral vascular dysfunction is also frequently observed, though findings vary and mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vascular abnormalities play a key role in the pathophysiology of HCM and are closely linked to disease progression and prognosis. Data are limited regarding the role of vascular dysfunction in genotype-positive\/phenotype-negative individuals and individuals with early or mild disease. Future research should focus on evaluating cardiac and peripheral vascular function across the disease spectrum to better understand underlying mechanisms and potential targets for intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag153","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:36:16Z","timestamp":1784028976000},"page":"1865-1879","source":"Crossref","is-referenced-by-count":0,"title":["Vascular changes in hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3549-2194","authenticated-orcid":false,"given":"Julia E","family":"Visch","sequence":"first","affiliation":[{"name":"Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Location VUmc, O2 Science building, De Boelelaan 1108, 1081 HZ, Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Location VUmc, O2 Science building, De Boelelaan 1108, 1081 HZ, Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Burchell","sequence":"additional","affiliation":[{"name":"Medical Library, Vrije Universiteit Amsterdam , De Boelelaan 1105, 1081 HV Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2781-0145","authenticated-orcid":false,"given":"Tjeerd","family":"Germans","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Location VUmc, O2 Science building, De Boelelaan 1108, 1081 HZ, Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Noordwest Ziekenhuisgroep , Wilhelminalaan 12, 1815 JD, Alkmaar ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-5788","authenticated-orcid":false,"given":"Jolanda","family":"van der Velden","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Location VUmc, O2 Science building, De Boelelaan 1108, 1081 HZ, Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam ,","place":["The Netherlands"]},{"name":"Netherlands Heart Institute , Moreelsepark 1, 3511 EP, Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026092413242843100_cvag153-B1","doi-asserted-by":"crossref","first-page":"S388","DOI":"10.21037\/cdt.2019.02.01","article-title":"Hypertrophic cardiomyopathy: genetics and clinical perspectives","volume":"9","author":"Wolf","year":"2019","journal-title":"Cardiovasc Diagn Ther"},{"key":"2026092413242843100_cvag153-B2","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/cvr\/cvaa124","article-title":"Abnormalities in sodium current and calcium homoeostasis as drivers of arrhythmogenesis in hypertrophic cardiomyopathy","volume":"116","author":"Coppini","year":"2020","journal-title":"Cardiovasc Res"},{"key":"2026092413242843100_cvag153-B3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232427","article-title":"Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy","volume":"15","author":"Nijenkamp","year":"2020","journal-title":"PLoS One"},{"key":"2026092413242843100_cvag153-B4","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10040575","article-title":"Small vessel disease: another component of the hypertrophic cardiomyopathy phenotype not necessarily associated with fibrosis","volume":"10","author":"De Gaspari","year":"2021","journal-title":"J Clin Med"},{"key":"2026092413242843100_cvag153-B5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijcard.2019.03.060","article-title":"Histopathological comparison of intramural coronary artery remodeling and myocardial fibrosis in obstructive versus end-stage hypertrophic cardiomyopathy","volume":"291","author":"Fo\u00e0","year":"2019","journal-title":"Int J Cardiol"},{"key":"2026092413242843100_cvag153-B6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020227","article-title":"Myocardial perfusion defects in hypertrophic cardiomyopathy mutation carriers","volume":"10","author":"Hughes","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026092413242843100_cvag153-B7","article-title":"Proteomics of hypertrophic cardiomyopathy (HCM) extracellular vesicles elucidates detrimental effects of in vitro HCM cardiomyocyte secretome on endothelial cells and cardiomyocytes","volume":"15","author":"Hilderink","year":"2026","journal-title":"J Mol Cell Cardiol Plus"},{"key":"2026092413242843100_cvag153-B8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.amjcard.2009.08.658","article-title":"Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy","volume":"105","author":"Heffernan","year":"2010","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B9","first-page":"183","article-title":"Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome","volume":"1","author":"Hadi","year":"2005","journal-title":"Vasc Health Risk Manag"},{"key":"2026092413242843100_cvag153-B10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jamacardio.2019.4268","article-title":"Association of obesity with adverse long-term outcomes in hypertrophic cardiomyopathy","volume":"5","author":"Fumagalli","year":"2020","journal-title":"JAMA Cardiol"},{"key":"2026092413242843100_cvag153-B11","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018641","article-title":"Unraveling the genotype\u2013phenotype relationship in hypertrophic cardiomyopathy: obesity-related cardiac defects as a major disease modifier","volume":"9","author":"Nollet","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2026092413242843100_cvag153-B12","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.jtcvs.2021.04.001","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"162","author":"Writing Committee Members","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026092413242843100_cvag153-B13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s42256-020-00287-7","article-title":"An open source machine learning framework for efficient and transparent systematic reviews","volume":"3","author":"van de Schoot","year":"2021","journal-title":"Nat Mach Intell"},{"key":"2026092413242843100_cvag153-B14","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.ejrad.2015.04.028","article-title":"Hypertrophic cardiomyopathy: cardiac structural and microvascular abnormalities as evaluated with multi-parametric MRI","volume":"84","author":"Zhang","year":"2015","journal-title":"Eur J Radiol"},{"key":"2026092413242843100_cvag153-B15","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1161\/CIRCULATIONAHA.106.657023","article-title":"Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging","volume":"115","author":"Petersen","year":"2007","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B16","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/ehjci\/jeu137","article-title":"Young patients with hypertrophic cardiomyopathy, but not subjects at risk, show decreased myocardial perfusion reserve quantified with CMR","volume":"15","author":"Gyllenhammar","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026092413242843100_cvag153-B17","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1007\/s00246-015-1214-5","article-title":"Regional stress-induced ischemia in non-fibrotic hypertrophied myocardium in young HCM patients","volume":"36","author":"Jablonowski","year":"2015","journal-title":"Pediatr Cardiol"},{"key":"2026092413242843100_cvag153-B18","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cardfail.2011.01.006","article-title":"Myocardial blood flow and fibrosis in hypertrophic cardiomyopathy","volume":"17","author":"Aquaro","year":"2011","journal-title":"J Card Fail"},{"key":"2026092413242843100_cvag153-B19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12968-014-0049-1","article-title":"Coronary microvascular ischemia in hypertrophic cardiomyopathy\u2014a pixel-wise quantitative cardiovascular magnetic resonance perfusion study","volume":"16","author":"Ismail","year":"2014","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026092413242843100_cvag153-B20","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jacc.2012.12.024","article-title":"Blunted myocardial oxygenation response during vasodilator stress in patients with hypertrophic cardiomyopathy","volume":"61","author":"Karamitsos","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B21","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/ehjci\/jey220","article-title":"Assessment of myocardial oxygenation, strain, and diastology in MYBPC3-related hypertrophic cardiomyopathy: a cardiovascular magnetic resonance and echocardiography study","volume":"20","author":"Grover","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026092413242843100_cvag153-B22","doi-asserted-by":"crossref","first-page":"e41974","DOI":"10.1371\/journal.pone.0041974","article-title":"In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness","volume":"7","author":"Hueper","year":"2012","journal-title":"PLoS One"},{"key":"2026092413242843100_cvag153-B23","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s10554-017-1189-9","article-title":"3.0 T magnetic resonance myocardial perfusion imaging for semi-quantitative evaluation of coronary microvascular dysfunction in hypertrophic cardiomyopathy","volume":"33","author":"Yin","year":"2017","journal-title":"Int J Cardiovasc Imaging"},{"key":"2026092413242843100_cvag153-B24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.crad.2013.01.003","article-title":"Assessment of coronary microvascular dysfunction in hypertrophic cardiomyopathy: first-pass myocardial perfusion cardiovascular magnetic resonance imaging at 1.5 T","volume":"68","author":"Huang","year":"2013","journal-title":"Clin Radiol"},{"key":"2026092413242843100_cvag153-B25","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijcard.2007.06.023","article-title":"Cardiovascular magnetic resonance signs of ischemia in hypertrophic cardiomyopathy","volume":"128","author":"Melacini","year":"2008","journal-title":"Int J Cardiol"},{"key":"2026092413242843100_cvag153-B26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1590\/S0066-782X2009001000017","article-title":"Late enhancement and myocardial perfusion in hypertrophic cardiomyopathy (comparison between groups)","volume":"93","author":"Barbosa","year":"2009","journal-title":"Arq Bras Cardiol"},{"key":"2026092413242843100_cvag153-B27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ejrad.2014.01.008","article-title":"The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy patients with or without left ventricular outflow tract obstruction: assessment with first-pass perfusion imaging using 3.0-T cardiac magnetic resonance","volume":"83","author":"Xu","year":"2014","journal-title":"Eur J Radiol"},{"key":"2026092413242843100_cvag153-B28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1536\/ihj.20-479","article-title":"Prediction of serious adverse events of patients with hypertrophic cardiomyopathy by magnetic resonance","volume":"62","author":"Komuro","year":"2021","journal-title":"Int Heart J"},{"key":"2026092413242843100_cvag153-B29","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.2337\/dc22-0083","article-title":"Coexistent diabetes is associated with the presence of adverse phenotypic features in patients with hypertrophic cardiomyopathy","volume":"45","author":"Jex","year":"2022","journal-title":"Diabetes Care"},{"key":"2026092413242843100_cvag153-B30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00004728-200605000-00011","article-title":"Magnetic resonance imaging of delayed enhancement in hypertrophic cardiomyopathy: relationship with left ventricular perfusion and contractile function","volume":"30","author":"Soler","year":"2006","journal-title":"J Comput Assist Tomogr"},{"key":"2026092413242843100_cvag153-B31","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/eurheartj\/ehv120","article-title":"Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction","volume":"36","author":"Dass","year":"2015","journal-title":"Eur Heart J"},{"key":"2026092413242843100_cvag153-B32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00380-017-1088-y","article-title":"Myocardial perfusion reserve quantified by cardiac magnetic resonance imaging is associated with late gadolinium enhancement in hypertrophic cardiomyopathy","volume":"33","author":"Tezuka","year":"2018","journal-title":"Heart Vessels"},{"key":"2026092413242843100_cvag153-B33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/ehjci\/jeab210","article-title":"Phenotyping hypertrophic cardiomyopathy using cardiac diffusion magnetic resonance imaging: the relationship between microvascular dysfunction and microstructural changes","volume":"23","author":"Das","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026092413242843100_cvag153-B34","first-page":"A1","article-title":"Microstructural & microvascular phenotype of hypertrophic cardiomyopathy\u2014from mutation to hypertrophy; a multicentre collaborative study of 192-subjects","volume":"109","author":"Joy","year":"2023","journal-title":"Heart"},{"key":"2026092413242843100_cvag153-B35","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.2967\/jnumed.107.050138","article-title":"Spatial relationship between coronary microvascular dysfunction and delayed contrast enhancement in patients with hypertrophic cardiomyopathy","volume":"49","author":"Sotgia","year":"2008","journal-title":"J Nucl Med"},{"key":"2026092413242843100_cvag153-B36","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMoa025050","article-title":"Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy","volume":"349","author":"Cecchi","year":"2003","journal-title":"N Engl J Med"},{"key":"2026092413242843100_cvag153-B37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/oxfordjournals.eurheartj.a015090","article-title":"Coronary vasodilator reserve in primary and secondary left ventricular hypertrophy. A study with positron emission tomography","volume":"18","author":"Choudhury","year":"1997","journal-title":"Eur Heart J"},{"key":"2026092413242843100_cvag153-B38","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1136\/hrt.2006.110460","article-title":"Assessment of intravascular and extravascular mechanisms of myocardial perfusion abnormalities in obstructive hypertrophic cardiomyopathy by myocardial contrast echocardiography","volume":"93","author":"Soliman","year":"2007","journal-title":"Heart"},{"key":"2026092413242843100_cvag153-B39","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s00259-015-3101-y","article-title":"Validation of pixel-wise parametric mapping of myocardial blood flow with 13NH3 PET in patients with hypertrophic cardiomyopathy","volume":"42","author":"Sciagr\u00e0","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2026092413242843100_cvag153-B40","doi-asserted-by":"crossref","first-page":"H986","DOI":"10.1152\/ajpheart.00233.2007","article-title":"Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy","volume":"294","author":"Knaapen","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026092413242843100_cvag153-B41","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/eurjhf\/hfr135","article-title":"Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction","volume":"13","author":"Timmer","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026092413242843100_cvag153-B42","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jacc.2011.05.018","article-title":"Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations","volume":"58","author":"Olivotto","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B43","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.nuclcard.2006.05.018","article-title":"Regional heterogeneity of resting perfusion in hypertrophic cardiomyopathy is related to delayed contrast enhancement but not to systolic function: a PET and MRI study","volume":"13","author":"Knaapen","year":"2006","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B44","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1007\/s12350-022-02911-y","article-title":"Evaluation of stress myocardial blood flow patterns in patients with apical hypertrophic cardiomyopathy","volume":"29","author":"Calabretta","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B45","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s12350-018-01521-x","article-title":"Higher incidence of vasodilator-induced left ventricular cavity dilation by PET when compared to treadmill exercise-ECHO in hypertrophic cardiomyopathy","volume":"27","author":"Lu","year":"2020","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nuclcard.2006.12.329","article-title":"Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study","volume":"14","author":"Tuunanen","year":"2007","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0002-9149(93)90160-E","article-title":"Regional systolic function, myocardial blood flow and glucose uptake at rest in hypertrophic cardiomyopathy","volume":"72","author":"Perrone-Filardi","year":"1993","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B48","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0002-9149(97)00778-9","article-title":"Comparison of coronary vasodilator reserve in elite rowing athletes versus hypertrophic cardiomyopathy","volume":"80","author":"Radvan","year":"1997","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B49","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12350-008-9005-5","article-title":"Relationship between atrial fibrillation and blunted hyperemic myocardial blood flow in patients with hypertrophic cardiomyopathy","volume":"16","author":"Sciagr\u00e0","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B50","first-page":"923","article-title":"Delayed contrast enhancement and perfusable tissue index in hypertrophic cardiomyopathy: comparison between cardiac MRI and PET","volume":"46","author":"Knaapen","year":"2005","journal-title":"J Nucl Med"},{"key":"2026092413242843100_cvag153-B51","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0002-8703(98)70152-8","article-title":"Coronary vasodilator reserve is impaired in patients with hypertrophic cardiomyopathy and left ventricular dysfunction","volume":"136","author":"Lorenzoni","year":"1998","journal-title":"Am Heart J"},{"key":"2026092413242843100_cvag153-B52","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1093\/oxfordjournals.eurheartj.a015204","article-title":"Syncope and ventricular arrhythmias in hypertrophic cardiomyopathy are not related to the derangement of coronary microvascular function","volume":"18","author":"Lorenzoni","year":"1997","journal-title":"Eur Heart J"},{"key":"2026092413242843100_cvag153-B53","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jacc.2005.10.050","article-title":"Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy","volume":"47","author":"Olivotto","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B54","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.amjcard.2018.01.022","article-title":"Stress myocardial blood flow heterogeneity is a positron emission tomography biomarker of ventricular arrhythmias in patients with hypertrophic cardiomyopathy","volume":"121","author":"Lu","year":"2018","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B55","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1007\/s00259-016-3465-7","article-title":"Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal","volume":"43","author":"Castagnoli","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2026092413242843100_cvag153-B56","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0735-1097(22)01231-1","article-title":"Systolic blood pressure \u2264110 mmHg is associated with higher risk for ventricular arrhythmias in hypertrophic cardiomyopathy","volume":"79","author":"Lu","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B57","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtcvs.2003.11.003","article-title":"Regional myocardial ischemia in hypertrophic cardiomyopathy: impact of myectomy","volume":"128","author":"J\u00f6rg-Ciopor","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026092413242843100_cvag153-B58","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9149(94)90404-9","article-title":"Effect of verapamil on absolute myocardial blood flow in hypertrophic cardiomyopathy","volume":"74","author":"Gistri","year":"1994","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B59","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/01.CIR.96.3.834","article-title":"Changes in phasic coronary blood flow velocity profile and relative coronary flow reserve in patients with hypertrophic obstructive cardiomyopathy","volume":"96","author":"Kyriakidis","year":"1997","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B60","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1291\/hypres.25.711","article-title":"Difference in coronary blood flow dynamics between patients with hypertension and those with hypertrophic cardiomyopathy","volume":"25","author":"Misawa","year":"2002","journal-title":"Hypertens Res"},{"key":"2026092413242843100_cvag153-B61","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1253\/circj.66.30","article-title":"Coronary endothelium-dependent and independent vasomotor responses in patients with hypertrophic cardiomyopathy","volume":"66","author":"Yokohama","year":"2002","journal-title":"Circ J"},{"key":"2026092413242843100_cvag153-B62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0894-7317(14)80413-6","article-title":"Phasic coronary flow characteristics in patients with hypertrophic cardiomyopathy: a study by coronary Doppler catheter","volume":"7","author":"Akasaka","year":"1994","journal-title":"J Am Soc Echocardiogr"},{"key":"2026092413242843100_cvag153-B63","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-2004-821165","article-title":"Determination of the coronary flow reserve of the LAD in patients with HOCM using the intracoronary Doppler catheter","volume":"52","author":"Litmathe","year":"2004","journal-title":"Thorac Cardiovasc Surg"},{"key":"2026092413242843100_cvag153-B64","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1253\/jcj.63.350","article-title":"Abnormal coronary flow profiles at rest and during rapid atrial pacing in patients with hypertrophic cardiomyopathy","volume":"63","author":"Kawamura","year":"1999","journal-title":"Jpn Circ J"},{"key":"2026092413242843100_cvag153-B65","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/01.CIR.97.14.1342","article-title":"Effects of cardiac versus circulatory angiotensin-converting enzyme inhibition on left ventricular diastolic function and coronary blood flow in hypertrophic obstructive cardiomyopathy","volume":"97","author":"Kyriakidis","year":"1998","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B66","first-page":"6","article-title":"Effects of intravenous disopyramide on coronary hemodynamics and vasodilator reserve in hypertrophic obstructive cardiomyopathy","volume":"87","author":"Hongo","year":"1996","journal-title":"Cardiology"},{"key":"2026092413242843100_cvag153-B67","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1253\/circj.71.1263","article-title":"Impact of delta-sarcoglycan gene polymorphism on the occurrence of coronary spastic angina in Japanese patients with hypertrophic cardiomyopathy","volume":"71","author":"Honda","year":"2007","journal-title":"Circ J"},{"key":"2026092413242843100_cvag153-B68","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00109-005-0641-9","article-title":"Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) in patients with coexistent hypertrophic cardiomyopathy and coronary spastic angina","volume":"83","author":"Ogimoto","year":"2005","journal-title":"J MolMed (Berl)"},{"key":"2026092413242843100_cvag153-B69","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/0002-9149(90)90327-W","article-title":"Decreased coronary vasodilatory capacity in hypertrophic cardiomyopathy determined by split-dose thallium-dipyridamole myocardial scintigraphy","volume":"65","author":"Koga","year":"1990","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B70","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0735-1097(03)00854-4","article-title":"Myocardial bridging in adult patients with hypertrophic cardiomyopathy","volume":"42","author":"Sorajja","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0002-8703(99)70466-7","article-title":"Abnormal course, abnormal flow, and systolic compression of the septal perforator associated with impaired myocardial perfusion in hypertrophic cardiomyopathy","volume":"137","author":"Hirasaki","year":"1999","journal-title":"Am Heart J"},{"key":"2026092413242843100_cvag153-B72","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/01.CIR.79.4.836","article-title":"Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy","volume":"79","author":"Brush","year":"1989","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B73","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1161\/01.CIR.71.2.234","article-title":"Myocardial ischemia in patients with hypertrophic cardiomyopathy: contribution of inadequate vasodilator reserve and elevated left ventricular filling pressures","volume":"71","author":"Cannon","year":"1985","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0735-1097(87)80159-6","article-title":"Differences in coronary flow and myocardial metabolism at rest and during pacing between patients with obstructive and patients with nonobstructive hypertrophic cardiomyopathy","volume":"10","author":"Cannon","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B75","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.amjcard.2004.05.046","article-title":"Coronary hemodynamics in patients with symptomatic hypertrophic cardiomyopathy","volume":"94","author":"Yang","year":"2004","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B76","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0167-5273(86)90267-6","article-title":"Systolic compression of coronary artery in hypertrophic cardiomyopathy","volume":"12","author":"Navarro-Lopez","year":"1986","journal-title":"Int J Cardiol"},{"key":"2026092413242843100_cvag153-B77","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/0002-9149(89)90428-1","article-title":"Significance of positive or negative thallium-201 scintigraphy in hypertrophic cardiomyopathy","volume":"64","author":"von Dohlen","year":"1989","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B78","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.CIR.85.3.1039","article-title":"Impact of surgical relief of outflow obstruction on thallium perfusion abnormalities in hypertrophic cardiomyopathy","volume":"85","author":"Cannon","year":"1992","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B79","first-page":"1717","article-title":"Relationship between exercise-induced myocardial ischemia and reduced left ventricular distensibility in patients with nonobstructive hypertrophic cardiomyopathy","volume":"44","author":"Isobe","year":"2003","journal-title":"J Nucl Med"},{"key":"2026092413242843100_cvag153-B80","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1161\/01.CIR.83.5.1660","article-title":"Myocardial metabolic, hemodynamic, and electrocardiographic significance of reversible thallium-201 abnormalities in hypertrophic cardiomyopathy","volume":"83","author":"Cannon","year":"1991","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B81","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1136\/hrt.44.6.650","article-title":"Assessment of chest pain in hypertrophic cardiomyopathy using exercise thallium-201 myocardial scintigraphy","volume":"44","author":"Pitcher","year":"1980","journal-title":"Br Heart J"},{"key":"2026092413242843100_cvag153-B82","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/ehjci\/jes285","article-title":"Diagnostic performance of ultrasonic tissue characterization for subendocardial ischaemia in patients with hypertrophic cardiomyopathy","volume":"14","author":"Kawasaki","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026092413242843100_cvag153-B83","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jjcc.2008.04.004","article-title":"No reflow-like pattern in intramyocardial coronary artery suggests myocardial ischemia in patients with hypertrophic cardiomyopathy","volume":"52","author":"Kim","year":"2008","journal-title":"J Cardiol"},{"key":"2026092413242843100_cvag153-B84","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1253\/circj.72.953","article-title":"Septal Q wave as a marker of septal ischemia in hypertrophic cardiomyopathy","volume":"72","author":"Akakabe","year":"2008","journal-title":"Circ J"},{"key":"2026092413242843100_cvag153-B85","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1542-474X.2000.tb00247.x","article-title":"Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy","volume":"5","author":"Yamanari","year":"2000","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2026092413242843100_cvag153-B86","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/ehf2.13218","article-title":"Predicting the clinical course in hypertrophic cardiomyopathy using thallium-201 myocardial scintigraphy","volume":"8","author":"Hamada","year":"2021","journal-title":"ESC Heart Fail"},{"key":"2026092413242843100_cvag153-B87","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/01.CIR.76.6.1214","article-title":"Myocardial perfusion abnormalities in patients with hypertrophic cardiomyopathy: assessment with thallium-201 emission computed tomography","volume":"76","author":"O'Gara","year":"1987","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B88","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF02767047","article-title":"Effect of regional myocardial perfusion abnormalities on regional myocardial early diastolic function in patients with hypertrophic cardiomyopathy","volume":"12","author":"Yamanari","year":"1997","journal-title":"Heart Vessels"},{"key":"2026092413242843100_cvag153-B89","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1053\/euhj.1997.0769","article-title":"Dipyridamole stress thallium-201 perfusion abnormalities in patients with hypertrophic cardiomyopathy. Relationship to clinical presentation and outcome","volume":"19","author":"Yamada","year":"1998","journal-title":"Eur Heart J"},{"key":"2026092413242843100_cvag153-B90","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1253\/circj.71.256","article-title":"Gated single-photon emission computed tomography detects subendocardial ischemia in hypertrophic cardiomyopathy","volume":"71","author":"Kawasaki","year":"2007","journal-title":"Circ J"},{"key":"2026092413242843100_cvag153-B91","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/BF03006666","article-title":"Comparison of myocardial fatty acid metabolism with left ventricular function and perfusion in cardiomyopathies: by 123I-BMIPP SPECT and 99mTc-tetrofosmin electrocardiographically gated SPECT","volume":"17","author":"Zhao","year":"2003","journal-title":"Ann Nucl Med"},{"key":"2026092413242843100_cvag153-B92","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF03164915","article-title":"Reverse redistribution of Tc-99m-tetrofosmin in exercise myocardial SPECT in patients with hypertrophic cardiomyopathy","volume":"12","author":"Sugihara","year":"1998","journal-title":"Ann Nucl Med"},{"key":"2026092413242843100_cvag153-B93","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12350-008-9045-x","article-title":"Myocardial perfusion SPECT in the diagnosis of apical hypertrophic cardiomyopathy","volume":"16","author":"Cianciulli","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B94","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/00006231-199311000-00012","article-title":"Discrepancies between myocardial perfusion and free fatty acid metabolism in patients with hypertrophic cardiomyopathy","volume":"14","author":"Shimonagata","year":"1993","journal-title":"Nucl Med Commun"},{"key":"2026092413242843100_cvag153-B95","first-page":"E81","article-title":"Myocardial impairment detected by late gadolinium enhancement in hypertrophic cardiomyopathy: comparison with 99mTc-MIBI\/tetrofosmin and 123I-BMIPP SPECT","volume":"59","author":"Hashimura","year":"2013","journal-title":"Kobe J Med Sci"},{"key":"2026092413242843100_cvag153-B96","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.nuclcard.2004.05.008","article-title":"Do myocardial perfusion SPECT and radionuclide angiography studies in adult patients with hypertrophic cardiomyopathy have prognostic implications?","volume":"11","author":"Romero-Farina","year":"2004","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B97","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MNM.0000000000000109","article-title":"Evaluation of left ventricular myocardial perfusion and function using gated SPECT in patients with hypertrophic obstruction cardiomyopathy following percutaneous transluminal septal myocardial ablation","volume":"35","author":"Zhang","year":"2014","journal-title":"Nucl Med Commun"},{"key":"2026092413242843100_cvag153-B98","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1161\/01.CIR.79.5.1052","article-title":"Verapamil prevents silent myocardial perfusion abnormalities during exercise in asymptomatic patients with hypertrophic cardiomyopathy","volume":"79","author":"Udelson","year":"1989","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B99","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00380-017-1104-2","article-title":"Correlation of left ventricular dyssynchrony on gated myocardial perfusion SPECT analysis with extent of late gadolinium enhancement on cardiac magnetic resonance imaging in hypertrophic cardiomyopathy","volume":"33","author":"Yuki","year":"2018","journal-title":"Heart Vessels"},{"key":"2026092413242843100_cvag153-B100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1253\/jcj.62.167","article-title":"Myocardial metabolic abnormalities in hypertrophic cardiomyopathy assessed by iodine-123-labeled beta-methyl-branched fatty acid myocardial scintigraphy and its relation to exercise-induced ischemia","volume":"62","author":"Matsuo","year":"1998","journal-title":"Jpn Circ J"},{"key":"2026092413242843100_cvag153-B101","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/clc.4960190510","article-title":"Relationship between regional abnormality of left ventricular rapid filling and coronary microcirculation disturbance in hypertrophic cardiomyopathy","volume":"19","author":"Kakoi","year":"1996","journal-title":"Clin Cardiol"},{"key":"2026092413242843100_cvag153-B102","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0002-8703(93)91002-V","article-title":"31P MR spectroscopy in hypertrophic cardiomyopathy: comparison with Tl-201 myocardial perfusion imaging","volume":"125","author":"Sakuma","year":"1993","journal-title":"Am Heart J"},{"key":"2026092413242843100_cvag153-B103","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1253\/jcj.62.903","article-title":"Impaired peripheral vasoconstriction in response to alpha-adrenergic stimulation in patients with idiopathic hypertrophic cardiomyopathy","volume":"62","author":"Kawano","year":"1998","journal-title":"Jpn Circ J"},{"key":"2026092413242843100_cvag153-B104","first-page":"4532","article-title":"Modeling cardiac hemodynamic response during exercise in health and hypertrophic cardiomyopathy","volume":"2018","author":"Farro","year":"2018","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"2026092413242843100_cvag153-B105","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9149(02)02354-8","article-title":"Comparison of hemodynamic adaptation to orthostatic stress in patients with hypertrophic cardiomyopathy with or without syncope and in vasovagal syncope","volume":"89","author":"Manganelli","year":"2002","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B106","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1136\/hrt.2008.141507","article-title":"Episodic syncope in hypertrophic cardiomyopathy: evidence for inappropriate vasodilation","volume":"94","author":"Prasad","year":"2008","journal-title":"Heart"},{"key":"2026092413242843100_cvag153-B107","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0735-1097(98)00102-8","article-title":"Reduced cardiopulmonary baroreflex sensitivity in patients with hypertrophic cardiomyopathy","volume":"31","author":"Thomson","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B108","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jacc.2005.05.053","article-title":"Reversal of inappropriate peripheral vascular responses in hypertrophic cardiomyopathy","volume":"46","author":"Thaman","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B109","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/clc.4960260206","article-title":"Hemodynamic changes and prognosis in patients with hypertrophic cardiomyopathy and abnormal blood pressure responses during exercise","volume":"26","author":"Nagata","year":"2003","journal-title":"Clin Cardiol"},{"key":"2026092413242843100_cvag153-B110","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/ajh.2011.66","article-title":"Impaired endothelium independent vasodilation in nonobstructive hypertrophic cardiomyopathy","volume":"24","author":"Bartolomucci","year":"2011","journal-title":"Am J Hypertens"},{"key":"2026092413242843100_cvag153-B111","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1067\/mnc.2003.9","article-title":"Hemodynamic effects of isometric exercise in hypertrophic cardiomyopathy: comparison with normal subjects","volume":"10","author":"Ciampi","year":"2003","journal-title":"J Nucl Cardiol"},{"key":"2026092413242843100_cvag153-B112","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/000331979905000401","article-title":"Impaired response of the forearm resistance but not conductance vessels to reactive hyperemia in hypertrophic cardiomyopathy","volume":"50","author":"Dimitrow","year":"1999","journal-title":"Angiology"},{"key":"2026092413242843100_cvag153-B113","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF02059911","article-title":"Limited maximal vasodilator capacity of forearm resistance vessels in patients with hypertrophic cardiomyopathy","volume":"5","author":"Imaizumi","year":"1990","journal-title":"Heart Vessels"},{"key":"2026092413242843100_cvag153-B114","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.amjcard.2011.03.083","article-title":"Comparison of prevalence, clinical course, and pathological findings of left ventricular systolic impairment versus normal systolic function in patients with hypertrophic cardiomyopathy","volume":"108","author":"Fern\u00e1ndez","year":"2011","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B115","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0735-1097(86)80181-4","article-title":"Intramural (\u201csmall vessel\u201d) coronary artery disease in hypertrophic cardiomyopathy","volume":"8","author":"Maron","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B116","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/01.CIR.75.6.1130","article-title":"Quantitative analysis of narrowings of intramyocardial small arteries in normal hearts, hypertensive hearts, and hearts with hypertrophic cardiomyopathy","volume":"75","author":"Tanaka","year":"1987","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B117","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0046-8177(84)80328-7","article-title":"Idiopathic cardiomyopathy: the pathologic roles of arteriolopathy","volume":"15","author":"Matsubara","year":"1984","journal-title":"Hum Pathol"},{"key":"2026092413242843100_cvag153-B118","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0002-9149(98)00020-4","article-title":"Comparison of clinical and morphologic cardiac findings in patients having cardiac transplantation for ischemic cardiomyopathy, idiopathic dilated cardiomyopathy, and dilated hypertrophic cardiomyopathy","volume":"81","author":"Waller","year":"1998","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B119","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/MD.0000000000000038","article-title":"Morphologic features of the recipient heart in patients having cardiac transplantation and analysis of the congruence or incongruence between the clinical and morphologic diagnoses","volume":"93","author":"Roberts","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"2026092413242843100_cvag153-B120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/B:BEBM.0000046948.97099.ce","article-title":"Pathomorphology and pathogenic role of myocardial bridges in sudden cardiac death","volume":"138","author":"Rozenberg","year":"2004","journal-title":"Bull Exp Biol Med"},{"key":"2026092413242843100_cvag153-B121","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/eurheartj\/ehp121","article-title":"Myocardial bridging, a frequent component of the hypertrophic cardiomyopathy phenotype, lacks systematic association with sudden cardiac death","volume":"30","author":"Basso","year":"2009","journal-title":"Eur Heart J"},{"key":"2026092413242843100_cvag153-B122","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1053\/hupa.2000.16659","article-title":"Hypertrophic cardiomyopathy and sudden death in the young: pathologic evidence of myocardial ischemia","volume":"31","author":"Basso","year":"2000","journal-title":"Hum Pathol"},{"key":"2026092413242843100_cvag153-B123","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0002-9149(01)01640-X","article-title":"Relation between myocyte disarray and outcome in hypertrophic cardiomyopathy","volume":"88","author":"Varnava","year":"2001","journal-title":"Am J Cardiol"},{"key":"2026092413242843100_cvag153-B124","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jcmg.2012.09.018","article-title":"Myocardial fibrosis in hypertrophic cardiomyopathy: accurate reflection of histopathological findings by CMR","volume":"6(5)","author":"Moravsky","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026092413242843100_cvag153-B125","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.athoracsur.2020.05.156","article-title":"Matrix metalloproteinases increase because of hypoperfusion in obstructive hypertrophic cardiomyopathy","volume":"111","author":"Bi","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"2026092413242843100_cvag153-B126","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/545219","article-title":"Hyaluronan and collagen in human hypertrophic cardiomyopathy: a morphological analysis","volume":"2012","author":"Hellstr\u00f6m","year":"2012","journal-title":"Cardiol Res Pract"},{"key":"2026092413242843100_cvag153-B127","first-page":"1145","article-title":"Routine histopathology of septal myectomy for hypertrophic obstructive cardiomyopathy in a Greek cohort","volume":"36","author":"Ioakeimidis","year":"2021","journal-title":"Histol Histopathol"},{"key":"2026092413242843100_cvag153-B128","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1054-8807(03)00036-X","article-title":"Surgical pathology of subaortic septal myectomy associated with hypertrophic cardiomyopathy. A study of 204 cases (1996\u20132000)","volume":"12","author":"Lamke","year":"2003","journal-title":"Cardiovasc Pathol"},{"key":"2026092413242843100_cvag153-B129","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/eci.12544","article-title":"Left ventricular outflow tract gradient is associated with reduced capillary density in hypertrophic cardiomyopathy irrespective of genotype","volume":"45","author":"G\u00fc\u00e7l\u00fc","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"2026092413242843100_cvag153-B130","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000493005","article-title":"Microvascular rarefaction and myocardial fibrosis in hypertrophic obstructive cardiomyopathy","volume":"141","author":"Tian","year":"2018","journal-title":"Cardiology"},{"key":"2026092413242843100_cvag153-B131","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ijcard.2007.04.003","article-title":"Myocardial capillary supply is limited in hypertrophic cardiomyopathy: a morphological analysis","volume":"126","author":"Johansson","year":"2008","journal-title":"Int J Cardiol"},{"key":"2026092413242843100_cvag153-B132","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ahj.2013.06.011","article-title":"Association between septal strain rate and histopathology in symptomatic hypertrophic cardiomyopathy patients undergoing septal myectomy","volume":"166","author":"Kobayashi","year":"2013","journal-title":"Am Heart J"},{"key":"2026092413242843100_cvag153-B133","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jacc.2009.04.026","article-title":"Cardiac magnetic resonance detection of myocardial scarring in hypertrophic cardiomyopathy: correlation with histopathology and prevalence of ventricular tachycardia","volume":"54","author":"Kwon","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2026092413242843100_cvag153-B134","doi-asserted-by":"crossref","first-page":"e12790","DOI":"10.1111\/micc.12790","article-title":"RNA-seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy","volume":"29","author":"Pisano","year":"2022","journal-title":"Microcirculation"},{"key":"2026092413242843100_cvag153-B135","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/eurjhf\/hfs125","article-title":"Coronary telangiectasia associated with hypertrophic cardiomyopathy","volume":"14","author":"Frustaci","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2026092413242843100_cvag153-B136","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s004280050098","article-title":"Structural analysis of arteriolar and myocardial remodelling in the subendocardial region of patients with hypertensive heart disease and hypertrophic cardiomyopathy","volume":"431","author":"Mundhenke","year":"1997","journal-title":"Virchows Arch"},{"key":"2026092413242843100_cvag153-B137","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/hrt.45.5.475","article-title":"Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. I: morphological and morphometric aspects","volume":"45","author":"Baandrup","year":"1981","journal-title":"Br Heart J"},{"key":"2026092413242843100_cvag153-B138","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jjcc.2012.06.009","article-title":"Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure","volume":"60","author":"Dai","year":"2012","journal-title":"J Cardiol"},{"key":"2026092413242843100_cvag153-B139","doi-asserted-by":"crossref","first-page":"762950","DOI":"10.1155\/2015\/762950","article-title":"Vascular endothelial growth factor is associated with the morphologic and functional parameters in patients with hypertrophic cardiomyopathy","volume":"2015","author":"Pudil","year":"2015","journal-title":"Biomed Res Int"},{"key":"2026092413242843100_cvag153-B140","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1054-8807(99)00015-0","article-title":"Immunohistochemical analysis of platelet-derived growth factor-B expression in myocardial tissues in hypertrophic cardiomyopathy","volume":"8","author":"Suzuki","year":"1999","journal-title":"Cardiovasc Pathol"},{"key":"2026092413242843100_cvag153-B141","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1023\/B:CAIM.0000004262.48898.5d","article-title":"Is I-123-beta-methyl-p-iodophenyl-methylpentadecanoic acid imaging useful to evaluate asymptomatic patients with hypertrophic cardiomyopathy? I-123 BMIPP imaging to evaluate asymptomatic hypertrophic cardiomyopathy","volume":"19","author":"Narita","year":"2003","journal-title":"Int J Cardiovasc Imaging"},{"key":"2026092413242843100_cvag153-B142","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/01.CIR.70.4.724","article-title":"Quantification of regional myocardial blood flow in vivo with H215O","volume":"70","author":"Bergmann","year":"1984","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B143","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/j.semnuclmed.2014.06.011","article-title":"Cardiac PET perfusion tracers: current status and future directions","volume":"44","author":"Maddahi","year":"2014","journal-title":"Semin Nucl Med"},{"key":"2026092413242843100_cvag153-B144","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41569-020-0341-8","article-title":"Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia","volume":"17","author":"Dewey","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2026092413242843100_cvag153-B145","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1004::AID-MRM2>3.0.CO;2-M","article-title":"The relationship between the BOLD-induced T(2) and T(2)(*): a theoretical approach for the vasculature of myocardium","volume":"42","author":"Bauer","year":"1999","journal-title":"Magn Reson Med"},{"key":"2026092413242843100_cvag153-B146","first-page":"e64149","article-title":"Oxygenation-sensitive cardiac MRI with vasoactive breathing maneuvers for the non-invasive assessment of coronary microvascular dysfunction","volume":"186","author":"Hillier","year":"2022","journal-title":"J Vis Exp"},{"key":"2026092413242843100_cvag153-B147","first-page":"37","article-title":"Radionuclide tracers for myocardial perfusion imaging and blood flow quantification","volume":"34","author":"deKemp","year":"2016","journal-title":"Cardiol Clin"},{"key":"2026092413242843100_cvag153-B148","doi-asserted-by":"crossref","first-page":"357","DOI":"10.7861\/clinmed.2023-0194","article-title":"The weight of obesity in hypertrophic cardiomyopathy","volume":"23","author":"Zaromytidou","year":"2023","journal-title":"Clin Med (Lond)"},{"key":"2026092413242843100_cvag153-B149","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2337\/diab.44.7.721","article-title":"Microvascular function in human diabetes. A physiological perspective","volume":"44","author":"Tooke","year":"1995","journal-title":"Diabetes"},{"key":"2026092413242843100_cvag153-B150","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1161\/01.CIR.0000129772.26647.6F","article-title":"Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance","volume":"109","author":"de Jongh","year":"2004","journal-title":"Circulation"},{"key":"2026092413242843100_cvag153-B151","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00019501-199301000-00009","article-title":"Evidence for a systemic defect of resistance-sized arterioles in hypertrophic cardiomyopathy","volume":"4","author":"Pedrinelli","year":"1993","journal-title":"Coron Artery Dis"},{"key":"2026092413242843100_cvag153-B152","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/01.RES.87.8.644","article-title":"Selective downregulation of VEGF-A(165), VEGF-R(1), and decreased capillary density in patients with dilative but not ischemic cardiomyopathy","volume":"87","author":"Abraham","year":"2000","journal-title":"Circ Res"},{"key":"2026092413242843100_cvag153-B153","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/01.CIR.0000091085.12422.19","article-title":"Impaired VE-cadherin\/beta-catenin expression mediates endothelial cell degeneration in dilated cardiomyopathy","volume":"108","author":"Schafer","year":"2003","journal-title":"Circulation"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvag153\/68883605\/cvag153.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/13\/1865\/68883605\/cvag153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/13\/1865\/68883605\/cvag153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:24:55Z","timestamp":1790270695000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/122\/13\/1865\/8734740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":153,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7,15]]},"published-print":{"date-parts":[[2026,9,24]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvag153","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,15]]}}}