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B cells contribute to atherosclerosis progression by antibody secretion, antigen presentation and T-cell regulation. During aging, CD11c+CD21low B cells accumulate, but it is unclear whether these age-associated B cells (ABCs) are linked with incident cardiovascular events in humans and if they contribute to the progression of atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>To investigate associations with first-time coronary events (CEs), circulating B cells were phenotyped with flow cytometry in a case\u2013control study (N = 604) nested in the Malm\u00f6 Diet and Cancer study cohort with a median of 14 years follow-up. Splenic B cells in young (5 months) and aged (21 months) female Ldlr\u2212\/\u2212 mice were characterized with single-cell RNA-sequencing coupled with B-cell receptor (BCR)-sequencing. Atherogenicity of ABCs was determined by adoptive transfer to Ldlr\u2212\/\u2212 and Ldlr\u2212\/\u2212Rag1\u2212\/\u2212 mice. Compared with other B-cell populations, ABCs showed a significant positive correlation with age (Spearman\u2019s rho 0.24; P &amp;lt; 0.0001; across 46\u201368 years of age) and accumulated in aged atherosclerotic mice. CE cases had higher counts of ABCs than controls and regression analysis revealed an association with incident CEs, that was independent of cardiovascular risk factors [odds ratio: 1.92 (95% confidence interval 1.13\u20133.27), P = 0.016, comparing the fourth vs. first quartile]. Adoptive transfer of ABCs to recipient mice promoted atherosclerotic lesion development. In Ldlr\u2212\/\u2212 Rag1\u2212\/\u2212 mice, ABCs also increased necrotic cores (P &amp;lt; 0.05). B cells recovered from recipient mice after transfer expressed CD138 and secreted antibodies. In line with these findings, we demonstrated that ABCs expressed plasma cell (PC) differentiation genes and showed the greatest clonal expansion within the B-cell compartment, with extensive clonal overlap with PCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We show that ABCs predict first-time CEs in humans and contribute to the immunopathology of atherosclerosis in mice, indicating that clonal expansion and accumulation of ABCs contribute to the strong association between age and CVD. ABCs may serve as potential prognostic and therapeutic targets for CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag154","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:52:07Z","timestamp":1783684327000},"page":"1789-1802","source":"Crossref","is-referenced-by-count":0,"title":["Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis"],"prefix":"10.1093","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-9912","authenticated-orcid":false,"given":"Jill","family":"de Mol","sequence":"first","affiliation":[{"name":"Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University , Einsteinweg 55, Leiden 2333CC ,","place":["The 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