{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:02:03Z","timestamp":1791892923370,"version":"4.3.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Left ventricular non-compaction (LVNC) is a genetic cardiomyopathy with presentations ranging from asymptomatic disease to heart failure, stroke, and sudden cardiac death. LVNC-related structural and functional abnormalities may increase atrial fibrillation (AF) risk, but data are limited. We assessed AF incidence in LVNC and compared outcomes in patients with vs. without AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Two cohorts of patients were identified using the TriNetX platform: (i) patients with LVNC without a prior history of AF and (ii) patients with LVNC and AF. The primary objective was to assess the 3 year risk of a composite of all-cause mortality, stroke, acute myocardial infarction, and heart failure in the two cohorts. Hazard ratios (HRs) were derived from univariable Cox proportional models before and after propensity score matching (PSM). Matching was conducted using a greedy nearest-neighbour approach with a calliper of 0.1. Patients with LVNC and AF (N = 29 356) were older and exhibited a higher burden of comorbidities compared with LVNC patients without AF (N = 39 339). In this observational analysis, after PSM, AF in patients with LVNC was associated with higher risks of stroke [HR 1.466, 95% confidence interval (CI) 1.359\u20131.581], new-onset heart failure (HR 1.439, 95% CI 1.358\u20131.526), all-cause death (HR 1.255, 95% CI 1.200\u20131.312), and the composite outcome (HR 1.301, 95% CI 1.269\u20131.334) compared with LVNC patients without AF. The 1 year incidence of AF in patients with LVNC was 36 per 1000 person-years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this observational cohort, LVNC was associated with a high incidence of AF, and the presence of AF was associated with higher risks of stroke, heart failure, and all-cause death. Further prospective studies are warranted to assess the prognostic impact of AF in patients with LVNC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag156","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:51:18Z","timestamp":1783511478000},"page":"1761-1769","source":"Crossref","is-referenced-by-count":2,"title":["Atrial fibrillation in patients with left ventricular non-compaction: incidence and associations with stroke, heart failure, and mortality"],"prefix":"10.1093","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-079X","authenticated-orcid":false,"given":"Amir","family":"Askarinejad","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Sciences at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital , 6 W Derby St, Liverpool L7 8TX ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-538X","authenticated-orcid":false,"given":"Thomas F","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"Center for Molecular Cardiology, University of Z\u00fcrich , 4th Floor Wagistrasse, Schlieren 12 8952 ,","place":["Switzerland"]},{"name":"Heart Division, Royal Brompton and Harefield Hospitals , Sydney Street, London SW3 6NP ,","place":["UK"]},{"name":"National Heart and Lung Institute, Imperial College London , Guy Scadding Building, Dovehouse St, London SW3 6LY ,","place":["UK"]},{"name":"School of Cardiovascular and Metabolic Medicine & Sciences, King's College London , Strand, London WC2R 2LS ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Sciences at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital , 6 W Derby St, Liverpool L7 8TX ,","place":["UK"]},{"name":"Department of Clinical Medicine, Aalborg University , Fredrik Bajers Vej 7K, Aalborg 9220 ,","place":["Denmark"]},{"name":"Department of Invasive Cardiology, Medical University of Bialystok , Jana Kili\u0144skiego 1, Bialystok 15-089 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"2026092413240466100_cvag156-B1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/heart.86.6.666","article-title":"Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy","volume":"86","author":"Jenni","year":"2001","journal-title":"Heart"},{"key":"2026092413240466100_cvag156-B2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3390\/jpm15100484","article-title":"Left 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