{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:19Z","timestamp":1792785859057,"version":"4.5.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000764","name":"King\u2019s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre for Biomolecular Spectroscopy"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["221604\/Z\/20\/Z"],"award-info":[{"award-number":["221604\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Barts Metabolism Network","award":["G-002145"],"award-info":[{"award-number":["G-002145"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL177461"],"award-info":[{"award-number":["R01-HL177461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016674","name":"Novo Foundation","doi-asserted-by":"publisher","award":["NNF21OC0068683"],"award-info":[{"award-number":["NNF21OC0068683"]}],"id":[{"id":"10.13039\/100016674","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRC Mouse Biochem Lab"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00014\/5"],"award-info":[{"award-number":["MC_UU_00014\/5"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"UKRI-Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["COG 2018 - 819600_FIRM"],"award-info":[{"award-number":["COG 2018 - 819600_FIRM"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["ARCLEADER2022020004901"],"award-info":[{"award-number":["ARCLEADER2022020004901"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["AIRC-MFAG 21903"],"award-info":[{"award-number":["AIRC-MFAG 21903"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"MIUR","doi-asserted-by":"publisher","award":["PRIN-2022 Prot. 202252ZLSX"],"award-info":[{"award-number":["PRIN-2022 Prot. 202252ZLSX"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["ref.202767\/Z\/16\/Z"],"award-info":[{"award-number":["ref.202767\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["IG\/16\/2\/32273"],"award-info":[{"award-number":["IG\/16\/2\/32273"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre of Excellence in Medical Engineering","award":["WT 203148\/Z\/16\/Z"],"award-info":[{"award-number":["WT 203148\/Z\/16\/Z"]}]},{"name":"BHF Centre of Research Excellence","award":["RE\/18\/2\/34213"],"award-info":[{"award-number":["RE\/18\/2\/34213"]}]},{"name":"NIHR Biomedical Research Centre at Guy's"},{"name":"St Thomas\u2019 NHS Foundation Trust"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Barts Cardiovascular Biomedical Research Centre"},{"DOI":"10.13039\/501100000851","name":"Queen Mary University of London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000851","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust Senior Research Fellowship","id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Basic Biomedical Sciences","award":["214290\/Z\/18\/Z"],"award-info":[{"award-number":["214290\/Z\/18\/Z"]}]},{"name":"Oxford-Bristol Myers Squibb Fellowship","award":["R39207\/CN063"],"award-info":[{"award-number":["R39207\/CN063"]}]},{"name":"EPSRC Impact Acceleration Account Technology","award":["0016113"],"award-info":[{"award-number":["0016113"]}]},{"name":"COST Action EU-METAHEART","award":["CA22169"],"award-info":[{"award-number":["CA22169"]}]},{"DOI":"10.13039\/501100000921","name":"COST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is associated with uraemic cardiomyopathy characterized by early metabolic dysfunction. Elevated myocardial intracellular sodium (Na\u1d62) has emerged as a driver of cardiometabolic remodelling, however, its role in CKD and therapeutic modulation remains unclear. We investigated whether dual sodium-glucose cotransporter (SGLT)1\/2 inhibition with sotagliflozin (SOTA) targets Na\u1d62 and improves cardiac metabolism in CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>CKD was induced in male Wistar rats by 5\/6 nephrectomy and assessed after 4 weeks. Cardiac phenotype was evaluated using in vivo echocardiography and ex vivo Langendorff perfusion combined with 23Na and 31P NMR spectroscopy. CKD hearts exhibited preserved systolic but impaired diastolic function and a marked elevation in myocardial Na\u1d62, identifying Na\u1d62 overload as an early feature of uraemic cardiomyopathy. Cardiac metabolomic profiling and flux modelling demonstrated widespread suppression of central carbon metabolism, redox imbalance despite preserved PCr\/ATP. In silico electrophysiological simulations predicted Na\u1d62-driven Ca2+ dysregulation consistent with in vivo diastolic dysfunction. Chronic SOTA treatment (3 weeks, in vivo) normalized myocardial Na\u1d62 and partially reversed metabolic remodelling. Acute SOTA exposure (20 min, Langendorff-perfusion) similarly reduced Na\u1d62 in CKD hearts but not in controls, indicating a direct, disease-selective myocardial effect. Na\u1d62 normalization was accompanied by improved redox state and restoration of mitochondrial metabolic flux, without changes in expression of canonical Na + -handling proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Myocardial Na\u1d62 overload emerges as an early and potentially modifiable feature of uraemic cardiomyopathy. Dual SGLT1\/2 inhibition with SOTA directly lowers Na\u1d62 and improves cardiac metabolic homeostasis, supporting Na\u1d62 as a mechanistically relevant and potentially targetable pathway in CKD-related cardiac remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag167","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:12:22Z","timestamp":1786101142000},"page":"2039-2054","source":"Crossref","is-referenced-by-count":0,"title":["Dual inhibition of SGLT 1 and 2 by sotagliflozin alleviates intracellular sodium overload and improves cardiometabolic remodelling in uraemic cardiomyopathy"],"prefix":"10.1093","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2178-3755","authenticated-orcid":false,"given":"Megan","family":"Young","sequence":"first","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Karlstaedt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center , Los Angeles ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanushi","family":"Dambure","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack J J J","family":"Miller","sequence":"additional","affiliation":[{"name":"The MR Research Centre and The PET Centre, Clinical Medicine, Aarhus University , Aarhus 8200 ,","place":["Denmark"]},{"name":"Clarendon Laboratory, Department of Physics, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Guo","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenouska","family":"Ramchunder","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jair","family":"Gonzalez Marques Junior","sequence":"additional","affiliation":[{"name":"Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Nobles","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7703-4151","authenticated-orcid":false,"given":"Andrew","family":"Tinker","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuongmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center , Los Angeles ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R","family":"Purcell","sequence":"additional","affiliation":[{"name":"University of Sydney, Faculty of Medicine and Health , Sydney, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J","family":"Glastras","sequence":"additional","affiliation":[{"name":"University of Sydney, Faculty of Medicine and Health , Sydney, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenn","family":"Cullen","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Eykyn","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, St Thomas\u2019 Hospital , London ,","place":["UK"]},{"name":"British Heart Foundation Centre of Research Excellence, King\u2019s College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Von Kriegsheim","sequence":"additional","affiliation":[{"name":"Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-4184","authenticated-orcid":false,"given":"Michelangelo","family":"Campanella","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]},{"name":"UMR 9018 CNRS, Institute Gustave Roussy , Villejeuif ,","place":["France"]},{"name":"Department of Biomedical Sciences, University of Padua , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Shattock","sequence":"additional","affiliation":[{"name":"British Heart Foundation Centre of Research Excellence, King\u2019s College London , London ,","place":["UK"]},{"name":"Rayne Institute, School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King\u2019s College London, St Thomas\u2019 Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-1611","authenticated-orcid":false,"given":"Nay","family":"Aung","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia P","family":"Cabrera","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]},{"name":"National Institute for Health and Care Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdi M","family":"Yaqoob","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-6727","authenticated-orcid":false,"given":"Dunja","family":"Aksentijevic","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, John Vane Science Centre, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026101011122551500_cvag167-B1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.120.050686","article-title":"Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options","volume":"143","author":"Jankowski","year":"2021","journal-title":"Circulation"},{"key":"2026101011122551500_cvag167-B2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41581-022-00576-x","article-title":"Cardiac metabolic remodelling in chronic kidney disease","volume":"18","author":"Patel","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"2026101011122551500_cvag167-B3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ki.2008.691","article-title":"Insulin resistance and altered glucose transporter 4 expression in experimental uremia","volume":"75","author":"Aksentijevic","year":"2009","journal-title":"Kidney Int"},{"key":"2026101011122551500_cvag167-B4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1042\/BST20170508","article-title":"Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?","volume":"46","author":"Aksentijevic","year":"2018","journal-title":"Biochem Soc Trans"},{"key":"2026101011122551500_cvag167-B5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.yjmcc.2021.08.003","article-title":"With a grain of salt: sodium elevation and metabolic remodelling in heart failure","volume":"161","author":"Aksentijevic","year":"2021","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B6","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/cvr\/cvae095","article-title":"Empagliflozin inhibits increased Na influx in atrial cardiomyocytes of patients with HFpEF","volume":"120","author":"Trum","year":"2024","journal-title":"Cardiovasc Res"},{"key":"2026101011122551500_cvag167-B7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/CIRCULATIONAHA.121.057237","article-title":"Empagliflozin reverses late Na(+) current enhancement and cardiomyocyte proarrhythmia in a translational murine model of heart failure with preserved ejection fraction","volume":"145","author":"Hegyi","year":"2022","journal-title":"Circulation"},{"key":"2026101011122551500_cvag167-B8","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1038\/s41467-024-48474-z","article-title":"Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart","volume":"15","author":"Chung","year":"2024","journal-title":"Nat Commun"},{"key":"2026101011122551500_cvag167-B9","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1038\/s41467-020-18160-x","article-title":"Intracellular sodium elevation reprograms cardiac metabolism","volume":"11","author":"Aksentijevi\u0107","year":"2020","journal-title":"Nat Commun"},{"key":"2026101011122551500_cvag167-B10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/ndt\/15.6.791","article-title":"L-type calcium current of isolated rat cardiac myocytes in experimental uraemia","volume":"15","author":"Donohoe","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"2026101011122551500_cvag167-B11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/ndt\/17.5.759","article-title":"Prolonged calcium transients and myocardial remodelling in early experimental uraemia","volume":"17","author":"McMahon","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"2026101011122551500_cvag167-B12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.ki.5000193","article-title":"Diastolic dysfunction and abnormality of the Na+\/Ca2+ exchanger in single uremic cardiac myocytes","volume":"69","author":"McMahon","year":"2006","journal-title":"Kidney Int"},{"key":"2026101011122551500_cvag167-B13","article-title":"Altered expression of myocardial [Ca2+] handling proteins in experimental uraemia","volume":"42","author":"Aksentijevic","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B14","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1681\/ASN.2016060662","article-title":"Skin sodium concentration correlates with left ventricular hypertrophy in CKD","volume":"28","author":"Schneider","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2026101011122551500_cvag167-B15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa2030186","article-title":"Sotagliflozin in patients with diabetes and chronic kidney disease","volume":"384","author":"Bhatt","year":"2021","journal-title":"N Engl J Med"},{"key":"2026101011122551500_cvag167-B16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12933-020-01208-z","article-title":"Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF","volume":"20","author":"Bode","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"2026101011122551500_cvag167-B17","first-page":"e45525","article-title":"Sotagliflozin vs dapagliflozin: a systematic review comparing cardiovascular mortality","volume":"15","author":"Iyer","year":"2023","journal-title":"Cureus"},{"key":"2026101011122551500_cvag167-B18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2215\/CJN.0000000000000414","article-title":"Sotagliflozin and kidney outcomes, kidney function, and albuminuria in type 2 diabetes and CKD: a secondary analysis of the SCORED trial","volume":"19","author":"Sridhar","year":"2024","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026101011122551500_cvag167-B19","doi-asserted-by":"crossref","first-page":"e0130605","DOI":"10.1371\/journal.pone.0130605","article-title":"Expression of SGLT1 in human hearts and impairment of cardiac glucose uptake by phlorizin during ischemia-reperfusion injury in mice","volume":"10","author":"Kashiwagi","year":"2015","journal-title":"PLoS One"},{"key":"2026101011122551500_cvag167-B20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12933-019-0889-y","article-title":"Cardiac ischemia-reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity","volume":"18","author":"Yoshii","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"2026101011122551500_cvag167-B21","doi-asserted-by":"crossref","first-page":"e002183","DOI":"10.1161\/JAHA.115.002183","article-title":"Intracellular na+ concentration ([Na+]i) is elevated in diabetic hearts due to enhanced Na+-glucose cotransport","volume":"4","author":"Lambert","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2026101011122551500_cvag167-B22","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s00125-016-4134-x","article-title":"Empagliflozin decreases myocardial cytoplasmic Na(+) through inhibition of the cardiac Na(+)\/H(+) exchanger in rats and rabbits","volume":"60","author":"Baartscheer","year":"2017","journal-title":"Diabetologia"},{"key":"2026101011122551500_cvag167-B23","doi-asserted-by":"crossref","first-page":"116477","DOI":"10.1016\/j.biopha.2024.116477","article-title":"Empagliflozin mitigates cardiac hypertrophy through cardiac RSK\/NHE-1 inhibition","volume":"174","author":"Chen","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026101011122551500_cvag167-B24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00395-024-01067-9","article-title":"Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2","volume":"119","author":"Chen","year":"2024","journal-title":"Basic Res Cardiol"},{"key":"2026101011122551500_cvag167-B25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/CIRCULATIONAHA.122.061688","article-title":"Sodium glucose cotransporter-2 inhibitor empagliflozin reduces infarct size independently of sodium glucose cotransporter-2","volume":"147","author":"Chen","year":"2023","journal-title":"Circulation"},{"key":"2026101011122551500_cvag167-B26","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/cvr\/cvaa323","article-title":"Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+\/H+ exchanger-1 or lower [Na + ]i in the heart","volume":"117","author":"Chung","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2026101011122551500_cvag167-B27","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3389\/fphys.2018.01575","article-title":"Direct cardiac actions of sodium glucose cotransporter 2 inhibitors target pathogenic mechanisms underlying heart failure in diabetic patients","volume":"9","author":"Uthman","year":"2018","journal-title":"Front Physiol"},{"key":"2026101011122551500_cvag167-B28","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1161\/CIRCULATIONAHA.121.053350","article-title":"Cardiac late sodium channel current is a molecular target for the sodium\/glucose cotransporter 2 inhibitor empagliflozin","volume":"143","author":"Philippaert","year":"2021","journal-title":"Circulation"},{"key":"2026101011122551500_cvag167-B29","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.2741\/e208","article-title":"Functional and metabolic adaptation in uraemic cardiomyopathy","volume":"2","author":"Smith","year":"2010","journal-title":"Front Biosci (Elite Ed)"},{"key":"2026101011122551500_cvag167-B30","volume-title":"Myocardial Insulin Resistance in Experimental Uraemia PhD Thesis","author":"Aksentijevic","year":"2008"},{"key":"2026101011122551500_cvag167-B31","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.yjmcc.2006.03.048","article-title":"The impact of increasing calcium on myocardial function in experimental uraemia","volume":"40","author":"Aksentijevi\u0107","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B32","author":"Aksentijevic"},{"key":"2026101011122551500_cvag167-B33","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.yjmcc.2007.03.897","article-title":"Myocardial GLUT 4 expression in experimental uraemia","volume":"42","author":"Aksentijevic","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B34","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/j.yjmcc.2007.03.796","article-title":"The effect of increased [Ca2+] on myocardial function and energy provision in experimental uraemia","volume":"42","author":"Aksentijevi\u0107","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B35","doi-asserted-by":"crossref","first-page":"41382","DOI":"10.1038\/s41598-025-25314-8","article-title":"Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes","volume":"15","author":"Young","year":"2025","journal-title":"Sci Rep"},{"key":"2026101011122551500_cvag167-B36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yjmcc.2015.07.009","article-title":"Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: ratio of triple\/double quantum filtered signals correlates with [Na]i","volume":"86","author":"Eykyn","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B37","doi-asserted-by":"crossref","first-page":"e21765","DOI":"10.1096\/fj.202100394R","article-title":"Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia","volume":"35","author":"Kerr","year":"2021","journal-title":"FASEB J"},{"key":"2026101011122551500_cvag167-B38","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/mrm.28647","article-title":"Rapid, B1 -insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux","volume":"85","author":"Miller","year":"2021","journal-title":"Magn Reson Med"},{"key":"2026101011122551500_cvag167-B39","doi-asserted-by":"crossref","first-page":"e0185356","DOI":"10.1371\/journal.pone.0185356","article-title":"OXSA: an open-source magnetic resonance spectroscopy analysis toolbox in MATLAB","volume":"12","author":"Purvis","year":"2017","journal-title":"PLoS One"},{"key":"2026101011122551500_cvag167-B40","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1113\/EP085380","article-title":"Is rate-pressure product of any use in the isolated rat heart? Assessing cardiac \u2018effort\u2019 and oxygen consumption in the langendorff-perfused heart","volume":"101","author":"Aksentijevic","year":"2016","journal-title":"Exp Physiol"},{"key":"2026101011122551500_cvag167-B41","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1038\/s41467-024-46470-x","article-title":"Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles","volume":"15","author":"Faulkes","year":"2024","journal-title":"Nat Commun"},{"key":"2026101011122551500_cvag167-B42","doi-asserted-by":"crossref","first-page":"179484","DOI":"10.1016\/j.scitotenv.2025.179484","article-title":"Short-term aircraft noise stress induces a fundamental metabolic shift in heart proteome and metabolome that bears the hallmarks of cardiovascular disease","volume":"979","author":"Marques","year":"2025","journal-title":"Sci Total Environ"},{"key":"2026101011122551500_cvag167-B43","author":"King"},{"key":"2026101011122551500_cvag167-B44","author":"Andrews"},{"key":"2026101011122551500_cvag167-B45","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"2026101011122551500_cvag167-B46","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"2026101011122551500_cvag167-B47","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"key":"2026101011122551500_cvag167-B48","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2026101011122551500_cvag167-B49","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2026101011122551500_cvag167-B50","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026101011122551500_cvag167-B51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1752-0509-6-114","article-title":"CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism","volume":"6","author":"Karlst\u00e4dt","year":"2012","journal-title":"BMC Syst Biol"},{"key":"2026101011122551500_cvag167-B52","author":"Gurobi Optimization"},{"key":"2026101011122551500_cvag167-B53","doi-asserted-by":"crossref","first-page":"e15766","DOI":"10.14814\/phy2.15766","article-title":"Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes","volume":"11","author":"Howlett","year":"2023","journal-title":"Physiol Rep"},{"key":"2026101011122551500_cvag167-B54","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.108.175919","article-title":"Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching","volume":"103","author":"Liu","year":"2008","journal-title":"Circ Res"},{"key":"2026101011122551500_cvag167-B55","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-025-01167-6","article-title":"Mechano-energetic uncoupling in heart failure","volume":"22","author":"Aksentijevic","year":"2025","journal-title":"Nat Rev Cardiol"},{"key":"2026101011122551500_cvag167-B56","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1161\/01.CIR.0000016701.85760.97","article-title":"Intracellular Na(+) concentration is elevated in heart failure but Na\/K pump function is unchanged","volume":"105","author":"Despa","year":"2002","journal-title":"Circulation"},{"key":"2026101011122551500_cvag167-B57","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0008-6363(02)00841-6","article-title":"[Na+]i handling in the failing human heart","volume":"57","author":"Pieske","year":"2003","journal-title":"Cardiovasc Res"},{"key":"2026101011122551500_cvag167-B58","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/CIRCRESAHA.108.189050","article-title":"Regulation of intracellular and mitochondrial sodium in health and disease","volume":"104","author":"Murphy","year":"2009","journal-title":"Circ Res"},{"key":"2026101011122551500_cvag167-B59","doi-asserted-by":"crossref","first-page":"H1972","DOI":"10.1152\/ajpheart.2000.279.4.H1972","article-title":"Na(+)-K(+)-ATPase alpha(2)-isoform expression in Guinea pig hearts during transition from compensation to decompensation","volume":"279","author":"Trouve","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026101011122551500_cvag167-B60","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0022-2828(02)00280-8","article-title":"Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure","volume":"35","author":"Verdonck","year":"2003","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B61","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ajh.2009.22","article-title":"Endogenous cardiotonic steroids and differential patterns of sodium pump inhibition in NaCl-loaded salt-sensitive and normotensive rats","volume":"22","author":"Bagrov","year":"2009","journal-title":"Am J Hypertens"},{"key":"2026101011122551500_cvag167-B62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/pr.108.000711","article-title":"Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets","volume":"61","author":"Bagrov","year":"2009","journal-title":"Pharmacol Rev"},{"key":"2026101011122551500_cvag167-B63","doi-asserted-by":"crossref","first-page":"F922","DOI":"10.1152\/ajprenal.90605.2008","article-title":"The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition","volume":"296","author":"Fedorova","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"2026101011122551500_cvag167-B64","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1046\/j.1523-1755.2001.00053.x","article-title":"Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function","volume":"60","author":"Periyasamy","year":"2001","journal-title":"Kidney Int"},{"key":"2026101011122551500_cvag167-B65","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11010-014-2262-5","article-title":"Dapagliflozin reduces the amplitude of shortening and Ca(2+) transient in ventricular myocytes from streptozotocin-induced diabetic rats","volume":"400","author":"Hamouda","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"2026101011122551500_cvag167-B66","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.yjmcc.2022.03.005","article-title":"Cardiac mechanisms of the beneficial effects of SGLT2 inhibitors in heart failure: evidence for potential off-target effects","volume":"167","author":"Jason","year":"2022","journal-title":"J Mol Cell Cardiol"},{"key":"2026101011122551500_cvag167-B67","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/cvr\/cvp190","article-title":"SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states","volume":"84","author":"Banerjee","year":"2009","journal-title":"Cardiovasc Res"},{"key":"2026101011122551500_cvag167-B68","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.jacc.2018.07.061","article-title":"Genetic variants in SGLT1, glucose tolerance, and cardiometabolic risk","volume":"72","author":"Seidelmann","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026101011122551500_cvag167-B69","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00395-025-01136-7","article-title":"Cardiac sodium-glucose co-transporter 1 (SGLT1) contributes to heart failure in a mouse model of diabetic cardiomyopathy","volume":"120","author":"Li","year":"2025","journal-title":"Basic Res Cardiol"},{"key":"2026101011122551500_cvag167-B70","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.2337\/db14-1560","article-title":"Increasing pyruvate dehydrogenase flux as a treatment for diabetic cardiomyopathy: a combined 13C hyperpolarized magnetic resonance and echocardiography study","volume":"64","author":"Le Page","year":"2015","journal-title":"Diabetes"},{"key":"2026101011122551500_cvag167-B71","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/nbm.1668","article-title":"Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate","volume":"24","author":"Schroeder","year":"2011","journal-title":"NMR Biomed"},{"key":"2026101011122551500_cvag167-B72","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11897-017-0320-5","article-title":"Endothelial glycocalyx as biomarker for cardiovascular diseases: mechanistic and clinical implications","volume":"14","author":"Kim","year":"2017","journal-title":"Curr Heart Fail Rep"},{"key":"2026101011122551500_cvag167-B73","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/HYPERTENSIONAHA.109.147256","article-title":"Syndecan-1: a critical mediator in cardiac fibrosis","volume":"55","author":"Frangogiannis","year":"2010","journal-title":"Hypertension"},{"key":"2026101011122551500_cvag167-B74","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3892\/mmr.2021.12492","article-title":"Diallyl sulfide protects against dilated cardiomyopathy via inhibition of oxidative stress and apoptosis in mice","volume":"24","author":"Pang","year":"2021","journal-title":"Mol Med Rep"},{"key":"2026101011122551500_cvag167-B75","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12964-025-02197-w","article-title":"Cytochrome P450 2E1 aggravates DXR-induced myocardial injury through imbalanced mitochondrial OPA1","volume":"23","author":"Ma","year":"2025","journal-title":"Cell Commun Signal"},{"key":"2026101011122551500_cvag167-B76","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1007\/s11010-021-04168-4","article-title":"In-depth review: is hepcidin a marker for the heart and the kidney?","volume":"476","author":"Afsar","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"2026101011122551500_cvag167-B77","doi-asserted-by":"crossref","first-page":"e19804","DOI":"10.7554\/eLife.19804","article-title":"An essential cell-autonomous role for hepcidin in cardiac iron homeostasis","volume":"5","author":"Lakhal-Littleton","year":"2016","journal-title":"Elife"},{"key":"2026101011122551500_cvag167-B78","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41569-024-00988-1","article-title":"Iron deficiency and supplementation in heart failure","volume":"21","author":"Lakhal-Littleton","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"2026101011122551500_cvag167-B79","doi-asserted-by":"crossref","first-page":"e137593","DOI":"10.1172\/jci.insight.137593","article-title":"Cardiac retinoic acid levels decline in heart failure","volume":"6","author":"Yang","year":"2021","journal-title":"JCI Insight"},{"key":"2026101011122551500_cvag167-B80","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/jpet.121.000806","article-title":"A retinoic acid receptor beta (2) agonist improves cardiac function in a heart failure model","volume":"379","author":"Tang","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"key":"2026101011122551500_cvag167-B81","doi-asserted-by":"crossref","first-page":"H792","DOI":"10.1152\/ajpheart.00871.2024","article-title":"Retinoic acid signaling and metabolism in heart failure","volume":"328","author":"Parker","year":"2025","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026101011122551500_cvag167-B82","doi-asserted-by":"crossref","first-page":"e202305010","DOI":"10.1083\/jcb.202305010","article-title":"Mitochondrial sites of contact with the nucleus","volume":"223","author":"Campanella","year":"2024","journal-title":"J Cell Biol"},{"key":"2026101011122551500_cvag167-B83","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear communication in homeostasis and stress","volume":"17","author":"Quiros","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026101011122551500_cvag167-B84","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41467-023-37291-5","article-title":"A defect in mitochondrial protein translation influences mitonuclear communication in the heart","volume":"14","author":"Gao","year":"2023","journal-title":"Nat Commun"},{"key":"2026101011122551500_cvag167-B85","doi-asserted-by":"crossref","first-page":"eabc9955","DOI":"10.1126\/sciadv.abc9955","article-title":"Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response","volume":"6","author":"Desai","year":"2020","journal-title":"Sci Adv"},{"key":"2026101011122551500_cvag167-B86","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/cvr\/cvab129","article-title":"SGLT2 inhibitor empagliflozin inhibits the cardiac Na+\/H+ exchanger 1: persistent inhibition under various experimental conditions","volume":"117","author":"Zuurbier","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2026101011122551500_cvag167-B87","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/cvr\/cvab129","article-title":"Sodium-glucose co-transporter 2 inhibitor empagliflozin inhibits the cardiac Na+\/H+ exchanger 1: persistent inhibition under various experimental conditions","volume":"117","author":"Zuurbier","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2026101011122551500_cvag167-B88","doi-asserted-by":"crossref","first-page":"H341","DOI":"10.1152\/ajpheart.00391.2022","article-title":"Empagliflozin attenuates arrhythmogenesis in diabetic cardiomyopathy by normalizing intracellular ca(2+) handling in ventricular cardiomyocytes","volume":"324","author":"Kadosaka","year":"2023","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026101011122551500_cvag167-B89","doi-asserted-by":"crossref","first-page":"H338","DOI":"10.1152\/ajpheart.00003.2023","article-title":"New cardiac targets for empagliflozin: O-GlcNAcylation, CaMKII, and calcium handling","volume":"324","author":"Hegyi","year":"2023","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026101011122551500_cvag167-B90","doi-asserted-by":"crossref","first-page":"104781","DOI":"10.1016\/j.phrs.2020.104781","article-title":"Amelioration of diastolic dysfunction by dapagliflozin in a non-diabetic model involves coronary endothelium","volume":"157","author":"Cappetta","year":"2020","journal-title":"Pharmacol Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvag167\/70608375\/cvag167.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/14\/2039\/70608375\/cvag167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/122\/14\/2039\/70608375\/cvag167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:12:45Z","timestamp":1791645165000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/122\/14\/2039\/8758793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":90,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,8,11]]},"published-print":{"date-parts":[[2026,10,10]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvag167","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,11]]}}}