{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:06:12Z","timestamp":1789124772859,"version":"build-2803163510"},"reference-count":65,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570396"],"award-info":[{"award-number":["82570396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570397"],"award-info":[{"award-number":["82570397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400156"],"award-info":[{"award-number":["82400156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fudan University Zhongshan Hospital\u2019s Science Foundation","award":["2025ZSRC-005"],"award-info":[{"award-number":["2025ZSRC-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Thyroid-stimulating hormone (TSH), elevated in conditions like subclinical hypothyroidism, has been clinically linked to a higher risk of morbidity and mortality in patients with coronary artery disease (CAD). Here, we aim to investigate the effects of TSH on CAD-associated platelet activation and arterial thrombosis, along with the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Clinical studies demonstrated that higher TSH levels are associated with an increased risk of major adverse cardiovascular events in CAD patients. In vitro human and mouse platelet function studies found that TSH potentiates agonist-induced platelet aggregation, dense granule adenosine triphosphate release, integrin alpha-IIb beta-3 activation, P-selectin release from \u03b1-granules, platelet spreading, and clot retraction. Furthermore, in vivo animal studies demonstrated that TSH enhances thrombosis, whole blood thrombus formation, and middle cerebral artery occlusion-induced brain injury. Mechanistic studies revealed that platelets express the TSH receptor (TSHR). TSH binds to platelet TSHR and activates both the Gs\/cAMP\/PKA and Gq\/Ca2+\/PKC\/MAPK signalling pathways. Activation of the Gq pathway is more pronounced than that of the Gs pathway, thereby potentiating platelet activation. Finally, our in vivo work showed that TSH aggravates microvascular obstruction and promotes myocardial infarction expansion in a mouse myocardial ischaemia\/reperfusion injury model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TSH augments platelet activation and in vivo thrombus formation through engagement of platelet TSHR, subsequently activating downstream signalling cascades involving Gs\/cAMP\/PKA and Gq\/Ca2+\/PKC\/MAPK pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag187","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:41:38Z","timestamp":1787658098000},"source":"Crossref","is-referenced-by-count":0,"title":["Thyroid-stimulating hormone enhances platelet activation and arterial thrombosis"],"prefix":"10.1093","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"Institutes of Biomedical Sciences, Fudan University , 131 Dongan Road, Shanghai 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"NHC Key Laboratory of Ischemic Heart Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"NHC Key Laboratory of Ischemic Heart Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 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Sciences, Fudan University, 131 Dongan Road, Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"NHC Key Laboratory of Ischemic Heart Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032 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,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"NHC Key Laboratory of Ischemic Heart Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032 ,","place":["China"]},{"name":"Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026091106120034400_cvag187-B1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112772","article-title":"Platelets and their role in hemostasis and thrombosis-from physiology to pathophysiology and therapeutic 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