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However, the effect of metabolic alterations such as hypertriglyceridaemia (HTG) on this inter-organ communication remains unknown. In the present study, we have investigated, in a rat model of crossed-BM transplant, the impact of HTG on the BM\u2013heart axis response to AMI under constant metabolic stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Wistar rats (n = 56) were assigned to two groups: one fed a high-sucrose diet to induce HTG and the other fed a regular chow [normolipemic (NL)-animals]. After 3 weeks, all combinations of crossed-BM transplants were performed (NL-BM\/NL-recipient, NL-BM\/HTG-recipient, HTG-BM\/NL-recipient, and HTG-BM\/HTG-recipient) following total body irradiation (9.5\u2005Gy). All animals, except for the NL-BM\/NL-recipient group, continued on a high-sucrose diet for 3 weeks. Then, AMI was induced by transient coronary artery ligation, and 5 days later, animals were sacrificed. We determined infarct size and performed echocardiography, 1H-NMR spectroscopy, and multiple molecular and histological analyses. NL-BM\/HTG-recipients exhibited smaller infarcts vs. the other groups and showed a resolving inflammatory response, lower lipotoxicity, higher \u03c93 content, increased AMPK activation and S1P-related enzymes, and reparative fibrosis in the healing scar. Although no differences were detected in left ventricular ejection fraction post-AMI among all groups, NL-BM\/HTG-recipients exhibited improved systolic and diastolic parameters. Circulating triglyceride levels were significantly reduced in NL-BM\/HTG-recipients 3 weeks post-BM transplant, whereas, conversely, they were found to be enhanced in HTG-BM\/NL-recipients developing a HTG state. Furthermore, recipients of a HTG-BM showed a worsened lipid profile, liver steatosis and inflammation, higher weight gain, leptin levels and lower lipoprotein lipase, AMPK, and acetyl-CoA carboxylase activity in the visceral adipose tissue vs. NL-BM-recipient animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transplantation of healthy BM into HTG animals enhances the capacity to counteract myocardial injury post-AMI and restores metabolic disturbances, improving overall recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvag204","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:34:53Z","timestamp":1790076893000},"source":"Crossref","is-referenced-by-count":0,"title":["Healthy bone marrow transplantation into hypertriglyceridemic rats improves cardiac reparative fibrosis post-myocardial infarction"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3512-8474","authenticated-orcid":false,"given":"Lisaidy","family":"Ramos-Regalado","sequence":"first","affiliation":[{"name":"Institut de Recerca Sant Pau (IR SANT PAU) \u00a0 Barcelona 08041 ,","place":["Spain"]},{"name":"Faculty of Biology, Universitat de Barcelona , Barcelona 08028 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-1769","authenticated-orcid":false,"given":"Sebasti\u00e0","family":"Alcover","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Pau (IR SANT PAU) \u00a0 Barcelona 08041 ,","place":["Spain"]},{"name":"Faculty of Biology, Universitat de Barcelona , Barcelona 08028 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-954X","authenticated-orcid":false,"given":"Teresa","family":"Padr\u00f3","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Pau (IR SANT PAU) \u00a0 Barcelona 08041 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares (CIBERCV) , Av. Monforte de Lemos, 3\u20135, Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8559-7218","authenticated-orcid":false,"given":"Malcolm","family":"Walker","sequence":"additional","affiliation":[{"name":"University College Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"G\u00f3mez de Segura-Melc\u00f3n","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Pau (IR SANT PAU) \u00a0 Barcelona 08041 ,","place":["Spain"]},{"name":"Deparment of Medical Physics, Hospital de la Santa Creu i Sant Pau , Barcelona 08025 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2266-6172","authenticated-orcid":false,"given":"Gemma","family":"Sancho-Pardo","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Pau (IR SANT PAU) \u00a0 Barcelona 08041 ,","place":["Spain"]},{"name":"Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau , Barcelona 08025 ,","place":["Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB) Department of Medicine, , Barcelona 08193 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-2459","authenticated-orcid":false,"given":"Lina","family":"Badimon","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Pau (IR SANT PAU) \u00a0 Barcelona 08041 ,","place":["Spain"]},{"name":"Cardiovascular Research Foundation for Health Prevention and Innovation (FICSI) , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-4106","authenticated-orcid":false,"given":"Gemma","family":"Arderiu","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Pau (IR SANT PAU) \u00a0 Barcelona 08041 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares (CIBERCV) , Av. 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