{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:17Z","timestamp":1792785857641,"version":"4.5.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["2023-03332"],"award-info":[{"award-number":["2023-03332"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["2025-0805"],"award-info":[{"award-number":["2025-0805"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2024-03314"],"award-info":[{"award-number":["2024-03314"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-STG-2015-679242"],"award-info":[{"award-number":["ERC-STG-2015-679242"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gothenburg University"},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5ne University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish National Health Service"},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wallenberg Center for Molecular Medicine in Lund","award":["Dnr 349-2006-237"],"award-info":[{"award-number":["Dnr 349-2006-237"]}]},{"name":"Strategic Research Area Exodiab","award":["Dnr 2009-1039"],"award-info":[{"award-number":["Dnr 2009-1039"]}]},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"publisher","award":["Dnr IRC15-0067"],"award-info":[{"award-number":["Dnr IRC15-0067"]}],"id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lund University Diabetes Center","id":[{"id":"https:\/\/ror.org\/012a77v79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Stig and Ragna Gorthon Foundation","award":["2018-1480"],"award-info":[{"award-number":["2018-1480"]}],"id":[{"id":"https:\/\/ror.org\/0192sgm30","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Thorsten-Birger Segerfalk Foundation"},{"name":"SciLifeLab & Wallenberg Data Driven Life Science Program","award":["KAW 2020.0239"],"award-info":[{"award-number":["KAW 2020.0239"]}]},{"name":"SciLifeLab & Wallenberg Data Driven Life Science Program","award":["2022-01529_VR"],"award-info":[{"award-number":["2022-01529_VR"]}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/COE14"],"award-info":[{"award-number":["10.55776\/COE14"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010109","name":"Medical University of Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019802","name":"BioTechMed-Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019802","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/cvr\/cvag221","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:42:59Z","timestamp":1790682179000},"source":"Crossref","is-referenced-by-count":0,"title":["Age-related changes in spermidine and association with incident heart failure"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8904-504X","authenticated-orcid":false,"given":"Andrew I","family":"Lyon","sequence":"first","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Faculty of Medicine, Lund University , Lund SE-221 85 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Lejonberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Faculty of Medicine, Lund University , Lund SE-221 85 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-4318","authenticated-orcid":false,"given":"Ulrika","family":"Ericson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Czuba","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Faculty of Medicine, Lund University , Lund SE-221 85 ,","place":["Sweden"]},{"name":"The Wallenberg Laboratory\/Department of Molecular and Clinical Medicine, Institute of Medicine and SciLifeLab, Gothenburg University , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5042-9054","authenticated-orcid":false,"given":"Mahmoud","family":"Abdellatif","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-0273","authenticated-orcid":false,"given":"Jakub","family":"Morze","sequence":"additional","affiliation":[{"name":"The Wallenberg Laboratory\/Department of Molecular and Clinical Medicine, Institute of Medicine and SciLifeLab, Gothenburg University , Gothenburg ,","place":["Sweden"]},{"name":"Department of Life Sciences, SciLifeLab, Chalmers University of Technology , Gothenburg ,","place":["Sweden"]},{"name":"College of Medical Sciences, SGMK Copernicus University , Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-484X","authenticated-orcid":false,"given":"Olle","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-279X","authenticated-orcid":false,"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-877X","authenticated-orcid":false,"given":"Clemens","family":"Wittenbecher","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, SciLifeLab, Chalmers University of Technology , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-6821","authenticated-orcid":false,"given":"Simon","family":"Sedej","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Graz , Graz ,","place":["Austria"]},{"name":"Institute of Physiology, Faculty of Medicine , University of Maribor, Maribor ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Levin","sequence":"additional","affiliation":[{"name":"The Wallenberg Laboratory\/Department of Molecular and Clinical Medicine, Institute of Medicine and SciLifeLab, Gothenburg University , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-2503","authenticated-orcid":false,"given":"Marju","family":"Orho-Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-9152","authenticated-orcid":false,"given":"Gunnar","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7402-3139","authenticated-orcid":false,"given":"Olof","family":"Gidl\u00f6f","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Faculty of Medicine, Lund University , Lund SE-221 85 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Gustav","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences, Faculty of Medicine, Lund University , Lund SE-221 85 ,","place":["Sweden"]},{"name":"The Wallenberg Laboratory\/Department of Molecular and Clinical Medicine, Institute of Medicine and SciLifeLab, Gothenburg University , Gothenburg ,","place":["Sweden"]},{"name":"Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University , Lund ,","place":["Sweden"]},{"name":"Department of Heart Failure and Valvular Disease, Sk\u00e5ne University Hospital , Lund ,","place":["Sweden"]},{"name":"Department of Cardiology, Sahlgrenska University Hospital , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"2026101313281292100_cvag221-B1","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat Med"},{"key":"2026101313281292100_cvag221-B2","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1093\/eurheartj\/ehag110","article-title":"Heart failure in the elderly: epidemiology, mechanisms, and management","volume":"47","author":"de Boer","year":"2026","journal-title":"Eur Heart J"},{"key":"2026101313281292100_cvag221-B3","doi-asserted-by":"crossref","first-page":"650","DOI":"10.18632\/aging.102647","article-title":"Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"2026101313281292100_cvag221-B4","doi-asserted-by":"crossref","first-page":"e016055","DOI":"10.1161\/JAHA.120.016055","article-title":"N8-acetylspermidine: a polyamine biomarker in ischemic cardiomyopathy with reduced ejection fraction","volume":"9","author":"Nayak","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2026101313281292100_cvag221-B5","doi-asserted-by":"crossref","first-page":"e039248","DOI":"10.1161\/JAHA.124.039248","article-title":"Metabolite profiles of heart failure, central hemodynamic derangement, and response to heart transplantation","volume":"14","author":"Lejonberg","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"2026101313281292100_cvag221-B6","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1038\/s41467-019-13306-y","article-title":"Profiling of the plasma proteome across different stages of human heart failure","volume":"10","author":"Egerstedt","year":"2019","journal-title":"Nat Commun"},{"key":"2026101313281292100_cvag221-B7","doi-asserted-by":"crossref","first-page":"8933","DOI":"10.1038\/s41598-024-59388-7","article-title":"Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts","volume":"14","author":"Ghosh","year":"2024","journal-title":"Sci Rep"},{"key":"2026101313281292100_cvag221-B8","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s43587-022-00322-9","article-title":"Mechanisms of spermidine-induced autophagy and geroprotection","volume":"2","author":"Hofer","year":"2022","journal-title":"Nat Aging"},{"key":"2026101313281292100_cvag221-B9","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2788","article-title":"Spermidine in health and disease","volume":"359","author":"Madeo","year":"2018","journal-title":"Science"},{"key":"2026101313281292100_cvag221-B10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/jcmm.12674","article-title":"Correlation between endogenous polyamines in human cardiac tissues and clinical parameters in patients with heart failure","volume":"20","author":"Meana","year":"2016","journal-title":"J Cell Mol Med"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvag221\/71487497\/cvag221.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvag221\/71487497\/cvag221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:28:22Z","timestamp":1791912502000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/advance-article\/doi\/10.1093\/cvr\/cvag221\/8849016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvag221","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"cvag221"}}