{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:40:27Z","timestamp":1784133627822,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"DOI":"10.1093\/cvr\/cvn101","type":"journal-article","created":{"date-parts":[[2008,4,26]],"date-time":"2008-04-26T00:25:49Z","timestamp":1209169549000},"page":"448-457","source":"Crossref","is-referenced-by-count":36,"title":["Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency"],"prefix":"10.1093","volume":"79","author":[{"given":"Simon T.","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D.","family":"Bamforth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiann-Mun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra R.","family":"Farthing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Franklyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Broadbent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen E.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Saga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lewandoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoumo","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,25]]},"reference":[{"key":"key\n\t\t\t\t20170523015308_CVN101C1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1101\/gad.13.1.64","article-title":"Functional role of p35srj, a novel p300\/CBP binding protein, during transactivation by HIF-1","volume":"13","author":"Bhattacharya","year":"1999","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170523015308_CVN101C2","doi-asserted-by":"crossref","first-page":"16021","DOI":"10.1074\/jbc.M208144200","article-title":"Physical and functional interactions among AP-2 transcription factors, p300\/CREB-binding protein, and CITED2","volume":"278","author":"Braganca","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015308_CVN101C3","doi-asserted-by":"crossref","first-page":"36159","DOI":"10.1074\/jbc.274.51.36159","article-title":"MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression","volume":"274","author":"Glenn","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015308_CVN101C4","doi-asserted-by":"crossref","first-page":"24053","DOI":"10.1074\/jbc.M401489200","article-title":"Identification of the CREB-binding protein\/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator","volume":"279","author":"Tien","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015308_CVN101C5","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1038\/sj.onc.1209552","article-title":"Cited2 modulates TGF-beta-mediated upregulation of MMP9","volume":"25","author":"Chou","year":"2006","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170523015308_CVN101C6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ng768","article-title":"Cardiac malformations, adrenal agenesis, neural crest defects exencephaly in mice lacking Cited2 a new Tfap2 co-activator","volume":"29","author":"Bamforth","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C7","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/ng1446","article-title":"Cited2 controls left-right patterning and heart development through a Nodal\u2192Pitx2c pathway","volume":"36","author":"Bamforth","year":"2004","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C8","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1242\/dev.01696","article-title":"Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development","volume":"132","author":"Weninger","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C9","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1073\/pnas.162371799","article-title":"The essential role of Cited2, a negative regulator for HIF-1{alpha}, in heart development and neurulation","volume":"99","author":"Yin","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523015308_CVN101C10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nrg732","article-title":"Establishment of vertebrate left-right asymmetry","volume":"3","author":"Hamada","year":"2002","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.07.038","article-title":"Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination","volume":"288","author":"Ramsdell","year":"2005","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170523015308_CVN101C12","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/humu.20262","article-title":"Identification and functional analysis of CITED2 mutations in patients with congenital heart defects","volume":"26","author":"Sperling","year":"2005","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20170523015308_CVN101C13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0925-4773(98)00011-2","article-title":"Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis","volume":"72","author":"Dunwoodie","year":"1998","journal-title":"Mech Dev"},{"key":"key\n\t\t\t\t20170523015308_CVN101C14","volume-title":"Short Protocols in Molecular Biology","author":"Ausubel","year":"1995"},{"key":"key\n\t\t\t\t20170523015308_CVN101C15","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/S0925-4773(03)00099-6","article-title":"Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain","volume":"119","author":"Hayashi","year":"2002","journal-title":"Mech Dev"},{"key":"key\n\t\t\t\t20170523015308_CVN101C16","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/dev.127.8.1607","article-title":"Fate of the mammalian cardiac neural crest","volume":"127","author":"Jiang","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C17","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1242\/dev.126.15.3437","article-title":"MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube","volume":"126","author":"Saga","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C18","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1242\/dev.01945","article-title":"Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development","volume":"132","author":"Perantoni","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/gene.10225","article-title":"Maternal inheritance of Cre activity in a Sox2Cre deleter strain","volume":"37","author":"Hayashi","year":"2003","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170523015308_CVN101C20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-213X-4-16","article-title":"Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique","volume":"4","author":"Schneider","year":"2004","journal-title":"BMC Dev Biol"},{"key":"key\n\t\t\t\t20170523015308_CVN101C21","first-page":"75","article-title":"Whole mount in situ hybridization of vertebrate embryos","volume-title":"In situ Hybridization","author":"Wilkinson","year":"1992"},{"key":"key\n\t\t\t\t20170523015308_CVN101C22","first-page":"107","article-title":"Quantitative analysis of ocular gene expression","volume-title":"Real-time PCR","author":"Peirson","year":"2006"},{"key":"key\n\t\t\t\t20170523015308_CVN101C23","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1093\/nar\/gng073","article-title":"Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis","volume":"31","author":"Peirson","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170523015308_CVN101C24","first-page":"41","article-title":"Data analysis and reporting","volume-title":"Real-time PCR","author":"Adams","year":"2006"},{"key":"key\n\t\t\t\t20170523015308_CVN101C25","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1242\/dev.00241","article-title":"Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells","volume":"130","author":"Tallquist","year":"2003","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C26","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1050-1738(01)00069-X","article-title":"Mesp1 expression is the earliest sign of cardiovascular development","volume":"10","author":"Saga","year":"2000","journal-title":"Trends Cardiovasc Med"},{"key":"key\n\t\t\t\t20170523015308_CVN101C28","volume-title":"The Anatomical Basis of Mouse Development","author":"Kaufman","year":"1999"},{"key":"key\n\t\t\t\t20170523015308_CVN101C29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ng785","article-title":"Phenotyping transgenic embryos: a rapid 3-D screening method based on episcopic fluorescence image capturing","volume":"30","author":"Weninger","year":"2002","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C30","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170523015308_CVN101C31","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1242\/dev.02086","article-title":"Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development","volume":"132","author":"Zhang","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C32","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev Cell"},{"key":"key\n\t\t\t\t20170523015308_CVN101C33","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00006.2003","article-title":"Cardiac chamber formation: development, genes, and evolution","volume":"83","author":"Moorman","year":"2003","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170523015308_CVN101C34","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1242\/dev.128.11.2039","article-title":"Regulation of left-right asymmetry by thresholds of Pitx2c activity","volume":"128","author":"Liu","year":"2001","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C35","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1242\/dev.126.20.4643","article-title":"Dosage requirement of Pitx2 for development of multiple organs","volume":"126","author":"Gage","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170523015308_CVN101C36","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jacc.2003.05.004","article-title":"NKX2.5 mutations in patients with congenital heart disease","volume":"42","author":"McElhinney","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170523015308_CVN101C37","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1161\/hc4601.098427","article-title":"NKX2.5 mutations in patients with tetralogy of fallot","volume":"104","author":"Goldmuntz","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523015308_CVN101C38","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1172\/JCI8154","article-title":"Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways","volume":"104","author":"Benson","year":"1999","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170523015308_CVN101C39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/81695","article-title":"Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects","volume":"26","author":"Bamford","year":"2000","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C40","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1086\/339079","article-title":"CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle","volume":"70","author":"Goldmuntz","year":"2002","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/sj.ejhg.5200526","article-title":"X-linked transposition of the great arteries and incomplete penetrance among males with a nonsense mutation in ZIC3","volume":"8","author":"Megarbane","year":"2000","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C42","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/ng1197-305","article-title":"X-linked situs abnormalities result from mutations in ZIC3","volume":"17","author":"Gebbia","year":"1997","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1086\/380998","article-title":"Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects","volume":"74","author":"Ware","year":"2004","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170523015308_CVN101C44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1097-2765(01)00162-9","article-title":"Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2","volume":"7","author":"Shiratori","year":"2001","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20170523015308_CVN101C45","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1101\/gad.13.19.2527","article-title":"Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation","volume":"13","author":"Yan","year":"1999","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170523015308_CVN101C46","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0960-9822(00)80059-7","article-title":"A role of the cryptic gene in the correct establishment of the left-right axis","volume":"9","author":"Gaio","year":"1999","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170523015308_CVN101C47","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1242\/dev.129.9.2293","article-title":"A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice","volume":"129","author":"Purandare","year":"2002","journal-title":"Development"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/79\/3\/448\/17391812\/cvn101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:30:36Z","timestamp":1631147436000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvn101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,25]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,4,25]]},"published-print":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvn101","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4,25]]}}}