{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:19:13Z","timestamp":1773299953943,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,15]]},"DOI":"10.1093\/cvr\/cvn107","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T00:23:50Z","timestamp":1209428630000},"page":"304-312","source":"Crossref","is-referenced-by-count":25,"title":["Vascular tolerance to nitroglycerin in ascorbate deficiency"],"prefix":"10.1093","volume":"79","author":[{"given":"Gerald","family":"W\u00f6lkart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Verena","family":"Wenzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Stessel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,4,28]]},"reference":[{"key":"key\n\t\t\t\t20170518151007_CVN107C1","first-page":"23","article-title":"Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine","volume":"3","author":"Katsuki","year":"1977","journal-title":"J Cycl Nucl Res"},{"key":"key\n\t\t\t\t20170518151007_CVN107C2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-4165(80)90297-4","article-title":"Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols","volume":"631","author":"Ignarro","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170518151007_CVN107C3","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.freeradbiomed.2004.06.013","article-title":"Nitrates and NO release: contemporary aspects in biological and medicinal chemistry","volume":"37","author":"Thatcher","year":"2004","journal-title":"Free Rad Biol Med"},{"key":"key\n\t\t\t\t20170518151007_CVN107C4","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1073\/pnas.122225199","article-title":"Identification of the enzymatic mechanism of nitroglycerin bioactivation","volume":"99","author":"Chen","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170518151007_CVN107C5","doi-asserted-by":"crossref","first-page":"12159","DOI":"10.1073\/pnas.0503723102","article-title":"An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation","volume":"102","author":"Chen","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170518151007_CVN107C6","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/01.ATV.0000179599.71086.89","article-title":"Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans","volume":"25","author":"Mackenzie","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1172\/JCI26564","article-title":"Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin","volume":"116","author":"Li","year":"2006","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518151007_CVN107C8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tcm.2006.05.001","article-title":"Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase","volume":"16","author":"Chen","year":"2006","journal-title":"Trends Cardiovasc Med"},{"key":"key\n\t\t\t\t20170518151007_CVN107C9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1074\/jbc.M606477200","article-title":"Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity: Implications for mitochondrial oxidative stress and nitrate tolerance","volume":"282","author":"Wenzel","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518151007_CVN107C10","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/01.RES.0000184694.03262.6d","article-title":"Explaining the phenomenon of nitrate tolerance","volume":"97","author":"M\u00fcnzel","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518151007_CVN107C11","first-page":"316","article-title":"Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines","volume":"250","author":"Bennett","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170518151007_CVN107C12","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/BJ20050565","article-title":"Effects of nitroglycerin\/L-cysteine on soluble guanylate cyclase: evidence for an activation\/inactivation equilibrium controlled by nitric oxide binding and haem oxidation","volume":"390","author":"Gorren","year":"2005","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170518151007_CVN107C13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1124\/mol.107.035642","article-title":"Bioactivation of nitroglycerin by ascorbate","volume":"72","author":"Kollau","year":"2007","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C14","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1093\/jn\/135.11.2530","article-title":"Scurvy leads to endoplasmic reticulum stress and apoptosis in the liver of guinea pigs","volume":"135","author":"Margittai","year":"2005","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20170518151007_CVN107C15","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(99)00056-4","article-title":"Interaction between capsaicin and nitrate tolerance in isolated guinea-pig heart","volume":"368","author":"Oroszi","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1042\/BJ20041354","article-title":"Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide","volume":"385","author":"Kollau","year":"2005","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170518151007_CVN107C17","doi-asserted-by":"crossref","first-page":"C895","DOI":"10.1152\/ajpcell.00028.2004","article-title":"Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay","volume":"287","author":"Fink","year":"2004","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C18","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cardiores.2006.08.004","article-title":"Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS","volume":"73","author":"Anselm","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518151007_CVN107C19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170518151007_CVN107C20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00500277","article-title":"Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle","volume":"310","author":"Kukovetz","year":"1979","journal-title":"Naunyn Schmiedeber\u01f5s Arch Pharmacol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C21","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.bjp.0707325","article-title":"Chronic endothelin-A receptor antagonism is as protective as angiotensin converting enzyme inhibition against cardiac dysfunction in diabetic rats","volume":"151","author":"W\u00f6lkart","year":"2007","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C22","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/sj.ejcn.1602655","article-title":"Stability of whole blood and plasma ascorbic acid","volume":"61","author":"Karlsen","year":"2007","journal-title":"Eur J Clin Nutr"},{"key":"key\n\t\t\t\t20170518151007_CVN107C23","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0891-5849(98)00259-7","article-title":"Effects of combined irradiation and doxorubicin treatment on cardiac function and antioxidant defenses in the rat","volume":"26","author":"Dalloz","year":"1999","journal-title":"Free Rad Biol Med"},{"key":"key\n\t\t\t\t20170518151007_CVN107C24","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/jn\/119.5.734","article-title":"Relationship between dietary intake and tissue levels of reduced and total vitamin C in the nonscorbutic guinea pig","volume":"119","author":"Berger","year":"1989","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20170518151007_CVN107C25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1172\/JCI977","article-title":"Dietary supplement with vitamin C prevents nitrate tolerance","volume":"102","author":"Bassenge","year":"1998","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518151007_CVN107C26","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0735-1097(98)00085-0","article-title":"Randomized, double-blind, placebo-controlled study of the preventive effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance","volume":"31","author":"Watanabe","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C27","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/01.CIR.97.9.886","article-title":"Randomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure","volume":"97","author":"Watanabe","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518151007_CVN107C28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-5793(98)00506-7","article-title":"Vitamin C attenuates nitrate tolerance independently of its antioxidant effect","volume":"428","author":"Hinz","year":"1998","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170518151007_CVN107C29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/niox.2001.0412","article-title":"The effect of oxidative stress on endothelium-dependent and nitric oxide donor-induced relaxation: Implications for nitrate tolerance","volume":"6","author":"Hanspal","year":"2002","journal-title":"Nitric Oxide Biol Chem"},{"key":"key\n\t\t\t\t20170518151007_CVN107C30","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/S0891-5849(00)00269-0","article-title":"How does ascorbic acid prevent endothelial dysfunction?","volume":"28","author":"May","year":"2000","journal-title":"Free Rad Biol Med"},{"key":"key\n\t\t\t\t20170518151007_CVN107C31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/00005344-199905000-00002","article-title":"Biochemical, hemodynamic, and vascular evidence concerning the free radical hypothesis of nitrate tolerance","volume":"33","author":"Milone","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1161\/01.CIR.0000021600.84149.78","article-title":"Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of supplemental ascorbate","volume":"106","author":"McVeigh","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518151007_CVN107C33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0021-9258(18)56291-8","article-title":"Effect of ascorbic acid deficiency on collagen content of guinea pig tissues","volume":"186","author":"Elster","year":"1950","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518151007_CVN107C34","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1083\/jcb.92.2.462","article-title":"Changes in the components of extracellular matrix and in growth properties of cultured aortic smooth muscle cells upon ascorbate feeding","volume":"92","author":"Schwartz","year":"1982","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C35","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/BF02631124","article-title":"Regulation of angiogenesis in vitro by collagen metabolism","volume":"27A","author":"Nicosia","year":"1991","journal-title":"In Vitro Cell Dev Biol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/jn\/129.1.83","article-title":"Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels","volume":"129","author":"Mahmoodian","year":"1999","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20170518151007_CVN107C37","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.97.2.841","article-title":"Aortic wall damage in mice unable to synthesize ascorbic acid","volume":"97","author":"Maeda","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170518151007_CVN107C38","first-page":"E1131","article-title":"Ascorbic acid-independent synthesis of collagen in mice","volume":"290","author":"Parsons","year":"2006","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170518151007_CVN107C39","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1161\/01.RES.86.1.e7","article-title":"Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability","volume":"86","author":"M\u00fcnzel","year":"2000","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518151007_CVN107C40","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI200419267","article-title":"Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance","volume":"113","author":"Sydow","year":"2004","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518151007_CVN107C41","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0022-3565(24)37672-4","article-title":"Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate tolerance","volume":"286","author":"Dikalov","year":"1998","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/79\/2\/304\/17197381\/cvn107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T23:01:59Z","timestamp":1738191719000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvn107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,28]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,4,28]]},"published-print":{"date-parts":[[2008,7,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvn107","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4,28]]}}}