{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:49:35Z","timestamp":1776257375903,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"DOI":"10.1093\/cvr\/cvq390","type":"journal-article","created":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T01:48:53Z","timestamp":1293760133000},"page":"38-48","source":"Crossref","is-referenced-by-count":39,"title":["Insights into sick sinus syndrome from an inducible mouse model"],"prefix":"10.1093","volume":"90","author":[{"given":"Stefan","family":"Herrmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Fabritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Layh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,12,30]]},"reference":[{"key":"key\n\t\t\t\t20170519081047_CVQ390C1","first-page":"1725","article-title":"Diagnosis and treatment of sick sinus syndrome","volume":"67","author":"Adan","year":"2003","journal-title":"Am Fam Physician"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/978-3-662-10315-9_23","article-title":"Sick sinus syndrome (and carotid sinus syndrome)","volume-title":"The ECG: a Two-Step Approach to Diagnosis","author":"Gertsch","year":"2004"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C3","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1161\/CIRCULATIONAHA.106.616011","article-title":"New insights into pacemaker activity: promoting understanding of sick sinus syndrome","volume":"115","author":"Dobrzynski","year":"2007","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1056\/NEJM200003093421006","article-title":"The evaluation and management of bradycardia","volume":"342","author":"Mangrum","year":"2000","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0002-9149(73)90302-0","article-title":"Tachycardia-bradycardia syndrome (so-called \u201csick sinus syndrome\u201d). Pathology, mechanisms and treatment","volume":"31","author":"Kaplan","year":"1973","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C6","first-page":"26","article-title":"Update on sick sinus syndrome, a cardiac disorder of aging","volume":"45","author":"Rodriguez","year":"1990","journal-title":"Geriatrics"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJM199601113340206","article-title":"Cardiac pacing","volume":"334","author":"Kusumoto","year":"1996","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C8","article-title":"Sinus node dysfunction","author":"Yang","year":"2010","journal-title":"eMedicine Cardiology"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yjmcc.2008.04.008","article-title":"Tamoxifen-inducible gene deletion in the cardiac conduction system","volume":"45","author":"Hoesl","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/gene.20162","article-title":"In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A","volume":"43","author":"Ivanova","year":"2005","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C11","doi-asserted-by":"crossref","first-page":"15235","DOI":"10.1073\/pnas.2434235100","article-title":"The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart","volume":"100","author":"Stieber","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C13","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1038\/sj.emboj.7601868","article-title":"HCN4 provides a \u2018depolarization reserve\u2019 and is not required for heart rate acceleration in mice","volume":"26","author":"Herrmann","year":"2007","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/emboj\/cdg032","article-title":"Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2","volume":"22","author":"Ludwig","year":"2003","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C15","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.hrthm.2010.08.016","article-title":"Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability","volume":"7","author":"Blana","year":"2010","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1997.7124","article-title":"Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains","volume":"237","author":"Feil","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C17","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1046\/j.1432-1327.2001.02036.x","article-title":"Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues","volume":"268","author":"Moosmang","year":"2001","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C18","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/01.RES.0000101913.95604.B9","article-title":"Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart","volume":"93","author":"Dobrzynski","year":"2003","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cardiores.2006.11.016","article-title":"Organisation of the mouse sinoatrial node: structure and expression of HCN channels","volume":"73","author":"Liu","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/jphysiol.2004.074047","article-title":"Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart","volume":"562","author":"Marionneau","year":"2005","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C21","first-page":"1215","volume-title":"Sinus Node Dysfunction: Pathophysiology, Clinical Features, Evaluation, and Treatment","author":"Benditt","year":"1995","edition":"2nd ed."},{"key":"key\n\t\t\t\t20170519081047_CVQ390C22","first-page":"77","article-title":"Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels: from genes to function","volume-title":"Cardiac Electrophysiology: From Cell to Bedside","author":"Stieber","year":"2009","edition":"5th ed"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jelectrocard.2005.06.096","article-title":"Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation","volume":"38","author":"Kohl","year":"2005","journal-title":"J Electrocardiol"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C24","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1161\/CIRCULATIONAHA.108.804369","article-title":"Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker","volume":"119","author":"Chandler","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1050-1738(01)00134-7","article-title":"Arrhythmogenic ionic remodeling: adaptive responses with maladaptive consequences","volume":"11","author":"Nattel","year":"2001","journal-title":"Trends Cardiovasc Med"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCEP.107.754564","article-title":"Atrial remodeling and atrial fibrillation: mechanisms and implications","volume":"1","author":"Nattel","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/419132b","article-title":"Biological pacemaker created by gene transfer","volume":"419","author":"Miake","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cardiores.2004.05.012","article-title":"Genes, stem cells and biological pacemakers","volume":"64","author":"Rosen","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11517-006-0138-x","article-title":"Embryological development of pacemaker hierarchy and membrane currents related to the function of the adult sinus node: implications for autonomic modulation of biopacemakers","volume":"45","author":"Opthof","year":"2007","journal-title":"Med Biol Eng Comput"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.yjmcc.2008.12.001","article-title":"Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells","volume":"46","author":"Barbuti","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170519081047_CVQ390C31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.109.212936","article-title":"Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices?","volume":"106","author":"Cho","year":"2010","journal-title":"Circ Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/90\/1\/38\/17235959\/cvq390.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T19:26:59Z","timestamp":1503430019000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvq390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,30]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,12,30]]},"published-print":{"date-parts":[[2011,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvq390","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12,30]]}}}