{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:02:02Z","timestamp":1793278922780,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"DOI":"10.1093\/cvr\/cvr209","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T02:58:47Z","timestamp":1311908327000},"page":"218-225","source":"Crossref","is-referenced-by-count":150,"title":["Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model"],"prefix":"10.1093","volume":"92","author":[{"given":"Olympia","family":"Bikou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dierk","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Trappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lugenbiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla","family":"Kelemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radim","family":"Soucek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,28]]},"reference":[{"key":"key\n\t\t\t\t20170523011103_CVR209C1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0140-6736(10)60096-7","article-title":"New antiarrhythmic drugs for treatment of atrial fibrillation","volume":"375","author":"Dobrev","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170523011103_CVR209C2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0002-8703(83)90208-9","article-title":"Coronary heart disease and atrial fibrillation: the Framingham Study","volume":"106","author":"Kannel","year":"1983","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20170523011103_CVR209C3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0002-9343(99)80348-9","article-title":"The natural history of atrial fibrillation: incidence, risk factors, and prognosis in the Manitoba Follow-Up Study","volume":"98","author":"Krahn","year":"1995","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t20170523011103_CVR209C4","doi-asserted-by":"crossref","first-page":"2D","DOI":"10.1016\/S0002-9149(02)03373-8","article-title":"Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy","volume":"91","author":"Maisel","year":"2003","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C5","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.CIR.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: the Framingham Heart Study","volume":"98","author":"Benjamin","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011103_CVR209C6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00001573-199701000-00005","article-title":"Drug treatment of atrial fibrillation: what have we learned?","volume":"12","author":"Hohnloser","year":"1997","journal-title":"Curr Opin Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Haissaguerre","year":"1998","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170523011103_CVR209C8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jacc.2004.10.035","article-title":"Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural failure","volume":"45","author":"Verma","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1540-8167.2008.01187.x","article-title":"State of the art: catheter ablation of atrial fibrillation","volume":"19","author":"Wright","year":"2008","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/jama.2009.2029","article-title":"Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial","volume":"303","author":"Wilber","year":"2010","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170523011103_CVR209C11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/HCO.0b013e3282f2e27c","article-title":"Atrial-fibrillation ablation should be considered first-line therapy for some patients","volume":"23","author":"Verma","year":"2008","journal-title":"Curr Opin Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/415219a","article-title":"New ideas about atrial fibrillation 50 years on","volume":"415","author":"Nattel","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170523011103_CVR209C13","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nm.2124","article-title":"Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation","volume":"16","author":"Rudolph","year":"2010","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170523011103_CVR209C14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00232-001-0129-7","article-title":"Isolation and community: a review of the role of gap-junctional communication in embryonic patterning","volume":"185","author":"Levin","year":"2002","journal-title":"J Membr Biol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C15","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1161\/01.RES.76.3.366","article-title":"The stochastic nature of cardiac propagation at a microscopic level. Electrical description of myocardial architecture and its application to conduction","volume":"76","author":"Spach","year":"1995","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523011103_CVR209C16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yjmcc.2009.05.014","article-title":"Connexin40 and connexin43 determine gating properties of atrial gap junction channels","volume":"48","author":"Lin","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C17","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1006\/jmcc.1999.0937","article-title":"Chamber-related differences in connexin expression in the human heart","volume":"31","author":"Vozzi","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C18","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1161\/01.RES.0000141134.64811.0a","article-title":"Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation","volume":"95","author":"Firouzi","year":"2004","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523011103_CVR209C19","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1056\/NEJMoa052800","article-title":"Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation","volume":"354","author":"Gollob","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170523011103_CVR209C20","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1161\/CIRCULATIONAHA.110.961227","article-title":"Paradigm of genetic mosaicism and lone atrial fibrillation: physiological characterization of a connexin 43-deletion mutant identified from atrial tissue","volume":"122","author":"Thibodeau","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011103_CVR209C21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/cvr\/cvp203","article-title":"The role of connexin40 in atrial fibrillation","volume":"84","author":"Chaldoupi","year":"2009","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523011103_CVR209C22","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000092579","article-title":"Cx40 polymorphism in human atrial fibrillation","volume":"42","author":"Hauer","year":"2006","journal-title":"Adv Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCEP.110.959726","article-title":"A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation","volume":"4","author":"Wirka","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.yjmcc.2007.08.016","article-title":"Is there a role for remodeled connexins in AF? No simple answers","volume":"44","author":"Duffy","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.00014.2006","article-title":"Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation","volume":"87","author":"Nattel","year":"2007","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170523011103_CVR209C26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000210398","article-title":"Decreased connexin 43 and increased fibrosis in atrial regions susceptible to complex fractionated atrial electrograms","volume":"114","author":"Liu","year":"2009","journal-title":"Cardiology"},{"key":"key\n\t\t\t\t20170523011103_CVR209C27","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cardiores.2003.12.013","article-title":"Pathophysiological findings in a model of persistent atrial fibrillation and severe congestive heart failure","volume":"61","author":"Bauer","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523011103_CVR209C28","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1161\/01.CIR.0000147185.31974.BE","article-title":"Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation","volume":"110","author":"Bauer","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011103_CVR209C29","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1365-201X.2003.01093.x","article-title":"Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research","volume":"177","author":"Gehl","year":"2003","journal-title":"Acta Physiol Scand"},{"key":"key\n\t\t\t\t20170523011103_CVR209C30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s003950170068","article-title":"Effects of propafenone on anisotropic conduction properties within the three-dimensional structure of the canine ventricular wall","volume":"96","author":"Bauer","year":"2001","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/01.CIR.0000153338.47507.83","article-title":"Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer","volume":"111","author":"Kikuchi","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011103_CVR209C32","first-page":"H310","article-title":"Intrapericardial administration of adenovirus for gene transfer","volume":"272","author":"Lamping","year":"1997","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C33","doi-asserted-by":"crossref","first-page":"11498","DOI":"10.1073\/pnas.90.24.11498","article-title":"Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo","volume":"90","author":"Kass-Eisler","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523011103_CVR209C34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/156652306778520656","article-title":"Electrotransfer into skeletal muscle for protein expression","volume":"6","author":"Trollet","year":"2006","journal-title":"Curr Gene Ther"},{"key":"key\n\t\t\t\t20170523011103_CVR209C35","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCEP.107.754564","article-title":"Atrial remodeling and atrial fibrillation: mechanisms and implications","volume":"1","author":"Nattel","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2009.08.018","article-title":"Cardiac connexins and impulse propagation","volume":"48","author":"Jansen","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170523011103_CVR209C37","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1161\/01.RES.84.10.1144","article-title":"Hetero-domain interactions as a mechanism for the regulation of connexin channels","volume":"84","author":"Stergiopoulos","year":"1999","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523011103_CVR209C38","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1161\/CIRCULATIONAHA.109.911156","article-title":"Selective molecular potassium channel blockade prevents atrial fibrillation","volume":"121","author":"Amit","year":"2010","journal-title":"Circulation"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/92\/2\/218\/17390552\/cvr209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T21:11:42Z","timestamp":1503436302000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvr209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,28]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,7,28]]},"published-print":{"date-parts":[[2011,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvr209","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,28]]}}}