{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:56:13Z","timestamp":1791294973167,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Research"],"published-print":{"date-parts":[[2012,2,1]]},"DOI":"10.1093\/cvr\/cvr301","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T02:20:26Z","timestamp":1320805226000},"page":"311-319","source":"Crossref","is-referenced-by-count":97,"title":["Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A\/C gene"],"prefix":"10.1093","volume":"93","author":[{"given":"A.","family":"Muchir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Worman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,11,8]]},"reference":[{"issue":"7","key":"1_35261261","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1172\/JCI37679","volume":"119","author":"Worman","year":"2009","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"3","key":"2_10751660","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/6799","volume":"21","author":"Bonne","year":"1999","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"23","key":"3_6375178","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1056\/NEJM199912023412302","volume":"341","author":"Fatkin","year":"1999","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"9","key":"4_10319474","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/hmg\/9.9.1453","volume":"9","author":"Muchir","year":"2000","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"5","key":"5_17532814","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/S0735-1097(02)02954-6","volume":"41","author":"Taylor","year":"2003","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"1","key":"6_31404092","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ahj.2008.01.026","volume":"156","author":"Parks","year":"2008","journal-title":"American heart journal","ISSN":"https:\/\/id.crossref.org\/issn\/0002-8703","issn-type":"print"},{"issue":"6","key":"7_16961479","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/S0735-1097(02)01724-2","volume":"39","author":"Arbustini","year":"2002","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"1","key":"8_18611904","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00109-004-0589-1","volume":"83","author":"van Berlo","year":"2005","journal-title":"Journal of molecular medicine (Berlin, Germany)","ISSN":"https:\/\/id.crossref.org\/issn\/0377-046X","issn-type":"print"},{"issue":"15","key":"9_32015918","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.jacc.2008.06.044","volume":"52","author":"Pasotti","year":"2008","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"10","key":"10_28825329","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1016\/j.yexcr.2007.03.026","volume":"313","author":"Stewart","year":"2007","journal-title":"Experimental cell research","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4827","issn-type":"print"},{"issue":"1","key":"11_18576023","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/hmg\/ddi017","volume":"14","year":"2005","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"5","key":"12_28494742","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1172\/JCI29042","volume":"117","author":"Muchir","year":"2007","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"2","key":"13_32212766","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/hmg\/ddn343","volume":"18","year":"2009","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"7-8","key":"14_37108276","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbadis.2010.04.001","volume":"1802","author":"Wu","year":"2010","journal-title":"Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"issue":"1","key":"15_38852058","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1161\/CIRCULATIONAHA.110.970673","volume":"123","year":"2011","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"16_41382607","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-8722-3-8","volume":"3","year":"2010","journal-title":"J HEMAT ONCOL"},{"key":"17_41382608","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00280-010-1323-z","volume":"67","year":"2010","journal-title":"Cancer chemotherapy and pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0344-5704","issn-type":"print"},{"key":"18_41382609","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1158\/1078-0432.CCR-06-1150","volume":"13","year":"2001","journal-title":"Clinical Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"issue":"13","key":"19_30776904","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1200\/JCO.2007.14.4956","volume":"26","year":"2008","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"17","key":"20_39789885","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1200\/JCO.2010.33.9473","volume":"29","year":"2011","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"17","key":"21_39789915","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1200\/JCO.2010.33.9432","volume":"29","year":"2011","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"key":"22_41382610","first-page":"285","volume":"114","year":"2009","journal-title":"BLOOD ASH ANNUAL MEETING ABSTRACTS"},{"key":"23_18173880","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1472-6750-3-18","volume":"3","author":"Ponchel","year":"2003","journal-title":"BMC biotechnology [electronic resource]","ISSN":"https:\/\/id.crossref.org\/issn\/1472-6750","issn-type":"print"},{"key":"24_23863854","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2307\/2281868","volume":"53","year":"1958","ISSN":"https:\/\/id.crossref.org\/issn\/0162-1459","issn-type":"print"},{"issue":"14","key":"25_36936658","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.jacc.2009.10.065","volume":"55","author":"Arimura","year":"2010","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"13","key":"26_37710255","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1016\/j.ejca.2010.06.121","volume":"46","author":"Hutson","year":"2010","journal-title":"European journal of cancer (Oxford, England : 1990)","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8049","issn-type":"print"},{"issue":"41","key":"27_19557378","doi-asserted-by":"publisher","first-page":"38988","DOI":"10.1074\/jbc.M205511200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"5 Suppl 1","key":"28_10547544","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1097\/00005344-200036051-00046","volume":"36","author":"Huang","year":"2000","journal-title":"Journal of cardiovascular pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0160-2446","issn-type":"print"},{"issue":"3","key":"29_39293057","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1172\/JCI44929","volume":"121","author":"Wu","year":"2011","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"5","key":"30_11047091","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1161\/01.CIR.103.5.670","volume":"103","author":"Haq","year":"2001","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"1","key":"31_31345761","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/CIRCULATIONAHA.108.776831","volume":"118","author":"Chen","year":"2008","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/93\/2\/311\/17393661\/cvr301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T04:16:11Z","timestamp":1593231371000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvr301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,8]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,1,16]]},"published-print":{"date-parts":[[2012,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvr301","relation":{},"ISSN":["0008-6363"],"issn-type":[{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,8]]}}}