{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:45:09Z","timestamp":1773290709760,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"DOI":"10.1093\/cvr\/cvr305","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T06:23:35Z","timestamp":1321943015000},"page":"397-405","source":"Crossref","is-referenced-by-count":30,"title":["Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis"],"prefix":"10.1093","volume":"93","author":[{"given":"Andrey","family":"Kazakov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Jagoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Semenov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Laufs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"key\n\t\t\t\t20170523011206_CVR305C1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7326\/0003-4819-71-1-89","article-title":"Left ventricular hypertrophy by electrocardiogram. Prevalence, incidence, and mortality in the Framingham study","volume":"71","author":"Kannel","year":"1969","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20170523011206_CVR305C2","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1161\/01.CIR.0000039105.49749.6F","article-title":"Lifetime risk for developing congestive heart failure: the Framingham Heart Study","volume":"106","author":"Lloyd-Jones","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011206_CVR305C3","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/00005344-198700106-00006","article-title":"Physiologic versus pathologic hypertrophy and the pressure-overloaded myocardium","volume":"10","author":"Weber","year":"1987","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/jmcc.1996.0014","article-title":"Coronary vascular morphology in pressure-overload left ventricular hypertrophy","volume":"28","author":"Bishop","year":"1996","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170523011206_CVR305C6","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170523011206_CVR305C7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.mvr.2009.12.004","article-title":"Endothelial progenitor cells\u2014an evolving story","volume":"79","author":"Pearson","year":"2010","journal-title":"Microvasc Res"},{"key":"key\n\t\t\t\t20170523011206_CVR305C8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ijcard.2010.04.018","article-title":"Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: focus on PI3K\/AKT\/eNOS pathway","volume":"144","author":"Everaert","year":"2010","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/cvr\/cvp123","article-title":"ACE inhibition promotes upregulation of endothelial progenitor cells and neoangiogenesis in cardiac pressure overload","volume":"83","author":"M\u00fcller","year":"2009","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523011206_CVR305C10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00392-007-0494-z","article-title":"Hormonal status modulates circulating endothelial progenitor cells","volume":"96","author":"Bulut","year":"2007","journal-title":"Clin Res Cardiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00392-008-0739-5","article-title":"Endothelial progenitor cells in adolescents: impact of overweight, age, smoking, sport and cytokines in younger age","volume":"98","author":"Jung","year":"2009","journal-title":"Clin Res Cardiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijcard.2008.08.033","article-title":"Endothelial progenitor cells and cardiovascular homeostasis: clinical implications","volume":"131","author":"Pompilio","year":"2009","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C13","doi-asserted-by":"crossref","first-page":"H2371","DOI":"10.1152\/ajpheart.00383.2002","article-title":"Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis","volume":"283","author":"Zhao","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C14","doi-asserted-by":"crossref","first-page":"H1070","DOI":"10.1152\/ajpheart.00940.2003","article-title":"Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency","volume":"286","author":"Ichinose","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C15","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.cardiores.2005.01.021","article-title":"Concentric left ventricular remodeling in endothelial nitric oxide synthase knockout mice by chronic pressure overload","volume":"66","author":"Ruetten","year":"2005","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523011206_CVR305C16","doi-asserted-by":"crossref","first-page":"H620","DOI":"10.1152\/ajpheart.01236.2006","article-title":"Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload","volume":"293","author":"Buys","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.CIR.0000109141.48980.37","article-title":"Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis","volume":"109","author":"Laufs","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011206_CVR305C18","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.ATV.0000036417.43987.D8","article-title":"Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition","volume":"22","author":"Werner","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/cvr\/cvm037","article-title":"Pressure-induced cardiac overload induces upregulation of endothelial and myocardial progenitor cells","volume":"77","author":"M\u00fcller","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523011206_CVR305C20","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/01.RES.0000083812.30141.74","article-title":"Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury","volume":"93","author":"Werner","year":"2003","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523011206_CVR305C21","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nm948","article-title":"Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells","volume":"9","author":"Aicher","year":"2003","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170523011206_CVR305C22","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/01.CIR.0000157144.24888.7E","article-title":"Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via \u2018imported\u2019 nitric oxide synthase activity","volume":"111","author":"Masaaki","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011206_CVR305C23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/CIRCULATIONAHA.105.589937","article-title":"Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy","volume":"114","author":"You","year":"2006","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011206_CVR305C24","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1073\/pnas.0604144103","article-title":"Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy","volume":"103","author":"Sasaki","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523011206_CVR305C25","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1161\/01.CIR.103.23.2839","article-title":"Dysfunctional regulation of endothelial nitric oxide synthase (eNOS) expression in response to exercise in mice lacking one eNOS gene","volume":"103","author":"Kojda","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523011206_CVR305C26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00421-006-0161-5","article-title":"Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosis","volume":"97","author":"Lee","year":"2006","journal-title":"Eur J Appl Physiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C27","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.yjmcc.2010.02.005","article-title":"Beneficial effects of exercise training after myocardial infarction require full eNOS expression","volume":"48","author":"de Waard","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C28","doi-asserted-by":"crossref","first-page":"H285","DOI":"10.1152\/ajpheart.00560.2006","article-title":"Chronic NOS inhibition actuates endothelial\u2013mesenchymal transformation","volume":"292","author":"O'Riordan","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C29","doi-asserted-by":"crossref","first-page":"L301","DOI":"10.1152\/ajplung.00065.2010","article-title":"Functional consequences of the collagen\/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS\u2212\/\u2212, and iNOS\u2212\/\u2212 mice","volume":"299","author":"Steed","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C30","doi-asserted-by":"crossref","first-page":"F317","DOI":"10.1152\/ajprenal.90450.2008","article-title":"Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse","volume":"296","author":"Nakayama","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2008.04.034","article-title":"Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways and apoptosis","volume":"52","author":"Werner","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170523011206_CVR305C32","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1474-9726.2010.00567.x","article-title":"Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status","volume":"9","author":"Le","year":"2010","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20170523011206_CVR305C33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/cvr\/cvp215","article-title":"Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction","volume":"84","author":"Perry","year":"2009","journal-title":"Cardiovasc Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/93\/3\/397\/17391200\/cvr305.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:56:43Z","timestamp":1503449803000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvr305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2012,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvr305","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11,21]]}}}