{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:39:38Z","timestamp":1790872778644,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,15]]},"DOI":"10.1093\/cvr\/cvs130","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T20:58:48Z","timestamp":1333573128000},"page":"241-250","source":"Crossref","is-referenced-by-count":61,"title":["Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1\/2 pathway in apoE\u2212\/\u2212 mice"],"prefix":"10.1093","volume":"95","author":[{"given":"Xiaoqin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"key\n\t\t\t\t20170518142619_CVS130C1","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully","year":"1969","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00043798-199808000-00001","article-title":"Homocysteine and cardiovascular disease. Overview","volume":"5","author":"Clarke","year":"1998","journal-title":"J Cardiovasc Risk"},{"key":"key\n\t\t\t\t20170518142619_CVS130C3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes","volume":"274","author":"Boushey","year":"1995","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170518142619_CVS130C4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00045415-199903000-00013","article-title":"Homocysteine: evidence for a causal relationship with cardiovascular disease","volume":"7","author":"Scott","year":"1999","journal-title":"Cardiol Rev"},{"key":"key\n\t\t\t\t20170518142619_CVS130C5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-2000-8096","article-title":"Mild hyperhomocysteinemia is an independent risk factor of arterial vascular disease","volume":"26","author":"Boers","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"key\n\t\t\t\t20170518142619_CVS130C6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170518142619_CVS130C7","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170518142619_CVS130C8","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"Bonaa","year":"2006","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170518142619_CVS130C9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease","volume":"337","author":"Nygard","year":"1997","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170518142619_CVS130C10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/ajcn\/74.6.723","article-title":"Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine","volume":"74","author":"Kerins","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t20170518142619_CVS130C11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jn\/138.2.311","article-title":"Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine","volume":"138","author":"Liu","year":"2008","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20170518142619_CVS130C12","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1017\/S0007114509993552","article-title":"Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations","volume":"103","author":"Green","year":"2010","journal-title":"Br J Nutr"},{"key":"key\n\t\t\t\t20170518142619_CVS130C13","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/jn\/138.5.980","article-title":"Plasma S-adenosylhomocysteine versus homocysteine as a marker for vascular disease","volume":"138","author":"Wagner","year":"2008","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20170518142619_CVS130C14","doi-asserted-by":"crossref","first-page":"C1466","DOI":"10.1152\/ajpcell.00304.2009","article-title":"Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin","volume":"297","author":"Jiang","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C15","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/physrev.00047.2003","article-title":"Role of oxidative modifications in atherosclerosis","volume":"84","author":"Stocker","year":"2004","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170518142619_CVS130C16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.RES.0000108264.67601.2C","article-title":"Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress","volume":"94","author":"Au-Yeung","year":"2004","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142619_CVS130C17","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2007.1750","article-title":"Vascular oxidant stress and inflammation in hyperhomocysteinemia","volume":"9","author":"Papatheodorou","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170518142619_CVS130C18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1523-1755.2004.00795.x","article-title":"Activation of mesangial cell MAPK in response to homocysteine","volume":"66","author":"Ingram","year":"2004","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170518142619_CVS130C19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1385\/MB:14:3:197","article-title":"A flow cytometric protocol for titering recombinant adenoviral vectors containing the green fluorescent protein","volume":"14","author":"Hitt","year":"2000","journal-title":"Mol Biotechnol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C20","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/01.RES.81.5.829","article-title":"Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice","volume":"81","author":"Carmeliet","year":"1997","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142619_CVS130C21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0014-5793(94)80588-1","article-title":"Expression of protein kinase C isoforms in smooth muscle cells in various states of differentiation","volume":"342","author":"Assender","year":"1994","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170518142619_CVS130C22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0378-4347(91)80407-4","article-title":"Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum","volume":"565","author":"Ubbink","year":"1991","journal-title":"J Chromatogr"},{"key":"key\n\t\t\t\t20170518142619_CVS130C23","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1373\/clinchem.2004.046995","article-title":"Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma","volume":"51","author":"Gellekink","year":"2005","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t20170518142619_CVS130C24","doi-asserted-by":"crossref","first-page":"H540","DOI":"10.1152\/ajpheart.91478.2007","article-title":"TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation","volume":"297","author":"Tsai","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C25","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1158\/0008-5472.CAN-05-1103","article-title":"Cancer-associated PP2A alpha subunits induce functional haploinsufficiency and tumorigenicity","volume":"65","author":"Chen","year":"2005","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170518142619_CVS130C26","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/hy0302.105295","article-title":"Aldosterone and D-glucose stimulate the proliferation of human cardiac myofibroblasts in vitro","volume":"39","author":"Neumann","year":"2002","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170518142619_CVS130C27","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1172\/JCI200111927","article-title":"p47phox is required for atherosclerotic lesion progression in ApoE(\u2212\/\u2212) mice","volume":"108","author":"Barry-Lane","year":"2001","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518142619_CVS130C28","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/intimm\/8.7.1139","article-title":"S-adenosylhomocysteine as a physiological modulator of Apo-1-mediated apoptosis","volume":"8","author":"Ratter","year":"1996","journal-title":"Int Immunol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C29","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.bcp.2005.09.021","article-title":"Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine","volume":"70","author":"Kharbanda","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170518142619_CVS130C31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-0115(00)00178-6","article-title":"The multiple actions of angiotensin II in atherosclerosis","volume":"93","author":"Schmidt-Ott","year":"2000","journal-title":"Regul Pept"},{"key":"key\n\t\t\t\t20170518142619_CVS130C32","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.91.14.6369","article-title":"Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis","volume":"91","author":"Tsai","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl. 1","key":"key\n\t\t\t\t20170518142619_CVS130C33","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.cdd.4401451","article-title":"Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease","volume":"11","author":"Austin","year":"2004","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170518142619_CVS130C34","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1161\/ATVBAHA.107.148544","article-title":"Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells","volume":"27","author":"Jiang","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C35","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1096\/fasebj.11.13.9367351","article-title":"Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats","volume":"11","author":"Durand","year":"1997","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170518142619_CVS130C36","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/01.CIR.98.18.1848","article-title":"Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults","volume":"98","author":"Bellamy","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518142619_CVS130C37","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/hq0901.096582","article-title":"Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice","volume":"21","author":"Zhou","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170518142619_CVS130C38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/cvr\/cvr009","article-title":"Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats","volume":"90","author":"Lim","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518142619_CVS130C39","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.100.11.1161","article-title":"Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans","volume":"100","author":"Kanani","year":"1999","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518142619_CVS130C40","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s10495-007-0077-5","article-title":"Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis","volume":"12","author":"Sipkens","year":"2007","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t20170518142619_CVS130C41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cca.2007.01.007","article-title":"Synergistic effects of S-adenosylhomocysteine and homocysteine on DNA damage in a murine microglial cell line","volume":"379","author":"Lin","year":"2007","journal-title":"Clin Chim Acta"},{"key":"key\n\t\t\t\t20170518142619_CVS130C42","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1160\/TH05-04-0221","article-title":"Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways","volume":"94","author":"Doronzo","year":"2005","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t20170518142619_CVS130C43","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1074\/jbc.271.8.4138","article-title":"Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury","volume":"271","author":"Guyton","year":"1996","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142619_CVS130C44","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1194\/jlr.M007948","article-title":"Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease","volume":"51","author":"Wang","year":"2010","journal-title":"J Lipid Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/95\/2\/241\/17199824\/cvs130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T19:04:43Z","timestamp":1561575883000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvs130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,4,4]]},"published-print":{"date-parts":[[2012,7,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvs130","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}