{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:11:45Z","timestamp":1780938705890,"version":"3.54.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"DOI":"10.1093\/cvr\/cvs186","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:50:47Z","timestamp":1339030247000},"page":"375-384","source":"Crossref","is-referenced-by-count":13,"title":["Prolonged hypoxia augments l-citrulline transport by System A in the newborn piglet pulmonary circulation"],"prefix":"10.1093","volume":"95","author":[{"given":"Candice D.","family":"Fike","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sidoryk-Wegrzynowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Summar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kaplowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy L.","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"key\n\t\t\t\t20170523015435_CVS186C1","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1242\/jeb.00361","article-title":"The caveolar nitric oxide synthase\/arginine regneration system for NO production in endothelial cells","volume":"206","author":"Solomonson","year":"2003","journal-title":"J Exp Biol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C2","doi-asserted-by":"crossref","first-page":"L506","DOI":"10.1152\/ajplung.00017.2009","article-title":"L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets","volume":"297","author":"Ananthakrishnan","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C3","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/nm.2544","article-title":"Requirement of argininosuccinate lyase for systemic nitric oxide production","volume":"17","author":"Erez","year":"2011","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170523015435_CVS186C4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1203\/PDR.0b013e3181f90278","article-title":"L-Citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats","volume":"68","author":"Vadivel","year":"2010","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t20170523015435_CVS186C5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ymgme.2009.02.009","article-title":"Quantitative RT-PCR comparison of the urea and nitric oxide cycle gene transcripts in adult human tissues","volume":"97","author":"Neill","year":"2009","journal-title":"Mol Genet Metab"},{"key":"key\n\t\t\t\t20170523015435_CVS186C6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.clnu.2010.07.006","article-title":"Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?","volume":"29","author":"Cynober","year":"2010","journal-title":"Clin Nutr"},{"key":"key\n\t\t\t\t20170523015435_CVS186C7","doi-asserted-by":"crossref","first-page":"E473","DOI":"10.1152\/ajpendo.1981.241.6.E473","article-title":"Source and fate of circulating citrulline","volume":"241","author":"Windmueller","year":"1981","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170523015435_CVS186C8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1152\/ajplung.00405.2001","article-title":"Stereoselective transport of histidine in rat lung microvascular endothelial cells","volume":"282","author":"Sakurai","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1152\/physrev.00022.2002","article-title":"Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells","volume":"83","author":"Mann","year":"2003","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170523015435_CVS186C10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj2990321","article-title":"Regulatory and molecular aspects of mammalian amino acid transport","volume":"299","author":"McGivan","year":"1994","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170523015435_CVS186C11","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1152\/physrev.1998.78.4.969","article-title":"Molecular biology of mammalian plasma membrane amino acid transporters","volume":"78","author":"Palacin","year":"1998","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170523015435_CVS186C12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s00424-003-1117-9","article-title":"Sodium-coupled neutral amino acid (System N\/A) transporters of the SLC38 gene family","volume":"447","author":"Mackenzie","year":"2004","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20170523015435_CVS186C13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbrc.2010.06.051","article-title":"The contribution of SNAT1 to system A amino acid transporter activity in human placental trophoblast","volume":"398","author":"Desforges","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523015435_CVS186C14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00726-010-0664-6","article-title":"Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in freshly isolated rat cardiomyocytes","volume":"40","author":"King","year":"2011","journal-title":"Amino Acids"},{"key":"key\n\t\t\t\t20170523015435_CVS186C15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/toxsci\/kfm095","article-title":"Manganese induces oxidative impairment in cultured rat astrocytes","volume":"98","author":"Milatovic","year":"2007","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170523015435_CVS186C16","doi-asserted-by":"crossref","first-page":"L581","DOI":"10.1152\/ajplung.1995.269.5.L581","article-title":"Hypoxia inhibits L-arginine synthesis from L-citrulline in porcine pulmonary artery endothelial cells","volume":"269","author":"Su","year":"1995","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C17","doi-asserted-by":"crossref","first-page":"L517","DOI":"10.1152\/ajplung.1998.274.4.L517","article-title":"Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs","volume":"274","author":"Fike","year":"1998","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C18","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1152\/jappl.1986.60.3.826","article-title":"Hyperoxia reduces plasma membrane fluidity: a mechanism for endothelial cell dysfunction","volume":"60","author":"Block","year":"1986","journal-title":"J Appl Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1083\/jcb.92.2.289","article-title":"Functional angiotensin II receptors in cultured vascular smooth muscle cells","volume":"92","author":"Gunther","year":"1982","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C20","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1161\/01.CIR.86.6.1977","article-title":"Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures","volume":"86","author":"Rothman","year":"1992","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523015435_CVS186C21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1471-4159.2009.06172.x","article-title":"Manganese disrupts astrocyte glutamine transporter expression and function","volume":"110","author":"Sidoryk-Wegrzynowicz","year":"2009","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170523015435_CVS186C22","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1152\/ajplung.00345.2003","article-title":"Impaired NO signaling in small pulmonary arteries of chronically hypoxic newborn pigs","volume":"286","author":"Fike","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C23","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/S0021-9258(19)85625-9","article-title":"Characteristics of amino acid transport system in rat liver for glutamin, asparagine, histidine, and closely related analogs","volume":"255","author":"Kilberg","year":"1980","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015435_CVS186C24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0005-2736(01)00310-8","article-title":"Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A","volume":"1512","author":"Ling","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170523015435_CVS186C25","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1006\/bbrc.2001.4504","article-title":"Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N","volume":"281","author":"Nakanishi","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523015435_CVS186C26","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.2001.281.6.C1757","article-title":"Cloning and functional characterization of a new subtype of the amino acid transport system N","volume":"281","author":"Nakanishi","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/01.RES.0000097761.19223.0D","article-title":"Role of neutral amino acid transport and protein breakdown supply of nitric oxide synthase in human endothelial cells","volume":"93","author":"Simon","year":"2003","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523015435_CVS186C28","doi-asserted-by":"crossref","first-page":"C310","DOI":"10.1152\/ajpcell.00253.2002","article-title":"Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts","volume":"284","author":"Nelson","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C29","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1152\/jappl.2000.89.4.1425","article-title":"Hypoxia inhibits amino acid uptake in human lung fibroblasts","volume":"89","author":"Berk","year":"2000","journal-title":"J Appl Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000097410","article-title":"The effects of hypoxia-ischemia on neutral amino acid transporters in the developing rat brain","volume":"29","author":"Leibovici","year":"2007","journal-title":"Dev Neurosci"},{"key":"key\n\t\t\t\t20170523015435_CVS186C31","doi-asserted-by":"crossref","first-page":"C305","DOI":"10.1152\/ajpcell.00258.2005","article-title":"SNAT4 isoform of system A amino acid transporter is expressed in human placenta","volume":"290","author":"Desforges","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C32","doi-asserted-by":"crossref","first-page":"E596","DOI":"10.1152\/ajpendo.00359.2005","article-title":"Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)","volume":"291","author":"Jones","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170523015435_CVS186C33","doi-asserted-by":"crossref","first-page":"E1059","DOI":"10.1152\/ajpendo.00062.2006","article-title":"Characterization and regulationof the gene expression of amino acid transport system A (SNAT2) in rat mammary gland","volume":"291","author":"Lopez","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170523015435_CVS186C34","doi-asserted-by":"crossref","first-page":"F71","DOI":"10.1152\/ajprenal.90662.2008","article-title":"Organic anion transporter OAT1 is involved in renal handling of citruliine","volume":"297","author":"Nakakariya","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/bdd.653","article-title":"Transport characteristics of L-citrulline in reanl apical membrane of proximal tubular cells","volume":"30","author":"Mitsuoka","year":"2009","journal-title":"Biopharm Drug Dispos"},{"key":"key\n\t\t\t\t20170523015435_CVS186C36","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.clnu.2008.08.003","article-title":"Mechanisms and kinetics of citrulline uptake in a model of human intestinal epithelial cells","volume":"27","author":"Bahri","year":"2008","journal-title":"Clin Nutr"},{"key":"key\n\t\t\t\t20170523015435_CVS186C37","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1203\/00006450-199210000-00019","article-title":"Characteristics of L-citrulline transport across rat small intestine in vitro","volume":"32","author":"Vadgama","year":"1992","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t20170523015435_CVS186C38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1159\/000017468","article-title":"Transport of L-citrulline in neural cell cultures","volume":"22","author":"Schmidlin","year":"2000","journal-title":"Dev Neurosci"},{"key":"key\n\t\t\t\t20170523015435_CVS186C39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.bjp.0705407","article-title":"Role of L-citrulline transport in nitric oxide synthesis in rat aortic smooth muscle cells activated with LPS and interferon-\u03b3","volume":"140","author":"Wileman","year":"2003","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C40","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1476-5381.1994.tb13099.x","article-title":"Discrimination between citrulline and arginine transport in activated murine macrophages: inefficient synthesis of NO from recycling of citrulline to arginine","volume":"112","author":"Baydoun","year":"1994","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/abbi.1999.1643","article-title":"P1,P4-Diadenosine 5-tetraphosphate modulates L-arginine and l-citrulline uptake by bovine aortic endothelial cells","volume":"375","author":"Hilderman","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20170523015435_CVS186C42","doi-asserted-by":"crossref","first-page":"H1965","DOI":"10.1152\/ajpheart.1993.265.6.H1965","article-title":"Regulation of L-arginine synthesis from L-citrulline by L-glutamine in endothelial cells","volume":"265","author":"Wu","year":"1993","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C43","doi-asserted-by":"crossref","first-page":"L241","DOI":"10.1152\/ajplung.1991.260.4.L241","article-title":"Characterization of L-glutamine transport by pulmonary artery endothelial cells","volume":"260","author":"Herskowitz","year":"1991","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/0148607195019006477","article-title":"Inhibition of pulmonary microvascular endothelial glutamine transport by glucocorticoids and endotoxin","volume":"19","author":"Pan","year":"1995","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"key\n\t\t\t\t20170523015435_CVS186C45","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1152\/jappl.1987.63.5.1961","article-title":"Characterization of glutamic acid uptake by bovine pulmonary arterial cells","volume":"63","author":"Steiger","year":"1987","journal-title":"J Appl Physiol"},{"key":"key\n\t\t\t\t20170523015435_CVS186C46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.vph.2009.09.005","article-title":"Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow","volume":"51","author":"Sharma","year":"2009","journal-title":"Vascul Pharmacol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/95\/3\/375\/17392103\/cvs186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T22:19:17Z","timestamp":1642371557000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvs186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,6]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,6,6]]},"published-print":{"date-parts":[[2012,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvs186","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6,6]]}}}