{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T05:13:34Z","timestamp":1785042814593,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"DOI":"10.1093\/cvr\/cvs255","type":"journal-article","created":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T00:49:39Z","timestamp":1344300579000},"page":"494-503","source":"Crossref","is-referenced-by-count":27,"title":["Calcineurin regulates endothelial barrier function by interaction with and dephosphorylation of myosin phosphatase"],"prefix":"10.1093","volume":"96","author":[{"given":"Bernadett","family":"Kolozsv\u00e1ri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Bak\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"B\u00e9csi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Czikora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"V\u00e1mosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Gergely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Erd\u0151di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,6]]},"reference":[{"key":"key\n\t\t\t\t20170518142630_CVS255C1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1152\/physrev.00012.2005","article-title":"Signaling mechanisms regulating endothelial permeability","volume":"86","author":"Mehta","year":"2006","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170518142630_CVS255C2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mvr.2008.06.003","article-title":"The role of cytoskeleton in the regulation of vascular endothelial barrier function","volume":"76","author":"Bogatcheva","year":"2008","journal-title":"Microvasc Res"},{"key":"key\n\t\t\t\t20170518142630_CVS255C3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/MOH.0b013e3282f97d86","article-title":"Vascular permeability in cardiovascular disease and cancer","volume":"15","author":"Weis","year":"2008","journal-title":"Curr Opin Hematol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C4","doi-asserted-by":"crossref","first-page":"L843","DOI":"10.1152\/ajplung.00120.2007","article-title":"Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family","volume":"293","author":"Csortos","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.130.3.613","article-title":"Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation","volume":"130","author":"Goeckeler","year":"1995","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C6","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170518142630_CVS255C7","doi-asserted-by":"crossref","first-page":"37211","DOI":"10.1074\/jbc.R400018200","article-title":"Role of protein phosphatase type 1 in contractile functions: myosin phosphatase","volume":"279","author":"Hartshorne","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C8","doi-asserted-by":"crossref","first-page":"37385","DOI":"10.1074\/jbc.274.52.37385","article-title":"Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase","volume":"274","author":"Feng","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C9","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1016\/j.febslet.2005.10.055","article-title":"Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells","volume":"579","author":"Mur\u00e1nyi","year":"2005","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170518142630_CVS255C10","doi-asserted-by":"crossref","first-page":"35273","DOI":"10.1074\/jbc.R109.059972","article-title":"Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors","volume":"284","author":"Eto","year":"2009","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C11","doi-asserted-by":"crossref","first-page":"L970","DOI":"10.1152\/ajplung.00398.2003","article-title":"Role of CPI-17 in the regulation of endothelial cytoskeleton","volume":"287","author":"Kolosova","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/cvr\/cvq065","article-title":"cAMP\/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17","volume":"87","author":"Aslam","year":"2010","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518142630_CVS255C13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mvr.2003.09.007","article-title":"Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction","volume":"67","author":"Birukova","year":"2004","journal-title":"Microvasc Res"},{"key":"key\n\t\t\t\t20170518142630_CVS255C14","doi-asserted-by":"crossref","first-page":"30503","DOI":"10.1074\/jbc.M802648200","article-title":"Apolipoprotein(a), through its strong lysine-binding site in KIV(10\u2032), mediates increased endothelial cell contraction and permeability via a Rho\/Rho kinase\/MYPT1-dependent pathway","volume":"283","author":"Cho","year":"2008","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C15","doi-asserted-by":"crossref","first-page":"C1234","DOI":"10.1152\/ajpcell.00551.2007","article-title":"Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA\/Rho kinase-myosin phosphatase axis","volume":"294","author":"van Nieuw Amerongen","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(02)02451-1","article-title":"Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17","volume":"515","author":"Takizawa","year":"2002","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170518142630_CVS255C17","first-page":"L788","article-title":"Role of Ca2+\/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses","volume":"275","author":"Verin","year":"1998","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C18","doi-asserted-by":"crossref","first-page":"L546","DOI":"10.1152\/ajplung.2001.281.3.L546","article-title":"Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction","volume":"281","author":"Lum","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/cyto.a.20707","article-title":"Role of calcineurin in thrombin-mediated endothelial cell contraction","volume":"75","author":"Kolozsv\u00e1ri","year":"2009","journal-title":"Cytometry A"},{"key":"key\n\t\t\t\t20170518142630_CVS255C20","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1074\/jbc.272.6.3683","article-title":"Interactions of the subunits of smooth muscle myosin phosphatase","volume":"272","author":"Hirano","year":"1997","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C21","article-title":"Epigallocatechin-3-gallate and penta-O-galloyl-beta-d-glucose inhibit protein phosphatase-1","author":"Kiss","year":"2012","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20170518142630_CVS255C22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0076-6879(83)02025-X","article-title":"Purification and radioimmunoassay of calmodulin-dependent protein phosphatase from bovine brain","volume":"102","author":"Tallant","year":"1983","journal-title":"Methods Enzymol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C23","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.cellsig.2008.07.018","article-title":"Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A","volume":"20","author":"Kiss","year":"2008","journal-title":"Cell Signal"},{"key":"key\n\t\t\t\t20170518142630_CVS255C24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/cne.20273","article-title":"Localization of myosin phosphatase target subunit 1 in rat brain and in primary cultures of neuronal cells","volume":"478","author":"Lontay","year":"2004","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C25","doi-asserted-by":"crossref","first-page":"34496","DOI":"10.1074\/jbc.M405957200","article-title":"Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides","volume":"279","author":"Wooldridge","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1165\/ajrcmb.17.4.2502","article-title":"Thrombin-mediated focal adhesion plaque reorganization in endothelium: role of protein phosphorylation","volume":"17","author":"Schaphorst","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20170518142630_CVS255C27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/366591a0","article-title":"A morphological biosensor for mammalian cells","volume":"366","author":"Giaever","year":"1993","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170518142630_CVS255C28","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1073\/pnas.97.11.6013","article-title":"Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts","volume":"97","author":"Vereb","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170518142630_CVS255C29","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1074\/jbc.M411494200","article-title":"Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin","volume":"280","author":"Wang","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C30","doi-asserted-by":"crossref","first-page":"30361","DOI":"10.1074\/jbc.274.43.30361","article-title":"Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho\/Rho kinase and inhibition of myosin light chain phosphatase","volume":"274","author":"Essler","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C31","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1074\/jbc.M608288200","article-title":"Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin","volume":"282","author":"Singh","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142630_CVS255C32","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.cellsig.2005.01.008","article-title":"Okadaic acid induces phosphorylation and translocation of myosin phosphatase target subunit 1 influencing myosin phosphorylation, stress fiber assembly and cell migration in HepG2 cells","volume":"17","author":"Lontay","year":"2005","journal-title":"Cell Signal"},{"key":"key\n\t\t\t\t20170518142630_CVS255C33","doi-asserted-by":"crossref","first-page":"re9","DOI":"10.1126\/scisignal.2100re9","article-title":"Cracking the phosphatase code: docking interactions determine substrate specificity","volume":"2","author":"Roy","year":"2009","journal-title":"Sci Signal"},{"key":"key\n\t\t\t\t20170518142630_CVS255C34","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1046\/j.1432-1327.2000.01158.x","article-title":"Study of the subunit interactions in myosin phosphatase by surface plasmon resonance","volume":"267","author":"T\u00f3th","year":"2000","journal-title":"Eur J Biochem"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/96\/3\/494\/17200136\/cvs255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T15:42:52Z","timestamp":1562082172000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvs255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,6]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,8,6]]},"published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvs255","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,6]]}}}