{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:05:02Z","timestamp":1791104702153,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"DOI":"10.1093\/cvr\/cvs257","type":"journal-article","created":{"date-parts":[[2012,8,12]],"date-time":"2012-08-12T01:32:12Z","timestamp":1344735132000},"page":"533-542","source":"Crossref","is-referenced-by-count":34,"title":["The Cav3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice"],"prefix":"10.1093","volume":"96","author":[{"given":"Bing-Hsiean","family":"Tzeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Shiou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Rong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,10]]},"reference":[{"key":"key\n\t\t\t\t20170518142644_CVS257C1","doi-asserted-by":"crossref","first-page":"6H","DOI":"10.1016\/S0002-9149(00)01094-8","article-title":"The comparative pathobiology of atherosclerosis and restenosis","volume":"86","author":"Orford","year":"2000","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1046\/j.1538-7836.2003.00292.x","article-title":"The role of inflammation in vascular injury and repair","volume":"1","author":"Davis","year":"2003","journal-title":"J Thromb Haemost"},{"key":"key\n\t\t\t\t20170518142644_CVS257C3","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI27196","article-title":"Platelets in inflammation and atherogenesis","volume":"115","author":"Gawaz","year":"2005","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518142644_CVS257C4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/01.CIR.0000028335.31300.DA","article-title":"Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial","volume":"106","author":"Holmes","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518142644_CVS257C5","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1053\/euhj.2001.2627","article-title":"The TRAPIST Study. A multicentre randomized placebo controlled clinical trial of trapidil for prevention of restenosis after coronary stenting, measured by 3-D intravascular ultrasound","volume":"22","author":"Serruys","year":"2001","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20170518142644_CVS257C6","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1161\/01.CIR.91.6.1689","article-title":"Long-term effects of angiopeptin treatment in coronary angioplasty. Reduction of clinical events but not angiographic restenosis. European Angiopeptin Study Group","volume":"91","author":"Emanuelsson","year":"1995","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518142644_CVS257C7","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1161\/01.CIR.96.5.1482","article-title":"Effects of octreotide treatment on restenosis After coronary angioplasty: results of the VERAS study","volume":"96","author":"von Essen","year":"1997","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518142644_CVS257C8","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2174\/0929867043365008","article-title":"Blocking Ca2+ entry: a way to control cell proliferation","volume":"11","author":"Munaron","year":"2004","journal-title":"Curr Med Chem"},{"key":"key\n\t\t\t\t20170518142644_CVS257C9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/01.RES.80.5.617","article-title":"c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells","volume":"80","author":"Husain","year":"1997","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.ph.51.030189.002055","article-title":"Classes of calcium channels in vertebrate cells","volume":"51","author":"Bean","year":"1989","journal-title":"Annu Rev Physiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C11","doi-asserted-by":"crossref","first-page":"412S","DOI":"10.1093\/ajh\/4.7.412S","article-title":"Differences of calcium channels in vascular muscle in hypertension","volume":"4","author":"Hermsmeyer","year":"1991","journal-title":"Am J Hypertens"},{"key":"key\n\t\t\t\t20170518142644_CVS257C12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4161\/chan.5.6.17996","article-title":"Multi-tasking at the protein level: L-type calcium channels function as ionotropic and metabotropic activators of smooth muscle contraction","volume":"5","author":"Braun","year":"2011","journal-title":"Channels (Austin)"},{"key":"key\n\t\t\t\t20170518142644_CVS257C13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.RES.79.1.14","article-title":"Cell cycle-dependent expression of L- and T-type Ca2+ currents in rat aortic smooth muscle cells in primary culture","volume":"79","author":"Kuga","year":"1996","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00018.2002","article-title":"Molecular physiology of low-voltage-activated T-type calcium channels","volume":"83","author":"Perez-Reyes","year":"2003","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170518142644_CVS257C15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ceca.2006.04.026","article-title":"T-type Ca2+ channels in vascular smooth muscle: multiple functions","volume":"40","author":"Cribbs","year":"2006","journal-title":"Cell calcium"},{"key":"key\n\t\t\t\t20170518142644_CVS257C16","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.0000163066.07472.ff","article-title":"Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes","volume":"96","author":"Rodman","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C17","doi-asserted-by":"crossref","first-page":"24025","DOI":"10.1074\/jbc.M109.017061","article-title":"T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation","volume":"284","author":"Akaike","year":"2009","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142644_CVS257C18","doi-asserted-by":"crossref","first-page":"C517","DOI":"10.1152\/ajpcell.00107.2010","article-title":"Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells","volume":"300","author":"Pluteanu","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0002-9149(94)90805-2","article-title":"A meta-analysis of randomized trials of calcium antagonists to reduce restenosis after coronary angioplasty","volume":"73","author":"Hillegass","year":"1994","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C20","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0735-1097(99)00599-9","article-title":"Restenosis and clinical outcome in patients treated with amlodipine after angioplasty: results from the Coronary AngioPlasty Amlodipine REStenosis Study (CAPARES)","volume":"35","author":"Jorgensen","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C21","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1016\/j.jacc.2004.02.047","article-title":"Evaluation of the effect of oral verapamil on clinical outcome and angiographic restenosis after percutaneous coronary intervention: the randomized, double-blind, placebo-controlled, multicenter Verapamil Slow-Release for Prevention of Cardiovascular Events After Angioplasty (VESPA) Trial","volume":"43","author":"Bestehorn","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1067\/mhj.2003.171","article-title":"An updated meta-analysis of calcium-channel blockers in the prevention of restenosis after coronary angioplasty","volume":"145","author":"Dens","year":"2003","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20170518142644_CVS257C23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.fjc.0000154374.88283.15","article-title":"Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (\u03b11G) expressed in Xenopus oocytes","volume":"45","author":"Furukawa","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/mol.110.069492","article-title":"Verapamil block of T-type calcium channels","volume":"79","author":"Bergson","year":"2011","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C25","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.ATV.15.8.1161","article-title":"Mibefradil prevents neointima formation after vascular injury in rats. Possible role of the blockade of the T-type voltage-operated calcium channel","volume":"15","author":"Schmitt","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0896-6273(01)00343-9","article-title":"Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking \u03b11G T-type Ca2+ channels","volume":"31","author":"Kim","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170518142644_CVS257C27","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1126\/science.1089268","article-title":"Abnormal coronary function in mice deficient in \u03b11H T-type Ca2+ channels","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170518142644_CVS257C28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1023\/A:1016357510143","article-title":"Isolation of vascular smooth muscle cells from a single murine aorta","volume":"23","author":"Lynn Ray","year":"2001","journal-title":"Methods in Cell Science"},{"key":"key\n\t\t\t\t20170518142644_CVS257C29","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/3-540-26574-0_33","article-title":"In vitro cultivation of vascular smooth muscle cells","volume-title":"Practical methods in cardiovascular research","author":"Sedding","year":"2005"},{"key":"key\n\t\t\t\t20170518142644_CVS257C30","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0008-6363(00)00304-7","article-title":"Inhibition by leukocyte depletion of neointima formation after balloon angioplasty in a rabbit model of restenosis","volume":"49","author":"Miller","year":"2001","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C31","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1161\/01.STR.0000241068.50156.82","article-title":"Increased balloon-induced inflammation, proliferation, and neointima formation in apolipoprotein E (ApoE) knockout mice","volume":"37","author":"Matter","year":"2006","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20170518142644_CVS257C32","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/01.RES.0000225862.14314.49","article-title":"Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1\/\u03b11G T-type calcium channels","volume":"98","author":"Mangoni","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C33","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1126\/science.1329201","article-title":"Association of human cyclin E with a periodic G1-S phase protein kinase","volume":"257","author":"Dulic","year":"1992","journal-title":"Science"},{"key":"key\n\t\t\t\t20170518142644_CVS257C34","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0955-0674(00)00151-4","article-title":"Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle","volume":"12","author":"Ekholm","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.HYP.0000082360.65547.7C","article-title":"Different cell cycle regulation of vascular smooth muscle in genetic hypertension","volume":"42","author":"Tanner","year":"2003","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170518142644_CVS257C36","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/01.RES.0000223059.19250.91","article-title":"A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1\/S transitions in vascular smooth muscle cells","volume":"98","author":"Choi","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C37","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/CIRCRESAHA.110.239483","article-title":"Peptide-mediated disruption of calmodulin-cyclin E interactions inhibits proliferation of vascular smooth muscle cells and neointima formation","volume":"108","author":"Hui","year":"2011","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C38","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1074\/jbc.275.4.2676","article-title":"De novo design of peptides targeted to the EF hands of calmodulin","volume":"275","author":"Villain","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518142644_CVS257C39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000151767","article-title":"The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles","volume":"46","author":"Braunstein","year":"2009","journal-title":"J Vasc Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C40","doi-asserted-by":"crossref","first-page":"H1371","DOI":"10.1152\/ajpheart.01368.2006","article-title":"Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?","volume":"293","author":"Figueroa","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C41","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/01.RES.85.9.e33","article-title":"Molecular cloning and characterization of the intermediate-conductance Ca2+-activated K+ channel in vascular smooth muscle: relationship between KCa channel diversity and smooth muscle cell function","volume":"85","author":"Neylon","year":"1999","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C42","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1161\/01.RES.0000194322.91255.13","article-title":"Contribution of Kv channels to phenotypic remodeling of human uterine artery smooth muscle cells","volume":"97","author":"Miguel-Velado","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C43","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/cvr\/cvq305","article-title":"Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers","volume":"89","author":"Cheong","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C44","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.CIR.0000086464.04719.DD","article-title":"Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis","volume":"108","author":"Kohler","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170518142644_CVS257C45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ceca.2006.04.017","article-title":"T-type calcium channels in differentiation and proliferation","volume":"40","author":"Lory","year":"2006","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20170518142644_CVS257C46","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1006\/jmcc.1998.0675","article-title":"Cell cycle-related changes in the voltage-gated Ca2+ currents in cultured newborn rat ventricular myocytes","volume":"30","author":"Guo","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170518142644_CVS257C47","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/bies.950170605","article-title":"Calcium signalling and cell proliferation","volume":"17","author":"Berridge","year":"1995","journal-title":"Bioessays"},{"key":"key\n\t\t\t\t20170518142644_CVS257C48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/bbrc.1998.8086","article-title":"The role of calcium in the cell cycle: facts and hypotheses","volume":"244","author":"Santella","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170518142644_CVS257C49","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1210\/er.2003-0008","article-title":"Regulation of cell cycle progression by calcium\/calmodulin-dependent pathways","volume":"24","author":"Kahl","year":"2003","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170518142644_CVS257C50","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jcb.10295","article-title":"Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta","volume":"87","author":"Ihara","year":"2002","journal-title":"J Cell Biochem"},{"key":"key\n\t\t\t\t20170518142644_CVS257C51","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0008-6363(00)00210-8","article-title":"Transient down-regulation of L-type Ca2+ channel and dystrophin expression after balloon injury in rat aortic cells","volume":"49","author":"Quignard","year":"2001","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518142644_CVS257C52","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.103.060814","article-title":"NNC55\u20130396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels","volume":"309","author":"Huang","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170518142644_CVS257C53","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1124\/dmd.107.020115","article-title":"The mibefradil derivative NNC55\u20130396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil","volume":"36","author":"Bui","year":"2008","journal-title":"Drug Metab Dispos"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/96\/3\/533\/17200198\/cvs257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T19:43:43Z","timestamp":1562096623000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvs257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,10]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,8,10]]},"published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvs257","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,10]]}}}