{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:12:05Z","timestamp":1789877525982,"version":"4.0.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"DOI":"10.1093\/cvr\/cvt064","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T20:58:41Z","timestamp":1363899521000},"page":"24-34","source":"Crossref","is-referenced-by-count":70,"title":["Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension"],"prefix":"10.1093","volume":"99","author":[{"given":"Yvonne","family":"Dempsie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"MacRitchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Morecroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey F.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Nilsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Loughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty M.","family":"Mair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"MacLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"key\n\t\t\t\t20170523020239_CVT064C1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1164\/rccm.200510-1668OC","article-title":"Pulmonary arterial hypertension in France: results from a national registry","volume":"173","author":"Humbert","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170523020239_CVT064C2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1183\/09031936.00092306","article-title":"An epidemiological study of pulmonary arterial hypertension","volume":"30","author":"Peacock","year":"2007","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20170523020239_CVT064C3","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1183\/09031936.00042107","article-title":"A USA-based registry for pulmonary arterial hypertension: 1982\u20132006","volume":"30","author":"Thenappan","year":"2007","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20170523020239_CVT064C4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1465-9921-12-159","article-title":"Development of pulmonary arterial hypertension in mice over-expressing S100A4\/Mts1 is specific to females","volume":"12","author":"Dempsie","year":"2011","journal-title":"Respir Res"},{"key":"key\n\t\t\t\t20170523020239_CVT064C5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/cvr\/cvq408","article-title":"The serotonin transporter, gender, and 17beta oestradiol in the development of pulmonary arterial hypertension","volume":"90","author":"White","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523020239_CVT064C6","first-page":"3440","article-title":"Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity","volume":"60","author":"Hanna","year":"2000","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170523020239_CVT064C7","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1053\/meta.2001.25592","article-title":"Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol","volume":"50","author":"Badawi","year":"2001","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20170523020239_CVT064C8","first-page":"3026","article-title":"Tumor-specific expression of cytochrome P450 CYP1B1","volume":"57","author":"Murray","year":"1997","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170523020239_CVT064C9","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1158\/1535-7163.MCT-10-0673","article-title":"Cytochrome P450 1B1 gene polymorphisms as predictors of anticancer drug activity: studies with in vitro models","volume":"9","author":"Laroche-Clary","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"key\n\t\t\t\t20170523020239_CVT064C10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/hmg\/6.4.641","article-title":"Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21","volume":"6","author":"Stoilov","year":"1997","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170523020239_CVT064C11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/HYPERTENSIONAHA.110.154518","article-title":"Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology","volume":"56","author":"Jennings","year":"2010","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523020239_CVT064C12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1755-8794-1-45","article-title":"Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance","volume":"1","author":"West","year":"2008","journal-title":"BMC Med Genomics"},{"key":"key\n\t\t\t\t20170523020239_CVT064C13","doi-asserted-by":"crossref","first-page":"L474","DOI":"10.1152\/ajplung.00202.2011","article-title":"Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension","volume":"302","author":"Johnson","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C14","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/CIRCULATIONAHA.111.062927","article-title":"Activity of the estrogen metabolising enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension","volume":"126","author":"White","year":"2012","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523020239_CVT064C15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1152\/physiolgenomics.00249.2010","article-title":"Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH","volume":"43","author":"White","year":"2011","journal-title":"Physiol Genomics"},{"key":"key\n\t\t\t\t20170523020239_CVT064C16","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1056\/NEJM199608293350901","article-title":"Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group","volume":"335","author":"Abenhaim","year":"1996","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170523020239_CVT064C17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0895-4356(97)00289-8","article-title":"Aminorex, dexfenfluramine, and primary pulmonary hypertension","volume":"51","author":"Kramer","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C18","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/01.CIR.100.8.869","article-title":"Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates - implications for primary pulmonary hypertension","volume":"100","author":"Rothman","year":"1999","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523020239_CVT064C19","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1161\/CIRCULATIONAHA.108.767558","article-title":"Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice","volume":"117","author":"Dempsie","year":"2008","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523020239_CVT064C20","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1378\/chest.130.6.1657","article-title":"Is methamphetamine use associated with idiopathic pulmonary arterial hypertension?","volume":"130","author":"Chin","year":"2006","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170523020239_CVT064C21","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1183\/09031936.00188611","article-title":"Pulmonary hypertension associated with benfluorex exposure","volume":"40","author":"Savale","year":"2012","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20170523020239_CVT064C22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1081\/DMR-100101929","article-title":"Cytochrome P450-null mice","volume":"31","author":"Buters","year":"1999","journal-title":"Drug Metab Rev"},{"key":"key\n\t\t\t\t20170523020239_CVT064C23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/cvr\/cvp306","article-title":"In vivo effects of a combined 5-HT1B receptor\/SERT antagonist in experimental pulmonary hypertension","volume":"85","author":"Morecroft","year":"2010","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523020239_CVT064C24","doi-asserted-by":"crossref","first-page":"L531","DOI":"10.1152\/ajplung.00247.2003","article-title":"Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine","volume":"286","author":"Hong","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C25","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.vph.2006.05.007","article-title":"2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension","volume":"45","author":"Tofovic","year":"2006","journal-title":"Vasc Pharmacol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C26","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1183\/09031936.00010409","article-title":"Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females","volume":"34","author":"Austin","year":"2009","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20170523020239_CVT064C27","doi-asserted-by":"crossref","first-page":"e17735","DOI":"10.1371\/journal.pone.0017735","article-title":"Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension","volume":"6","author":"Rothman","year":"2011","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170523020239_CVT064C28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/bjp.2008.241","article-title":"Pulmonary hypertension: therapeutic targets within the serotonin system","volume":"155","author":"Dempsie","year":"2008","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1742-1241.2007.01497.x","article-title":"Pulmonary hypertension and the serotonin hypothesis: where are we now?","volume":"156","author":"MacLean","year":"2007","journal-title":"Int J Clin Pract Suppl"},{"key":"key\n\t\t\t\t20170523020239_CVT064C30","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/01.CIR.94.9.2216","article-title":"Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction","volume":"94","author":"Weir","year":"1996","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523020239_CVT064C31","doi-asserted-by":"crossref","first-page":"L662","DOI":"10.1152\/ajplung.1999.277.3.L662","article-title":"Dexfenfluramine increases pulmonary smooth muscle intracellular Ca2+ independent of membrane potential","volume":"277","author":"Reeve","year":"1999","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1378\/chest.116.4.921","article-title":"The acute effects of dexfenfluramine on human and porcine pulmonary vascular tone and resistance","volume":"116","author":"Higenbottam","year":"1999","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170523020239_CVT064C33","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1096\/fj.00-0431fje","article-title":"Dexfenfluramine as a mitogen signal via the formation of superoxide anion","volume":"15","author":"Lee","year":"2001","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170523020239_CVT064C34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0163-7258(02)00234-6","article-title":"Therapeutic and adverse actions of serotonin transporter substrates","volume":"95","author":"Rothman","year":"2002","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t20170523020239_CVT064C35","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nm764","article-title":"Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension","volume":"8","author":"Launay","year":"2002","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170523020239_CVT064C36","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.cardiores.2003.09.023","article-title":"Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats","volume":"60","author":"Hironaka","year":"2003","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523020239_CVT064C37","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1006\/bbrc.1994.2107","article-title":"Circulating nitrite\/nitrate levels increase with follicular development: indirect evidence for estradiol-mediated NO release","volume":"202","author":"Rosselli","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523020239_CVT064C38","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1164\/ajrccm.158.4.9802113","article-title":"Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension","volume":"158","author":"Archer","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170523020239_CVT064C39","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1183\/09031936.02.01762002","article-title":"BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives","volume":"20","author":"Humbert","year":"2002","journal-title":"Eur Respir J"},{"issue":"3 suppl","key":"key\n\t\t\t\t20170523020239_CVT064C40","doi-asserted-by":"crossref","first-page":"195S","DOI":"10.1378\/chest.114.3_Supplement.195S","article-title":"Primary pulmonary hypertension associated with the use of fenfluramine derivatives","volume":"114","author":"Simonneau","year":"1998","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170523020239_CVT064C41","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1164\/rccm.201107-1293OC","article-title":"17beta-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects","volume":"185","author":"Lahm","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170523020239_CVT064C42","first-page":"25","article-title":"Progesterone inhibits vascular remodeling and attenuates monocrotaline-induced pulmonary hypertension in estrogen-deficient rats","volume":"30","author":"Tofovic","year":"2009","journal-title":"Prilozi"},{"key":"key\n\t\t\t\t20170523020239_CVT064C43","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1161\/01.CIR.0000127375.56172.92","article-title":"Overexpression of the 5-hydroxytryptamine transporter gene\u2014effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension","volume":"109","author":"MacLean","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523020239_CVT064C44","doi-asserted-by":"crossref","first-page":"L1556","DOI":"10.1152\/ajplung.00305.2006","article-title":"Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH","volume":"292","author":"Tada","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C45","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1165\/rcmb.2010-0316OC","article-title":"Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension","volume":"45","author":"Weng","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20170523020239_CVT064C46","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4103\/2045-8932.101647","article-title":"Testosterone negatively regulates right ventricular load stress responses in mice","volume":"2","author":"Hemnes","year":"2012","journal-title":"Pulm Circ"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/99\/1\/24\/17393806\/cvt064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T02:31:52Z","timestamp":1562812312000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvt064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,20]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,3,20]]},"published-print":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvt064","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3,20]]}}}