{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:43:35Z","timestamp":1785509015008,"version":"3.56.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"DOI":"10.1093\/cvr\/cvt087","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:47:47Z","timestamp":1365468467000},"page":"215-224","source":"Crossref","is-referenced-by-count":40,"title":["Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation"],"prefix":"10.1093","volume":"99","author":[{"given":"Sarah","family":"Kettlewell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis L.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony J.","family":"Workman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,8]]},"reference":[{"key":"key\n\t\t\t\t20170624112705_CVT087C1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/europace\/eup328","article-title":"Animal models for atrial fibrillation: clinical insights and scientific opportunities","volume":"12","author":"Nishida","year":"2010","journal-title":"Europace"},{"key":"key\n\t\t\t\t20170624112705_CVT087C2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2009","article-title":"Pathophysiological mechanisms of atrial fibrillation: a translational appraisal","volume":"91","author":"Schotten","year":"2011","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170624112705_CVT087C3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.hrthm.2008.01.016","article-title":"Cellular bases for human atrial fibrillation","volume":"5","author":"Workman","year":"2008","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20170624112705_CVT087C4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1540-8167.2003.02519.x","article-title":"Characterization of sustained atrial tachycardia in dogs with rapid ventricular pacing-induced heart failure","volume":"14","author":"Stambler","year":"2003","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/CIRCEP.107.754788","article-title":"Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure","volume":"1","author":"Yeh","year":"2008","journal-title":"Circ Arrhythmia Electrophysiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C6","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.CIR.101.22.2631","article-title":"Effects of experimental heart failure on atrial cellular and ionic electrophysiology","volume":"101","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624112705_CVT087C7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/cvr\/cvp216","article-title":"Chronic heart failure and the substrate for atrial fibrillation","volume":"84","author":"Sridhar","year":"2009","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C8","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1113\/jphysiol.2010.203984","article-title":"Impaired \u03b2-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure","volume":"589","author":"Briston","year":"2011","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/CIRCEP.112.973214","article-title":"Role for microRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure","volume":"5","author":"Cardin","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.CIR.0000080327.32573.7C","article-title":"Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction. Implications for atrial fibrillation","volume":"108","author":"Miyauchi","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624112705_CVT087C11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0008-6363(99)00360-0","article-title":"Heterogeneous changes in action potential and intracellular Ca2+ in left ventricular myocyte sub-types from rabbits with heart failure","volume":"45","author":"McIntosh","year":"2000","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0008-6363(97)00255-1","article-title":"Non-uniform prolongation of intracellular Ca2+ transients recorded from the epicardial surface of isolated hearts from rabbits with heart failure","volume":"37","author":"Ng","year":"1998","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1161\/01.CIR.0000020009.30736.3F","article-title":"Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease","volume":"106","author":"Bolger","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624112705_CVT087C14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00210-009-0474-0","article-title":"Cardiac adrenergic control and atrial fibrillation","volume":"381","author":"Workman","year":"2010","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/hh1901.096702","article-title":"Mechanisms of L-type Ca2+ current downregulation in rat atrial myocytes during heart failure","volume":"89","author":"Boixel","year":"2001","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C16","first-page":"H1047","article-title":"Regulation of cardiac alternans by \u03b2-adrenergic signaling pathways","volume":"303","author":"Florea","year":"2012","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C17","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1161\/CIRCULATIONAHA.110.977827","article-title":"Repolarization alternans reveals vulnerability to human atrial fibrillation","volume":"123","author":"Narayan","year":"2011","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624112705_CVT087C18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1113\/jphysiol.2002.025239","article-title":"Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes","volume":"546","author":"Blatter","year":"2003","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C19","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cardiores.2006.12.001","article-title":"Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart","volume":"73","author":"Ng","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C20","first-page":"H2310","article-title":"Refractoriness of sarcoplasmic reticulum Ca2+ release determines Ca2+ alternans in atrial myocytes","volume":"302","author":"Shkryl","year":"2012","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/01.CIR.100.1.87","article-title":"Promotion of atrial fibrillation by heart failure in dogs. Atrial remodeling of a different sort","volume":"100","author":"Li","year":"1999","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624112705_CVT087C22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pharmthera.2011.02.002","article-title":"Mechanisms of termination and prevention of atrial fibrillation by drug therapy","volume":"131","author":"Workman","year":"2011","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t20170624112705_CVT087C23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/cvr\/cvn133","article-title":"Remodelling of gap junctions and connexin expression in diseased myocardium","volume":"80","author":"Severs","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/CIRCHEARTFAILURE.109.852228","article-title":"Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure","volume":"2","author":"Dibb","year":"2009","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20170624112705_CVT087C25","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1006\/jmcc.2000.1186","article-title":"Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium","volume":"32","author":"Workman","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1113\/jphysiol.2003.050716","article-title":"Myocardial infarction causes increased expression but decreased activity of the myocardial Na+-Ca2+ exchanger in the rabbit","volume":"553","author":"Quinn","year":"2003","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/01.RES.0000081596.90205.E2","article-title":"Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes","volume":"93","author":"Seidler","year":"2003","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C28","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0735-1097(03)00578-3","article-title":"Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat","volume":"42","author":"Boixel","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.hrthm.2007.12.010","article-title":"Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure","volume":"5","author":"Shimano","year":"2008","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20170624112705_CVT087C30","first-page":"H1385","article-title":"Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences","volume":"303","author":"Zhang","year":"2012","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C31","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/CIRCRESAHA.108.183400","article-title":"Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure","volume":"105","author":"Burstein","year":"2009","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1540-8167.2011.02197.x","article-title":"Spontaneous atrial fibrillation initiated by tyramine in canine atria with increased sympathetic nerve sprouting","volume":"23","author":"Numata","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C33","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/eurjhf\/hfs163","article-title":"Further insights into the underlying electrophysiological mechanisms for reduction of atrial fibrillation by ranolazine in an experimental model of chronic heart failure","volume":"14","author":"Frommeyer","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20170624112705_CVT087C34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00210-011-0723-x","article-title":"Differential expression of potassium channels and abnormal conduction in experimental tachycardia-induced heart failure","volume":"385","author":"Birner","year":"2012","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2002.026468","article-title":"Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito)","volume":"546","author":"Sah","year":"2003","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.hrthm.2008.12.028","article-title":"Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF","volume":"6","author":"Workman","year":"2009","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20170624112705_CVT087C37","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1113\/jphysiol.2012.235986","article-title":"Transient outward K+ current reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes","volume":"17","author":"Workman","year":"2012","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C38","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1172\/JCI116315","article-title":"Downregulation of cardiac guanosine 5\u2032-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive heart failure","volume":"91","author":"Roth","year":"1993","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170624112705_CVT087C39","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/BF00265923","article-title":"Regional distribution of \u03b21- and \u03b22-adrenoceptors in the failing and nonfailing human heart","volume":"42","author":"Steinfath","year":"1992","journal-title":"Eur J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1006\/jmcc.1996.0301","article-title":"Sympathetic modulation of the effect of nifedipine on myocardial contraction and Ca current in the rat","volume":"29","author":"Legssyer","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C41","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1113\/jphysiol.2008.164368","article-title":"The effects of membrane potential, SR Ca2+ content and RyR responsiveness on systolic Ca2+ alternans in rat ventricular myocytes","volume":"587","author":"Li","year":"2009","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C42","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1113\/jphysiol.2010.197715","article-title":"Sarcoplasmic reticulum and L-type Ca2+ channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytes","volume":"589","author":"Llach","year":"2011","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C43","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.yjmcc.2005.06.004","article-title":"Molecular correlates of repolarization alternans in cardiac myocytes","volume":"39","author":"Wan","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.2002.025502","article-title":"Subcellular Ca2+ alternans represents a novel mechanism for the generation of arrhythmogenic Ca2+ waves in cat atrial myocytes","volume":"545","author":"Kockskamper","year":"2002","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C45","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1536\/ihj.51.354","article-title":"Electrical remodeling in fibrillating canine atrium: action potential alternans during rapid atrial pacing and late phase 3 early afterdepolarization after cessation of rapid atrial pacing","volume":"51","author":"Watanabe","year":"2010","journal-title":"Int Heart J"},{"key":"key\n\t\t\t\t20170624112705_CVT087C46","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1161\/CIRCRESAHA.109.206276","article-title":"Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation","volume":"105","author":"Lenaerts","year":"2009","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624112705_CVT087C47","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1161\/CIRCEP.109.933036","article-title":"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs","volume":"3","author":"Wakili","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.yjmcc.2003.11.002","article-title":"\u03b2-adrenergic stimulation restores the Ca transient of ventricular myocytes lacking t-tubules","volume":"36","author":"Brette","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170624112705_CVT087C49","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.bpj.2012.03.007","article-title":"Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation study","volume":"102","author":"Li","year":"2012","journal-title":"Biophys J"},{"key":"key\n\t\t\t\t20170624112705_CVT087C50","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1073\/pnas.1120188109","article-title":"Action potential propagation in transverse-axial tubular system is impaired in heart failure","volume":"109","author":"Sacconi","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170624112705_CVT087C51","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1161\/01.CIR.0000141296.59876.87","article-title":"Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes","volume":"110","author":"Hove-Madsen","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624112705_CVT087C52","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1161\/CIRCULATIONAHA.111.067306","article-title":"Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation","volume":"125","author":"Voigt","year":"2012","journal-title":"Circulation"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/99\/1\/215\/17878157\/cvt087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T23:02:49Z","timestamp":1503442969000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvt087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,8]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,4,8]]},"published-print":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvt087","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,8]]}}}