{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:35:16Z","timestamp":1787654116656,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"DOI":"10.1093\/cvr\/cvt129","type":"journal-article","created":{"date-parts":[[2013,5,26]],"date-time":"2013-05-26T00:45:23Z","timestamp":1369529123000},"page":"404-411","source":"Crossref","is-referenced-by-count":21,"title":["Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization"],"prefix":"10.1093","volume":"99","author":[{"given":"Igor V.","family":"Kizub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ievgen V.","family":"Strielkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Shaifta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Prieto-Lloret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A.","family":"Snetkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly I.","family":"Soloviev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip I.","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.T.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,5,25]]},"reference":[{"key":"key\n\t\t\t\t20170624112801_CVT129C1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physrev.00041.2010","article-title":"Hypoxic pulmonary vasoconstriction","volume":"92","author":"Sylvester","year":"2012","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170624112801_CVT129C2","doi-asserted-by":"crossref","first-page":"L223","DOI":"10.1152\/ajplung.1994.266.3.L223","article-title":"Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries","volume":"266","author":"Leach","year":"1994","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1469-7793.2000.t01-1-00669.x","article-title":"Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat","volume":"525","author":"Robertson","year":"2000","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C4","doi-asserted-by":"crossref","first-page":"L318","DOI":"10.1152\/ajplung.2001.281.2.L318","article-title":"Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle","volume":"281","author":"Dipp","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/sj.bjp.0703537","article-title":"Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat","volume":"131","author":"Robertson","year":"2000","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/cvr\/cvn209","article-title":"Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery","volume":"80","author":"Knock","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112801_CVT129C7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1469-7793.2001.00211.x","article-title":"Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor","volume":"536","author":"Leach","year":"2001","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C8","doi-asserted-by":"crossref","first-page":"L1121","DOI":"10.1152\/ajplung.00422.2002","article-title":"Ca2+ sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium dependent","volume":"284","author":"Robertson","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.vph.2012.06.001","article-title":"Selective glycolysis blockade in guinea pig pulmonary artery and aorta reverses contractile and electrical responses to acute hypoxia","volume":"57","author":"Soloviev","year":"2012","journal-title":"Vascul Pharmacol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/ars.2008.2117","article-title":"Gap junctions in the control of vascular function","volume":"11","author":"Figueroa","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170624112801_CVT129C11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/ars.2008.2115","article-title":"Connexins in vascular physiology and pathology","volume":"11","author":"Brisset","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170624112801_CVT129C12","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","article-title":"Plasma membrane channels formed by connexins: their regulation and functions","volume":"83","author":"Saez","year":"2003","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170624112801_CVT129C13","doi-asserted-by":"crossref","first-page":"e6432","DOI":"10.1371\/journal.pone.0006432","article-title":"Vascular smooth muscle modulates endothelial control of vasoreactivity via reactive oxygen species production through myoendothelial communications","volume":"4","author":"Billaud","year":"2009","journal-title":"PloS one"},{"key":"key\n\t\t\t\t20170624112801_CVT129C14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0026-2862(86)90043-9","article-title":"The structure of the wall of the rat intraacinar pulmonary artery: an electron microscopic study of microdissected preparations","volume":"32","author":"Davies","year":"1986","journal-title":"Microvasc Res"},{"key":"key\n\t\t\t\t20170624112801_CVT129C15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1465-9921-12-30","article-title":"Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension","volume":"12","author":"Billaud","year":"2011","journal-title":"Respir Res"},{"key":"key\n\t\t\t\t20170624112801_CVT129C16","doi-asserted-by":"crossref","first-page":"H1762","DOI":"10.1152\/ajpheart.00831.2002","article-title":"EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs","volume":"284","author":"Morio","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C17","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1172\/JCI59176","article-title":"Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction","volume":"122","author":"Wang","year":"2012","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170624112801_CVT129C18","first-page":"94","article-title":"Pharmacokinetic analysis of alpha and beta epimers of glycyrrhetinic acid in rat plasma: differences in singly and combined administrations","volume":"47","author":"Sun","year":"2012","journal-title":"Yao Xue Xue Bao"},{"key":"key\n\t\t\t\t20170624112801_CVT129C19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cardiores.2004.01.019","article-title":"Pharmacology of gap junctions in the cardiovascular system","volume":"62","author":"Dhein","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112801_CVT129C20","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1124\/jpet.106.112045","article-title":"Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)","volume":"319","author":"Bai","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170624112801_CVT129C21","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1096\/fj.02-0037rev","article-title":"2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release","volume":"16","author":"Bootman","year":"2002","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170624112801_CVT129C22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.bjp.0705408","article-title":"Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat","volume":"140","author":"Snetkov","year":"2003","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C23","doi-asserted-by":"crossref","first-page":"H301","DOI":"10.1152\/ajpheart.1995.268.1.H301","article-title":"Hypoxic vasoconstriction and intracellular Ca2+ in pulmonary arteries: evidence for PKC-independent Ca2+ sensitization","volume":"268","author":"Robertson","year":"1995","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.coph.2009.02.006","article-title":"Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem","volume":"9","author":"Ward","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1113\/jphysiol.2005.098855","article-title":"Hypoxic pulmonary vasoconstriction: mechanisms and controversies","volume":"570","author":"Aaronson","year":"2006","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1615\/IntJPhysPathophys.v1.i2.40","article-title":"Hypoxic pulmonary hypertension: The role of phosphatidylcholine-specific phospholipase C","volume":"1","author":"Strielkov","year":"2010","journal-title":"Int J Phys Pathophys"},{"key":"key\n\t\t\t\t20170624112801_CVT129C27","doi-asserted-by":"crossref","first-page":"19093","DOI":"10.1073\/pnas.0606728103","article-title":"Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange","volume":"103","author":"Weissmann","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170624112801_CVT129C28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/japplphysiol.00903.2004","article-title":"Two temporal components within the human pulmonary vascular response to approximately 2 h of isocapnic hypoxia","volume":"98","author":"Talbot","year":"2005","journal-title":"J Appl Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C29","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1476-5381.2009.00353.x","article-title":"Organ culture mimics the effects of hypoxia on membrane potential, K(+) channels and vessel tone in pulmonary artery","volume":"158","author":"Manoury","year":"2009","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C30","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0024-3205(95)00001-M","article-title":"Modulation of alpha 1-adrenergic contractility in isolated vascular tissues by heptanol: a functional demonstration of the potential importance of intercellular communication to vascular response generation","volume":"56","author":"Christ","year":"1995","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20170624112801_CVT129C31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2174\/1389450023347399","article-title":"The physiology, pathophysiology and therapeutic potential of gap junctions in smooth muscle","volume":"3","author":"Lagaud","year":"2002","journal-title":"Curr Drug Targets"},{"key":"key\n\t\t\t\t20170624112801_CVT129C32","doi-asserted-by":"crossref","first-page":"H2677","DOI":"10.1152\/ajpheart.00016.2004","article-title":"Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries","volume":"287","author":"Earley","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2008.01.018","article-title":"Pharmacological profile of store-operated Ca(2+) entry in intrapulmonary artery smooth muscle cells","volume":"584","author":"McElroy","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C34","doi-asserted-by":"crossref","first-page":"L5","DOI":"10.1152\/ajplung.00044.2005","article-title":"Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channels","volume":"289","author":"Weigand","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C35","doi-asserted-by":"crossref","first-page":"11388","DOI":"10.1073\/pnas.1434298100","article-title":"Gating and regulation of connexin 43 (Cx43) hemichannels","volume":"100","author":"Contreras","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170624112801_CVT129C36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/sj.ki.5002673","article-title":"Expression and role of connexins in the rat renal vasculature","volume":"73","author":"Takenaka","year":"2008","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170624112801_CVT129C37","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/sj.bjp.0705870","article-title":"Junctional and nonjunctional effects of heptanol and glycyrrhetinic acid derivates in rat mesenteric small arteries","volume":"142","author":"Matchkov","year":"2004","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C38","doi-asserted-by":"crossref","first-page":"L657","DOI":"10.1152\/ajplung.1998.274.4.L657","article-title":"Hypoxic pulmonary endothelial cells release a diffusible contractile factor distinct from endothelin","volume":"274","author":"Gaine","year":"1998","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0008-6363(01)00192-4","article-title":"Hypoxia induces the release of a pulmonary-selective, Ca2+-sensitising, vasoconstrictor from the perfused rat lung","volume":"50","author":"Robertson","year":"2001","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624112801_CVT129C40","doi-asserted-by":"crossref","first-page":"L767","DOI":"10.1152\/ajplung.00183.2012","article-title":"Serotonin passes through myoendothelial gap junctions to promote pulmonary arterial smooth muscle cell differentiation","volume":"303","author":"Gairhe","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170624112801_CVT129C41","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1164\/rccm.200805-691OC","article-title":"RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling","volume":"179","author":"Guilluy","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170624112801_CVT129C42","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/hh1201.091960","article-title":"Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing","volume":"88","author":"Waypa","year":"2001","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624112801_CVT129C43","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.freeradbiomed.2008.11.015","article-title":"Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca2+ sensitization","volume":"46","author":"Knock","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t20170624112801_CVT129C44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2009.2861","article-title":"Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells","volume":"12","author":"Chi","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20170624112801_CVT129C45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1465-9921-12-20","article-title":"Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6","volume":"12","author":"Fuchs","year":"2011","journal-title":"Respir Res"},{"key":"key\n\t\t\t\t20170624112801_CVT129C46","first-page":"PC358","article-title":"Evidence of phosphatidylcholine-specific phospholipase C involvement in hypoxic pulmonary vasoconstriction","volume":"23","author":"Strielkov","year":"2011","journal-title":"Proc Physiol Soc"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/99\/3\/404\/17878182\/cvt129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T04:46:17Z","timestamp":1563079577000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvt129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,25]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,5,25]]},"published-print":{"date-parts":[[2013,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvt129","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,25]]}}}